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Snail is involved in the regulation of epithelial-mesenchymal transition and metastasis. Here, the authors show that the metabolite β-hydroxybutyrate promotes pancreatic cancer metastasis through protecting Snail from degradation.

The most up-to-date combination of results on the properties of the Higgs boson is reported, which indicate that its properties are consistent with the standard model predictions, within the precision achieved to date.

Recent measurements in the Amazon rainforest indicate missing sources of volatile organic compounds (VOCs). Here the authors show that soil microorganisms are a strong, unaccounted source of highly reactive sesquiterpenes, a class of VOCs that can regulate ozone chemistry within the forest canopy.

Kamiya and colleagues examine the effects of chronic social-defeat stress on the intestinal microbiome and show a pathological role played by dectin-1 and interleukin-17 expressed by gut γδ T cells on this behavioral vulnerability.

Kletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties of the cytoplasm are a determinant in organelle size control.

Power densities of existing microbial biophotovoltaics (BPV) are low and unendurable. Here, the authors develop a BPV based on d-lactate mediated microbial consortium, which can generate an average power density of 135 mW·m⁻² for over 40 days in a spatial-temporal separation setup with medium replenishment.

Here they show that HDAC6 inhibition regulates fumarate hydratase (FH), disrupts mitochondria, increases fumarate, and causes cancer cell death. This suggests that HDAC6 inhibition could be a strategy to target tumour metabolism indirectly.

This work presents a highly versatile open-top, dual-view and dual-illumination light-sheet microscope for live imaging of large specimens.

The remarkable fidelity of the cyanobacterial clock is poorly understood. Here, the authors reconstitute the clock in cell-like vesicles and reveal that high protein concentrations, associated regulators, and transcription translation feedback buffer stochastic variation in protein levels to maintain high fidelity and phase synchrony.

Dietary n-6 PUFAs enhance adipose tissue expandability through the PPARγ–LPCAT3 membrane remodelling axis.

Cixutumumab is an anti-IGF-1R monoclonal antibody and is used to treat cancer; however, tumours can develop resistance to the therapy. Here, the authors show that the resistance is mediated by activation of STAT3 that results in an IGF2/IGF-2R signalling loop and recruitment of macrophages.

To improve annotation in non-targeted metabolomics studies, authors develop a Multiplexed Chemical Metabolomics (MCheM) platform, combining post-column derivatization with integrated data processing. MCheM enables feature-resolved chemical tagging across complex mixtures, which provides orthorgonal chemical information about unknown metabolites.

Investigating the melting curves of transition metals like iridium is vital for understanding planetary cores and advancing high-pressure technology, yet their high-pressure phase diagrams remain poorly understood. Here, the authors use advanced diamond anvil cell techniques and synchrotron X-ray diffraction to map iridium’s phase diagram, confirming its face-centered cubic structure up to 101 GPa and 5600 K, and providing critical data for technological applications.

Combined single-molecule spectroscopy, hydrogen–deuterium exchange and molecular dynamics approaches reveal that agonist activation of metabotropic glutamate receptors entails population of several intermediary states before G protein coupling.

Microbes structure biogeochemical cycles and food webs in the marine environment. Here, the authors sample coral reef-associated microbes across a 24-hour period, showing clear day–night patterns of microbial populations and thus calling for more studies to consider temporal variation in microbiomes at this scale.

DMSP is a ubiquitous organosulfur compound in the ocean that, once degraded by bacteria, plays key roles in global biogeochemical cycles and climate regulation. Here, the authors use single-cell measurements of transcription to investigate the intricate dynamics of bacterial DMSP degradation.

Plant recolonization after rewetting in a fen results in an intermediate phase with strongly increased net greenhouse gas fluxes due to wave-like changes in methane emissions, indicating underestimation of carbon emissions in rewetted fens, based on 5 years of automatic chamber measurements.

Neuropixels 1.0 NHP is a 45-mm, high-density silicon probe capable of recording large numbers of neurons with single-neuron resolution from most areas in a macaque’s brain.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

The way in which metastatic tumour cells control endocytic vesicular trafficking networks to establish a front-rear polarity axis that facilitates motility remains unclear. Here, the authors show that the EMT activator ZEB1 influences vesicular trafficking dynamics to execute cell polarity change.

Different sensory experiences can affect longevity in Drosophila. Here the authors find that exposure of Drosophila directly to dead conspecifics affects longevity via a serotonergic mechanism, and that Drosophila exposed to dead conspecifics also become an aversive stimulus to naïve choosers.

Methane emissions from aquatic systems contribute approximately half of global methane emissions, according to meta-analysis of natural, impacted and human-made aquatic ecosystems and indicating potential mitigation strategies to reduce emissions.

Cell-penetrating peptides can deliver molecular cargoes into living cells, and cross biological membranes by transduction—a non-endocytic mechanism. Here, the transduction efficiency of cyclic arginine-rich peptides is shown to be higher than that of more flexible linear peptides.

