Nature Search

Disease prediction with multi-omics and biomarkers empowers case–control genetic discoveries in the UK Biobank

MILTON uses phenotype information in the UK Biobank to identify clinical biomarkers and other quantitative traits that characterize diseases. It then constructs augmented cohorts by predicting undiagnosed individuals, improving power to discover gene–disease relationships.

Manik Garg
Marcin Karpinski
Dimitrios Vitsios
ResearchOpen Access11 Sept 2024
Nature Genetics

Volume: 56, P: 1821-1831
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages

IL-10 can limit inflammation in part by inhibiting miR-155. Here the authors show how this axis induces mitochondrial arginase-2 to alter the mitochondrial dynamics and bioenergetics of macrophages and make these cells less pro-inflammatory.

Jennifer K. Dowling
Remsha Afzal
Claire E. McCoy
ResearchOpen Access05 Mar 2021
Nature Communications

Volume: 12, P: 1-14
Cholinergic and Monoaminergic Systems of the Brain

C. C. D. SHUTE
P. R. LEWIS
Research12 Nov 1966
Nature

Volume: 212, P: 710-711
Detailed mapping of Bifidobacterium strain transmission from mother to infant via a dual culture-based and metagenomic approach

Here, the authors combine isolation and sequencing of bacteria from both mothers and infants and to show that several microbial strains are commonly transferred, including from the genus Bifidobacterium, with factors that influencing transfer including delivery mode and exposure to antibiotics in labour.

Conor Feehily
Ian J. O’Neill
Paul D. Cotter
ResearchOpen Access25 May 2023
Nature Communications

Volume: 14, P: 1-14
Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology

Osmotic compensation by electroneutral ion transport buffers TORC1-mediated changes in the cytosolic proteome, and maintains intracellular homeostasis and cell volume over the circadian cycle. Here, the authors find such ion content changes drive daily rhythms in cardiomyocyte electrical activity.

Alessandra Stangherlin
Joseph L. Watson
John S. O’Neill
ResearchOpen Access15 Oct 2021
Nature Communications

Volume: 12, P: 1-14
Mammal responses to global changes in human activity vary by trophic group and landscape

Analysing camera-trap data of 163 mammal species before and after the onset of COVID-19 lockdowns, the authors show that responses to human activity are dependent on the degree to which the landscape is modified by humans, with carnivores being especially sensitive.

A. Cole Burton
Christopher Beirne
Roland Kays
ResearchOpen Access18 Mar 2024
Nature Ecology & Evolution

Volume: 8, P: 924-935
PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects

Tom Glaser
Lisa Jepeal
Richard L. Maas
Research01 Aug 1994
Nature Genetics

Volume: 7, P: 463-471
Western diets and faecal nitrosamines

J. D. POTTER
Research22 Apr 1982
Nature

Volume: 296, P: 780
A search for human influences on the thermal structure of the atmosphere

B. D. Santer
K. E. Taylor
S. Tett
Research04 Jul 1996
Nature

Volume: 382, P: 39-46
The osmium isotopic composition of the Earth's primitive upper mantle

T. Meisel
R. J. Walker
J. W. Morgan
Research10 Oct 1996
Nature

Volume: 383, P: 517-520
Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon

Infectious disease associated with excessive inflammation can result in coagulopathy. Here the authors show use of the clinically approved therapy dimethyl fumarate, as well as the pre-clinical tool compound 4- octyl itaconate, modulate tissue factor related coagulopathy via inhibition of the myeloid type I interferon pathway-tissue factor axis.

Tristram A. J. Ryan
Alexander Hooftman
Luke A. J. O’Neill
ResearchOpen Access14 Jun 2023
Nature Communications

Volume: 14, P: 1-15
2,6,10,14-Tetramethylpentadecane (Pristane) from Wool Wax

JAMES D. MOLD
ROBERT K. STEVENS
JOHN M. RUTH
Research20 Jul 1963
Nature

Volume: 199, P: 283-284
Protection of Mice Against Syngeneic Lymphomata

D A L Davies
A J Manstone
S Buckham
Research01 Oct 1974
British Journal of Cancer

Volume: 30, P: 297-304
A Comparison of Polysaccharides of Hypnea musciformis and Chondrus crispus

R. D. HAMILTON
J. J. CARROLL
Research22 Dec 1962
Nature

Volume: 196, P: 1200-1201
Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of esophageal cancer

Ganguli et al. show that CDKN2A loss in Barrett’s esophagus prevents esophageal adenocarcinoma initiation by counterselecting subsequent TP53 loss and report context-dependent effects of 9p21 gene co-deletions on disease progression.

