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Scientific Reports (29)
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Showing 1–50 of 60 results

Advanced filters: Author: Cheng Che Tsai Clear advanced filters

Uncertainty-aware ensemble of foundation models differentiates glioblastoma from its mimics

Distinguishing glioblastoma and primary central nervous system lymphoma (PCNSL) remains challenging due to their overlapping pathology features. Here, the authors develop a computational tool, PICTURE, for differentiating similar pathological features enabling improved diagnosis of CNS tumours.

Junhan Zhao
Shih-Yen Lin
Kun-Hsing Yu
ResearchOpen Access29 Sept 2025
Nature Communications

Volume: 16, P: 1-16
Cytoreductive nephroureterectomy for treatment of upper urinary tract urothelial carcinoma initially diagnosed as node-positive

Shu-Yu Wu
Chi-Ping Huang
Yao-Chou Tsai
ResearchOpen Access12 Aug 2025
Scientific Reports

Volume: 15, P: 1-11
Integration of freestanding hafnium zirconium oxide membranes into two-dimensional transistors as a high-κ ferroelectric dielectric

Freestanding membranes of hafnium zirconium oxide can be created using pulsed laser deposition method and used as the top-gate dielectric in molybdenum disulfide transistors.

Che-Yi Lin
Bo-Cia Chen
Yen-Fu Lin
ResearchOpen Access26 Jun 2025
Nature Electronics

Volume: 8, P: 560-570
Discovery and prioritization of genetic determinants of kidney function in 297,355 individuals from Taiwan and Japan

Here the authors present a large genetic study in East Asians that identifies 97 genetic regions linked to kidney function. These findings aim at better understanding chronic kidney disease in diverse populations.

Hung-Lin Chen
Hsiu-Yin Chiang
Chin-Chi Kuo
ResearchOpen Access29 Oct 2024
Nature Communications

Volume: 15, P: 1-16
Single-cell signaling network profiling during redox stress reveals dynamic redox regulation in immune cells

Maintaining proper reactive oxygen species (ROS) balance is critical for cellular and individual health, yet its dynamic nature encumbers monitoring and assessment. Here the authors propose a platform using mass cytometry-based detection, termed SN-ROP, to identify distinct ROS profiles associated with specific immune cell functions and disease states.

Yi-Chuan Wang
Ping-Hsun Wu
Shih-Yu Chen
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-18
Polymerised superparamagnetic antigen presenting cell lymphocyte capture for enriching tumour reactive T-cells and neoantigen identification

T-cell enrichment has attracted great interest but currently fails to fully replicate the complex natural immune interactions. Here, the authors report on magnetic polymerised antigen-presenting cells that mimic natural interactions to isolate rare tumour-reactive T cells, offering a platform for enhancing cancer immunotherapy and neoantigen discovery.

Chung-Yao Hsu
Po-Cheng Tsai
Che-Ming Jack Hu
ResearchOpen Access02 Jun 2025
Nature Communications

Volume: 16, P: 1-16
Preoperative ECOG performance status as a predictor of outcomes in upper tract urothelial cancer surgery

Tsung-Mu Yang
I-Hsuan Alan Chen
Hsin-Chih Yeh
ResearchOpen Access26 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
Autonomous cortisol secretion promotes vascular calcification in vivo and in vitro under hyperaldosteronism

Bo-Ching Lee
Chin-Chen Chang
Ying-Ying Chen
Research08 Nov 2024
Hypertension Research

Volume: 48, P: 366-377
Evaluating the effects of adrenalectomy and mineralocorticoid receptor antagonist on cardiac remodeling and diastolic function in patients with aldosterone-producing adenoma

Yu-Ching Chang
Xue-Ming Wu
Ying-Ying Chen
Research25 Oct 2024
Hypertension Research

Volume: 48, P: 529-539
Traditional versus blended CPR training program: A randomized controlled non-inferiority study

Cheng-Yu Chien
Shao-Yu Fang
Chip-Jin Ng
ResearchOpen Access22 Jun 2020
Scientific Reports

Volume: 10, P: 1-8
Genome-wide association study of age at menarche in the Taiwan Biobank suggests NOL4 as a novel associated gene

