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Showing 1–50 of 51 results

Advanced filters: Author: Hai-long Li Clear advanced filters

Covalent organic frameworks as infinite building units for metal–organic frameworks with compartmentalized pores

Metal–organic frameworks are typically assembled using discrete organic linkers and inorganic nodes. Now it has been shown that combining covalent organic chains and layers as infinite building units with metal clusters results in compartmentalized frameworks with well-defined pores.

Bo Liu
Yichen Wu
Qiaowei Li
Research07 Oct 2025
Nature Chemistry

P: 1-9
Publisher Correction: Metal–support frontier orbital interactions in single-atom catalysis

Xianxian Shi
Zhilin Wen
Junling Lu
Amendments and Corrections04 Jun 2025
Nature

Volume: 642, P: E25
Gene-modified pig-to-human liver xenotransplantation

A gene-edited pig liver transplanted into a human recipient remains functional after 10 days and indicates that porcine organs could help meet the growing demand for liver transplants.

Kai-Shan Tao
Zhao-Xu Yang
Ke-Feng Dou
ResearchOpen Access26 Mar 2025
Nature

Volume: 641, P: 1029-1036
Metal–support frontier orbital interactions in single-atom catalysis

The acetylene hydrogenation activity and stability of a palladium single-atom catalyst are both controlled by the lowest unoccupied molecular orbital of the oxide support.

Xianxian Shi
Zhilin Wen
Junling Lu
Research02 Apr 2025
Nature

Volume: 640, P: 668-675
Synthesis of high quality two dimensional covalent organic frameworks through a self-sacrificing guest strategy

The quality of covalent organic frameworks is often compromised by structural damages induced during their activation procedure which influences their subsequent applications. Here, the authors describe a self-sacrificing guest strategy to synthesize high-quality two-dimensional COFs by incorporating salt guests within the pores of the COF structure.

Tianwei Xue
Li Peng
Hai-Long Jiang
ResearchOpen Access27 Feb 2025
Nature Communications

Volume: 16, P: 1-11
Author Correction: Self-adaptive dual-metal-site pairs in metal-organic frameworks for selective CO₂ photoreduction to CH₄

Jian Li
Hongliang Huang
Chongli Zhong
Amendments and Corrections19 May 2022
Nature Catalysis

Volume: 5, P: 463
Lithocholic acid phenocopies anti-ageing effects of calorie restriction

Lithocholic acid is one of the metabolites upregulated during calorie restriction, and treatment of mice, worms and flies with this bile acid alone can reproduce the health benefits of calorie restriction.

Qi Qu
Yan Chen
Sheng-Cai Lin
ResearchOpen Access18 Dec 2024
Nature

Volume: 643, P: 192-200
Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

The molecular mechanism underlying how lithocholic acid recapitulates the lifespan and healthspan benefits of calorie restriction is revealed to involve TULP3, sirtuins, v-ATPase and AMPK.

Qi Qu
Yan Chen
Sheng-Cai Lin
ResearchOpen Access18 Dec 2024
Nature

Volume: 643, P: 201-209
The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK

A small-molecule aldolase inhibitor, aldolazin is reported and shown to selectively activate the lysosomal pool of AMPK, which has glucose-lowering effects in rodents.

Chen-Song Zhang
Mengqi Li
Sheng-Cai Lin
ResearchOpen Access10 Oct 2022
Nature Metabolism

Volume: 4, P: 1369-1401
Low-dose metformin targets the lysosomal AMPK pathway through PEN2

The molecular target of the antidiabetic medicine metformin is identified as PEN2, a subunit of γ-secretases, and the PEN2–ATP6AP1 axis offers potential targets for screening for metformin substitutes.

Teng Ma
Xiao Tian
Sheng-Cai Lin
ResearchOpen Access23 Feb 2022
Nature

Volume: 603, P: 159-165
Author Correction: Lithocholic acid phenocopies anti-ageing effects of calorie restriction

Qi Qu
Yan Chen
Sheng-Cai Lin
Amendments and CorrectionsOpen Access28 Jan 2025
Nature

Volume: 638, P: E6
t-SMILES: a fragment-based molecular representation framework for de novo ligand design

An efficient representation of molecular structures is crucial for the implementation of data-driven methods. Here the authors present t-SMILES, a representation that encodes molecular substructures into strings, giving more structure to the SMILES representation.

Juan-Ni Wu
Tong Wang
Ru-Qin Yu
ResearchOpen Access11 Jun 2024
Nature Communications

Volume: 15, P: 1-15
Self-adaptive dual-metal-site pairs in metal-organic frameworks for selective CO₂ photoreduction to CH₄

CH₄ selectivity in CO₂ photoreduction is a kinetic challenge as a result of the complex pathway involving many intermediates. Here, the authors present dual-metal-site pairs embedded in a metal-organic framework structure with flexible adaptive active sites leading to high CH₄ activity and selectivity.

