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Here the authors unveil the essential role of MCL-1 for adult hair follicle regeneration and inhibition of proliferation stress-induced apoptosis in mice. They also identify a P53/MCL-1/BAK axis balancing proliferation and death of activated hair follicle stem cells to ensure proper hair growth.

Chen et al. show that the endoplasmic reticulum stress sensor IRE1α acts in white and beige adipocytes to restrain beige adipocyte activation, through regulation of lipolysis and Pgc1α messenger RNA levels, respectively.

Microscale ferroelectric topological textures in freestanding BaTiO₃ nanomembranes enable dynamic vortex light manipulation via nonlinear spin-to-orbit conversion.

The red fluorescent protein mScarlet3-H is bright, photostable and very robust to high temperature, chaotropic conditions and oxidative environments. mScarlet3-H works well in correlative light and electron microscopy, tissue clearing and time-lapse super-resolution microscopy.

To maintain the efficacy of drugs metabolized by CYP3A4, pan-CYP3A inhibitor is often co-administered, but the high homology between CYP3A4 and CYP3A5 has hampered the development of selective CYP3A4 inhibitors. Here, the authors report a series of selective CYP3A4 inhibitors and show that differential C-terminal loop conformations and two distinct ligand binding surfaces disfavour the binding of selective CYP3A4 inhibitors to CYP3A5.

Solution-processed small-molecule solar cells with almost 100% internal quantum efficiency and a power conversion efficiency of 9% are reported. The cells make use of a donor molecule called DRCN7T and use PC71BM as an acceptor.

Here the authors developed a multi-phenotype imputation method termed PIXANT by leveraging efficient machine learning (ML)-based algorithms.

The mechanism of lipoprotein sorting to the bacterial cell surface is still unclear. Here, authors determine the crystal structures of paLptDE-LptM and apo-paLptDE, providing insights into how SLPs are transported to the cell surface via LptDE.

Graphene nanoribbons show promise for high-performance field-effect transistors, however they often suffer from short lengths and wide band gaps. Here, the authors use a bottom-up synthesis approach to fabricate 9- and 13-atom wide ribbons, enabling short-channel transistors with 10⁵ on-off current ratio.

Though bound states in the continuum (BICs) in acoustic systems are attractive for acoustic resonators design, acoustic BICs typically show low Q-factor. Here, the authors report a high performance open acoustic resonator that supports symmetry-protected, Friedrich-Wintgen and mirror symmetry-induced BICs.

This study reveals that phosphorus and nitrogen deficiency alters the abundance and profiles of extrachromosomal circular DNA in rice, underscoring its crucial role in genome plasticity and stress adaptation, which has implications for agricultural performance.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

To increase the efficiency, brightness and stability of next-generation light-emitting diodes (LEDs), the microstructure of CsPbI_3-xBr_x metal-halide perovskite, a good pure-red emitter, was altered to fix hole leakage, which was identified as decreasing efficiencies in overworked LEDs.

Traditional electrorefining process is limited by deposition potential of the metal itself. Here, the authors explore an in-situ anodic precipitation process based on different solubility of target metal chlorides that can efficiently separate components of aluminum alloys.

Single crystals of a helical covalent polymer have been obtained from an achiral monomer through spiroborate formation. Polymerization and crystallization occur simultaneously to give a network of pairs of entwined helical strands of the same handedness. No strong non-covalent interactions were observed between the two helical polymers forming a pair; instead, each interacts with neighbouring pairs through hydrogen bonding.

A meta-analysis of genome-wide association study data from 77,418 individuals of East Asian ancestry with type 2 diabetes identifies novel variants associated with increased risk of type 2 diabetes.

Embryo implantation failure is a leading cause of miscarriage, though the mechanisms underlying trophoblast defects are not well understood. Here they show that the histone acetyltransferase KAT8 is essential for proper activation of the trophoblast stemness gene CDX2, and that placental development can be partially rescued by inhibiting histone deacetylase activity.

Tailored to provide diabetes management recommendations from large training and validation datasets, an artificial intelligence system integrating language and computer vision capabilities is shown to improve self-management of patients in a prospective implementation study.

John Chambers, Jaspal Kooner, Pim van der Harst, Shyong Tai, Paul Elliott, Jiang He, Norihiro Kato and colleagues performed a genome-wide association study of blood pressure phenotypes in individuals of European, East Asian and South Asian ancestry. They find trait-associated SNPs at 12 loci, some of which are associated with methylation at nearby CpG sites.

Transcriptome-wide m⁶A RNA methylation profile in 162 primary prostate tumors identifies m⁶A association with prognostic clinical features and disease aggression.

Wastewater treatment plants are important reservoirs of antibiotic resistance genes (ARGs). Here, the authors analyze ARGs in a global collection of samples from wastewater treatment plants across six continents, providing insights into biotic and abiotic mechanisms that appear to control ARG diversity and distribution.

Strongly correlated systems exhibit universal dynamics near phase transitions, from particle to condensed matter physics. However, despite the successes of various theoretical approaches, systematic treatments of fluctuations are scarce. Here the authors unveil a universal damping of pseudo-Goldstone modes in systems with approximate symmetries, advancing our understanding of near-critical dynamics in several contexts.

Helicobacter pylori (H. pylori) establishes chronic infection in human, but the underlying mechanistic insights are lacking. Here the authors use single cell RNA and TCR sequencing to profile peripheral blood and mucosal cells from infected patients to report alterations in macrophage differentiation and T cell gene signature that may contribute to persisting H. pylori infection.

