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Analyses of consummatory reproductive behaviours in male mice uncover a brain mechanism whereby an internal state can attribute a social quality to a generic touch to initiate purposeful reproductive actions.

A new quasi-non-volatile 2D semi-floating gate memory with high speed and long refresh time could bridge the gap between volatile and non-volatile memory technologies.

The coherent bunching of anyons and their dissociation was observed in an interference experiment. 

KCNQ1 (Kv7.1) channels are critical for heart rhythm homeostasis. Here, the authors report the KCNQ1 structure in an intermediate state, revealing unique S1–S2 conformations that illuminate channel gating and may aid targeted drug development.

In mice, a population of astrocytes in the central striatum, characterized by expression of μ-crystallin, has a role in perseveration phenotypes that are often associated with human neuropsychiatric disorders.

Intrinsic molecular resources are used to implement a two-qubit iSWAP gate using individually trapped X¹Σ⁺ NaCs molecules.

The efficiency of running quantum algorithms can be improved by expanding the hardware operations that a quantum computer can perform. A high-fidelity three-qubit iToffoli gate has now been demonstrated using superconducting qubits.

Some bacterial species display gliding motility associated with slime secretion through nozzle-like structures at the cell poles. Here, Zuckerman, So & Hoiczyk show that the nozzles are composed of PilQ/GspD proteins usually associated with protein secretion, thus suggesting that secretins may be required for the secretion of non-proteinaceous polymers in these bacteria.

Interactions between qubits and defect-related two-level systems in superconducting qubit devices are a major source of noise fluctuations that hinder error-mitigation performance. Here, the authors experimentally show that modulating this interaction can reduce noise fluctuation and improve error mitigation performance.

CMOS-based circuits can be integrated with silicon-based spin qubits and can be controlled at milli-kelvin temperatures, which can potentially help scale up these systems.

Comparison of electrochemically gated charge transport through diphenyl benzene structures in meta and para configuration leads to the identification of anti-resonance features typical of destructive quantum interference.

The X-ray crystal structure of the potassium channel TASK-1 reveals the presence of an X-gate, which traps small-molecule inhibitors in the intramembrane vestibule and explains their low washout rates from the channel.

In the standard Si transistor gate stack, replacing conventional dielectric HfO₂ with an ultrathin ferroelectric–antiferroelectric HfO₂–ZrO₂ heterostructure exhibiting the negative capacitance effect demonstrates ultrahigh capacitance without degradation in leakage and mobility, promising for ferroelectric integration into advanced logic technology.

Ion channels open and close to allow the regulated passage of ions through the membrane. Here the authors use selective ion channel blockers to analyse this regulation in a potassium channel and show that the gate is in the selectivity filter, past the entrance to the channel.

Systematic comparison of genome-wide association results for disease risk and disease-specific mortality for nine common diseases across seven biobanks finds limited overlap between genetic effects on disease susceptibility and survival.

Magic state distillation is achieved with logical qubits on a neutral-atom quantum computer using a dynamically reconfigurable architecture for parallel quantum operations.

An interferometer design allows systematic investigation of the anyonic statistics of bulk fractional quantum Hall states.

Gate reflectometry on an ancillary dot coupled to an electron reservoir is used to read the spin of a qubit in a CMOS device in a single shot with an average fidelity above 98% within 0.5 ms.

Using a novel optical tweezers assay, this study visualises DNA decatenation by human Top2α in real time. It shows that TOP2α must load at DNA crossovers, becomes inefficient above 28pN of force, and that cohesin inhibits decatenation on DNA braids.

Strontium titanate is a common substrate for growing oxide heterostructures—from superconductors to interfaces that support several phases of matter. But in an all-strontium-titanate device with a liquid electrolyte and metal-oxide gate, the results are anything but common.

The authors use a combination of perceptual decision making in rats and computational modeling to explore the interplay of priors and sensory cues. They find that rats can learn to either alternate or repeat their actions based on reward likelihood and the influence of bias on their actions disappears after making an error.

In order to locate the voltage-dependent gate in the MthK potassium channel, intracellular quaternary ammonium blockers are used for electrophysiology and crystallographic analyses. The data conclusively show that the inactivation gate is located at the selectivity filter and not at the cytoplasmic bundle crossing entrance.

