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The Gilbert damping constant, a fundamental parameter to describe magnetization dynamics, is an isotropic scalar for most magnetic materials. Now, at a metal/semiconductor interface, the emergence of anisotropic magnetic damping has been observed.

Dissolving alkali metals in liquid ammonia leads to solvated electrons with varying concentration-dependent behavior. Here the authors shows that such systems can flip between electrolyte and metallic states at a sub-100 femtosecond timescale.

Immunotherapy has yet to demonstrate efficacy for patients with glioblastoma. Here, the authors employ human single-cell RNA-seq, spatial transcriptomics, and a preclinical mouse model to show that glioblastoma cell-derived synaptogenic factor Thrombospondin-1 promotes neuronal circuit remodeling and regional immunosuppression, highlighting a potential therapeutic target.

Molecular glues have great potential for drug discovery if they can be systematically discovered. Konstantinidou, et al describe a scaffold-hopping approach using multicomponent reaction chemistry to design molecular glues that induce 14-3- 3σ/ERα formation in cells.

Proline-rich antimicrobial peptides (PrAMPs) are inhibitors of bacterial protein synthesis. Here, the authors demonstrate that the antimicrobial peptide Api137 can disrupt assembly of the ribosomal 50S subunit by inducing misfolding of its components.

Neoadjuvant immunochemotherapy against NSCLC has been tested in clinical trials. Here, the authors follow up longer-term survival and measure immune cell phenotype changes in a single-arm phase II clinical trial of neoadjuvant immunochemotherapy, indicating association of intratumoural TCR diversity and CD8 T cell positioning.

Analysis of ground-sourced and satellite-derived models reveals a global forest carbon potential of 226 Gt outside agricultural and urban lands, with a difference of only 12% across these modelling approaches.

Microplastics research is often based on commercial model particles. Here, the authors show that nominally identical particles may differ significantly in their properties and thus in their interactions with cells.

Protein folding is facilitated by cellular machinery, but studying folding in the cellular context is challenging. Here, the authors developed Arrest Peptide Profiling to map co-translational folding and chaperone interactions in living cells.

Aircraft measurements over the Amazon show that new particle formation in the upper troposphere emerges when isoprene, emitted by forests, undergoes oxidation in the presence of nitrogen oxides produced by lightning.

The role of pathogenic mitochondrial DNA (mtDNA) mutation in cancer remains to be studied. Here the authors show that high mtDNA mutation burden in lung cancer models leads to increased glycolysis but limited de novo serine synthesis, rendering sensitivity to dietary serine and glycine deprivation.

In normal skin, Notch directs keratinocytes to terminally differentiate. Here the authors show that Notch1 has a wider role in skin repair; Notch1 is activated in keratinocytes after damage and drives transcription of TNFα and inflammatory chemokines, which in turn recruit ILC3s and macrophages that promote repair.

The spin state of a single electron is shown to control the transmission of single photons through a nanophotonic waveguide, thus realizing a spin-based photonic switch.

Two regions of superconductivity are observed in the phase diagram of magic-angle twisted trilayer graphene. This may yield insight into the superconducting mechanism in moiré materials.

Polymers that are both elastic and self-healing are desirable for a variety of applications, but often rely on hydrogen bonding which makes them moisture-sensitive. Now, by incorporating metal–ligand interactions with different bond strengths into flexible polymer backbones, an elastomer has been devised that combines high stretchability and high dielectric strength with autonomous self-healing and mechanical actuation capabilities.

Diffusion models excel at molecular generation. Here, authors present SiMGen, a complementary local similarity-based approach. SiMGen offers more control over the generation process and can guide existing models to generate specific fragments.

How the developing skin epidermis is transformed from a simple single-layered epithelium to a complex and stratified barrier is still an open question. Here, the authors provide a model based on high proliferation and delamination of the keratinocyte progenitors that support the stratification process.

The synthesis of organophosphorus compounds from elemental phosphorus is an inefficient process, using multiple steps, stoichiometric metal complexes and/or hazardous reagents such as chlorine gas. Here, a direct photocatalytic route to convert white phosphorus (P₄) into phosphines and phosphonium salts is reported.

This study reveals that brain aberrations after preterm birth are highly individual yet shaped by early injury and social environment, influencing long-term cognitive outcomes.

Full cosmological hydrodynamical simulations employing modified gravity find that disk galaxies can form and their stellar properties are only mildly affected. Modified gravity leaves signatures on large-scale structure observable with the Square Kilometre Array.

Over time, paralogous genes accumulate changes in their sequences that do not affect their function, which is called cryptic variation. Using paralogous myosins, this study shows how cryptic variation modulates the functional effect of mutations and biases duplicates to distinct evolutionary fates.

The flexibility of corals to associate with different bacteria in different environments has not been systematically investigated. Here, the authors study bacterial community dynamics for two coral species and show that bacterial community structure responds to environmental changes in a host-specific manner.

