Nature Search

Development of a genetic priority score to predict drug side effects using human genetic evidence

Here the authors develop a genetic priority score to predict side effects by integrating multiple lines of genetic evidence. By applying this score, they provide evidence of known side effects and suggest ones with no clinical trial evidence.

Áine Duffy
Robert Chen
Ron Do
ResearchOpen Access30 Sept 2025
Nature Communications

Volume: 16, P: 1-12
Polygenic and developmental profiles of autism differ by age at diagnosis

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

Xinhe Zhang
Jakob Grove
Varun Warrier
ResearchOpen Access01 Oct 2025
Nature

P: 1-12
Neutralizing and binding antibodies are a correlate of risk of COVID-19 in the CoVPN 3008 study in people with HIV

Using data from the CoVPN 3008 study, the authors show that the neutralizing antibody correlate of risk holds in people living with HIV. However, the nAb correlate was weaker and shorter-lived in a vaccine-immunity versus hybrid-immunity population.

Nonhlanhla N. Mkhize
Bo Zhang
Peter B. Gilbert
ResearchOpen Access06 Oct 2025
Nature Communications

Volume: 16, P: 1-19
Genetic analyses across cardiovascular traits: leveraging genetic correlations to empower locus discovery and prediction in common cardiovascular diseases

Paloma Jordà
Yiwei Lai
Rafik Tadros
ResearchOpen Access29 Sept 2025
npj Genomic Medicine

Volume: 10, P: 1-22
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Polygenic prediction of body mass index and obesity through the life course and across ancestries

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Roelof A. J. Smit
Kaitlin H. Wade
Ruth J. F. Loos
ResearchOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 3151-3168
Contamination of Hodgkin's disease cell cultures

Nancy L. Harris
David L. Gang
Stephen J. O'Brien
Research22 Jan 1981
Nature

Volume: 289, P: 228-230
No lubricants from fluorinated C₆₀

ROGER TAYLOR
ANTHONY G. AVENT
G. JOHN LANGLEY
Research02 Jan 1992
Nature

Volume: 355, P: 27-28
Impact of residual clonal plasma cells in S-phase at the time of autologous stem cell transplantation on clinical outcomes

Tamer Hellou
Daniel G. Packard
Morie A. Gertz
ResearchOpen Access29 Sept 2025
Blood Cancer Journal

Volume: 15, P: 1-6
Mitochondrial and chloroplast genomes of maize have a 12-kilobase DNA sequence in common

David B. Stern
David M. Lonsdale
Research21 Oct 1982
Nature

Volume: 299, P: 698-702
Refining PET-based response in extramedullary multiple myeloma using total lesion glycolysis

Saurabh Zanwar
Gokce Belge Bilgin
Shaji Kumar
Research28 Sept 2025
Leukemia

P: 1-6
Anti-PD-1 therapy in unresectable desmoplastic melanoma: the phase 2 SWOG S1512 trial

In cohort B of the phase 2 SWOG S1512 trial, pembrolizumab monotherapy in patients with unresectable desmoplastic melanoma elicited a complete response rate of 37% and an objective response rate of 89%, supporting a new treatment option for this tumor type.

Kari L. Kendra
Shay L. Bellasea
Antoni Ribas
Research14 Aug 2025
Nature Medicine

P: 1-7
Elliptic anisotropy measurement of the f₀(980) hadron in proton-lead collisions and evidence for its quark-antiquark composition

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

A. Hayrapetyan
A. Tumasyan
A. Zhokin
ResearchOpen Access27 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Magic numbers and stable structures for fullerenes, fullerides and fullerenium ions

Patrick W. Fowler
David E. Manolopoulos
Research30 Jan 1992
Nature

Volume: 355, P: 428-430
Joint, multifaceted genomic analysis enables diagnosis of diverse, ultra-rare monogenic presentations

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

Shilpa Nadimpalli Kobren
Mikhail A. Moldovan
Shamil R. Sunyaev
ResearchOpen Access07 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Isolation of a GCC repeat showing expansion in FRAXF, a fragile site distal to FRAXA and FRAXE