Piyali Ganguli
Celia C. Basanta
Francesca D. Ciccarelli
ResearchOpen Access03 Jan 2025
Nature Cancer

Volume: 6, P: 158-174
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
DNA sequence and expression of the B95-8 Epstein—Barr virus genome

R. Baer
A. T. Bankier
B. G. Barrell
Research19 Jul 1984
Nature

Volume: 310, P: 207-211
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
A question of reduction

Chris Ballhaus
News & Views11 Nov 1993
Nature

Volume: 366, P: 112-113
Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair

How adhesive forces are transduced and integrated into biochemical signals at focal adhesions (FAs) is poorly understood. Here authors show that force- FAK signaling coupling coordinates cell migration and tissue-scale forces to promote microtissue repair.

Dennis W. Zhou
Marc A. Fernández-Yagüe
Andrés J. García
ResearchOpen Access21 Apr 2021
Nature Communications

Volume: 12, P: 1-13
Isolation of L-Galactose-6-sulphate from a Seaweed Polysaccharide

J. R. TURVEY
D. A. REES
Research11 Mar 1961
Nature

Volume: 189, P: 831-832
Designed endocytosis-inducing proteins degrade targets and amplify signals

Computationally designed genetically encoded proteins can be used to target surface proteins, thereby triggering endocytosis and subsequent intracellular degradation, activating signalling or increasing cellular uptake in specific tissues.

Buwei Huang
Mohamad Abedi
David Baker
ResearchOpen Access25 Sept 2024
Nature

Volume: 638, P: 796-804
Erratum: The oxygen isotope effect in Ba_0.625K_0.375BiO₃

D. G. Hinks
D. R. Richards
A. W. Mitchell
Amendments and Corrections08 Dec 1988
Nature

Volume: 336, P: 604
Demonstration of intermolecular forces in cell adhesion using a new electrochemical technique

D. GINGELL
J. A. FORNES
Research17 Jul 1975
Nature

Volume: 256, P: 210-211
Family studies define a new histocompatibility locus, SB, between HLA-DR and GLO

Stephen Shaw
Paula Kavathas
Claude Mawas
Research29 Oct 1981
Nature

Volume: 293, P: 745-747
The complete sequence of a human Y chromosome

We present the complete 62,460,029-base-pair sequence of a human Y chromosome from the HG002 genome (T2T-Y) that corrects multiple errors in GRCh38-Y and adds over 30 million base pairs of sequence to the reference.

Arang Rhie
Sergey Nurk
Adam M. Phillippy
Research23 Aug 2023
Nature

Volume: 621, P: 344-354
Evidence from mtDNA sequences that common laboratory strains of inbred mice are descended from a single female

Stephen D. Ferris
Richard D. Sage
Allan C. Wilson
Research14 Jan 1982
Nature

Volume: 295, P: 163-165
Some Further Visual Phenomena associated with Regular Patterned Stimulation

D. M. MACKAY
Research23 Nov 1957
Nature

Volume: 180, P: 1145-1146
The evolution of Earth’s early continental crust

Continental crust is important for Earth’s habitability. This Review explores how the formation and stabilization of Earth’s early continental crust was modulated by internal and external factors such as subduction and bolide impacts, respectively.

Christopher L. Kirkland
Tim E. Johnson
Craig O’Neill
Reviews14 Aug 2025
Nature Reviews Earth & Environment

Volume: 6, P: 612-625
A Foot and Mouth Disease Syndrome in Pigs caused by an Enterovirus

L. NARDELLI
E. LODETTI
B. CARTWRIGHT
Research21 Sept 1968
Nature

Volume: 219, P: 1275-1276
Geographic variation of mutagenic exposures in kidney cancer genomes

Whole-genome sequencing of 962 clear cell renal cell carcinomas from 11 countries shows geographic variations in somatic mutation profiles, including a mutational signature of unknown cause in 70% of cases from Japan.

Sergey Senkin
Sarah Moody
Paul Brennan
ResearchOpen Access01 May 2024
Nature

Volume: 629, P: 910-918
An upper limit to violations of the Pauli exclusion principle

D. Kekez
A. Ljubic̆ić
B. A. Logan
Research15 Nov 1990
Nature

Volume: 348, P: 224
Eukaryotic cell biology is temporally coordinated to support the energetic demands of protein homeostasis

Yeast exhibit oscillations that share features with circadian rhythms. The authors show that bioenergetic constraints promote oscillatory behaviour: resources are stored until supplies can support translational bursting, this is licensed by ion transport and release from membrane-less compartments.

