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Striatal neural circuits control reward-associated behaviors but the role of astrocytes is still unclear. Here, the authors show that chemogenetic manipulation of striatal astrocyte in mice restore obesity-associated cognitive defect and exert a control on whole-body metabolism.

A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a promising candidate for tuberculosis treatment regimens.

This study reveals that CYBDOM proteins promote drought tolerance by regenerating apoplastic ascorbic acid (AsA) and activating autophagy through interaction with RbohD, and link AsA redox, ROS and selective autophagy in plant stress responses

Here, Zhang et al. succeed in creating a heavily distorted oxygen deficient film of lanthanum cobaltite. The new phase of LaCoO_2.5 has several unique properties, most notably, a Curie temperature of 284 K, significantly larger than the films from which it was derived.

Bacterial-host competition for micronutrients and inefficient immune responses undermine antimicrobial immunotherapy. Su et al. design an immunostimulatory metalloantibiotic and explore potential sono-metalloimmunotherapy (SMIT) for the treatment of clinical orthopaedic infections, in a murine model.

Osteoarthritis is closely linked to obesity. Here, the authors show that lipid overload in chondrocytes boosts fatty acid oxidation, fueling disease progression via SOX9 degradation and epigenetic dysregulation.

A template-free magnetization strategy for inverse programming of hard-magnetic domains embedded in solvent-responsive hydrogel is reported using a photodosage-based printing method, achieving shape morphing into 3D curved surfaces under the actuation of a magnetic field.

The suboptimal performance of perovskite solar cells based on non-fullerene acceptor as the electron-transporting layer underscores the need for their molecular engineering. Here, authors substitute the core of Y6 with phenanthroline and crown ether, achieving a certified efficiency of 25.59%.

Controlled doping of organic semiconductors is required to enhance charge injection in organic electronics, but the lack of suitable n-dopants with small ionization energy remains elusive. Here, the authors report air-stable metals that act as strong n-dopants in molecules with chelating ligands.

Endothelial injury drives vascular diseases like atherosclerosis, but key regulators are unclear. Here, the authors show that endothelial major vault protein (MVP) acts as an intracellular regulator promoting Parkin-mediated mitophagy, thereby antagonizing vascular remodeling and suggesting its role as a potential therapeutic target.

Semi-aquatic robots rely on surface tension for propulsion, which implies that breaking the water surface is a limitation. Here, the authors developed a soft robot with a superhydrophobic body, achieving high jumping height and take-off velocity.

Here the authors report an NIR-II gold probe for identification of early-stage AD. The probe enables non-invasive NIR-II imaging of elevated CTGF in brains of early AD mice and multimodally identifying AD patients’ brain sections before obvious Aβ deposition.

Experimentally probing the orbital population is highly desirable to resolve the redox mechanism of cathodes materials. Here the authors quantify the orbital populations of Co and O in LiCoO₂ and identify the ligand-to-metal charge transfer.

Propulsive motion in soft robotic systems requires the power amplification of stored energy. An accumulated strain energy-fracture power-amplification method is used to create light-driven soft robotic systems with a controlled launching ability.

The hypoxic microenvironment in solid tumors limits the efficacy of photodynamic therapy (PDT) since oxygen is necessary to produce high cytotoxic singlet oxygen species. Here, the authors develop an improved self-assembled single-atom nanozyme which allows oxygen generation to enhance PDT efficacy.

Fabrication of perovskite-polymer composites that simultaneously possesses strong mechanical strength, high stretchability, high stability towards harsh aqueous environments and self-healing properties is challenging. Here, the authors report a luminescent composite that is simultaneously transparent, tough and can autonomously self-heal in both dry and wet conditions.

The dynamic transformation in soft architected materials often brings in unusual properties. Here, Zhang et al. present magneto-elastomers with 3D heterogeneous magnetization profiles encoded by buckling instability to achieve the dynamic regulation.

The generation of induced pluripotent stem cells might be improved by replacing the reprogramming transgenes with small molecules. To provide cells suitable for small-molecule screening, Markoulaki et al. segregate the transgenes Oct4, Sox2, Klf4 and c-Myc through breeding, creating mice carrying all possible combinations of the four factors.

The supply of oxygen species for dynamic therapy is a major limitation. Here, the authors report on a complex of calcium peroxide with photo/chemo dynamic agents, where NIR heating causes the release of calcium peroxide to generate oxygen and hydrogen peroxide for photodynamic and chemodynamic therapy.

The success of a fluorescent dye as a molecular probe to monitor the intracellular activity of biomolecules depends on its physicochemical characteristics. Here, the authors use a predictive model to identify key features that allow them to design cell permeable, background-free fluorescent probes.

Favoured cathodes for batteries should include abundant and redox-active elements, such as manganese. Here the authors report a Na_0.6Li_0.2Mn_0.8O₂ cathode design featuring a unique layer stacking sequence that provides topological protection to oxygen redox to overcome the performance fading.

Fish can regenerate nephrons (the functional units of the kidney) de novo after kidney injury, whereas adult mammals lack this ability. This study identifies a pool of self renewing nephron stem/progenitor cells that are responsible for nephrogenesis during kidney growth and regeneration in zebrafish. The findings might provide an insight into how mammalian renal regeneration may be therapeutically activated.