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Showing 301–350 of 715 results

Advanced filters: Author: D Schaffer Clear advanced filters

A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

Schreiber et al characterize a common inhibitory mechanism for ifenprodil and its derived compounds acting on GluN2B-containing N-methyl-D-aspartate receptors (NMDARs). These insights, generated through mutagenesis of the receptor binding site, chemical modifications of the compounds and structural modeling, may aid in the treatment of neurodegenerative diseases where GluN2B is involved.

Julian A. Schreiber
Dirk Schepmann
Guiscard Seebohm
ResearchOpen Access15 Nov 2019
Communications Biology

Volume: 2, P: 1-14
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

Laura Schmidt
Fuh-Mei Duh
Berton Zbar
Research01 May 1997
Nature Genetics

Volume: 16, P: 68-73
Persistent inhibitory circuit defects and disrupted social behaviour following in utero exogenous cannabinoid exposure

G A Vargish
K A Pelkey
C J McBain
Research15 Mar 2016
Molecular Psychiatry

Volume: 22, P: 56-67
Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism

Plants contain small levels of cholesterol. Analysis of transcripts, proteins and individual gene silencing in tomato identifies a biosynthetic pathway involving 12 enzymes that is shown to be functional by expression of the full set in Arabidopsis.

Prashant D. Sonawane
Jacob Pollier
Asaph Aharoni
Research22 Dec 2016
Nature Plants

Volume: 3, P: 1-13
Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans

U Salzer
H M Chapel
B Grimbacher
Research10 Jul 2005
Nature Genetics

Volume: 37, P: 820-828
Cultural heritage and iconic elements for history education: a study with primary education prospective teachers in Spain

Diego Miguel-Revilla
Esther López-Torres
Sebastián Molina-Puche
ResearchOpen Access21 Nov 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-13
The fusion–fission optimization (FuFiO) algorithm

Behnaz Nouhi
Nima Darabi
Siamak Talatahari
ResearchOpen Access20 Jul 2022
Scientific Reports

Volume: 12, P: 1-44
Territoriality and adaptation

Jared M. Diamond
Books & Arts02 Feb 1978
Nature

Volume: 271, P: 485
A massive, cooling-flow-induced starburst in the core of a luminous cluster of galaxies

X-ray, optical and infrared observations reveal a very high rate of star formation in the core of an extremely luminous galaxy cluster; this starburst seems to be triggered by a cooling flow of the dense intracluster plasma.

M. McDonald
M. Bayliss
A. Zenteno
Research15 Aug 2012
Nature

Volume: 488, P: 349-352
Characterization of RNA content in individual phase-separated coacervate microdroplets

Here, the authors demonstrate that single cell RNA sequencing technology can be leveraged to characterize RNA content of individual membrane-free condensates formed by liquid-liquid phase separation processes such as coacervation.

Damian Wollny
Benjamin Vernot
Barbara Treutlein
ResearchOpen Access12 May 2022
Nature Communications

Volume: 13, P: 1-9
Synaptic control of DNA methylation involves activity-dependent degradation of DNMT3A1 in the nucleus

Gonca Bayraktar
PingAn Yuanxiang
Michael R. Kreutz
ResearchOpen Access29 Jul 2020
Neuropsychopharmacology

Volume: 45, P: 2120-2130
Age-related shift in LTD is dependent on neuronal adenosine A_2A receptors interplay with mGluR5 and NMDA receptors

Mariana Temido-Ferreira
Diana G. Ferreira
Luísa V. Lopes
ResearchOpen Access27 Jun 2018
Molecular Psychiatry

Volume: 25, P: 1876-1900
Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy

Sara Fernández-García
Anna Sancho-Balsells
Albert Giralt
ResearchOpen Access01 Jun 2020
Cell Death & Disease

Volume: 11, P: 1-17
Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion

Javier Castro-Hernández
Paul A. Adlard
David I. Finkelstein
ResearchOpen Access14 Mar 2017
Scientific Reports

Volume: 7, P: 1-16
Glycans and neural cell interactions

Ralf Kleene
Melitta Schachner
Reviews01 Mar 2004
Nature Reviews Neuroscience

Volume: 5, P: 195-208
How neurons exploit fractal geometry to optimize their network connectivity

Julian H. Smith
Conor Rowland
R. P. Taylor
ResearchOpen Access27 Jan 2021
Scientific Reports

Volume: 11, P: 1-13
Expression profiling using a hexamer-based universal microarray

Matthew E Roth
Li Feng
Paul M Lizardi
Research14 Mar 2004
Nature Biotechnology

Volume: 22, P: 418-426
Relationships between distance from the fovea to the disc and macular retinal layer thickness differ between normal and glaucomatous eyes

Tomomi Higashide
Sachiko Udagawa
Robert N. Weinreb
ResearchOpen Access04 Apr 2025
Scientific Reports

Volume: 15, P: 1-10
Late-phase long-term potentiation: getting to the nucleus

J. Paige Adams
Serena M. Dudek
Reviews01 Sept 2005
Nature Reviews Neuroscience

Volume: 6, P: 737-743
Nanonewton optical force trap employing anti-reflection coated, high-refractive-index titania microspheres

Researchers demonstrate an ultrastrong optical trap capable of operating with nanonewton optical forces by employing tailor-made high-refractive-index particles. This work could could lead to the development of highly efficient light-driven machines.