Meng-Che Tsai
Chih-Hui Hsu
Sheng-Hsiang Lin
Research30 Jan 2023
Journal of Human Genetics

Volume: 68, P: 339-345
The risk of fibromyalgia in patients with iron deficiency anemia: a nationwide population-based cohort study

Wei-Cheng Yao
Hsuan-Ju Chen
Shin-Yi Tsai
ResearchOpen Access18 May 2021
Scientific Reports

Volume: 11, P: 1-8
Aldosteronism is associated with more severe cerebral small vessel disease in hypertensive intracerebral hemorrhage

Bo-Ching Lee
Hsin-Hsi Tsai
Ying-Ying Chen
Research22 Nov 2023
Hypertension Research

Volume: 47, P: 608-617
The p53-S100A2 Positive Feedback Loop Negatively Regulates Epithelialization in Cutaneous Wound Healing

Shin-Chen Pan
Che-Yu Li
Li-Wha Wu
ResearchOpen Access03 Apr 2018
Scientific Reports

Volume: 8, P: 1-12
The relationship between tissue inhibitor of metalloproteinases-1 and KCNJ5 mutation in aldosterone-producing adenoma patients

No-Ting Lin
Tsung-Yan Chen
Ying-Ying Chen
Research17 Dec 2024
Hypertension Research

Volume: 48, P: 563-573
Unexpected mortality from the use of E. coli L-asparaginase during remission induction therapy for childhood acute lymphoblastic leukemia: a report from the Taiwan Pediatric Oncology Group

D-C Liang
I-J Hung
K-S Lin
Research05 Feb 1999
Leukemia

Volume: 13, P: 155-160
Receptor-interacting protein 140 attenuates endoplasmic reticulum stress in neurons and protects against cell death

Uncontrolled calcium release from the endoplasmic reticulum results in cell death and toxicity. Here, the authors show that in neurons, stress induces the export of receptor-interacting protein 140 from the nucleus to the cytosol where it interacts with IP3Receptor, preventing its opening and the detrimental effects of calcium release.

Xudong Feng
Kelly A. Krogh
Li-Na Wei
Research28 Jul 2014
Nature Communications

Volume: 5, P: 1-12
A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators

A common East Asian-specific defect of an alcohol metabolizing enzyme (ALDH2) causes glucose abnormality, obesity, and fatty liver. Here, the authors show an ALDH2 activator can treat these metabolic disorders in mice.

Yi-Cheng Chang
Hsiao-Lin Lee
Lee-Ming Chuang
ResearchOpen Access25 Sept 2023
Nature Communications

Volume: 14, P: 1-16
Speculating suitability of partial adrenalectomy for lateralized primary aldosteronism: With emphasis on partial and complete success as optimistic outcomes

Our results show that unilateral partial adrenalectomy is not a good surgical option for the majority of lateralized PA patients. In clinically lateralized PA patients, no matter which group they are in the HISTALDO classification, they would benefit from unilateral total adrenalectomy.

Tsae-Ni Lee
Chin-Chen Chang
Ying-Ying Chen
ResearchOpen Access03 Mar 2025
Hypertension Research

Volume: 48, P: 1739-1748
Children with chronic myeloid leukaemia treated with front-line imatinib have a slower molecular response and comparable survival compared with adults: a multicenter experience in Taiwan

Hsi-Che Liu
Ming-Chung Kuo
Lee-Yung Shih
Research30 Jan 2023
British Journal of Cancer

Volume: 128, P: 1294-1300
Observation of quantum entanglement with top quarks at the ATLAS detector

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s = 13 TeV and an integrated luminosity of 140 fb⁻¹.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access18 Sept 2024
Nature

Volume: 633, P: 542-547
A structure of the relict phycobilisome from a thylakoid-free cyanobacterium

Phycobilisomes are megacomplexes in cyanobacteria that capture light. Here, authors characterize a relict paddle-shaped phycobilisome structure, revealing phycobilisome diversity prior to the development of thylakoids.

