Nature Search

mRNA-based seasonal influenza and SARS-CoV-2 multicomponent vaccine in healthy adults: a phase 1/2 trial

An interim analysis shows that a new mRNA influenza and SAR-CoV-2 combination vaccine is safe and triggers an encouraging immune response.

Amanda K. Rudman Spergel
Jintanat Ananworanich
Christine A. Shaw
Research18 Mar 2025
Nature Medicine

Volume: 31, P: 1484-1493
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.

Peter Sandercock
Janet Darbyshire
Martin J. Landray
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-13
A Method for Determining Ice-Water Relationships by Measurements of Dielectric Constant Changes

LYLE T. ALEXANDER
THOMAS M. SHAW
Research26 Jun 1937
Nature

Volume: 139, P: 1109-1110
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

COVID-19 can be associated with neurological complications. Here the authors show that markers of brain injury, but not immune markers, are elevated in the blood of patients with COVID-19 both early and months after SARS-CoV-2 infection, particularly in those with brain dysfunction or neurological diagnoses.

Benedict D. Michael
Cordelia Dunai
David K. Menon
ResearchOpen Access22 Dec 2023
Nature Communications

Volume: 14, P: 1-15
The arrangement of myosin heads in relaxed crab muscle

Yuichiro Maéda
Research03 Mar 1983
Nature

Volume: 302, P: 69-72
Leucine-zipper motif update

MARTYN K. WHITE
MICHAEL J. WEBER
Research13 Jul 1989
Nature

Volume: 340, P: 103-104
BMAL1–HIF2A heterodimer modulates circadian variations of myocardial injury

The core circadian transcription factor BMAL1 regulates circadian-dependent myocardial injury.

Wei Ruan
Tao Li
Holger K. Eltzschig
ResearchOpen Access23 Apr 2025
Nature

Volume: 641, P: 1017-1028
Discontinuous Distribution in Bees

T. D. A. COCKERELL
Research09 Jul 1932
Nature

Volume: 130, P: 58-59
Domain coupling in activation of a family C GPCR

Combined single-molecule spectroscopy, hydrogen–deuterium exchange and molecular dynamics approaches reveal that agonist activation of metabotropic glutamate receptors entails population of several intermediary states before G protein coupling.

Naomi R. Latorraca
Sam Sabaat
Ehud Y. Isacoff
ResearchOpen Access25 Apr 2025
Nature Chemical Biology

Volume: 21, P: 1433-1443
Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate

John E. Harlan
Philip J. Hajduk
Stephen W. Fesik
Research08 Sept 1994
Nature

Volume: 371, P: 168-170
A genetically informed brain atlas for enhancing brain imaging genomics

GIANT, a genetically informed brain atlas, integrates genetic heritability with neuroanatomy. It shows strong neuroanatomical validity and surpasses traditional atlases in discovery power for brain imaging genomics.

Jingxuan Bao
Junhao Wen
Li Shen
ResearchOpen Access14 Apr 2025
Nature Communications

Volume: 16, P: 1-18
A machine learning approach to leveraging electronic health records for enhanced omics analysis

COMET, an artificial intelligence method that improves the analysis of small medical studies using large clinical databases, has been created. COMET can help develop better artificial intelligence tools and identify key biomarkers across many diseases, potentially changing medical research.

Samson J. Mataraso
Camilo A. Espinosa
Nima Aghaeepour
ResearchOpen Access16 Jan 2025
Nature Machine Intelligence

Volume: 7, P: 293-306
Structure of DNA in DNA replication mutants of yeast

THOMAS D. PETES
CAROL SHAW NEWLON
Research18 Oct 1974
Nature

Volume: 251, P: 637-639
Substance from Erythrocytes of Blood Group A

J. KOSCIELAK
K. ZAKRZEWSKI
Research06 Aug 1960
Nature

Volume: 187, P: 516-517
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Complete nucleotide sequence and identification of membrane components of the histidine transport operon of S. typhimurium

C. F. Higgins
P. D. Haag
G. Ferro-Luzzi Ames
Research19 Aug 1982
Nature

Volume: 298, P: 723-727
Activation and friction in enzymatic loop opening and closing dynamics

Enzymes present loops around active sites whose closing and opening dynamics are essential for its activity. Here the authors unveil the mechanism governing loop motion, showing that it involves an activated conformational rearrangement around a couple of torsional angles taking place under the strong friction exerted by the rest of loop torsions.

