Search

Large biospecimen banks are limited by a lack of fast, flexible, database-like retrieval. Here, authors encode metadata as DNA barcodes on silica-encapsulated samples and demonstrate numerical range, categorical, and Boolean queries, enabling rapid, precise recall from pooled DNA/RNA archives.

Schober and colleagues show that effector CD8⁺ T cells undergo metabolic shutdown, CD8⁺ central memory T cells are the most metabolically active, and naive-like memory T cells are quiescent during the acute phase of the immune response and represent the dominant population of memory CD8⁺ T cells after yellow fever vaccination in humans.

Amundsen Sea records show warm Circumpolar Deep Water drove major West Antarctic Ice Sheet retreat from 18,000–10,000 years ago. Subsequent cooling stabilized the grounding line, indicating ocean heat—not atmospheric warming—controlled long-term WAIS change.

Long COVID is associated with challenges in energy management, with limited interventions available. In this study, a just-in-time app-based energy management intervention for long COVID did not reduce postexertional malaise compared to usual care, though both groups improved over time, showing the approach was safe but not effective.

DNA methylation heterogeneity and dynamics hinder distinguishing early pathological changes from normal variation. Here, the authors identify stable sites whose disruption is linked to blood cancers, aging, and cardiovascular risk.

Little work has been done to describe and address the variability inherent in the agroinfiltration and genetic engineering of Nicotiana benthamiana. Here, the authors identify and quantify the sources of virtually all variation and develop recommendations for minimizing variation.

Neoadjuvant chemotherapy (NAC) has improved breast cancer patient outcomes but residual disease limits success. Here, the authors report a phase II clinical trial investigating talimogene laherparepvec (oncolytic virus engineered to express GM-CSF) combined with atezolizumab (anti-PD-L1) in HER2-negative breast cancer patients with residual disease following NAC.

A pragmatic, cluster randomized trial in rural Guangdong, China, showed that 12-month implementation of a comprehensive antibiotic stewardship program involving physician training, point-of-care prompts, monthly peer review feedback and smartphone-based patient education substantially reduced antibiotic prescriptions for acute respiratory infections compared to control consultations.

CRISPR/Cas9 screens have identified genetic contributions to many phenotypes. However, studying combinations of genes or regulatory elements remains challenging. Here, the authors use CRISPR/Cas12a to overcome those challenges and enable new approaches to study combinatorial genetic mechanisms.

The authors present evidence for the coexistence and coupling of ferroelectricity and superconductivity at amorphous LaAlO3/KTaO3(111) interfaces. Furthermore, flipping ferroelectric polarization reduces interfacial conductivity by more than 1000 times, and simultaneously suppresses superconductivity

Population-level analyses and in vitro experiments show that a specific genetic variant of cyclin D3 inhibits the growth of the malaria-causing parasite Plasmodium falciparum in erythrocytes, and suggest that its high frequency in Sardinia was driven by past endemic malaria.

ATF6α activation in human and preclinical models of hepatocellular carcinoma is significantly associated with an aggressive tumour phenotype characterized by reduced survival, glycolytic reprogramming and local immunosuppression.

How the brain supports speaking and listening during conversation of its natural form remains poorly understood. Here, by combining intracranial EEG recordings with Natural Language Processing, the authors show broadly distributed frontotemporal neural signals that encode context-dependent linguistic information during both speaking and listening..

After a heart attack, blood flow restoration often fails in small vessels, worsening outcome. Here, the authors show that remote ischaemic preconditioning releases the gut hormone GLP-1, which relaxes cardiac pericytes via K_ATP channels to reduce capillary constriction and no-reflow.

Authors uncover the tunable band structure in ferroelectric rhombohedral-stacked bilayer WSe₂ by optical spectroscopy, quantifying spontaneous polarization and demonstrating electric-field-driven domain switching for quantum device applications.