Han-Wei Jiang
Hsiang-Yi Wu
Ming-Yang Ho
ResearchOpen Access04 Dec 2023
Nature Communications

Volume: 14, P: 1-14
miR-548aq-3p is a novel target of Far infrared radiation which predicts coronary artery disease endothelial colony forming cell responsiveness

Wei-Che Tsai
Wei-Hui Chiang
Cheng-Chung Cheng
ResearchOpen Access22 Apr 2020
Scientific Reports

Volume: 10, P: 1-17
Myosteatosis and sarcopenia are linked to autonomous cortisol secretion in patients with aldosterone-producing adenomas

Bo-Ching Lee
Yu-Ling Chang
Ying-Ying Chen
ResearchOpen Access14 Oct 2024
Hypertension Research

Volume: 48, P: 519-528
Zinc oxide nanostructures enhanced photoluminescence by carbon-black nanoparticles in Moiré heterostructures

Chih-Chiang Wang
An-Ya Lo
He-Ting Tsai
ResearchOpen Access15 Jun 2023
Scientific Reports

Volume: 13, P: 1-10
YOLOSeg with applications to wafer die particle defect segmentation

Yen-Ting Li
Yu-Cheng Chan
Ssu-Han Chen
ResearchOpen Access17 Jan 2025
Scientific Reports

Volume: 15, P: 1-14
Care cascade of tuberculosis infection treatment for people living with HIV in the era of antiretroviral therapy scale-up

Kuan-Yin Lin
Chia-Jui Yang
Chen-Hsiang Lee
ResearchOpen Access27 Sept 2022
Scientific Reports

Volume: 12, P: 1-9
Tumor distribution affects bladder recurrence but not survival outcome of multifocal upper tract urothelial carcinoma treated with radical nephroureterectomy

Zai-Lin Sheu
Chi-Ping Huang
Hsin‑Chih Yeh
ResearchOpen Access24 Sept 2021
Scientific Reports

Volume: 11, P: 1-10
Kidney function predicts new-onset cardiorenal events and mortality in primary aldosteronism: approach of the 2021 race-free eGFR equation

Even with the glomerular hyperfiltration phenomenon, baseline eGFR in patients with primary aldosteronism is associated with subsequent cardiorenal outcomes. The results also firstly point to the validity of the 2021 race-free CKD-EPI eGFR equation in healthcare and clinical decision-making.

Chun-Fu Lai
Yen-Hung Lin
Ying-Ying Chen
Research16 Sept 2023
Hypertension Research

Volume: 47, P: 233-244
Beyond diversity: the impact mechanism of organizational inclusion on employee knowledge hoarding

Qingheng Cheng
Qiao Yan
Ting Nie
ResearchOpen Access15 Nov 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-10
Tinnitus and risk of Alzheimer’s and Parkinson’s disease: a retrospective nationwide population-based cohort study

Hsuan-Te Chu
Chih‐Sung Liang
Cheng-Che Shen
ResearchOpen Access22 Jul 2020
Scientific Reports

Volume: 10, P: 1-8
Optical coherence tomography-guided laser microsurgery for blood coagulation with continuous-wave laser diode

Feng-Yu Chang
Meng-Tsan Tsai
Ya-Ju Lee
ResearchOpen Access16 Nov 2015
Scientific Reports

Volume: 5, P: 1-9
Observation of electroweak production of two jets and a Z-boson pair

The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access09 Feb 2023
Nature Physics

Volume: 19, P: 237-253
Decreased succinate dehydrogenase B in human hepatocellular carcinoma accelerates tumor malignancy by inducing the Warburg effect

Po-Lin Tseng
Wei-Hsuan Wu
Wen-Tsan Chang
ResearchOpen Access15 Feb 2018
Scientific Reports

Volume: 8, P: 1-16
Associations of central precocious puberty with blood pressure trajectories: prospective cohort study

Hsien-Yu Fan
Wan-Ling Tsai
Yang-Ching Chen
Research24 Nov 2023
Pediatric Research

Volume: 95, P: 1147-1152
Publisher Correction: The risk of fibromyalgia in patients with iron deficiency anemia: a nationwide population‑based cohort study

Wei-Cheng Yao
Hsuan-Ju Chen
Shin-Yi Tsai
Amendments and CorrectionsOpen Access27 Jul 2021
Scientific Reports

Volume: 11, P: 1-2
Test of the universality of τ and μ lepton couplings in W-boson decays with the ATLAS detector

