Search

A study reports a dual quantum spin Hall insulator in monolayer TaIrTe₄, arising from the interplay of its single-particle topology and density-tuned electron correlations.

The electrical and optical properties of a material depend strongly on the details of its crystal structure. Here, the authors report a technique to mechanically deform the lattice of monolayer graphene with strain, and electrically detect the generation of a scalar potential that modifies the graphene work function.

MoS₂/hBN/graphene van der Waals heterostructures with a clean interface and optimized barrier height and gate coupling ratio enable the realization of ultrafast non-volatile flash memory.

A study of human and mouse models of pancreatic cancer finds that inhibiting the lipid kinase PIKfyve interferes with the cancer’s lipid homeostasis, making it a potential target for drug development.

Transferrin receptor (TfR) and CD98hc are increasingly used to enable more effective drug delivery to the central nervous system. Here, the authors reveal comprehensive and distinct brain cellular and whole body biodistribution patterns of TfR- and CD98hc-binding molecules.

Mutations in a protein active site can alter function in useful ways, but the active site is sensitive to changes. Here the authors present a general strategy to design combinatorial mutation libraries. Applied to GFP, the authors isolate thousands of fluorescent designs that exhibit large and useful changes in spectral properties.

Alarmone synthesis depletes GTP levels leading to a GTP-dependent switch that controls triggered, spontaneous and antibiotic-induced persister formation in Bacillus subtilis.

An antiferromagnetic diode effect was observed in a centrosymmetric crystal without directional charge separation. This effect could be used to create in-plane field-effect transistors and microwave-energy-harvesting devices.

An HbYX-like dipeptide induces gate-opening in archaeal, yeast, and mammalian 20S proteasomes, stimulates proteasome activity, and reverses inhibition of the proteasome by toxic protein oligomers that are implicated in various neurodegenerative diseases.

Here, the authors use a nanoscale probe to study the photoresponse within a single moiré unit cell of minimally twisted bilayer graphene, and observe an intricate photo-thermoelectric response attributed to the Seebeck coefficient variation at AB-BA domain boundaries.

Repetition codes running many cycles of quantum error correction achieve exponential suppression of errors with increasing numbers of qubits.

Here, the authors demonstrate the application of machine learning to optimize the device fabrication process for wafer-scale 2D semiconductors, and eventually fabricate digital, analog, and optoelectrical circuits.

Graphene–insulator–metal heterostructures show three orders of magnitude enhancement of the third-harmonic generation with respect to the bare graphene case.

Antibodies targeting a tumor antigen, GD2, show some efficacy for neuroblastoma but induce severe neuropathic pain and peripheral neuropathy. Here the authors design a gated chimeric antigen receptor (CAR), using GD2 as the gate and another tumor antigen, B7H3, as the target, to find this GD2-B7H3 CAR capable of suppressing neuroblastoma in mouse models with little adverse effects.

A new type of Hall effect—the layer Hall effect—is produced in a 2D antiferromagnet that does not exhibit any net magnetization.

A series of fluorescent probes is designed that act as dual agonists on both GLP1 and GIP receptors, and are used to image receptor binding activities in tissues and animals.

Monolayer and few-layer materials present interesting spin and pseudospin states. A study of the coupling between spin, valley and layer degrees of freedom in bilayer WSe₂ reveals coherent superpositions of distinct valley configurations and suggests the possibility of electrical control of the spin states.

When laser light is focused onto graphene devices in a magnetic field a long-range photo-Nernst effect causes photocurrents to be generated along the free edges.

The energy band offset can be estimated in core–shell nanowires using radial modulation doping.

Tools for diversifying genomic DNA in mammalian cells have long relied on base editors making C to T or A to G substitutions. Here, authors use RNA-guided DNA polymerases (EvolvR) to evolve mammalian cells using all twelve substitutions and show that nickase fidelity affects EvolvR’s mutation rates.

Experiments showing that a single layer of WTe₂ can conduct electricity along its edges while insulating in the interior suggests that this material is a two-dimensional topological insulator.

Using a graphene quantum dot creation and a wavefunction mapping technique, quantum scars are directly visualized for Dirac electrons with a scanning tunnelling microscope.

Controlling electron spin states with light is vital for quantum technologies but requires electronic excitations with net spin. Now a molecular diradical with two trityl radical groups coupled via a meta-linked fluorene bridge has been developed that features luminescent singlet and triplet excitons. The spins in the ground state can be written and read using photons, giving rise to broad magnetic and microwave modulation of the photoluminescence.

