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Circularly polarized luminescence materials having simultaneously high dissymmetry factor and high luminescent quantum yield are desirable to improve applicability. Here, the authors report a soft photonic crystal film with chiral nanopores fulfilling these requirements when loaded with luminescent dyes.

Oblivious transfer is a standard primitive for cryptography between two parties which do not trust each other. Here, the authors propose a continuous-variable protocol which is secure against a dishonest party with bounded quantum storage capacity, and realize a proof-of-principle implementation.

Type I PRMT inhibition elicits potent antitumor activity associated with increased interferon response and intron-retained dsRNA accumulation, suggesting its potential combination with immune checkpoint inhibitors for cancer treatment.

Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci significantly associated with adult height and find that these variants cluster in pathways involved in growth and together explain one-fifth of the heritability for this trait.

By assembling the genomes of 22 Fraxinus species and conducting comparisons including further species, the authors identify candidate loci for emerald ash borer resistance that have evolved convergently.

Circularly polarized luminescent materials with large dissymmetry and efficiency are in demand. Here, the authors investigate chirality-induced spin polarization in achiral gold nanorods decorated with chiral dye-loaded micelles to enhance chiroptic activity.

Mechanisms of sleep remain elusive. Here, authors developed mouse sleep fMRI based on simultaneous electrophysiology and mapped global and sequential state transition patterns, together with global patterns triggered by SWRs in NREM and awake states.

Food regulates taste perception, but the underlying molecular mechanisms are not clear. Here, the authors reveal that sugar intake in Drosophila induces the gut to secrete Hedgehog into the circulation that suppresses sweet taste, sugar perception and preference.

Coherent manipulation of hole-orbital states in semiconductor quantum dots is achieved through stimulated Auger processes, opening doors to new types of orbital-based solid-state quantum photonic devices.

The heterogeneity of colorectal cancer has important clinical and therapeutic implications. Here the authors analysed the responses of a large biobank of organoids and xenografts derived from colorectal patients to a panel of clinically relevant therapeutic agents to identify genes signatures associated with drug response.

Chuanpeng Hou and co-authors report their findings on the origin of interplanetary switchbacks in solar magnetic reconnection at chromospheric network boundaries. This link between in situ and remote-sensing solar observations is a major step towards understanding coronal heating and solar wind acceleration.

Stephanie London, Martin Tobin and colleagues report meta-analyses of genome-wide association studies for forced vital capacity (FVC), a spirometric measure of pulmonary function that reflects lung volume. They identify six regions newly associated with FVC and demonstrate that candidate genes at these loci are expressed in lung tissue and primary lung cells.

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.

Genome-wide analyses identify 27 loci associated with attention-deficit hyperactivity disorder and provide insights into its genetic architecture in relation to other psychiatric disorders and cognitive traits.

Researchers use a DNA-mediated approach for the programmable assembly of octahedron-shaped plasmonic gold nanocrystals into nonlinear optical metacrystals. A maximum second-harmonic generation conversion efficiency of 10⁻⁹ is demonstrated.

The genetic basis of atopic dermatitis is not fully understood. Here, the authors find 91 genetic loci associated with atopic dermatitis in a GWAS of >1million individuals, which highlight the importance of systemic immune regulation.

Investigating the inner structure of baryons is important to further our understanding of the strong interaction. Here, the BESIII Collaboration extracts the absolute value of the ratio of the electric to magnetic form factors and its relative phase for e + e − → J/ψ → ΛΣ decays, enhancing the signal thanks to the vacuum polarisation effect at the J/ψ peak.

Atomic transitions afford a convenient way of storing quantum bits. However, there are few ground-state transitions suitable for use with light at telecommunication wavelengths. Now, researchers show that ensembles of cold rubidium atoms not only make good quantum memories, but can also noiselessly convert the emitted photons into and out of the telecoms band.

Hashimoto’s thyroiditis (HT) is the main cause of hypothyroidism. Here the authors develop a deep learning model for diagnosis of HT on a large multi-site dataset including image and video data.

Thus far, pleiotropy analysis using individual-level Electronic Health Records data has been limited to data from one site. Here, the authors introduce Sum-Share, a method designed to efficiently and losslessly integrate EHR and genetic data from multiple sites to perform pleiotropy analysis.

