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Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation

Cholesterol homeostasis can modulate immunity via multiple pathways. Here the authors show that apolipoprotein E, an important regulator of cholesterol, produced by myeloid cells can regulate T cell activation by controlling the antigen presentation activity of dendritic cells in both humans and mice.

Fabrizia Bonacina
David Coe
Giuseppe D. Norata
ResearchOpen Access06 Aug 2018
Nature Communications

Volume: 9, P: 1-15
Liver fibrosis negatively impacts in vivo gene transfer to murine hepatocytes

Simoni et al. show that liver fibrosis has a negative impact on in vivo viral vector-mediated gene transfer to hepatocytes in chemically induced and genetic mouse models varying on the type and severity of the pre-existing fibrosis and vector used.

Chiara Simoni
Justine Nozi
Alessio Cantore
ResearchOpen Access10 Mar 2025
Nature Communications

Volume: 16, P: 1-13
Lysosomes in the immunometabolic reprogramming of immune cells in atherosclerosis

In this Review, the authors describe the bidirectional crosstalk between lysosome biology and immune cell function and polarization, focusing on immunometabolic reprogramming in the context of atherosclerosis and highlighting knowledge gaps and potential therapeutic strategies targeting immune cell lysosomes.

Fabrizia Bonacina
Xiangyu Zhang
Giuseppe D. Norata
Reviews20 Sept 2024
Nature Reviews Cardiology

Volume: 22, P: 149-164
Publisher Correction: The glucose transporter 2 regulates CD8+ T cell function via environment sensing

Hongmei Fu
Juho Vuononvirta
Federica M. Marelli-Berg
Amendments and CorrectionsOpen Access25 Feb 2025
Nature Metabolism

Volume: 7, P: 634
The glucose transporter 2 regulates CD8⁺ T cell function via environment sensing

In this study, Fu et al. provide mechanistic insight into how GLUT2 fine-tunes environmental nutrient sensing with T cell activation, which optimizes metabolic adaptation during acquisition of T cell effector function.

Hongmei Fu
Juho Vuononvirta
Federica M. Marelli-Berg
ResearchOpen Access26 Oct 2023
Nature Metabolism

Volume: 5, P: 1969-1985
Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans

Hendrix et al show that absence of hepatic Spring dramatically lowers levels of lipids in the liver and plasma in mice, and protects from development of diet-induced steatosis. In line, genetic variation in SPRING is associated with lipid levels in humans.

Sebastian Hendrix
Jenina Kingma
Noam Zelcer
ResearchOpen Access25 Aug 2023
Nature Communications

Volume: 14, P: 1-15
D-lactate and glycerol as potential biomarkers of sorafenib activity in hepatocellular carcinoma

Silvia Pedretti
Francesca Palermo
Nico Mitro
ResearchOpen Access27 Jun 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-20
PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling

The kinase PI3K is crucial for insulin signalling in the liver but the roles of individual PI3K isoforms are largely unclear. Using mice that lack class II PI3K isoform γ (PI3K-C2γ), the authors here show that PI3K-C2γ selectively activates endosomal Akt2 by regulating the localized production of PIP2.

Laura Braccini
Elisa Ciraolo
Emilio Hirsch
ResearchOpen Access23 Jun 2015
Nature Communications

Volume: 6, P: 1-15
Roadmap for alleviating the manifestations of ageing in the cardiovascular system

In this Roadmap, Stellos and colleagues discuss the mechanisms of cardiovascular system ageing and how the ageing of blood, vessels and heart relates to the decline in organ function, and highlight potential therapeutic interventions, challenges in ageing research and future directions for preclinical and clinical studies.

Luca Liberale
Simon Tual-Chalot
Konstantinos Stellos
Reviews19 Feb 2025
Nature Reviews Cardiology

Volume: 22, P: 577-605
Identification of seven loci affecting mean telomere length and their association with disease

Nilesh Samani and colleagues report a meta-analysis of genome-wide association studies for mean leukocyte telomere length in 37,684 individuals, with replication of selected variants in an additional 10,739 individuals. They identify seven loci associated with mean telomere length, including two that have been associated with several cancers, and also find that alleles associated with shorter telomere length were associated with a higher risk of coronary artery disease.

Veryan Codd
Christopher P Nelson
Nilesh J Samani
Research27 Mar 2013
Nature Genetics

Volume: 45, P: 422-427
Metabolic reprogramming of naïve regulatory T cells by IL-7 and IL-15 promotes their persistence and performance upon adoptive transfer

Regulatory T cells expanded with IL-7 and IL-15 exhibit enhanced survival both in vitro and in vivo. These improvements are driven by dynamic metabolic reprogramming, promoting greater functionality and adaptability.

Jessica Filoni
Arianna Ferrari
Paolo Monti
ResearchOpen Access21 Jan 2025
Communications Biology

Volume: 8, P: 1-10
Author Correction: Cluster-assembled zirconia substrates promote long-term differentiation and functioning of human islets of Langerhans

Alessandra Galli
Elisa Maffioli
Carla Perego
Amendments and CorrectionsOpen Access27 Nov 2018
Scientific Reports

Volume: 8, P: 1-2
Global epidemiology of dyslipidaemias

Dyslipidaemias, particularly hypercholesterolaemia, are major risk factors for cardiovascular disease. In this Review, Catapano and colleagues summarize the latest data on plasma lipid levels and associated deaths and trends in these parameters over the past four decades in different regions of the world.

Angela Pirillo
Manuela Casula
Alberico L. Catapano
Reviews08 Apr 2021
Nature Reviews Cardiology

Volume: 18, P: 689-700
Cluster-assembled zirconia substrates promote long-term differentiation and functioning of human islets of Langerhans

Alessandra Galli
Elisa Maffioli
Carla Perego
ResearchOpen Access02 Jul 2018
Scientific Reports

Volume: 8, P: 1-17

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