Julia E. Parrish
Ben A. Oostra
David L. Nelson
Research01 Nov 1994
Nature Genetics

Volume: 8, P: 229-235
Direct detection of novel expanded trinucleotide repeats in the human genome

Martin Schalling
Thomas J. Hudson
David E. Housman
Research01 Jun 1993
Nature Genetics

Volume: 4, P: 135-139
The observability of possible atmospheric removal processes for chlorfluorocarbons 11 and 12

Robert J. Gelinas
David K. Hall
Robert G. Nelson
Research01 Mar 1977
Nature

Volume: 266, P: 229-231
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Demonstration of Super-X divertor exhaust control for transient heat load management in compact fusion reactors

Managing power exhaust in fusion reactors is a key challenge, especially in compact designs for cost-effective commercial energy. This study shows how alternative divertor configurations improve exhaust control, enhance stability, absorb transients and enable independent plasma regulation.

B. Kool
K. Verhaegh
V. Zamkovska
ResearchOpen Access05 Sept 2025
Nature Energy

Volume: 10, P: 1116-1131
Research Objects: Towards Exchange and Reuse of Digital Knowledge

Sean Bechhofer
David De Roure
Iain Buchan
ResearchOpen Access06 Jul 2010
Nature Precedings

P: 1
Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2

Arthur L. Burnett
Devin G. Johns
Kenneth D. Poss
Research01 Jan 1998
Nature Medicine

Volume: 4, P: 84-87
A saturated map of common genetic variants associated with human height

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Loïc Yengo
Sailaja Vedantam
Joel N. Hirschhorn
ResearchOpen Access12 Oct 2022
Nature

Volume: 610, P: 704-712
Data mining of protein families using common peptides

Assaf Gottlieb
Uri Weingart
David Horn
ResearchOpen Access14 Aug 2008
Nature Precedings

P: 1
Release of Hydrocyanic Acid from Crushed Tissues of all Stages in the Life-Cycle of Species of the Zygaeninae (Lepidoptera)

DAVID A. JONES
JOHN PARSONS
MIRIAM ROTHSCHILD
Research06 Jan 1962
Nature

Volume: 193, P: 52-53
Lung disease in the cystic fibrosis mouse exposed to bacterial pathogens

Donald J. Davidson
Julia R. Dorin
David J. Porteous
Research01 Apr 1995
Nature Genetics

Volume: 9, P: 351-357
Advancing biological understanding of cellular senescence with computational multiomics

This Review discusses multiomic approaches for the characterization and biological understanding of cellular senescence, including detailed case studies on skeletal muscle and adipose tissue that highlight current outstanding issues in the field.

Sheng Li
Paula A. Agudelo Garcia
Rong Fan
Reviews15 Sept 2025
Nature Genetics

P: 1-14
Magnetic anisotropy in the electron momentum density of iron

Malcolm J. Cooper
Stephen P. Collins
David Laundy
Research12 May 1988
Nature

Volume: 333, P: 151-153
Observation of polarization density waves in SrTiO₃

Despite exhibiting ferroelectric features, SrTiO₃ fails to display long-range polar order at low temperatures due to quantum fluctuations. An ultrafast X-ray diffraction experiment now probes polar dynamics of this material at the nanometre scale.

Gal Orenstein
Viktor Krapivin
Mariano Trigo
Research07 Apr 2025
Nature Physics

Volume: 21, P: 961-965
The Production of Soluble and Cellular Interleukin-2 Receptors by Cord Blood Mononuclear Cells following In Vitro Activation

David L Nelson
Carole C Kurman
Laurence A Rubin
Research01 Feb 1986
Pediatric Research

Volume: 20, P: 136-139
Solution structure of the ets domain of Fli-1 when bound to DNA

Heng Liang
Xiaohong Mao
Stephen W. Fesik
Research01 Dec 1994
Nature Structural Biology

Volume: 1, P: 871-876
GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Genome-wide analyses identify common variants associated with 11 distinct neuropathology endophenotypes, providing insights into the mechanisms underlying the genetic risk of Alzheimer’s disease and related dementias.