Kirill Zinovjev
Paul Guénon
Iñaki Tuñón
ResearchOpen Access20 Mar 2024
Nature Communications

Volume: 15, P: 1-12
Decay characteristics of HIV-1-infected compartments during combination therapy

Alan S. Perelson
Paulina Essunger
David D. Ho
Research08 May 1997
Nature

Volume: 387, P: 188-191
Suppression of Homograft Immunity in Chickens grafted in ovo with Allogeneic Thymus

BRANISLAV D. JANKOVIĆ
KATARINA ISAKOVIĆ
Research02 Jul 1966
Nature

Volume: 211, P: 93-94
A second-generation linkage map of the human genome

Jean Weissenbach
Gabor Gyapay
Mark Lathrop
Research29 Oct 1992
Nature

Volume: 359, P: 794-801
Oxytocic Lipids in Human Amniotic Fluid

D. F. HAWKINS
Research09 Jun 1962
Nature

Volume: 194, P: 975-976
Vibrational Spectra and Structure of the Tricyanomethanide Ion C(CN)⁻₃

D. A. LONG
R. A. G. CARRINGTON
R. B. GRAVENOR
Research27 Oct 1962
Nature

Volume: 196, P: 371-372
Use of Ear Chamber with Uterine Muscle Transplant to differentiate Myometrial and Vascular Activity

W. J. CLIFF
J. D. MARTIN
C. A. MICHAEL
Research27 Jul 1963
Nature

Volume: 199, P: 399-400
Serological Relationship of Chrysanthemum Virus B to Carnation Latent Virus and Potato Viruses M and S

D. H. M. VAN SLOGTEREN
N. P. DE VOS
F. A. HAKKAART
Research25 Aug 1962
Nature

Volume: 195, P: 835-836
Long-term preservation of slab signatures in the mantle inferred from hydrogen isotopes

Subduction transports water into the mantle, but it is uncertain whether the water is preserved in the slab or is rapidly diffused. Analysis of hydrogen and boron isotopes in volcanic rocks sourced from an ancient subducted slab beneath the southwestern Pacific Ocean provides evidence for the long-term preservation of subducted water in the mantle.

A. M. Shaw
E. H. Hauri
J. M. Sinton
Research26 Feb 2012
Nature Geoscience

Volume: 5, P: 224-228
Diamonds in detonation soot

N. Roy Greiner
D. S. Phillips
Fred Volk
Research02 Jun 1988
Nature

Volume: 333, P: 440-442
Movement of Sodium Ions Associated with the Nerve Impulse

D. LANDOWNE
Research01 Apr 1973
Nature

Volume: 242, P: 457-459
Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells

Sinclair et al. combine quantitative proteomics and an autophagy flux reporter to map autophagy substrates and triggers during CD8 T cell differentiation. Proteins degraded and fueled by autophagy in naïve and effector T cells are identified and it is revealed that the regulation of amino acid transport allows antigen receptors and inflammatory cytokines to repress autophagy flux to shape T cell differentiation.

Linda V. Sinclair
Tom Youdale
Doreen A. Cantrell
ResearchOpen Access27 Feb 2025
Nature Immunology

Volume: 26, P: 429-443
High-potency ligands for DREADD imaging and activation in rodents and monkeys

Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a powerful tool for neuroscience, but the standard DREADD ligand, CNO, has significant drawbacks. Here the authors report two novel high-potency DREADD ligands and a novel DREADD radiotracer for imaging purposes.

Jordi Bonaventura
Mark A. G. Eldridge
Michael Michaelides
ResearchOpen Access11 Oct 2019
Nature Communications

Volume: 10, P: 1-12
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

Circulating tumour DNA profiling in early-stage non-small-cell lung cancer can be used to track single-nucleotide variants in plasma to predict lung cancer relapse and identify tumour subclones involved in the metastatic process.

Christopher Abbosh
Nicolai J. Birkbak
Charles Swanton
Research26 Apr 2017
Nature

Volume: 545, P: 446-451
Lucerne Saponin Fractionation and Bloat

C. B. COULSON
T. DAVIES
Research10 Dec 1960
Nature

Volume: 188, P: 947-948
Radar meteor rates and atmospheric density changes

C. D. Ellyett
J. A. Kennewell
Research09 Oct 1980
Nature

Volume: 287, P: 521-522
Dissociation between Antidiuretic and Vasopressor Activity in Rat Posterior Pituitaries on Incubation in vitro

E. VAN KAMMEN
D. DE WIED
Research02 Jul 1966
Nature

Volume: 211, P: 93
Specificity of Infra-Red Spectra

I. D. P. WOOTTON
Research21 Nov 1953
Nature

Volume: 172, P: 954-955
Hydrogenation of Chloroplast Lipids by Rumen Bacteria

D. E. WRIGHT
Research20 Feb 1960
Nature

Volume: 185, P: 546-547
AI-guided precision parenteral nutrition for neonatal intensive care units

An artificial intelligence model defines a data-driven set of total parenteral nutrition compositions to assist clinicians in personalized treatment of neonates in intensive care and is able to adapt recommendations to patient status, with validation from large external cohorts and a blinded reader study.