Organic semiconductor and colloidal quantum-dot-based thin-film image sensors show reduced noise, dark current and image lag when a pinned photodiode pixel structure, similar to those in silicon-based image sensors, is used.

Nadezhdin et al. present structures of human TRPV4 in complex with the GTPase RhoA, in the apo, agonist 4α-PDD and antagonist HC-067047 bound states, uncovering the mechanisms of channel activation, inhibition and disease-causing mutations.

The long spin lifetimes observed in polymeric semiconductors hold promise for potential applications. A careful study untangles the main mechanism behind them.

Gate tunable and ultrabroadband third-harmonic generation can be achieved in graphene, paving the way for electrically tunable broadband frequency converters for applications in optical communications and signal processing.

A high-resolution cryo-electron microscopy structure of a complete Tc holotoxin complex reveals the precise mechanism of Tc toxin assembly, gate opening and release of the cytotoxic enzyme into the translocation channel.

To unlock the potential of biological semiconductors for printed flexible electronics, experimental evidence that reveals the material’s charge transport mechanism is required. Here, the authors report the charge transport mechanism in hydrogen-bonded DNA topoisomerase inhibitors.

The microstructure of organic semiconductors affects their transport properties, but directly probing this relationship is challenging. He et al. show that step edges act as electron traps on the surfaces of n-type single crystals, resulting in a field effect transistor mobility that depends on step density.

The semiconducting ABC configuration of trilayer graphene is more challenging to grow on large scales than its semimetallic ABA counterpart. Here, an approach to trilayer growth via chemical vapor deposition is presented that utilizes substrate curvature to yield enhanced fraction and size of ABC domains.

Premature termination codon suppression therapy could be used to treat a range of genetic disorders. Here the authors present a high-throughput cell-based assay to identify anticodon engineered tRNAs with high suppression activity.

AMPA-type glutamate receptors, which mediate fast excitatory signaling throughout the brain, exhibit profound desensitization, causing a progressive current decline in the continued presence of agonist. Here authors show that homomeric Q/R edited AMPARs still allow ions to flow when the receptors are desensitized.

The cryo-electron microscopy structure of the hyperpolarization-activated K⁺ channel KAT1 points to a direct-coupling mechanism between S4 movement and the reorientation of the C-linker.

In monolayer semiconductors phonons with momentum vectors pointing to the corners of the hexagonal Brillouin zone couple strongly to carriers’ spin and valley degree of freedom. Here, the authors report the observation of multiple valley phonons and the resulting exciton complexes in the monolayer semiconductor WSe₂.

PIC-seq characterizes cellular crosstalk by sorting and sequencing physically interacting cells.

The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.

Lipid metabolism regulates stem cell states and differentiation. Here, the authors demonstrate a requirement in planarians for Apolipoprotein B-mediated neutral lipid transport from intestinal stores to stem cells and their progeny during differentiation and whole-body regeneration.

The authors present a partially fault-tolerant implementation of the quantum approximate optimization algorithm. By encoding circuits with the iceberg error detection code, the authors improve QAOA’s performance on problems with up to 20 logical qubits on a trapped-ion quantum computer, outlining conditions required to surpass classical algorithms.

Measurements and simulations of several high-mobility conjugated polymers show that their charge transport properties reflect an almost complete lack of disorder in the polymers, despite their amorphous microstructures, resulting from the resilience of the planar polymer backbone conformations to side-chain disorder.

A cryo-electron microscopy analysis of the Chlamydomonas reinhardtii TOC–TIC supercomplex reveals that Tic214 traverses the chloroplast inner membrane, the intermembrane space and the outer membrane, connecting the TOC complex with the TIC proteins.

The plasma absorption effect is demonstrated to enhance the performance of silicon ring modulators.

Group 2 Innate lymphoid cells (ILC2) are a source of type 2 cytokines, such as interleukin-5 (IL-5). Here Troch, Jakob et al. show a non-redundant role of ILC2-derived IL-5 required for the development and function of a subset of murine B cells.

Whether ballistic transport can occur in a system is usually governed by the number of impurities, but a ballistic transport regime is seen in charge-neutral graphene that is limited not by impurities or phonons, but electron–hole collisions.