Nature Search

Different Action of 2 : 4-Dinitrophenol on the Oxidation of Exogenous and Endogenous Substrates by Baker's Yeast

A. O. M. STOPPANI
E. H. RAMOS
I. WIDUCZYNSKI
Research31 Dec 1960
Nature

Volume: 188, P: 1188-1189
Age of the Baker's Hole Coombe Rock, Northfleet, Kent

H. BREUIL
Research13 Dec 1947
Nature

Volume: 160, P: 831
Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus

Here the authors perform a trans expression quantitative trait locus meta-analysis study of over 3,700 people and link a USP18 variant to expression of 50 inflammation genes and lupus risk, highlighting how genetic regulation of immune responses drives autoimmune disease and informs new therapies.

Krista Freimann
Anneke Brümmer
Kaur Alasoo
ResearchOpen Access02 Oct 2025
Nature Communications

Volume: 16, P: 1-15
Reprogramming neuroblastoma by diet-enhanced polyamine depletion

Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.

Sarah Cherkaoui
Christina S. Turn
Raphael J. Morscher
ResearchOpen Access24 Sept 2025
Nature

Volume: 646, P: 707-715
Native diversity buffers against severity of non-native tree invasions

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Camille S. Delavaux
Thomas W. Crowther
Daniel S. Maynard
ResearchOpen Access23 Aug 2023
Nature

Volume: 621, P: 773-781
Polygenic and developmental profiles of autism differ by age at diagnosis

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

Xinhe Zhang
Jakob Grove
Varun Warrier
ResearchOpen Access01 Oct 2025
Nature

P: 1-12
Species-specific serine metabolism differentially controls natural killer cell functions

Li et al. characterize overlapping and divergent metabolic requirements of human and murine NK cells in response to activation, with a focus on serine metabolism

Joey H. Li
Qinyan Feng
Timothy E. O’Sullivan
Research14 Aug 2025
Nature Metabolism

Volume: 7, P: 1905-1923
A systematic review and meta-analysis of the efficacy and safety of pharmacological treatments for obesity in adults

A systematic review and meta-analysis of clinical trials investigating the efficacy and safety of obesity management medications reported tirzepatide and semaglutide to be the most effective in reducing body weight and obesity-related complications.

Barbara McGowan
Andreea Ciudin
Volkan Yumuk
ResearchOpen Access02 Oct 2025
Nature Medicine

P: 1-13
Design of facilitated dissociation enables timing of cytokine signalling

A fresh approach to protein design that incorporates excited intermediate states enables precise control over the lifetime of protein interactions, with potential applications in cell-signalling modulation and in biosensors and synthetic circuits.

Adam J. Broerman
Christoph Pollmann
David Baker
ResearchOpen Access24 Sept 2025
Nature

P: 1-8
Development of clinical immunity to Plasmodium vivax following repeat controlled human malaria infection

Understanding the mechanisms behind clinical immunity to malaria is crucial for developing effective interventions. Here, the authors demonstrate that clinical immunity to Plasmodium vivax develops rapidly after a single controlled human malaria infection, reducing inflammatory responses and protecting against symptoms, while not significantly affecting parasite load.

Mimi M. Hou
Adam C. Harding
Angela M. Minassian
ResearchOpen Access25 Sept 2025
Nature Communications

Volume: 16, P: 1-13
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Origin of Tektites

H. C. UREY
Research03 Sept 1960
Nature

Volume: 187, P: 855-857
Measuring the semantic priming effect across many languages

In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

Erin M. Buchanan
Kelly Cuccolo
Savannah C. Lewis
Research24 Sept 2025
Nature Human Behaviour

P: 1-20
Accurate de novo design of high-affinity protein-binding macrocycles using deep learning

A method for de novo design of peptide macrocyles called RFpeptides has been developed. RFpeptides is an extension of RoseTTAFold2 and RFdiffusion and combines structure prediction and protein backbone generation for rapid and custom design of macrocyclic peptide binders.

Stephen A. Rettie
David Juergens
Gaurav Bhardwaj
ResearchOpen Access20 Jun 2025
Nature Chemical Biology

P: 1-9
Chemical Basis of Colour Vision and Colour Blindness

W. A. H. RUSHTON
Research12 Jun 1965
Nature

Volume: 206, P: 1087-1091
Melanin Granules and Mitochondria

RUTH V. BAKER
M. S. C. BIRBECK
M. SEIJI
Research30 Jul 1960
Nature

Volume: 187, P: 392-394
Collecting language, speech acoustics, and facial expression to predict psychosis and other clinical outcomes: strategies from the AMP® SCZ initiative

Zarina R. Bilgrami
Eduardo Castro
Phillip M. Wolff
ResearchOpen Access15 Oct 2025
Schizophrenia