Virtual nature exposure reduces self-reported pain and is associated with decreased brain responses linked to somatosensory and nociceptive processing, providing new insights into the underlying mechanisms of nature-induced analgesia.

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) have been associated with adverse effects affecting both the cardiovascular and gastrointestinal systems. Here the authors show that NSAIDs lower plasma tryptophan concentrations in humans and mice and that replacement of tryptophan in mice treated with naproxen leads to decreased adverse effects.

Neoantigen-based adoptive T cell therapies represent a personalized approach for cancer immunotherapy. Here the authors describe NEO-STIM, an ex vivo T cell induction platform to STIMulate peripheral blood T cells to generate responses against tumor NEOantigens.

The study shows that incorporating information on pre-existing moisture conditions into the atmospheric river scale improves early-warning identification of flood-generating events.

The existence of multi-centennial natural variability in the North Atlantic is demonstrated over the last millennia by compiling proxy data. This variability mode will potentially amplify northern Europe warming by up to 30% over 2000-2035.

Lazarevic et al. reveal a shared loss of a TBX5-dependent atrial gene network in cardiomyocytes and a disease-specific network gain in activated fibroblasts across atrial fibrillation and heart failure models.

Attention fluctuates over time and across contexts—how is this reflected in the brain? Fitting a dynamical systems model to fMRI data, Song and colleagues show that the geometry of neural dynamics along the attractor landscape reflects changes in attention.

The authors in this work present a study with multiplexed gene editing that is used to assess all possible mutations at a native drug binding site. The approach yields data that predicts spontaneous resistance, that aligns with in silico predictions, and that promises to facilitate drug discovery.

The authors realize two- and three-site Kitaev chains in semiconducting quantum dots coupled via superconductors and tune them to the sweet spot where zero-energy Majorana modes appear at the chain ends. To assess Majorana localization, they couple the system to an additional quantum dot.

Tunnel oxide passivating contact silicon solar cells are a promising next-generation photovoltaic technology. Yang et al. engineer the front and back contact, further increasing the power conversion efficiency to 26.66%.

A 3D soft electronic mesh allows high-resolution electrical recording and stimulation across the full surface of neural organoids, enabling long-term studies, drug testing and optogenetic control without compromising their viability owing to its porous design.

Reducing the assumptions required for certification of genuinely quantum behaviour is important both for quantum foundations and technologies. Here, the authors propose a theory-independent framework for quantum process tomography, and test it on a superconducting qubit, witnessing decoherence, loss of contextuality and non-Markovian evolution.

Soft and conducting organic materials are promising for electronic devices, though their nanostructures are not fully understood, due to the lack of high resolution real spacing imaging of these complex systems. Here the authors use cryogenic transmission electron microscopy methods to investigate the morphology of PEDOT:PSS in the presence of additives and upon hydration.

All-van der Waals multiferroic tunnel junctions exhibit four non-volatile resistance states with full layer tailorability, enabling up to 10⁶% tunnelling electroresistance, 10⁴ A cm⁻² ON-state current density and room temperature operation.

The study develops a printable concrete using cellulose nanofibers and limestone filler, enhancing rheological and mechanical properties while reducing cement content. It demonstrates improved buildability and sustainability, with potential for large-scale 3D printing applications in construction.

In a phase 1 trial, personalized mRNA vaccines tailored to individual tumour mutations in triple-negative breast cancer induced robust, long-lasting T cell responses and improved prognosis.

Native top-down proteomics reveals epidermal growth factor receptor–estrogen receptor-alpha (EGFR–ER) signaling crosstalk in breast cancer cells and dissociation of nuclear transport factor 2 (NUTF2) dimers to modulate ER signaling and cell growth.

The burden of dengue disease in infants has increased in Brazil over the last 25 years. Here, the authors analyse spatiotemporal heterogeneity in disease incidence to characterise the contribution of changing maternal immunity to infant dengue risk.

Over the past 40 years, 42% of tropical and subtropical ecosystems have experienced an increase in plant reliance on past precipitation, consistent with greening during the late growing season in drylands and drying during the wet-to-dry period in non-drylands.