Anita Jannasch
Ahmet F. Demirörs
Erik Schäffer
Research24 Jun 2012
Nature Photonics

Volume: 6, P: 469-473
DeepPrep: an accelerated, scalable and robust pipeline for neuroimaging preprocessing empowered by deep learning

DeepPrep is a preprocessing pipeline for functional and structural MRI data from humans. Deep learning-based modules and an efficient workflow allow DeepPrep to handle large datasets.

Jianxun Ren
Ning An
Hesheng Liu
ResearchOpen Access06 Feb 2025
Nature Methods

Volume: 22, P: 473-476
RETINAL SUPEROXIDE DISMUTASE ACTIVITY IN NEWBORN KITTENS EXPOSED TO NORMOBARIC HYPEROXIA EFFECT OF VITAMIN E

D Bougle
P Vert
E L Heng
Research01 May 1982
Pediatric Research

Volume: 16, P: 400-402
Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions

Bronchial premalignant lesions can potentially progress to lung squamous cell carcinoma. Here, the authors profile bronchial biopsies from high-risk smokers by RNA sequencing and identify four molecular subtypes of premalignant lesions and an immune molecular signature that associates with lesion progression.

Jennifer E. Beane
Sarah A. Mazzilli
Avrum E. Spira
ResearchOpen Access23 Apr 2019
Nature Communications

Volume: 10, P: 1-13
Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders

Sophie Breunig
Younga Heather Lee
Andrew D. Grotzinger
ResearchOpen Access21 Jul 2025
Translational Psychiatry

Volume: 15, P: 1-11
New discoveries of Australopithecus at Maka in Ethiopia

Tim D. White
Gen suwa
Elisabeth Vrba
Research18 Nov 1993
Nature

Volume: 366, P: 261-265
A hyper-activatable CAMK2A variant associated with intellectual disability causes exaggerated long-term potentiation and learning impairments

Miao Pan
Pin-Wu Liu
Sayaka Takemoto-Kimura
ResearchOpen Access26 Mar 2025
Translational Psychiatry

Volume: 15, P: 1-12
The Role of AMPARs in the Maturation and Integration of Caudal Ganglionic Eminence-Derived Interneurons into Developing Hippocampal Microcircuits

G. Akgül
D. Abebe
C. J. McBain
ResearchOpen Access01 Apr 2019
Scientific Reports

Volume: 9, P: 1-16
Maturation of Caffeine N-Demethylation in Infancy: A Study Using the ¹³CO₂ Breath Test

Gérard Pons
Jean-Claude Blais
Georges Olive
Research01 Jun 1988
Pediatric Research

Volume: 23, P: 632-636
Nerve growth factor(NGF) induces mRNA expression of the new transcription factor protein p48ZnF

Klaus Heese
Yasuo Nagai
Tohru Sawada
ResearchOpen Access01 Apr 2004
Experimental & Molecular Medicine

Volume: 36, P: 130-134
A lectin S-domain receptor kinase mediates lipopolysaccharide sensing in Arabidopsis thaliana

Plants have a vast array of pattern-recognition receptor to detect microbial ligands, but how they sense lipopolysaccharide has remained unknown. Ranf et al. identify the receptor-like kinase SD1-29 as a de facto pattern-recognition receptor for lipopolysaccharide in Arabidopsis.

Stefanie Ranf
Nicolas Gisch
Dierk Scheel
Research02 Mar 2015
Nature Immunology

Volume: 16, P: 426-433
Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit

Kenji Sakimura
Tatsuya Kutsuwada
Masayoshi Mishina
Research12 Jan 1995
Nature

Volume: 373, P: 151-155
Chromatin-remodeling factor SMARCD2 regulates transcriptional networks controlling differentiation of neutrophil granulocytes

Christoph Klein and colleagues identify loss-of-function mutations in SMARCD2 (BAF60b) that lead to neutropenia, specific granule deficiency and myelodysplasia. They show that SMARCD2 controls differentiation of myeloid–erythroid progenitor cells through interaction with CEBPɛ and that reduced SMARCD2 levels cause transcription and chromatin alterations in acute myeloid leukemia cells.

Maximilian Witzel
Daniel Petersheim
Christoph Klein
Research03 Apr 2017
Nature Genetics

Volume: 49, P: 742-752
Idiopathic Leucine-Sensitive Hypoglycemia Syndrome: Insulin and Glucagon Responses and Effects of Diazoxide

Thomas F Roe
Maurice D Kogut
Research01 Jan 1982
Pediatric Research

Volume: 16, P: 1-4
Indirect diode laser treatment for stage 3 retinopathy of prematurity

D I Clark
M Hero
Research01 Jul 1994
Eye

Volume: 8, P: 423-426
Impaired novelty acquisition and synaptic plasticity in congenital hyperammonemia caused by hepatic glutamine synthetase deficiency

Aisa N. Chepkova
Olga A. Sergeeva
Dieter Häussinger
ResearchOpen Access09 Jan 2017
Scientific Reports

Volume: 7, P: 1-13
Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development

Altered muscarinic acetylcholine receptor (mAChR) activity is implicated in many disorders including Alzheimer's disease, schizophrenia, pain, obesity and diabetes, but lack of knowledge of the precise functional roles of the individual mAChR subtypes has hampered drug development. Wess and colleagues review recent insights gained frommAChR-knockout mice that are helping to address this issue and discuss the therapeutic potential of subtype-selective mAChR modulation.