Volume: 11, P: 1-14
An electrical conductivity anomaly and rifting in southern Africa

J. H. de Beer
D. I. Gough
J. S. V. van Zijl
Research26 Jun 1975
Nature

Volume: 255, P: 678-680
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Dual Localization of β-Glucuronidase in Endoplasmic Reticulum and in Lysosomes

WILLIAM H. FISHMAN
STEPHEN S. GOLDMAN
RONALD DeLELLIS
Research04 Feb 1967
Nature

Volume: 213, P: 457-460
Genetic sexing technique for a mosquito sterile male release

RICHARD H. BAKER
RICHARD K. SAKAI
UMAIMA T. SAIFUDDIN
Research01 Jul 1978
Nature

Volume: 274, P: 253-255
Integrative spatial omics reveals distinct tumor-promoting multicellular niches and immunosuppressive mechanisms in Black American and White American patients with TNBC

Cellular niches are highly heterogenous in triple negative breast cancer. Here, the authors utilise imaging mass cytometry and spatial transcriptomics to characterise the microenvironment in Black American and White American patients.

Qian Zhu
Akhila Balasubramanian
Arun Sreekumar
ResearchOpen Access17 Jul 2025
Nature Communications

Volume: 16, P: 1-23
Geology and late Cainozoic lake sediments of the Suguta Trough, Kenya

P. H. Truckle
Research30 Sept 1976
Nature

Volume: 263, P: 380-383
New International Barometer Conventions

P. H. BIGG
Research18 Dec 1954
Nature

Volume: 174, P: 1127-1128
Estimation of Percentage Natural Cross-Pollination : Experiments on Rice

E. H. ROBERTS
R. Q. CRAUFURD
F. LE COCHEC
Research17 Jun 1961
Nature

Volume: 190, P: 1084-1085
Participation of ‘Brown Fat’ Tissue in the Alarm Reaction

H. SELYE
P. S. TIMIRAS
Research29 Oct 1949
Nature

Volume: 164, P: 745-746
Atmospheric Conductivities Over White Sands, New Mexico

J. S. KIM
H. Y. KIM
Research17 Nov 1962
Nature

Volume: 196, P: 630-634
Genetic variation of macronutrient tolerance in Drosophila melanogaster

Responses to diet composition may be linked to susceptibility to metabolic diseases such as type 2 diabetes. Here the authors report that Drosophila melanogaster displays genetic variation in survival on different diets and describe the importance for JNK-pathway and a conserved orphan nuclear hormone receptor tailless in regulating sugar tolerance.

E. Havula
S. Ghazanfar
A. M. Senior
ResearchOpen Access28 Mar 2022
Nature Communications

Volume: 13, P: 1-16
Geology and Geochronology of the Seychelles Islands and Structure of the Floor of the Arabian Sea

B. H. BAKER
J. A. MILLER
Research27 Jul 1963
Nature

Volume: 199, P: 346-348
De novo designed proteins neutralize lethal snake venom toxins

Deep learning methods have been used to design proteins that can neutralize the effects of three-finger toxins found in snake venom, which could lead to the development of safer and more accessible antivenom treatments.

Susana Vázquez Torres
Melisa Benard Valle
David Baker
ResearchOpen Access15 Jan 2025
Nature

Volume: 639, P: 225-231
Effect of climate on traits of dominant and rare tree species in the world’s forests

Species’ traits and environmental conditions determine the abundance of tree species across the globe. Here, the authors find that dominant tree species are taller and have softer wood compared to rare species and that these trait differences are more strongly associated with temperature than water availability.

Iris Hordijk
Lourens Poorter
Thomas W. Crowther
ResearchOpen Access22 May 2025
Nature Communications

Volume: 16, P: 1-15
One-hour extraction-free loop-mediated isothermal amplification HPV DNA assay for point-of-care testing in Maputo, Mozambique

Human papillomavirus (HPV) DNA testing is the preferred method for cervical cancer screening, but existing tests are inaccessible for resource-limited settings. Here, authors develop a low-cost, simple HPV DNA assay suitable for bedside testing and demonstrate strong performance in Mozambique.