Cell migration in confined environments is initiated by a cytoplasmic pool of anillin and Ect2 that promotes RhoA/myosin II-mediated activation at the poles of migrating cells, in a process dependent on the extracellular environment stiffness.

EchoNext, a deep learning model for electrocardiograms trained and validated in diverse health systems, successfully detects many forms of structural heart disease, supporting the potential of artificial intelligence to expand access to heart disease screening at scale.

Tissue-resident macrophages (TRM) are important mediators of local immunity. Here the authors show that the deficiency or inhibition of a kinase, WNK1, unlinks macrophage colony-stimulating factor signaling and resulted macropinocytosis with the downstream, potentially IRF8-mediated genetic program to bias progenitor differentiation to neutrophil instead of TRM.

Yeo and Zhou et al. profile whole-genome chromatin accessibility in different cell types of the adult neurogenic niche, which reveals a reversible decrease in the migration of proliferative neural stem cells in aged mice.

This study identifies the conversion of lysine to Δ¹-piperideine-6-carboxylic acid (P6C) via pipecolate oxidase as a conserved pathway in plants and humans. P6C interacts with vitamin B6, affecting its homeostasis. Imbalances in vitamin B6 homeostasis disrupt defence in plants and cause neuropathology in humans.

A lipid-nanoparticle-based formulation incorporating engineered lipids containing a blood–brain-barrier-crossing moiety effectively delivers mRNA to neurons and astrocytes following systemic administration in mice.

How neurons produce energy to fuel fast axonal transport is only partially understood. Authors here report that most glycolytic enzymes are enriched in motile vesicles, and such glycolytic machinery can produce ATP autonomously to propel vesicle movement along microtubules in a cell-free assay.

The non-invasive detection of microthrombi following acute ischemic stroke is challenging. Here the author develop an MRI-based contrast agent allowing the identification of microthrombi, investigating it in a mouse model of thromboembolic ischemic stroke.

It has been proposed that phylogenetic diversity can be used as a proxy to estimate functional diversity and to predict ecosystem functioning. Here, the rapid evolutionary response of marine bacteria is used to study the positive effects of evolutionary history and species diversity on ecosystem productivity.

The brain uses different valuation schemes across contexts. Elston and Wallis show this is supported by hippocampal encoding of context that is broadcast to prefrontal value subcircuits via theta synchronization.

DNA nanotubes are attractive building blocks for the assembly of complex arrays. An efficient solid-state synthesis for producing surface-grafted, robust nanotubes has now been devised. Rungs are incorporated in a stepwise manner so that each one is addressable. Using fluorescent tags, the nanotube growth was visualized at the single-molecule level.

Analysis of inherited zircons and sanidines from Miocene ignimbrites in the Central Andes shows that plutons were emplaced for up to 4 million years prior to onset of volcanism and that disruption of plutonic rock occurs a few decades or less just before or during super-eruptions.

Unpaired morphogen specifies migratory border-cell migration in a STAT-dependent manner, so that cells with low STAT signalling do not migrate. In a feedback loop, miR-279 generates a cell-fate threshold in STAT signalling in response to the Upd gradient to prevent inappropriate migration.

Inhibition of haem synthesis is shown to lead to the accumulation of branched-chain amino acids in the brown adipose tissue of mice, which reduces UCP1 levels and impairs thermogenesis.

Microtubules are built from GDP-tubulin lattices with small GTP caps at their plus-ends. Here, the authors reveal that microtubules that attach to kinetochores in mitosis contain, in addition to the GTP-cap and the GDP-lattices, a dynamic micron-sized mixed-nucleotide zone.

Here, using cryogenic electron microscopy and cryoDRGN, the authors delineate how the anaphase-promoting complex/cyclosome is reconfigurated to interact with its cognate E2s and thus polyubiquitinate its target. Unexpectedly, multiple ubiquitin moieties are shown to interact with the anaphase-promoting complex/cyclosome machinery, including its activator Cdh1.

Social experiences influence future decision making. The authors here establish a method for quantifying this phenomenon in mice and identify an amygdalo-frontal-striatal circuit controlling how social context shapes decisions.

Through non-cell-autonomous functions, senescent cells can induce secondary senescence in bystander cells. Sogabe et al. generate mouse models of MEK1- or MKK6-induced senescence and use double labeling to map primary and secondary senescence in vivo using single-cell and spatial analysis.

Transthoracic ultrasound localization microscopy enables super-resolution imaging of myocardial microvasculature and haemodynamics in patients with impaired myocardial function using data acquired within a breath hold.

The 3CL protease of SARS-CoV-2 is inhibited by PF-00835231 in vitro. Here, the authors show that the prodrug PF-07304814 has broad spectrum activity, inhibiting SARS-CoV and SARS-CoV-2 in mice and its ADME and safety profile support clinical development.

Analysis of a fossilized front flipper of the Jurassic ichthyosaur Temnodontosaurus that preserves details of soft tissue indicates the presence of a serrated trailing edge that would have reduced noise generated while swimming, enabling stealth hunting and hiding from predators.