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Showing 151–200 of 12411 results

Advanced filters: Author: D Lane Clear advanced filters

Response splicing quantitative trait loci in primary human chondrocytes identify putative osteoarthritis risk genes

The authors identify thousands of genetic variants affecting RNA splicing in primary human chondrocytes and link several of them to osteoarthritis risk using genome editing and computational approaches.

Seyoun Byun
Jacqueline Shine
Douglas H. Phanstiel
ResearchOpen Access26 Aug 2025
Nature Communications

Volume: 16, P: 1-17
Multiple oestradiol functions inhibit ferroptosis and acute kidney injury

17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.

Wulf Tonnus
Francesca Maremonti
Andreas Linkermann
ResearchOpen Access13 Aug 2025
Nature

Volume: 645, P: 1011-1019
Anti-restriction functions of injected phage proteins revealed by peeling back layers of bacterial immunity

Virus-host competition drives evolution of diverse antiviral defences in bacteria and antidefense systems in their viruses (phages). Here, Silas et al. use a functional screen of phage accessory genes to show how bacterial cell-surface sugars can be major determinants of phage host-range, and how some phage proteins injected into bacterial cells inhibit host immunity.

Sukrit Silas
Héloïse Carion
Joseph Bondy-Denomy
ResearchOpen Access22 Aug 2025
Nature Communications

Volume: 16, P: 1-16
Structural basis for a nucleoporin exportin complex between RanBP2, SUMO1-RanGAP1, the E2 Ubc9, Crm1 and the Ran GTPase

The nucleoporin RanBP2 functions in cellular transport, mitosis and SUMO conjugation. Here, the authors determine cryo-EM structures of RanBP2 complexed with SUMO1-RanGAP1, Ubc9, Crm1, Ran and use cell and biochemical assays to probe its functions.

Vladimir Baytshtok
Michael A. DiMattia
Christopher D. Lima
ResearchOpen Access11 Jul 2025
Nature Communications

Volume: 16, P: 1-19
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27^Kip1 by PKB/Akt-mediated phosphorylation in breast cancer

Giuseppe Viglietto
Maria Letizia Motti
Massimo Santoro
Research16 Sept 2002
Nature Medicine

Volume: 8, P: 1136-1144
Metastasis-associated protein 1 is an integral component of the circadian molecular machinery

Mammalian circadian clocks modulate the daily cycles of many cellular processes. Here the authors find that metastasis-associated protein 1, which is upregulated in human cancers, is an intrinsic regulator of the mammalian molecular clock.

Da-Qiang Li
Suresh B. Pakala
Rakesh Kumar
Research03 Oct 2013
Nature Communications

Volume: 4, P: 1-13
Adenovirus–mediated in vivo gene transfer and expression in normal rat liver

H. A. Jaffe
C. Danel
R. G. Crystal
Research01 Aug 1992
Nature Genetics

Volume: 1, P: 372-378
Broad-spectrum ubiquitin-specific protease inhibition as a mechanism for the cytotoxicity of YM155 in cancers

Xiang Li
Na He
Yiyou Chen
ResearchOpen Access01 Apr 2025
Scientific Reports

Volume: 15, P: 1-8
In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs

Guo-Liang Yu
John D. Bradley
Elizabeth H. Blackburn
Research08 Mar 1990
Nature

Volume: 344, P: 126-132
Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells

Shih-Feng Tsai
David I. K. Martin
Stuart H. Orkin
Research08 Jun 1989
Nature

Volume: 339, P: 446-451
Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

Claudia Friesen
Ingrid Herr
Klaus-Michael Debatin
Research01 May 1996
Nature Medicine

Volume: 2, P: 574-577
Discovery of a single-subunit oligosaccharyltransferase that enables glycosylation of full-length IgG antibodies in bacteria

Glycosylation of human IgG antibodies in bacterial hosts has proven challenging. Here, the authors identify a bacterial enzyme enabling E. coli to glycosylate IgGs at native sites, thereby advancing therapeutic antibody development in this host.

Belen Sotomayor
Thomas C. Donahue
Matthew P. DeLisa
ResearchOpen Access04 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Deep indel mutagenesis reveals the regulatory and modulatory architecture of alternative exon splicing

Altered pre-mRNA splicing frequently causes disease, yet how sequence variants alter splicing remains enigmatic. Here the authors use deep indel mutagenesis and deep learning tools to reveal the regulatory architecture of human exons and identify splicing-modulating antisense oligonucleotides.

Pablo Baeza-Centurión
Belén Miñana
Juan Valcárcel
ResearchOpen Access30 Aug 2025
Nature Communications

Volume: 16, P: 1-18
Intrachromosomal recombination between attP regions as a tool to remove selectable marker genes from tobacco transgenes

Elena Zubko
Charles Scutt
Peter Meyer
Research01 Apr 2000
Nature Biotechnology

Volume: 18, P: 442-445
A second DNA binding site in human BRCA2 promotes homologous recombination

BRCA2 is a well-characterized central player in homologous recombination in which it functions as the RAD51 loader. Here the authors identify an N-terminal region of BRCA2 that binds DNA and promotes efficient DNA repair.