Jürgen Wess
Richard M. Eglen
Dinesh Gautam
Reviews01 Sept 2007
Nature Reviews Drug Discovery

Volume: 6, P: 721-733
NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders

Lau and Zukin focus on the contribution of NMDARs to synaptic plasticity, reviewing the molecular mechanisms that underlie the regulation of subunit composition and receptor numbers in the postsynaptic density. They also discuss how these regulatory mechanisms are thought to contribute to addiction and neurological diseases.

C. Geoffrey Lau
R. Suzanne Zukin
Reviews01 Jun 2007
Nature Reviews Neuroscience

Volume: 8, P: 413-426
Synaptic plasticity at hippocampal mossy fibre synapses

Roger A. Nicoll
Dietmar Schmitz
Reviews01 Nov 2005
Nature Reviews Neuroscience

Volume: 6, P: 863-876
Circadian rhythms and memory formation

Circadian cycling of biological processes is widely conserved across phylogeny. Gerstner and Yin discuss how regulators of circadian rhythms — including clock genes, melatonin and the suprachiasmatic nucleus — affect synaptic plasticity and memory formation.

Jason R. Gerstner
Jerry C. P. Yin
Reviews01 Aug 2010
Nature Reviews Neuroscience

Volume: 11, P: 577-588
Frequency ratio measurements at 18-digit accuracy using an optical clock network

A network of optical atomic clocks based on three different atomic species is reported and their frequency ratios are measured with uncertainties at or below 8 × 10⁻¹⁸.

Kyle Beloy
Martha I. Bodine
Xiaogang Zhang
Research24 Mar 2021
Nature

Volume: 591, P: 564-569
The structural basis of Rubisco phase separation in the pyrenoid

The structural basis of the interactions between Rubisco and its intrinsically disordered linker protein provides insight into phase separation within the algal pyrenoid, an organelle responsible for around a third of global CO₂ fixation.

Shan He
Hui-Ting Chou
Martin C. Jonikas
Research23 Nov 2020
Nature Plants

Volume: 6, P: 1480-1490
An ancestral mitochondrial DNA resembling a eubacterial genome in miniature

B. Franz Lang
Gertraud Burger
Michael W. Gray
Research29 May 1997
Nature

Volume: 387, P: 493-497
A genome-based approach for the identification of essential bacterial genes

Fabrizio Arigoni
Francois Talabot
Hannes Loferer
Research01 Sept 1998
Nature Biotechnology

Volume: 16, P: 851-856
Synaptic vulnerability to amyloid-β and tau pathologies differentially disrupts emotional and memory neural circuits

Maria Dolores Capilla-López
Angel Deprada
Carlos A. Saura
ResearchOpen Access30 Jan 2025
Molecular Psychiatry

Volume: 30, P: 2966-2979
Enhanced synaptic plasticity and spatial memory in female but not male FLRT2-haplodeficient mice

Ana Cicvaric
Jiaye Yang
Francisco J. Monje
ResearchOpen Access27 Feb 2018
Scientific Reports

Volume: 8, P: 1-13
PCAP is the major known prostate cancer predisposing locus in families from south and west Europe

Géraldine Cancel-Tassin
Alain Latil
Olivier Cussenot
Research25 Mar 2001
European Journal of Human Genetics

Volume: 9, P: 135-142
Long-term depression in the CNS

In this comprehensive Review, Collingridge and colleagues describe the mechanisms underlying the induction and expression of various forms of long-term depression (LTD), and discuss the role of LTD in learning and memory as well as in various pathological processes.

Graham L. Collingridge
Stephane Peineau
Yu Tian Wang
Reviews01 Jul 2010
Nature Reviews Neuroscience

Volume: 11, P: 459-473
The molecular logic of endocannabinoid signalling

Daniele Piomelli
Reviews01 Nov 2003
Nature Reviews Neuroscience

Volume: 4, P: 873-884
Src kinases: a hub for NMDA receptor regulation

Michael W. Salter
Lorraine V. Kalia
Reviews01 Apr 2004
Nature Reviews Neuroscience

Volume: 5, P: 317-328
Optimal allocation of hybrid PVDG and DSVC devices into distribution grids using a modified NRBO algorithm considering the overcurrent protection characteristics

Nasreddine Belbachir
Mohamed Zellagui
Riyadh M. Al-Tam
ResearchOpen Access15 Apr 2025
Scientific Reports

Volume: 15, P: 1-23

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