The ATLAS Collaboration reports a measurement of the ratio of the decay rates of W bosons to τ leptons and muons, in agreement with universal lepton couplings as postulated in the standard model of particle physics.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access05 Jul 2021
Nature Physics

Volume: 17, P: 813-818
Search for charged-lepton-flavour violation in Z-boson decays with the ATLAS detector

The ATLAS experiment at the Large Hadron Collider reports a search for charged-lepton-flavour violation in decays of Z bosons into a τ lepton and an electron or muon of opposite charge.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access01 Jul 2021
Nature Physics

Volume: 17, P: 819-825
Glycosylation-dependent galectin-1/neuropilin-1 interactions promote liver fibrosis through activation of TGF-β- and PDGF-like signals in hepatic stellate cells

Ming-Heng Wu
Yuh-Ling Chen
Wan-Lin Tsui
ResearchOpen Access08 Sept 2017
Scientific Reports

Volume: 7, P: 1-16
Comorbidities associated with genetic abnormalities in children with intellectual disability

Jia-Shing Chen
Wen-Hao Yu
Yi-Fang Tu
ResearchOpen Access22 Mar 2021
Scientific Reports

Volume: 11, P: 1-8
Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences

Phosphorothioate (PT) DNA modifications are widespread in bacteria and play a critical role in cell physiology. Here, the authors develop two sequence-based technologies to map PT modifications across bacterial genomes.

Bo Cao
Chao Chen
Peter C. Dedon
Research05 Jun 2014
Nature Communications

Volume: 5, P: 1-13
Recalibration of deep learning models for abnormality detection in smartphone-captured chest radiograph

Po-Chih Kuo
Cheng Che Tsai
Leo Anthony Celi
ResearchOpen Access15 Feb 2021
npj Digital Medicine

Volume: 4, P: 1-10
The risk of herpes zoster is positively associated with obesity, especially morbid obesity

Hsiao-Lan Chen
Chia-Hung Chen
Chao-Yu Hsu
ResearchOpen Access21 Jun 2024
Scientific Reports

Volume: 14, P: 1-11
Scalable determination of multipartite entanglement in quantum networks

Wei-Ting Kao
Chien-Ying Huang
Che-Ming Li
ResearchOpen Access08 Aug 2024
npj Quantum Information

Volume: 10, P: 1-8
Validation of the molecular international prognostic scoring system in patients with myelodysplastic syndromes defined by international consensus classification

Wan-Hsuan Lee
Ming-Tao Tsai
Hwei-Fang Tien
ResearchOpen Access09 Aug 2023
Blood Cancer Journal

Volume: 13, P: 1-8
Vascular compactness of unruptured brain arteriovenous malformation predicts risk of hemorrhage after stereotactic radiosurgery

Po-Wei Huang
Syu-Jyun Peng
Cheng-Chia Lee
ResearchOpen Access18 Feb 2024
Scientific Reports

Volume: 14, P: 1-10
Discovering a trans-omics biomarker signature that predisposes high risk diabetic patients to diabetic kidney disease

I-Wen Wu
Tsung-Hsien Tsai
Ting-Fen Tsai
ResearchOpen Access02 Nov 2022
npj Digital Medicine

Volume: 5, P: 1-10
Epigenome-wide association study on asthma and chronic obstructive pulmonary disease overlap reveals aberrant DNA methylations related to clinical phenotypes

Yung-Che Chen
Ying-Huang Tsai
Inn-Wen Chong
ResearchOpen Access03 Mar 2021
Scientific Reports

Volume: 11, P: 1-14
Association between regional economic status and renal recovery of dialysis-requiring acute kidney injury among critically ill patients

Chih-Chung Shiao
Yu-Hsing Chang
Chiu-Ching Huang
ResearchOpen Access03 Sept 2020
Scientific Reports

Volume: 10, P: 1-10
Down-regulation of common NFκB-iNOS pathway by chronic Thalidomide treatment improves Hepatopulmonary Syndrome and Muscle Wasting in rats with Biliary Cirrhosis

Tzu-Hao Li
Pei-Chang Lee
Shou-Dong Lee
ResearchOpen Access23 Dec 2016
Scientific Reports

Volume: 6, P: 1-14

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