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Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.

Hundreds of genetic loci associated with age at menopause, combined with experimental evidence in mice, highlight mechanisms of reproductive ageing across the lifespan.

PFAS and OH-PCBs are associated with health effects. Here, the authors present an association between OH-PCB exposure and increased risk of multiple sclerosis, while increased PFAS levels were associated with reduced risk of disability worsening.

Optical anapoles in nanoresonators result in strong suppression of the electromagnetic radiation, which is challenging to detect in ideal settings. Here, the authors show that fast electrons are a powerful tool to circumvent this challenge due to their ability to access dark modes.

Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse transcriptase (TERT) expression via ZNF148.

Narcolepsy has genetic and environmental risk factors, but the specific genetic risk loci and interaction with environmental triggers are not well understood. Here, the authors identify genetic loci for narcolepsy, suggesting infection as a trigger and dendritic and helper T cell involvement.

Genome-wide association meta-analyses of waist-to-hip ratio adjusted for body mass index in more than 224,000 individuals identify 49 loci, 33 of which are new and many showing significant sexual dimorphism with a stronger effect in women; pathway analyses implicate adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution.

Detailed knowledge of how strain influences catalytic reactions remains elusive. Here, the authors experimentally measure the strain in supported Pt nanoparticles on alumina and ceria with atomic resolution and computationally explore how the strain affects the CO oxidation reaction.

Childhood acute lymphoblastic leukemia is characterised by a range of genetic aberrations. Here, the authors use multi-omics profiling of ALL cell lines to connect molecular phenotypes and drug responses to provide an interactive resource of drug sensitivity.

Here, the authors devise a scalable method, based on anisotropic wet etching, to fabricate hexagonally shaped transition metal dichalcogenide nanostructures with smooth edges, which may serve as metamaterials with tailored optical properties.

Dielectric metasurfaces with strong nonlinearities hold promise for integrated nanophotonics and quantum technologies, yet their fabrication is hindered by material-dependent challenges and limited material choices with second-order optical nonlinearities. Here, the authors employ top-down lithography and anisotropic wet etching to fabricate atomically precise, ultrathin metasurfaces highly efficient for second-harmonic generation.

Semiconductor–superconductor hybrids are used for realizing complex quantum phenomena but are limited in the accessible magnetic field and temperature range. Now, hybrid devices made from InAs nanowires and epitaxially matched, single-crystal, atomically flat Pb films present superior characteristics, doubling the available parameter space.

Doping through spontaneous electron transfer between donor and acceptor polymers is obtained by selecting organic semiconductors with suitable electron affinity and ionization energy, achieving high conductivity in blends and bilayer configuration.

Proximity effect may induce unconventional superconductivity in the topologically protected surface states of a topological insulator, however experimental evidence remains rare. Here, Charpentier et al. report proximity effect induced superconductivity in nanoscale Josephson junctions and suggest an unconventional p-wave order parameter.

Autoimmune Addison’s disease is a rare complex disease, which has not yet been characterized by non-biased genetic studies. Here, the authors perform the first GWAS for the disease, identifying nine loci including two coding variants in the gene Autoimmune Regulator (AIRE).

Bellodi, Dimitriou and colleagues report that pseudouridine-modified transfer-RNA fragments modulate the translation of transcripts sharing pyrimidine-enriched sequences at their 5′ untranslated regions and their dysregulation impacts myelodysplastic syndrome pathogenesis.

Wheat gluten is a bio-based alternative to fossil-based polymers in thermoplastic and crosslinked foams, and it has been shown that it is possible to extrude foams based on wheat gluten. Here, the authors explore the impact of three naturally occurring additives (genipin, gallic acid, and citric acid) on the mechanical and liquid absorption properties of foam-extruded wheat gluten.

Superabsorbent materials can absorb many times their weight in water, but are commonly derived from petroleum. Here, acylation of coagulated potato protein concentrate or soluble potato protein fruit juice yields an effective, mould-resistant, and biodegradable superabsorbent polymer.

The International Multiple Sclerosis Genetics Consortium reports the discovery of 48 new susceptibility variants for multiple sclerosis through targeted follow-up of immune-related loci. They also report fine mapping of association signals at established susceptibility loci and provide insights into the immune system processes underlying this disease.

Dietz, Juhl et al. examine the cellular and humoral immune response to SARS-CoV-2 in 655 Danish older citizens that received their SARS-CoV-2 vaccine. The findings provide insight into the impact of age and disease burden on SARS-CoV2 vaccine-induced T cell immunity.