Here, the authors show that short-term consumption of energy-dense diets deficient in fiber, similar to eating patterns for many people today, results in a transient depression of the mucosal and systemic immune systems such that susceptibility to bacterial infection is increased.

CLPP-deficiency-driven mitochondrial dysfunction in brown adipose tissue leads to the accumulation of d-2-hydroxyglutarate, in turn promoting lipid-droplet enlargement by altering gene expression and epigenetically regulating nuclear stiffness.

X-ray free-electron lasers offer a wealth of possibilities for future diffraction studies, but variations in successive pulses mean the wavefront is not well defined. Rutishauseret al. use grating interferometry to characterize the wavefronts shot to shot, both in situand under operating conditions.

Silicon vacancy centres in diamond have favourable optical properties for use in quantum information processing. Here, the authors demonstrate coherent control of silicon vacancy spins, a prerequisite for the implementation of quantum computing operations.

Kavšek et al. reveal in this C. elegans study that the LIN-39 and DAF-16 transcription factors cooperate to regulate enhancer activity in VC neurons and ensure proper neuron maturation. This in turn is required for longevity under reduced IIS conditions, linking chromatin dynamics to lifespan extension.

Phosphorus mononitride is highly unstable under atmospheric conditions and its utility for constructing elusive P–N π-bonded motifs has remained uncertain. Here, the authors show that Na(OCP) can transfer a P atom to an electrophilic osmium nitride complex to form a metal-bound P≡N ligand.

The involvement of cAMP-dependent regulation of HCN4 in the chronotropic heart rate response is a matter of debate. Here the authors use a knockin mouse model expressing cAMP-insensitive HCN4 channels to discover an inhibitory nonfiring cell pool in the sinoatrial node and a tonic and mutual interaction between firing and nonfiring pacemaker cells that is controlled by cAMP-dependent regulation of HCN4, with implications in chronotropic heart rate responses.

Prior experience is used by the brain to guide adaptive behaviour during decision making. Here, the authors show that mice also selectively use information learned through recent and longer-term experience beyond just prior actions and reward to guide adaptive behaviour.

Soft auditory brainstem implant in the cochlear nucleus of macaque evokes auditory-like perceptions with high resolution and tonotopic specificity.

FLiP–MS uses a library of protein–protein interaction markers to understand protein complex dynamics.

Nonreciprocal transport is sensitive to the broken inversion symmetry of the electronic state. Here, the authors demonstrate a spontaneous voltage signal which they suggest is time-reversal-even and arises from a ratchet-type electronic potential.

Coral-associated microbes could enhance the capacity of their host organism to respond to environmental change. Ziegler and colleagues use a reciprocal transplant experiment to show that microbiomes of heat-tolerant corals are more resilient to change than those of heat-sensitive corals.

Using a system to adjust the strength of cavity vacuum fields penetrating a Hall bar, a study describes the effect of the vacuum field of a cavity on electronic correlations in quantum Hall systems.

Traditional TIRF illumination is hampered by lack of precise quantification of single-molecule intensities. Here the authors combine flat-field illumination by using a standard πShaper with multi-angular TIR illumination by incorporating a spatial light modulator compatible with fast super-resolution structured illumination microscopy.

Theory predicts that extortioners, individuals that obtain advantages through forces and threats, can outperform any generous co-player. Here, Hilbe et al.show experimentally that humans punish extortion by refusing to cooperate, which reduces the extortioner’s gains, and suggest that generosity is more profitable in the long run.

Korobkina et al. show that ACLY in brown fat prevents metabolic overload in the tricarboxylic acid cycle, thus ensuring adequate thermogenesis by avoiding cellular stress.

Highly pathogenic H5N1 avian influenza lineage 2.3.4.4b has spread through the Americas in birds since 2021 with frequent spillover into mammals. Here, the authors characterise the dissemination of the virus in Chile and find evidence of sustained transmission between mammals.

Functional roles of natural acetylcholine (ACh) dynamics are not fully understood. This study reveals dynamic changes in ACh release across the mouse striatum during learning and extinction, identifying how and where release dynamics shape brain plasticity to gate learning and promote extinction of cue-reward associations.

Interfacial spin-orbit torque allows electrical manipulation of magnetization, but this has been shown mostly in polycrystalline metal bilayers. Here the authors show robust spin-orbit torque in single crystalline Fe/GaAs interface at room temperature, observing conversion between spin and charge current.

There is a limited endogenous subventricular zone (SVZ)-derived neurogenic response for brain repair. Here, the authors report that cortical stroke-evoked environmental changes in the SVZ alter microglia-neural stem/precursor cells cross-communication, limiting the neurogenic repair response.

During wound healing and infection in the skin there is a hypoxic environment involving HIF-1α and NK cells. Here the authors show that NK cells through HIF-1α provide a cross-regulatory balance to provide an adequate antimicrobial defence that can inhibit subsequent wound healing.

Complete sequences of chromosomes telomere-to-telomere from chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan and siamang provide a comprehensive and valuable resource for future evolutionary comparisons.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.