Cardenolides such as digoxin from foxglove (Digitalis spp.) have been used to treat congenital heart conditions, cancer and other chronic diseases for decades. Here, authors report CYP87A enzymes that catalyse pregnenolone formation, the key entry point to the cardenolide pathway in plants.
- Maritta Kunert
- Chloe Langley
- Prashant D. Sonawane