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This study reveals that CYBDOM proteins promote drought tolerance by regenerating apoplastic ascorbic acid (AsA) and activating autophagy through interaction with RbohD, and link AsA redox, ROS and selective autophagy in plant stress responses

The development of catalysts for practical asymmetric hydrogenation of ketones remains an important goal of synthetic organic chemistry. Here, an anionic iridium catalyst with excellent activity is reported and used in a hundred-kilogram-scale reduction as part of a route to chiral nicotine.

An atomically thin high-κ gate dielectric of Bi₂SeO₅ can be formed via layer-by-layer oxidization of an underlying two-dimensional semiconductor, allowing high-performance field-effect transistors and inverters to be fabricated.

The authors report the large low-field-driven electrocaloric effect in the novel organic-inorganic hybrid TMCM-CdCl₃, underlyingly from the disordering of organic cations and the low-symmetry interaction induced two-step meta-electric transition.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

This study maps the single-axon projections of 7,180 hypothalamic peptidergic neurons in male mice and uncovers extensive collateralization, topographic target innervation and modular intra-hypothalamic organization.

High morbidity and mortality in aquatic have been caused by iridovirids worldwide. Here the authors present a near-atomic SGIV capsid structure. Functional assays further reveal the relationships between identified capsid proteins and viral assembly.

Water sterilization demands high flux and antibacterial membranes. Here, authors realize such membranes by coupling covalent organic frameworks and Cu₂O nanoclusters. This coupling enhances the generation of reactive oxygen species under visible light, enabling fast and durable water purification.

The epitaxial synthesis of high-density, vertically aligned arrays of two-dimensional (2D) fin-oxide heterostructures is described, enabling the fabrication of 2D fin field-effect transistors with high electron mobility and desirable low-power specifications.

Mcm2 mutation or Pole3 deletion in mouse embryonic stem cells leads to asymmetric parental histone distribution and impaired neural differentiation. Mutation of the Mcm2 histone-binding domain causes defects in pre-implantation development and embryonic lethality.

Hydrogen bonds impact the chemical, physical and biological properties of molecular materials, but are rarely able to induce significant changes in electrical properties. Now a dynamic-to-static transition of hydrogen bonds in an organic–inorganic superlattice has been shown to yield a metal–insulator transition with an on–off ratio of 10⁷ in electrical resistivity.

The role of FGF21 in HFpEF is not fully understood. Here, the authors show that circulating levels of FGF21 are elevated in patients with HFpEF and that it protects against HFpEF by triggering multiorgan crosstalk among the liver, adipose tissue, and the heart, suggesting that FGF21 could be a promising therapeutic target for treating HFpEF.

The origin of nematicity in kagome superconductors has been hard to explain due to other entangled phases. Now, the role of orbital hybridization and coupling is revealed to induce electronic nematicity in the kagome superconductor RbTi₃Bi₅.

Varicella-zoster virus (VZV) is the causative agent of chickenpox and herpes zoster (shingles). Cryo-EM structure of VZV capsid provides insights into the capsid assembly and reveals a pocket that could potentially be targeted by antiviral drugs.

Cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in Chinese Han and white British participants identify autosomal and X-chromosomal associations in more diverse populations.

Here the authors show disturbing parental histone inheritance in cancer cells drives tumor progression by reprogramming the epigenetic profile and conferring fitness advantages to some of the newly emerged subclones.

Platelet-activating factor (PAF) and PAF-like phospholipids were identified as propagators of ferroptosis, whereas PAFAH2 suppressed synchronized ferroptosis and, thus, prevented tubular cell death in acute kidney injury.

A scheme to control the confinement within 2D/3D perovskite heterostructures results in stable, efficient inverted perovskite solar cells.

Genome-wide association meta-analyses in populations of East Asian and European ancestries identify variant–trait associations for 44 hippocampal traits and provide insight into the genetic architectures of hippocampal and subfield volumes.

The ultraviolet-assisted intercalative oxidation of high-mobility two-dimensional semiconductor Bi₂O₂Se can be used to create a single-crystalline native oxide dielectric—β-Bi₂SeO₅—that can yield top-gated transistors with an equivalent oxide thickness of 0.41 nm.

THADA has been identified as a type 2 diabetes-associated gene whose function is not fully understood. Here the authors report that THADA deficiency protects mice from hyperglycemia and glucose intolerance by promoting insulin secretion and inhibiting β-cell apoptosis, suggesting THADA could be explored as a potential therapeutic target for diabetes.

Sesame is a valuable oilseed crop with a small diploid genome and high seed-oil content making it an attractive model for genetic studies. Here, Wei et al.sequence more than 705 sesame varieties and perform a genome-wide association study to identify genes associated with important agronomic traits.

Large-size single-crystal van der Waals layered Bi₂SeO₅ has been synthesized with a high dielectric constant and high breakdown field strength for two-dimensional electronics applications.

Numerous methods for transition metal-catalysed hydrosilylation exist but iridium catalysis offers attractive advantages. Here the authors describe a broadly-applicable method for the Markovnikov hydrosilylation of terminal alkynes using a commercial iridium catalyst.

Single-crystal perovskite devices 2–3 mm thick exhibit 16.4% X-ray detection efficiency with sensitivity four times higher than α-Se X-ray detectors.

The genus Miscanthus has great potential for bio-energy production due to its high biomass yield and strong stress resistance. Here, the authors report the genome assembly of the diploid M. lutarioriparius, showing it has an allotetraploid origin and an expanded number of genes in families related to stress resistance.

Bin Han and colleagues report the draft genome of moso bamboo, an important non-timber forest product. RNA sequencing analysis of bamboo flowering tissues suggests a connection between drought-responsive genes and potential flowering genes.

Resequencing of 302 soybean accessions and GWAS provide a comprehensive resource for soybean geneticists and breeders.