John S. O’Neill
Nathaniel P. Hoyle
Helen C. Causton
ResearchOpen Access17 Sept 2020
Nature Communications

Volume: 11, P: 1-11
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Spatial and temporal transmission dynamics of respiratory syncytial virus in New Zealand before and after the COVID-19 pandemic

Non-pharmaceutical interventions for COVID-19 control impacted transmission of other pathogens including respiratory syncytial virus (RSV). Here, the authors perform phylodynamic analyses of RSV genomes from New Zealand to explore dynamics before, during, and after the COVID-19 pandemic.

Lauren Jelley
Jordan Douglas
Jemma L. Geoghegan
ResearchOpen Access11 Nov 2024
Nature Communications

Volume: 15, P: 1-11
Discovery of hardest known oxide

J. M. Léger
J. Haines
J. A. H. da Jornada
Research03 Oct 1996
Nature

Volume: 383, P: 401
Macromolecular condensation buffers intracellular water potential

Water thermodynamics drive changes in macromolecular assembly that rapidly restore intracellular water availability in response to physiological fluctuations in temperature, pressure and osmotic strength.

Joseph L. Watson
Estere Seinkmane
Emmanuel Derivery
ResearchOpen Access18 Oct 2023
Nature

Volume: 623, P: 842-852
Volcanic Dust and Climatic Change

W. J. HUMPHREYS
Research31 Mar 1923
Nature

Volume: 111, P: 431
Intensity of the near infrared OH airglow

W. HOFMANN
A. FREY
D. LEMKE
Research23 Aug 1974
Nature

Volume: 250, P: 636-637
Active Transport of Lysergic Acid Diethylamide

ERNEST M. WRIGHT
Research03 Nov 1972
Nature

Volume: 240, P: 53-54
Pyruvic Acid, a Unique Component of an Exocellular Bacterial Polysaccharide

J. H. SLONEKER
DANUTE G. ORENTAS
Research05 May 1962
Nature

Volume: 194, P: 478-479
Geochemistry of Holocene volcanic rocks associated with ridge subduction in Baja California, Mexico

G. Rogers
A. D. Saunders
G. F. Marriner
Research30 May 1985
Nature

Volume: 315, P: 389-392
Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs

In a new strategy for increasing the availability of lungs for transplantation, human lungs declined for transplantation because of their poor quality can be recuperated by connecting them to the circulation of a pig.

Ahmed E. Hozain
John D. O’Neill
Gordana Vunjak-Novakovic
Research13 Jul 2020
Nature Medicine

Volume: 26, P: 1102-1113
CD14 Modulates PI3K/AKT/p38-MAPK Licensing of Negative Regulators of TLR Signaling to Restrain Chronic Inflammation

Bikash Sahay
Rebeca Patsey
Timothy Sellati
ResearchOpen Access25 Jun 2008
Nature Precedings

P: 1
Observation of electroweak production of two jets and a Z-boson pair

The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access09 Feb 2023
Nature Physics

Volume: 19, P: 237-253
Neocentromere activity of structurally acentric mini-chromosomes in Drosophila

Byron C. Williams
Terence D. Murphy
Gary H. Karpen
Research01 Jan 1998
Nature Genetics

Volume: 18, P: 30-38
Aromatase activity in breast adipose tissue from women with benign and malignant breast diseases

JS O'Neill
WR Miller
Research01 Nov 1987
British Journal of Cancer

Volume: 56, P: 601-604
Test of the universality of τ and μ lepton couplings in W-boson decays with the ATLAS detector

The ATLAS Collaboration reports a measurement of the ratio of the decay rates of W bosons to τ leptons and muons, in agreement with universal lepton couplings as postulated in the standard model of particle physics.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access05 Jul 2021
Nature Physics

Volume: 17, P: 813-818
Increase in C3 plant water-use efficiency and biomass over Glacial to present C0₂ concentrations

H. Wayne Policy
Hyrum B. Johnson
Herman S. Mayeux
Research07 Jan 1993
Nature

Volume: 361, P: 61-64
A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection

Steven D. Marlin
Donald E. Staunton
Vincent J. Merluzzi
Research01 Mar 1990
Nature

Volume: 344, P: 70-72

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