The mechanisms that control intracellular Wnt trafficking and secretion are beginning to be unravelled. However, little is known about how Wnt proteins are transported once they reach extracellular space. Boutros and colleagues show that active Wnt proteins are secreted on exosomes from Drosophila and human cells, and provide insight into the cellular machinery that regulates their transport and release.
- Julia Christina Gross
- Varun Chaudhary
- Michael Boutros