Kinks are topological solitons and central to many physical systems. Here, the authors experimentally demonstrate control and generation of zero-energy kinks in a topological mechanical metamaterial via acoustic waves and numerically show rich acoustic-wavekink dynamics in highly discrete systems.

Hyperbolic phonon polaritons (HPhPs) in van der Waals materials are promising for nanophotonic applications, but they are normally limited to the mid-infrared range. Here, the authors report the observation of long-lived and highly confined HPhPs in the deep THz range in layered PbI₂.

High pathogenicity avian influenza (HPAI) may endanger not only domestic poultry but also wild birds. Here authors show that upon immunisation of king penguin chicks with a self-amplifying mRNA vaccine against a H5 HPAI clade 2.3.4.4b protein, the birds mount a lasting neutralising antibody response against avian influenza, with no natural infection occurring within the 250-day observation period.

Therapy to allergy often targets a specific allergen without addressing cross-reactivity. Here the authors develop a consensus, cross-reactive allergen, use mRNA-lipid nanoparticle immunization to induce specific, neutralizing IgG responses, but find no therapeutic effects in mouse allergy models, hinting the need for further optimization prior to translation.

Robust protein synthesis by the ribosome is required for rapid cancer growth. Here authors present interdictors, small molecule inhibitors of protein synthesis with context-dependent activity that inhibit MYC-driven cancer cell growth in a mouse model.

Biomolecular insights into significant cultural changes during the Central European Late Bronze Age (1300–800 BCE) have been limited by cremation. Here, the authors examine available inhumation burials with ancient DNA, stable isotopes, and osteoarchaeology to identify regional traditions and interconnectedness.

Tests of the predictions of the renormalization group in biological experiments have not yet been decisive. Now, a study on the collective dynamics of insect swarms provides a long-sought match between experiment and theory.

Bright electron bunches power particle physics and photon science. Here, reproducible bunches were generated in a plasma with simultaneous high charge per unit energy and low emittance, advancing a scheme to produce ultra-bright bunches in future.

Human metapneumovirus can cause severe lung disease in vulnerable people, yet no vaccines or treatments are available. Harris et al. identify 4F11, a potent monoclonal antibody with unique binding properties, and demonstrate its efficacy in reducing viral loads in vitro and in vivo.

Authors study links between amyloid secondary nucleation and growth defects, demonstrating these sites on Aβ40/Aβ42 fibrils are rare compared to the number of protein molecules. Re-analysis of published data suggests that defects may also drive secondary nucleation generally.

A single intravenous dose of the psychedelic dimethyltryptamine, combined with psychological support, produces rapid and lasting reductions in depressive symptoms in adults with major depressive disorder.

Dai and colleagues implicate defective dendritic cell migration in impaired vaccine responses in aged mice. Oral delivery of yeast-derived nanoparticles promotes migration of dendritic cells from the gut to lymph nodes and restores vaccine efficacy in aged mice.

A lab-scale proof-of-principle demonstration of a quantum network comprising one server chip and 20 client photonic chips implementing twin-field quantum key distribution shows excellent scalability and reliability and yields a pathway towards future large-scale networks.

Urban ecology traditionally focuses on single cities, yet cities play key roles in ecological processes such as migration. Radar analysis across the continental USA reveals that nearly half of stopover hotspots concentrate in metropolitan areas, linked to urbanization.

Here the authors compare genetic testing strategies in rare movement disorders, improve diagnostic yield with genome analysis, and establish CD99L2 as an X-linked spastic ataxia gene, showing that CD99L2–CAPN1 signaling disruption likely drives neurodegeneration.

Proteomic data from natural isolates of Saccharomyces cerevisiae provide insight into how these cells tolerate aneuploidy (an imbalance in the number of chromosomes), and reveal differences between lab-engineered aneuploids and diverse natural yeasts.