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While anti-retroviral therapy (ART) helps contain HIV, whether adoptive T cell therapy further improve the prognosis is unclear. Here the authors conduct an open-label, single-arm phase 1 study to assess the safety (primary outcome) and characteristic (secondary outcome) of autologous, HIV-specific T cell therapy to find it safe to warrant further efficacy assessment.

Hydrogels are essential for stem cell-based tissue regeneration but struggle with hard tissue repair. The authors report a shell-hardened macroporous hydrogel with spatiotemporally programmed mechanics to enhance stem cell-driven bone regeneration.

The quantum critical point associated with the antiferromagnetic spin-density wave transition occurs in many strongly correlated systems. Here the authors study this quantum critical point in a 2D spin-fermion model using an efficient hybrid Monte Carlo method and make predictions for future experiments.

Banana-shaped liquid crystals attract people’s attention nowadays because of their peculiar optical properties associated with a helical nanofilament phase. Here Zhang et al. report a doubly twisted packing of this phase, which is different from the parallel packing observed in the past.

Clinically significant genetic variation in Asian populations is under-characterized. Here, the authors show the diversity in prevalence and spectrum of human disease and pharmacogenetic variants in a multi-ethnic Asian population.

Liu and colleagues examine how severe acute respiratory syndrome coronavirus 2 variants evade CD8⁺ T cell epitope recognition.

STAAR is a powerful rare variant association test that incorporates variant functional categories and complementary functional annotations using a dynamic weighting scheme based on annotation principal components. STAAR accounts for population structure and relatedness and is scalable for analyzing large whole-genome sequencing studies.

Simultaneous mapping of activity across the cortex and dorsal striatum in mice shows that activity in each part of the striatum precisely mirrors that in topographically associated cortical regions, consistently across behavioural contexts.

The LHCb experiment at CERN has observed significant asymmetries between the decay rates of the beauty baryon and its CP-conjugated antibaryon, thus demonstrating CP violation in baryon decays.

Artificial muscles composed of carbon nanotube yarns have previously demonstrated fast, large-angle rotations. Here, the authors infiltrate carbon nanotube yarns with a paraffin wax and polystyrene-based copolymer mixture, achieving stable 9,800 r.p.m. rotation without apparent oscillation.

The CMS Collaboration reports evidence for off-shell Higgs boson contributions in the production of Z boson pairs, and measures the width of the Higgs boson, which is inversely related to its lifetime.

ACE2 and TMPRSS2 have received recent attention as entry factors for SARS-CoV-2. Here the authors analyze nasal airway transcriptome data from 695 children determining ACE2 and TMPRSS2 expression is induced by viral and type2 inflammation, respectively, and both exhibit eQTLs that vary across world populations.

Biological motors which convert energy into mechanical work inspire the fabrication of synthetic motors. Here the authors demonstrate self-assembled colloidal motors which are driven to a range of responses controlled by the feedback between light polarization and deformation of a liquid crystal.

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

The authors demonstrate the experimental generation and mode conversion of spatiotemporal Laguerre/Hermite-Gaussian wavepackets with controllable dual quantum numbers by imprinting two-dimensional complex modulation onto the spectrum of ultrashort laser pulses, opening new possibilities for spatiotemporally sculpturing of light.

The authors investigate the mechanical behavior of origami tessellations composed of trapezoid faces, which are more general but less studied compared to parallelogram faces. They develop analytical expressions for the deformation modes and test the model’s validity through laboratory scale experiments.

A coating made from densely packed hydroxyapatite particles in an organic matrix endows the dactyl club of mantis shrimps with high stiffness and energy damping.

This study proposes that the optimal allocation of roof area for rooftop agriculture and photovoltaics is 61% of the flat rooftop area to the former and the rest for the latter. However, maintaining this productivity requires considerable water use and materials.

Micro-C provides insights into genome organization in Plasmodium falciparum and defines the machinery used to spatially coordinate antigenic variation and stage-specific genes that are crucial for infection.

In a previous work, the authors have demonstrated the formation of localized waves in nematic liquid crystals driven by an electric field. Here they demonstrate the realization of solitary waves of (3+2)D type which can be steered along longitudinal and transverse directions by the electric field.

The state of charge, mechanical strain and temperature within lithium-ion 18650 cells operated at high rates are characterized and operando temperature rise is observed to be due to heat accumulation, strongly influenced by cell design and charging protocol.

The transcription factor CREM is a pivotal regulator of NK cell function, making CREM a valuable target to increase the efficacy of anticancer immunotherapies based on this cell population and chimeric antigen receptors.

Proteome profiling of plasma samples in human pan-cancer cohorts reveals patterns of biomarkers for diagnosis.

FRB 20221022A, detected by the Canadian Hydrogen Intensity Mapping Experiment Fast Radio Burst project, shows a pronounced change in polarization during the burst, providing important clues into the nature of the source.

Structural variations (SV) contribute to inter-individual variability. Here, the authors describe a first-generation multi-ancestry Asian SV catalogue containing 73,035 SVs from 8392 Singaporeans to provide insights into Asian SV diversity.

The full exploitation of back contact silicon solar cells is crucial to achieve a high performance for potential industrialization. Here, authors incorporate a double-sided light management strategy to reduce optical losses, achieving a total-area efficiency of 27.03% for 350 cm2 solar cells.

In this new study, the authors analyzed data from a longitudinal US-based survey during the first year of the pandemic, focusing on social distancing, psychiatric vulnerability and loneliness in adults.

The study of nematic hosts with anisotropic colloidal particles is reported, but not on the chiral counterparts. Here, the authors report on biaxial properties in a system of colloidal rods with designed surface anchoring doped into a chiral nematic host.

Low cadmium (Cd) accumulation in a rice cultivar is shown to be due to duplication of the manganese/cadmium transporter gene. Introgression of this allele into an elite rice cultivar lowered Cd accumulation in rice grain without penalty of grain yield and eating quality when grown in Cd-contaminated soil.

By measuring the thermal properties of eclogite at high pressures, the authors found that temperature of orogenic continental crust is sufficient to melt granite and phengite, leading to low-velocity and high-conductivity anomalies in orogenic belts.

The transport behavior of the carriers residing in the lowest Landau level is hard to observe in most topological materials. Here, Liu et al. report a surprising angular dependence of the interlayer magnetoresistivity and Hall conductivity arising from the lowest Landau level under high magnetic field in type II Weyl semimetal YbMnBi₂.

The vibrissa follicle is a blood-filled encapsulated mechano-transducer, the structure of which has been difficult to resolve. Here, Gerhardt et al. reveal 3D follicle-afferents architecture and accessorial structures by synchrotron X-ray tomography.

The Ising magnet LiHo_0.045Y_0.955F₄ allows experimental probes of disordered quantum dynamics. Silevitch et al. show that strongly-driven localized spin clusters form effectively decoupled two-level systems whose interactions and coherence can be tuned by external ac and dc magnetic fields.

It is unclear why some ocean island basalts at ‘hotspots’ have low ³He/⁴He ratios similar to mid-ocean ridge basalts. Here, the authors perform convection calculations and show that these isotopic ratios can be reproduced by the episodic entrainment of deep isolated mantle reservoirs into thermal plumes.