The authors develop a computational method to design small DNA-binding proteins (DBPs) that target specific sequences. Designed DBPs show structural accuracy and function in both bacterial and mammalian cells for transcriptional regulation.

A unified realization of the volt, ohm and ampere can be achieved by integrating a quantum anomalous Hall resistor and a programmable Josephson voltage standard in a single cryostat.

Here, the authors report that combining Army Liposome Formulation with QS21 saponin (ALFQ) and Alum to formulate the ΔV1gp120 boost decreases the risk of simian immunodeficiency virus (SIV) mac251 acquisition in female macaques.

The integration of 1,024 independent silicon quantum dot devices with on-chip digital and analogue electronics, all of which operate below 1 K, allows characteristic data across the quantum dot array to be acquired and analysed in under 10 min.

Electron pairing is of fundamental interest in condensed matter physics. Here, the authors demonstrate electrons forming not only pairs - but also triplets - in graphene quantum Hall Fabry-Pérot interferometers.

Qutrits, or quantum three-level systems, can provide advantages over qubits in certain quantum information applications, and high-fidelity single-qutrit gates have been demonstrated. Goss et al. realize high-fidelity entangling gates between two superconducting qutrits that are universal for ternary computation.

In this work, the authors report Cryo-EM imaging revealing diversity in amyloid fibril structures among ATTR patients with the same genetic mutation I84S. Further study is warranted to grasp the implications in ATTR amyloidosis pathology.

Vega-Gutiérrez et al. present cryo-electron microscopy structures of GluA4-containing AMPA receptors, which are key for brain signaling. They show GluA4-specific conformations and explain how subunit composition shapes receptor architecture, dynamics and function.

Measuring the bulk power laws of Luttinger liquids in semiconductors remains challenging. Here, the authors demonstrate the dominance of the end-tunneling effect in two fairly distinct Luttinger liquids coexisting in a single quantum wire.

Mutations in the cation channel PKD2 cause human autosomal dominant polycystic kidney disease but its channel function and gating mechanism are poorly understood. Here authors study PKD2 using electrophysiology and cryo-EM, which identifies hydrophobic gates and proposes a gating mechanism for PKD2.

Programmable and reversible CRISPRi-based genetic circuits function in a variety of plants.

Stabilizing non-trivial magnetic spin textures at room temperature remains challenging. Here, the authors propose introducing magnetic atoms into the van der Waals gap of 2D magnets Fe₃GaTe₂ to stabilize the magnetic spin textures beyond skyrmion.

Bosonic qubits can be engineered to feature intrinsic protection against certain kinds of errors, which makes quantum error correction across many bosonic qubits possible with less overhead.

The effects of disorder on the electrical characteristics of graphene are found to change drastically in a magnetic field. At zero field, disorder simply causes charge scattering. But at high fields it induces the formation of a network of quantum dots.

Instead of using capacitively coupled charge sensors, which imply additional complexity in the device architecture, radiofrequency reflectometry on the gate defining the quantum dot can read out the spin state of a double quantum dot in a single shot.

By using two-dimensional materials with different polarities, single neuristors can act as XNOR, NOR, OR and AND logic gates.

Enterololin is a narrow-spectrum antibiotic that selectively kills Enterobacteriaceae in vitro and in a mouse model of adherent-invasive Escherichia coli gut infection. AI-guided mechanism-of-action studies identified LolCDE as its molecular target.

A device architecture based on indium arsenide–aluminium heterostructures with a gate-defined superconducting nanowire allows single-shot interferometric measurement of fermion parity and demonstrates an assignment error probability of 1%.

Knots reduce the tensile strength of macroscopic threads and fibres. Now it has been shown that the presence of a well-defined overhand knot in a polymer chain can substantially increase the rate of scission of the polymer under tension, as deformation of the polymer backbone induced by the tightening knot activates otherwise unreactive covalent bonds.

Bilayer graphene has been shown to host fractional quantum Hall states. Here, the authors observe the fractional quantum Hall states at quarter- and half-filled Landau levels and the alternation of anti-Pfaffian and Pfaffian phases at half fillings.

Electrolyte gating enables the accumulation of large carrier densities in two-dimensional electron systems. Here, the authors demonstrate that a few-atom thick layer of hexagonal boron nitride can dramatically improve carrier mobility in an electrolyte-gated system by limiting chemical reactions and disorder.