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
ResearchOpen Access08 Oct 2024
Nature Genetics

Volume: 56, P: 2407-2421
Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients

Solid organ transplant recipients are at increased risk of infectious disease and have unique molecular pathophysiology. Here the authors use host-microbe profiling to assess SARS-CoV-2 infection and immunity in solid organ transplant recipients, showing enhanced viral abundance, impaired clearance, and increased expression of innate immunity genes.

Harry Pickering
Joanna Schaenman
Charles R. Langelier
ResearchOpen Access10 Jan 2025
Nature Communications

Volume: 16, P: 1-16
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

A genome-wide association study in ~3 million individuals identifies 3,952 independent variants associated with educational attainment. A polygenic index explains 12–16% of variance for this trait and contributes to risk prediction for ten diseases.

Aysu Okbay
Yeda Wu
Alexander I. Young
ResearchOpen Access31 Mar 2022
Nature Genetics

Volume: 54, P: 437-449
Lineament and polygon patterns on Europa

David C. Pieri
Research01 Jan 1981
Nature

Volume: 289, P: 17-21
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
Increased mu opioid receptor binding detected by PET in cocaine–dependent men is associated with cocaine craving

Jon-Kar Zubieta
David A. Gorelick
J. James Frost
Research01 Nov 1996
Nature Medicine

Volume: 2, P: 1225-1229
Nutrient depletion indicates high primary productivity in the Weddell Sea

Joe C. Jennings Jr
Louis I. Gordon
David M. Nelson
Research03 May 1984
Nature

Volume: 309, P: 51-54
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Seung Hoan Choi
Sean J. Jurgens
Patrick T. Ellinor
Research06 Mar 2025
Nature Genetics

Volume: 57, P: 548-562
The power of genetic diversity in genome-wide association studies of lipids

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Research09 Dec 2021
Nature

Volume: 600, P: 675-679
A generic non-invasive neuromotor interface for human-computer interaction

A high-bandwidth neuromotor interface offers performant out-of-the-box generalization across people.

Patrick Kaifosh
Thomas R. Reardon
Danny Zlobinsky
ResearchOpen Access23 Jul 2025
Nature

Volume: 645, P: 702-711
Length of uninterrupted CGG repeats determines instability in the FMR1 gene

Evan E. Eichler
Jeanette J.A. Holden
David L. Nelson
Research01 Sept 1994
Nature Genetics

Volume: 8, P: 88-94
Why overlearned sequences are special: distinct neural networks in the right hemisphere for ordinal sequences

Vani Pariyadath
Sara Churchill
David Eagleman
ResearchOpen Access04 Nov 2008
Nature Precedings

P: 1
Development of CD4⁻CD8⁺ cytotoxic T cells requires interactions with class I MHC determinants

Suzana Maruic-Galesic
David A. Stephany
Ada M. Kruisbeek
Research12 May 1988
Nature

Volume: 333, P: 180-183
Resistance of microorganisms to disinfection in dental and medical devices

David L. Lewis
Max Arens
Research01 Sept 1995
Nature Medicine

Volume: 1, P: 956-958
Inhibitory conformation of the reactive loop of α₁-antitrypsin

Peter R. Elliott
David A. Lomas
Jan Pieter Abrahams
Research01 Aug 1996
Nature Structural Biology

Volume: 3, P: 676-681
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Three-dimensional structure of a hammerhead ribozyme

Heinz W. Pley
Kevin M. Flaherty
David B. McKay
Research03 Nov 1994
Nature

Volume: 372, P: 68-74
Mapping genomic loci implicates genes and synaptic biology in schizophrenia

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

Vassily Trubetskoy
Antonio F. Pardiñas
Jim van Os
Research08 Apr 2022
Nature

Volume: 604, P: 502-508
Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes

Genome-wide association analyses identify new risk loci for heart failure and its subtypes, extending understanding of the underlying biological pathways and disease mechanisms.

Albert Henry
Xiaodong Mo
R. Thomas Lumbers
ResearchOpen Access04 Mar 2025
Nature Genetics

Volume: 57, P: 815-828

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