In this study, the authors use a combination of genetic methodologies to investigate the genetic associations between attention-deficit/hyperactivity disorder, cannabis use disorder and cannabis use.

Three decades of research in molecular nanomagnets have enabled the preparation of compounds displaying magnetic memory at liquid nitrogen temperature. Here, the authors provide an innovative framework for the design of molecular magnets based on data mining, and develop an interactive dashboard to visualize the dataset.

HLA-I plays a key role in triggering an immune response and predicting immune checkpoint efficacy. Here the authors develop a method for quantifying HLA-I neoantigen presentation capacity by integrating HLA-I allele divergence and neoantigens numbers, termed HAPS, to describe how immune checkpoint response may be mediated by HLA.

In this study, Hsu et al. show that inhibition of CDK7/12/13 attenuates maladaptive transcriptional activation in cultured cardiomyocytes and a mouse model of heart failure, suggesting that targeting the transcription machinery might be a therapeutic approach to treat heart failure with reduced ejection fraction.

Energy and chirality transfer play a crucial role in living systems. Here, the authors show that achiral acceptors and chiral donor gelators can assemble in a chirally-controlled manner into a supramolecular nanohelix that can additionally harvest circularly polarized energy.

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.

Here, the authors demonstrate an analogue reversed Cherenkov radiation at mid-infrared frequencies in MoO₃, a natural hyperbolic material, and show that the radiation angle and the quality factor can be increased by stacking hBN layers on the MoO₃ surface.

A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

Previously, the authors reported the primary analysis of a phase III randomized control trial investigating dual HER2 blockade in HER2-positive early/locally advanced breast cancer. Here, the authors report the long-term efficacy and safety analysis of this trial.

Nirmatrelvir, an oral antiviral targeting the 3CL protease of SARS-CoV-2, has been demonstrated to be clinically useful against COVID-19, but viral resistance to the drug was found to arise readily via multiple pathways in vitro.

Tong et al. describe a super pangenome assembled from long-read sequences of 545 wild and domesticated silkworms. Naturally selected (diapause, aposemantic coloration) or artificially selected (silk yield and fineness) sets of genes are delineated.

Combined with other westerly-sensitive records, a new stalagmite hydroclimate record from northern Italy reveals changing westerly wind directions over the past 6500 years that correspond to a migration of the North Atlantic centres of action.

Cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in Chinese Han and white British participants identify autosomal and X-chromosomal associations in more diverse populations.

Placing a single solid-state spin in an optical nanocavity results in a switch that operates at the fundamental quantum limit, where the spin modulates the polarization of a photon and a single photon flips the spin state.

A study shows that clonal haematopoiesis of indeterminate potential is associated with an increased risk of chronic liver disease specifically through the promotion of liver inflammation and injury.

The genome of the model fern species Ceratopteris richardii reveals a history of remarkably dynamic genome evolution, including rapid changes in genome content and structure following the most recent whole-genome duplication approximately 60 million years ago.

The goals, resources and design of the NHLBI Trans-Omics for Precision Medicine (TOPMed) programme are described, and analyses of rare variants detected in the first 53,831 samples provide insights into mutational processes and recent human evolutionary history.

The cumulative global warming potential-weighted emissions of hydrochlorofluorocarbons and hydrofluorocarbons are significant, which will be 21.2 (±3.7) gigatons CO₂-equivalent in 2022–2060 under a business-as-usual scenario.

Designing efficient high-density crossbar arrays are nowadays highly demanded for many artificial intelligence applications. Here, the authors propose a two-terminal ferroelectric fin diode non-volatile memory in which a ferroelectric capacitor and a fin-like semiconductor channel are combined to share both top and bottom electrodes with high performance and easy fabrication process

Quantitative live-cell superresolution imaging that maintains the linearity of fluorescence signals remains difficult. Here, the authors propose a physical model-based background filtering method for 2D-SIM, which allows for quantitative imaging and high signal completeness.

In patients with alcoholic hepatitis, cytolysin-positive Enterococcus faecalis strains are correlated with liver disease severity and increased mortality, and in mouse models these strains can be specifically targeted by bacteriophages.