Selective conversion of CO₂ and H₂ into aromatics remains challenging due to the high unsaturation degree and complex structure of aromatics. Here the authors report a composite catalyst of ZnAlOx and H-ZSM-5 which promotes the formation of aromatics with high selectivity while inhibiting CO and CH₄ formation in CO₂ hydrogenation reactions.

Precipitation enables the straightforward production of a variety of inorganic materials, but the rapid reaction rates involved typically make controlling their morphologies difficult. Now, the growth of either one-, two- or three-dimensional materials has been promoted by tuning of the reactants’ electrolytic dissociation and solution supersaturation, without the need for capping agents and templates.

A flat stanene layer can be grown on Cu (111) by MBE growth, exhibiting topological properties as revealed by a combination of ARPES, STM and DFT calculations.

Kim and colleagues perform a phase 2 clinical trial (ELM-2) of odronextamab monotherapy in patients with relapsed/refractory diffuse large B cell lymphoma and report on the primary analyses of the efficacy and safety profile.

Here, the authors identify a copy number variation containing three enhancers (PIHEC) that drives bilateral constricted ear by co-ordinately regulating HMX1 expression, revealing how aberrant Hmx1 expression in neural crest-derived fibroblasts disrupts outer ear development.

GRB2 is an adaptor protein that plays a role in cell signal transduction. Here, the authors reveal an attenuation of GRB2 in endometrium from infertile women and show GRB2 knockout in mice results in infertility due to implantation and decidualization defects.

Constructing organic fluorophosphines via direct fluorination of alkyl phosphonates is challenging. Herein, the authors show that alkyl phosphonates are electrophilically activated with triflic anhydride and N-heteroaromatic bases, enabling nucleophilic fluorination at room temperature to form fluorophosphines via reactive phosphine intermediates.

The mechanisms underlying the invasiveness and aggressiveness of pituitary neuroendocrine tumours (PitNETs) remain poorly understood. Here, the authors perform single-cell RNA sequencing and spatial transcriptomics to characterise the tumour microenvironment of PitNETs and identify potential therapeutic targets.

Glycogen phosphorylase kinase (PhK) initiates glycogen degradation by phosphorylating glycogen phosphorylase (GP), positioning itself at the core of glycogenolysis. Here, the authors utilize cryo-EM to elucidate the mechanisms by which human PhK is regulated by phosphorylation and calcium ions, and reveal its binding mode with the substrate GP.

A recombinant vaccine that targets the receptor-binding domain of the spike protein of SARS-CoV-2 induces a potent antibody response in immunized mice, rabbits and non-human primates, and protects primates from infection with the virus.

Urinary albumin-to-creatinine ratio (UCAR) is associated with various clinical outcomes such as kidney disease and cardiovascular disease. Here, the authors report genome-wide meta-analysis in over 500,000 individuals and find 68 UACR loci, followed by statistical fine-mapping, gene prioritization and experimental validation in flies.

Population genomic analyses reveal the migration route and the molecular basis associated with adaptations to the nonnative range for an obligate fig wasp pollinating an invasive fig tree species.

Genomic analyses of large population-based cohorts uncover the genetic determinants of perivascular space burden, an MRI marker of cerebral small vessel disease, across the lifespan, and reveal potential pathways implicated in the etiology of stroke and dementia.

Asparagales is the largest monocot order. Here, the authors produce the phylogeny of Asparagales with transcriptomic data from 455 species and investigate the evolution of genes involved with allium flavor biosynthesis.

Globally, as a major public health problem, low back pain has been the leading cause of disability worldwide for the past 30 years. Here, the authors propose a segmentation network and a quantitative method lumbar intervertebral disc degeneration assessment.

Early-stage liver metastasis of pancreatic ductal adenocarcinoma (PDAC) makes radical surgery not efficacious. Here, the authors show that MLKL-driven necroptosis contributes to PDAC early-stage metastasis by inducing tumour CD47 upregulation and macrophage extracellular traps formation.

XPR1 is the only known protein that exports inorganic phosphate from cells. This study demonstrates that XPR1 uses a channel-like mechanism for phosphate transport, offering insights into potential therapeutic strategies for XPR1-linked diseases.

Arsenic contamination of groundwater and soils threatens the health of tens of millions people worldwide. A series of laboratory experiments suggest that in Arabidopsis, inositol transporters are responsible for arsenite loading into the phloem, the key source of arsenic in seeds.

A round-robin differential phase shift protocol, in which monitoring of the signal disturbance is unnecessary, has been experimentally realized. With 65 pulses in each packet, the system can distribute a secret key over a distance of 90 km.

The growth of stanene on bismuth telluride has been achieved using molecular beam epitaxy. Photoemission spectroscopy and theoretical calculations are used to investigate the effects of the substrate on the electronic properties of the Sn layers.

The lateral and vertical integration of ZnO piezoelectric nanowires allows for voltage and power outputs sufficient to power nanowire-based sensors.

Circadian rhythms influence key physiological functions. Here, the authors defined rhythmic quantitative trait loci that reveal novel genotype-specific rhythmic genes, explaining individual variations in rhythmic gene expression and disease risk.

The feasibility of satellite-assisted quantum communication is demonstrated by a field test on the ground. To supress noise due to sunlight the wavelength of 1,550 nm is chosen, and spectrum and spatial filtering technology developed.

Qu et al. report a self-assembled material with π-expanded conjugation to form hydrophilic ordered bilayer as hole selective layer for inverted perovskite solar cells. The enhanced interfacial charge extraction and transport enable certified efficiency of 26.39% and 25.21% for 7.15 mm² - and 99.12 mm² -devices, respectively.