Maria J. Barra
Alexis F. Wilkinson
Rebecca R. Richards-Kortum
ResearchOpen Access07 Aug 2025
Nature Communications

Volume: 16, P: 1-12
Familial hyperinsulinism maps to chromosome 11p14–15.1, 30 cM centromeric to the insulin gene

B. Glaser
K.C. Chiu
M.A. Permutt
Research01 Jun 1994
Nature Genetics

Volume: 7, P: 185-188
Geochronology of the St Helena Volcanoes

I. BAKER
N. H. GALE
J. SIMONS
Research30 Sept 1967
Nature

Volume: 215, P: 1451-1456
Mechanistic model for triple junction fracture geometry

S. Bhattacharji
H. Koide
Research01 May 1975
Nature

Volume: 255, P: 21-24
Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds

De novo designed interleukin-4 mimetics were engineered that induce biased signaling activation and exhibit high thermal stability. These mimetics offer insight into cytokine signaling and can be directly incorporated into 3D-printed biomaterials

Huilin Yang
Umut Y. Ulge
Jamie B. Spangler
Research06 Apr 2023
Nature Chemical Biology

Volume: 19, P: 1127-1137
Estimation of Mass-Scattering Coefficient of Biological Samples

N. H. SARKAR
P. SADHUKHAN
Research30 Mar 1963
Nature

Volume: 197, P: 1263-1264
Quantitative measurement of phenotype dynamics during cancer drug resistance evolution using genetic barcoding

Understanding the dynamics of how drug resistance originates in cancer remains crucial, but it is not possible to observe them directly. Here, the authors construct a mathematical framework to infer drug resistance dynamics in cancer using lineage tracing and population size data, which is confirmed with experimental evidence and single-cell sequencing.

Frederick J. H. Whiting
Maximilian Mossner
Trevor A. Graham
ResearchOpen Access20 Jun 2025
Nature Communications

Volume: 16, P: 1-20
Ultraviolet photoabsorption by halocarbons 11 and 12 from electron impact measurements

RUSSELL H. HUEBNER
DAVID L. BUSHNELL JR
C. E. KUYATT
Research02 Oct 1975
Nature

Volume: 257, P: 376-378
Adsorption of Krypton and Xenon on Evaporated Metal Films in Relation to the Determination of Surface Area and the Nature of Adsorbed Carbon Monoxide

D. BRENNAN
M. J. GRAHAM
F. H. HAYES
Research21 Sept 1963
Nature

Volume: 199, P: 1152-1154
Spermidine is essential for fasting-mediated autophagy and longevity

Hofer et al. show that fasting promotes the synthesis of spermidine, which stimulates eIF5A hypusination to induce autophagy and increase lifespan in various species in a conserved manner.

Sebastian J. Hofer
Ioanna Daskalaki
Frank Madeo
ResearchOpen Access08 Aug 2024
Nature Cell Biology

Volume: 26, P: 1571-1584
Hæmoglobin α^A

E. R. HUEHNS
E. M. SHOOTER
K. V. SHOOTER
Research16 Dec 1961
Nature

Volume: 192, P: 1057-1059
Photoelectron spectromicroscopy

G. Beamson
H. Q. Porter
D. W. Turner
Research16 Apr 1981
Nature

Volume: 290, P: 556-561
Process innovations to enable viable enzymatic poly(ethylene terephthalate) recycling

Enzymatic recycling is an emerging technology to circularize the ubiquitous polyester poly(ethylene terephthalate). Here the authors evaluate and implement multiple process changes to improve the scalability and viability of this recycling technology. Process modeling demonstrates that these changes could enable cost competitiveness and greatly reduce overall life cycle impacts.

Natasha P. Murphy
Stephen H. Dempsey
Gregg T. Beckham
Research06 May 2025
Nature Chemical Engineering

Volume: 2, P: 309-320
De novo design of miniprotein antagonists of cytokine storm inducers

Here, the authors computationally designed and produced small protein antagonists to target IL-6 and IL-1β signaling to develop modulators of CRS.

Buwei Huang
Brian Coventry
David Baker
ResearchOpen Access16 Aug 2024
Nature Communications

Volume: 15, P: 1-11
Massively parallel de novo protein design for targeted therapeutics

A massively parallel computational and experimental approach for de novo designing and screening small hyperstable proteins targeting influenza haemagglutinin and botulinum neurotoxin B identifies new therapeutic candidates more robust than traditional antibody therapies.

Aaron Chevalier
Daniel-Adriano Silva
David Baker
Research27 Sept 2017
Nature

Volume: 550, P: 74-79
Variation with Temperature of Young's Modulus of Polycrystalline Graphite

I. B. MASON
R. H. KNIBBS
Research01 Oct 1960
Nature

Volume: 188, P: 33-35
Relationship of Growth-Phase to the Reducing Activity of Bacterial Cells

PAUL H. KOPPER
Research09 Jun 1951
Nature

Volume: 167, P: 951-952
Relationship of Liver Composition to Intensity of Protein Metabolism in Different Mammals

H. N. MUNRO
EILEEN D. DOWNIE
Research08 Aug 1964
Nature

Volume: 203, P: 603-604
Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division

Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing stem cells, and peroxisome inheritance influences daughter cell fate.

Hien Bui
Simon Andersson
Pekka Katajisto
ResearchOpen Access26 Apr 2025
Nature Communications

Volume: 16, P: 1-14

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