Catharina von Nicolai
Åsa Ehlén
Aura Carreira
ResearchOpen Access15 Sept 2016
Nature Communications

Volume: 7, P: 1-8
Asymmetric gene conversion at inserted segments on yeast mitochondrial DNA

R. L. Strausberg
R. D. Vincent
R. A. Butow
Research07 Dec 1978
Nature

Volume: 276, P: 577-583
Capture of an early fusion-active conformation of HIV-1 gp41

Rika A. Furuta
Carl T. Wild
Carol D. Weiss
Research01 Apr 1998
Nature Structural Biology

Volume: 5, P: 276-279
An integrated transcriptomic and proteomic map of the mouse hippocampus at synaptic resolution

Understanding the brain’s diversity requires spatially resolved maps of transcripts and proteins. Here, the authors construct an integrated molecular atlas of the mouse hippocampus revealing local enrichment profiles and compartmental organization.

Eva Kaulich
Quinn Waselenchuk
Erin M. Schuman
ResearchOpen Access26 Aug 2025
Nature Communications

Volume: 16, P: 1-22
Allele specific inactivation of insulin 1 and 2, in the mouse yolk sac, indicates imprinting

Stephen J. Giddings
Christopher D. King
Lynn R. Carnaghi
Research01 Mar 1994
Nature Genetics

Volume: 6, P: 310-313
A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia

In mammals, the enzyme TGDS produces UDP-4-keto-6-deoxyglucose, which binds to the catalytic pocket of UDP-xylose synthase, thereby regenerating the essential NAD⁺ cofactor of UDP-xylose synthase in conditions of low NAD⁺.

Jean Jacobs
Hristiana Lyubenova
Guido T. Bommer
ResearchOpen Access20 Aug 2025
Nature

Volume: 646, P: 218-226
Synthetic lacoperator DNA is functional in vivo

Herbert L. Heyneker
John Shine
Arthur D. Riggs
Research28 Oct 1976
Nature

Volume: 263, P: 748-752
Rapid epigenomic classification of acute leukemia

The authors present a molecular classification of acute leukemia using 5-methylcytosine signatures, together with a neural network-based classifier for clinical use.

Til L. Steinicke
Salvatore Benfatto
Volker Hovestadt
ResearchOpen Access22 Sept 2025
Nature Genetics

Volume: 57, P: 2456-2467
Linear chromosome maintenance in the absence of essential telomere-capping proteins

Mikhajlo K. Zubko
David Lydall
Research11 Jun 2006
Nature Cell Biology

Volume: 8, P: 734-740
Reversible inhibition of translation by Xenopus oocyte-specific proteins

Joel D. Richter
L. Dennis Smith
Research24 May 1984
Nature

Volume: 309, P: 378-380
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

The role of IFI16 as a DNA sensor is highly controversial. With support from a Nature Communications back-to-back publication from Almineet al. the authors here provide functional evidence that IFI16 is required for DNA sensing via the cGAS-STING pathway in human macrophages.

K. L. Jønsson
A. Laustsen
M. R. Jakobsen
ResearchOpen Access10 Feb 2017
Nature Communications

Volume: 8, P: 1-17
Primary structure and functional expression from complementary DNA of a brain calcium channel

Yasuo Mori
Thomas Friedrich
Shosaku Numa
Research04 Apr 1991
Nature

Volume: 350, P: 398-402
Control of transcription by Krüppel through interactions with TFIIB and TFIIEβ

Frank Sauer
Joseph D. Fondell
Herbert Jäckle
Research11 May 1995
Nature

Volume: 375, P: 162-164
Importin-α-16 is a translocon-associated protein involved in sorting membrane proteins to the nuclear envelope

Suraj Saksena
Max D Summers
Sharon C Braunagel
Research21 May 2006
Nature Structural & Molecular Biology

Volume: 13, P: 500-508
A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

Raymond J. Deshaies
Bruce D. Koch
Randy Schekman
Research28 Apr 1988
Nature

Volume: 332, P: 800-805
Selective repopulation of normal mouse liver by Fas/CD95-resistant hepatocytes

Alexandre Mignon
Jacques E. Guidotti
Axel Kahn
Research01 Oct 1998
Nature Medicine

Volume: 4, P: 1185-1188
Cytoadhesion of Plasmodium falciparum ring-stage-infected erythrocytes

B. Pouvelle
P.A. Buffet
J. Gysin
Research01 Nov 2000
Nature Medicine

Volume: 6, P: 1264-1268
Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2

Tumor suppressor PALB2 is known to interact with BRCA1 and BRCA2, and to be required for the latter's localization to sites of DNA damage. Now PALB2 is shown to bind directly to DNA, to recombinase RAD51 and its accessory factor RAD51AP1. PALB2 also stimulates D loop formation by RAD51 in a synergistic manner with RAD51AP1.