Thanaphong Phongpreecha
Marc Ghanem
Nima Aghaeepour
ResearchOpen Access25 Mar 2025
Nature Medicine

Volume: 31, P: 1882-1894
Alterations in the surface properties of cells responsive to nerve growth factor

D. Schubert
M. LaCorbiere
W. Stallcup
Research29 Jun 1978
Nature

Volume: 273, P: 718-723
Plasma protease inhibitors in mouse and man: divergence within the reactive centre regions

Robert E. Hill
Phillip H. Shaw
Nicholas D. Hastie
Research13 Sept 1984
Nature

Volume: 311, P: 175-177
Retinoblastoma gene product activates expression of the human TGF-β2 gene through transcription factor ATF-2

Seong-Jin Kim
Susanne Wagner
Michael R. Green
Research23 Jul 1992
Nature

Volume: 358, P: 331-334
Relation of Crystal Size and Shape to Contact Toxicity of D.D.T. Suspensions

ANDREW. H. MCINTOSH
Research21 Sept 1946
Nature

Volume: 158, P: 417
ImmuneLENS characterizes systemic immune dysregulation in aging and cancer

Immune lymphocyte estimation from nucleotide sequencing (ImmuneLENS) infers B cell and T cell fractions from whole-genome sequencing data. Applied to the 100,000 Genomes Project datasets, circulating T cell fraction provides sex-dependent and prognostic insights in patients.

Robert Bentham
Thomas P. Jones
Nicholas McGranahan
ResearchOpen Access18 Feb 2025
Nature Genetics

Volume: 57, P: 694-705
Parallel polymorphism in the heterochromatin of Trillium species

C D Darlington
G W Shaw
Research01 Feb 1959
Heredity

Volume: 13, P: 89-121
Change of deep subduction seismicity after a large megathrust earthquake

In this study, the authors analyze the spatio-temporal variations of the seismicity in Japan due to the Tohoku-Oki earthquake. They show that a megathrust earthquake can affect the stress state of the slab over large lateral and depth ranges.

Blandine Gardonio
David Marsan
Alexandre Schubnel
ResearchOpen Access02 Jan 2024
Nature Communications

Volume: 15, P: 1-9
CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

Alterations in the tumour suppressor genes STK11 and/or KEAP1 can identify patients with advanced non-small-cell lung cancer who are likely to benefit from combinations of PD-(L)1 and CTLA4 immune checkpoint inhibitors added to chemotherapy.

Ferdinandos Skoulidis
Haniel A. Araujo
John V. Heymach
ResearchOpen Access09 Oct 2024
Nature

Volume: 635, P: 462-471
Bleaching of Visual Purple in Solutions of Inorganic Salts

C. D. B. BRIDGES
Research20 Oct 1956
Nature

Volume: 178, P: 860-861
Chaos, randomness and dimension

T. Geisel
News & Views22 Jul 1982
Nature

Volume: 298, P: 322-323
Ubiquitous nature of ambient metastable aerosol

M. J. Rood
M. A. Shaw
D. S. Covert
Research09 Feb 1989
Nature

Volume: 337, P: 537-539
Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction

A national prospective study of patients requiring hospitalization for COVID-19 demonstrates global cognitive deficits at 1 year, associated with elevated brain injury markers and reduced gray matter volume.

Greta K. Wood
Brendan F. Sargent
E. Charles Leek
ResearchOpen Access23 Sept 2024
Nature Medicine

Volume: 31, P: 245-257
Crystal structure of an HIV-binding recombinant fragment of human CD4

Seong-Eon Ryu
Peter D. Kwong
Wayne A. Hendrickson
Research29 Nov 1990
Nature

Volume: 348, P: 419-426
A novel mechanism for regulating the excitation of photosystem II in a green alga

Assaf Sukenik
Kevin D. Wyman
Paul G. Falkowski
Research25 Jun 1987
Nature

Volume: 327, P: 704-707

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