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Tumor-infiltrating lymphocyte (TIL) therapy has demonstrated clinical benefit in patients with solid tumors. Here the authors propose a protocol for isolating and enriching TILs from cavitron ultrasonic aspirator emulsions of patients with glioma, showing the successful expansion of functional tumor-reactive TILs for personalized cell therapy.

The spontaneous emergence of autocatalytic RNAs is central to origin of life. Here, the authors use machine learning, high-throughput screening and statistical physics to explore large neutral space of catalytic RNAs.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Reabsorption losses in luminescent solar concentrators can be avoided by the use of indirect-bandgap semiconductor nanostructures. The technology has been used to demonstrate flexible luminescent solar concentrators with performance comparable to flat concentrators.

The accretion geometry of X-ray binary Cygnus X-3 is determined here from IXPE observations. X-ray polarization reveals a narrow funnel with reflecting walls, which focuses emission, making Cyg X-3 appear as an ultraluminous X-ray source.

Dengue and chikungunya are an increasing public health concern in Europe, and Italy is particularly affected. Here, the authors analyse travel-related cases and outbreaks in Italy from 2006 to 2023 and assess current transmission risks.

Patchy colloids are colloidal particles with chemically or physically patterned surfaces that result in complex interactions arising between them. By means of numerical simulations, Romano and Sciortino show that suitably tailored patches can induce the crystallization of patchy colloids into specific crystal structures.

Spatially resolved JWST spectroscopy of a massive, quiescent galaxy at a redshift of ~4 reveals that it formed its stars and quenched rapidly, despite being surrounded by an abundant gas reservoir and gravitationally bound to a star-bursting companion.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Vibrational fiber photometry enables Raman spectroscopy in the mouse brain with low impact, owing to the use of tapered fibers.

Double Asteroid Redirection Test (DART) mission impact on asteroid Dimophos resulted in an elliptical ejecta plume. Here, the authors show that this elliptical ejecta is due to the curvature of the asteroid and makes kinetic momentum transfer less efficient.

A direct proxy for past dissolved organic carbon signatures using co-precipitated organic carbon in iron ooids enables reconstruction of marine dissolved organic carbon signals dating back to the Palaeoproterozoic.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

In Drosophila, dosage compensation involves a twofold transcriptional upregulation of the single male chromosome X. Here the authors show that global conformational differences are specifically present in the male X chromosome and detectable using Hi-C data, indicating that dosage compensation affects global chromosome structure.

X-ray polarimetry observations with the Imaging X-ray Polarimetry Explorer constrain the accretion geometry in an X-ray pulsar and provide evidence for a misalignment of the spin, magnetic and orbital axes in Her X-1.

This flagship study from the European Solve-Rare Diseases Consortium presents a diagnostic framework including bioinformatic analysis of clinical, pedigree and genomic data coupled with expert panel review, leading to 500 new diagnoses in a cohort of 6,000 families with suspected rare diseases.

Colourless panels that can concentrate solar light and improve the efficiency of solar cells can now be fabricated with non-toxic quantum dots.

Tomonaga-Luttinger liquid behavior has been observed within 1D defects in transition metal dichalcogenides. Here, using complementary experiments and engineered defects, the authors demonstrate the importance of graphene as a substrate and its role in the formation of this quasiparticle excitation in 2D WS₂.

The roles of CoQ10 and producing enzymes in cancer have not been well explored. Here, the authors identify that the CoQ10-biosynthetic enzyme UBIAD1 is a tumor suppressor in breast cancer. CoQ10 induced alterations in plasma membrane mechanical properties lead to increased cellular stiffness and impaired tumorigenic signaling, as well as enhanced sensitivity to ferroptosis.

Supercooled water undergoes a liquid–liquid phase transition. The authors show that the two phases have distinct hydrogen-bond networks, differing in their degree of entanglement, and thus the transition can be described by the topological changes of the network.

Poly(methyl methacrylate) nanocomposites embedding CsPbBr₃ perovskite nanocrystals can be used to simultaneously achieve optimized parameters in scintillator devices.

Scalable solutions for data regeneration of multiple parallel channels are elusive. Here the authors report a scalable wavelength-division multiplexing technique for phase regeneration and demonstrate the highest reported number of regenerated wavelength-division multiplexed channels in a single phase regenerator.