Eloïse Dray
Julia Etchin
Patrick Sung
Research26 Sept 2010
Nature Structural & Molecular Biology

Volume: 17, P: 1255-1259
Author Correction: Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes

Takeshi Ohya
Marta Miaczynska
Marino Zerial
Amendments and Corrections25 Jan 2024
Nature

Volume: 626, P: E8-E9
Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1

Monica Autiero
Johannes Waltenberger
Peter Carmeliet
Research08 Jun 2003
Nature Medicine

Volume: 9, P: 936-943
p45^SKP2 promotes p27^Kip1 degradation and induces S phase in quiescent cells

Hedwig Sutterlüty
Eric Chatelain
Wilhelm Krek
Research05 Jul 1999
Nature Cell Biology

Volume: 1, P: 207-214
Drosophila small cytoplasmic 19S ribonucleoprotein is homologous to the rat multicatalytic proteinase

Patricia-E. Falkenburg
Christian Haass
Burkhardt Dahlmann
Research01 Jan 1988
Nature

Volume: 331, P: 190-192
Reversible bond formation enables the replication and amplification of a crosslinking salen complex as an orthogonal base pair

Adding one further base pair to the classic Watson–Crick scheme not only expands the genetic code but also offers opportunities to modify the structure and function of DNA. It has now been shown that an artificial metal–salen base pair can be enzymatically incorporated into DNA duplexes and even amplified by PCR.

Corinna Kaul
Markus Müller
Thomas Carell
Research28 Aug 2011
Nature Chemistry

Volume: 3, P: 794-800
Type III restriction enzymes need two inversely oriented recognition sites for DNA cleavage

Andreas Meisel
Thomas A. Bickle
Cornelia Schroeder
Research30 Jan 1992
Nature

Volume: 355, P: 467-469
Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states

CRISPR activation of 1,836 human transcription factors recapitulates fibroblast transcriptional states observed in vivo and identifies regulators that can revert inflammatory states.

Kaden M. Southard
Rico C. Ardy
Thomas M. Norman
Research06 Aug 2025
Nature Genetics

Volume: 57, P: 2323-2334
Conservation of dark CPD photolyase function in blind cavefish

By investigating the paradoxical retention of a photolyase gene in a light-deprived blind cavefish, the authors reveal a novel light-independent function for CPD photolyase in the repair of oxidative stress-induced DNA damage

Hongxiang Li
Carina Scheitle
Nicholas S. Foulkes
ResearchOpen Access11 Aug 2025
Nature Communications

Volume: 16, P: 1-13
Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability

The DNA-dependent protease SPRTN cleaves toxic DNA-protein crosslinks (DPCs). Here, the authors show that SPRTN is activated by DPC-ubiquitylation through an allosteric ubiquitin binding interface. This regulatory mechanism enables precise control of SPRTN activity during DNA repair.

Sophie Dürauer
Hyun-Seo Kang
Julian Stingele
ResearchOpen Access21 Jul 2025
Nature Communications

Volume: 16, P: 1-17
Multistep assembly of the protein import channel of the mitochondrial outer membrane

Kirstin Model
Chris Meisinger
Michael T. Ryan
Research01 Apr 2001
Nature Structural Biology

Volume: 8, P: 361-370
Unconventional tethering of Ulp1 to the transport channel of the nuclear pore complex by karyopherins

Vikram Govind Panse
Bernhard Küster
Ed Hurt
Research09 Dec 2002
Nature Cell Biology

Volume: 5, P: 21-27
Cyclic AMP–dependent protein kinase phosphorylation facilitates GABA_B receptor–effector coupling

Andrés Couve
Philip Thomas
Stephen J. Moss
Research25 Mar 2002
Nature Neuroscience

Volume: 5, P: 415-424
Fragile X syndrome without CCG amplification has an FMR1 deletion

A.K. Gedeon
E. Baker
J.C. Mulley
Research01 Aug 1992
Nature Genetics

Volume: 1, P: 341-344
Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2

J. David Farrar
Janice D. Smith
Kenneth M. Murphy
Research01 Jul 2000
Nature Immunology

Volume: 1, P: 65-69
ras-Related gene sequences identified and isolated from Saccharomyces cerevisiae

D. DeFeo-Jones
E. M. Scolnick
R. Dhar
Research15 Dec 1983
Nature

Volume: 306, P: 707-709
SLAMseq reveals potential transfer of RNA from liver to kidney in the mouse

Hunter et al. use RNA labelling to investigate RNA transfer between organs in mice. They show that RNA potentially moves en masse from liver to kidney and that this movement is augmented in acute liver injury, although the physiological relevance of the phenomenon is not yet known.

Robert W. Hunter
Jialin Sun
James W. Dear
ResearchOpen Access11 Aug 2025
Nature Communications

Volume: 16, P: 1-14
Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product

Sylvain Latour
Gerald Gish
André Veillette
Research01 Aug 2001
Nature Immunology

Volume: 2, P: 681-690
Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1

The BRCA2 tumour suppressor protein is known to play an important role in homologous recombination. Here the authors reveal how the phosphorylation of BRCA2 by Polo-like kinase 1 (PLK1) contributes to the regulation of mitosis.

Åsa Ehlén
Charlotte Martin
Aura Carreira
ResearchOpen Access14 Apr 2020
Nature Communications

Volume: 11, P: 1-21

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