A massive galaxy hosting an accreting supermassive black hole two billion years after the Big Bang shows fast neutral-gas outflows that are capable of stopping star formation by removing its fuel while the stars keep rotating in a disk.

The mechanism by which two-dimensional materials remain stable at a finite temperature is still under debate. Now, numerical calculations suggest that rotational symmetry is crucial in suppressing anharmonic effects that lead to structural instability.

Understanding species’ spatiotemporal dynamics is key to predicting their responses to climate change. Here, the authors combine landscape genomics, demographic reconstructions, and species distribution models to assess lineage-specific responses to past and future climate in a migratory raptor.

X-ray polarization measurements of the Crab nebula and pulsar by the IXPE satellite reveal a global toroidal magnetic field with large variations in local polarization, suggesting a more complex turbulence distribution than anticipated.

Polarization can exceed 60% at the leading edge of the inner part of the Vela pulsar wind nebula; in contrast with the case of the supernova remnant, the electrons in the pulsar wind nebula are accelerated with little or no turbulence in a highly uniform magnetic field.

Here the authors fabricate a fibre-coupled electrode ‘fibertrode’ that integrates light emission sites and platinum microelectrodes on tapered optical fibre neural implants, for combined stimulation and recording of neural activity over small brain volumes in vivo with reduced photoelectric artefacts.

Slow heterogeneous dynamics and the absence of visible structural order make it difficult to numerically and theoretically investigate glass-forming materials. This Technical Review outlines the role that machine learning tools can have and identifies key challenges, possible approaches and appropriate benchmarks.

A quantum kernel estimation by which feature data points are evaluated through the unitary evolution of two-boson Fock states is experimentally demonstrated on a photonic integrated processor. This model provides enhanced accuracy with respect to commonly used classical methods for several classification tasks.

A quantum-to-quantum Bernoulli factory is demonstrated by using a reconfigurable Clements’s squared unitary circuit in an integrated quantum photonic platform. Three interferometer designs are proposed for the basic operations of a field on qubit states.

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

To prevent ligand-independent dimerisation the epidermal growth factor receptor (EGFR) is autoinhibited by an extracellular dimer interaction. Here, the authors use several imaging technologies and simulations to provide structural insights on the inactive species and on how intracellular mutations circumvent the autoinhibition of the basal state.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Rather than cooling down according to a well-established rate, some ~70% of the white dwarfs in globular cluster M13 are delaying their stellar demise by burning left-over hydrogen conserved by skipping the third dredge-up event.

Genetic mosaicism is frequently present in monogenic diseases of the central nervous system. Here the authors design a dual-colour reporter system that can be used to tune the degree of mosaicism in mouse models.

Systems comprising water and hydrophobic cavities, with scales ranging from nanometres to millimetres, are shown to expand upon compression, an unusual mechanical property of technological and biological relevance known as negative compressibility.

Loss-of-function variants in thyroid hormone transporter MCT8 cause a neurodevelopmental and metabolic disorder. Here the authors identify genotype-phenotype relationships, advance insights in MCT8 (dys)function and create a pathogenicity-severity variant classifier.

Here the authors induce asymmetric transmission in planar Fabry–Pérot microcavities by embedding organic thin films exhibiting apparent circular dichroism (ACD), an optical phenomenon based on 2D chirality.

Mapping the three-dimensional trajectory of a Neptune-mass exoplanet across the disk of its cool star reveals that its orbit is nearly perpendicular to the stellar equator, implying the existence of a yet-undetected outer companion planet.

Extending quantum photonics’ capabilities from simple linear-optics-based schemes to universal quantum computing presents several challenges, but intermediate regimes with some degree of adaptivity might already bring practical advantages. Here, the authors experimentally emulate an adaptive Boson Sampling scheme using post-selection, and apply it to a data classification task.

Luminescent solar concentrators (LSCs) offer a unique opportunity to ‘invisibly’ integrate semi-transparent photovoltaic architectural elements, such as electrodeless glazing units, into the building envelope. This Review highlights the advancements making LSCs a realistic technology for near zero-energy buildings, along with the remaining challenges and strategies for further device optimization.