Jian Li
Hongliang Huang
Chongli Zhong
Research19 Aug 2021
Nature Catalysis

Volume: 4, P: 719-729
Incidence rate of schizophrenia after the Tangshan earthquake in China: a 44-year retrospective birth cohort study

Yun-Shu Zhang
Wen-Wang Rao
Yu-Tao Xiang
ResearchOpen Access06 Sept 2022
Translational Psychiatry

Volume: 12, P: 1-5
Decreased expression of CHIP leads to increased angiogenesis via VEGF-VEGFR2 pathway and poor prognosis in human renal cell carcinoma

Chao Sun
Hai-long Li
Jun-nian Zheng
ResearchOpen Access29 May 2015
Scientific Reports

Volume: 5, P: 1-10
Axial length as a predictor of myopic macular degeneration: a meta-analysis and clinical study

Tong Mu
Hai-Long He
Zi-Bing Jin
ResearchOpen Access25 Apr 2025
Eye

Volume: 39, P: 2073-2082
Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma

Alterations in cholesterol homeostasis may contribute to hepatic cancer aggressiveness. Liu, Tian, and Zhang et al. identify the long non-coding RNA SNHG6 as an important player in this process by linking cholesterol sensing with cancer cell growth through mTORC1 signaling.

Fangzhou Liu
Tian Tian
Aifu Lin
Research22 Aug 2022
Nature Metabolism

Volume: 4, P: 1022-1040
A low-profile broadband crossed-dipole antenna with fractal structure and inverted-L plates

Guirong Feng
Tianyi Qi
Hai-long Yang
ResearchOpen Access02 Sept 2022
Scientific Reports

Volume: 12, P: 1-8
p38 MAPK Inhibition Improves Synaptic Plasticity and Memory in Angiotensin II-dependent Hypertensive Mice

Hai-long Dai
Wei-yuan Hu
Zhi-cheng Xiao
ResearchOpen Access10 Jun 2016
Scientific Reports

Volume: 6, P: 1-10
Long noncoding RNA MALAT1 suppresses breast cancer metastasis

Targeted inactivation, restoration and overexpression of MALAT1 in multiple in vivo models demonstrate that the lncRNA MALAT1 suppresses breast cancer metastasis through binding and inactivation of the pro-metastatic transcription factor TEAD.

Jongchan Kim
Hai-Long Piao
Li Ma
Research22 Oct 2018
Nature Genetics

Volume: 50, P: 1705-1715
Deubiquitylation and stabilization of PTEN by USP13

The stability of the PTEN tumour suppressor protein is regulated by polyubiquitylation. Ma and colleagues identify USP13 as an enzyme reversing polyubiquitylation of PTEN, leading to PTEN stabilization and tumour suppression.

Jinsong Zhang
Peijing Zhang
Li Ma
Research24 Nov 2013
Nature Cell Biology

Volume: 15, P: 1486-1494
α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling

Ma and colleagues report that in E-cadherin-deficient basal-like breast cancer cells, α-catenin acts as a tumour suppressor by interacting with and stabilizing IκBα, leading to inhibition of NF-κB signalling.

Hai-long Piao
Yuan Yuan
Li Ma
Research09 Feb 2014
Nature Cell Biology

Volume: 16, P: 245-254
Exploring the metabolic signaling network of GFPT in cancer

Chibuzo Sampson
Pengfei Li
Yegang Ma
ReviewsOpen Access19 Aug 2025
Cell Death Discovery

Volume: 11, P: 1-20
Diosmetin has therapeutic efficacy in colitis regulating gut microbiota, inflammation, and oxidative stress via the circ-Sirt1/Sirt1 axis

Hai-long Li
Yi-ying Wei
Cheng Yang
Research14 Jul 2021
Acta Pharmacologica Sinica

Volume: 43, P: 919-932
Malate initiates a proton-sensing pathway essential for pH regulation of inflammation

Yu-jia-nan Chen
Rong-chen Shi
Kang-lai Tang
ResearchOpen Access30 Dec 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-25
Correction: KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC

Jinghan Li
Daiwang Shi
Hong-Xu Liu
Amendments and CorrectionsOpen Access07 Jan 2025
Cell Death & Disease

Volume: 16, P: 1-4
Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

Glucose starvation activates AMPK via an AMP/ADP-independent mechanism that involves fructose-1,6-bisphosphate and aldolase.

Chen-Song Zhang
Simon A. Hawley
Sheng-Cai Lin
Research19 Jul 2017
Nature

Volume: 548, P: 112-116
Neuron-derived FGF10 ameliorates cerebral ischemia injury via inhibiting NF-κB-dependent neuroinflammation and activating PI3K/Akt survival signaling pathway in mice

Yong-Hua Li
Hai-Long Fu
Hong-Bin Yuan
ResearchOpen Access27 Jan 2016
Scientific Reports

Volume: 6, P: 1-12
AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

Mengqi Li
Yu Wang
Sheng-Cai Lin
ResearchOpen Access19 Jun 2024
Cell Research

Volume: 34, P: 683-706
A new recombinant MS-superoxide dismutase alleviates 5-fluorouracil-induced intestinal mucositis in mice

Xiao-xia Yan
Hai-long Li
Li-kun Gong
Research10 Sept 2019
Acta Pharmacologica Sinica

Volume: 41, P: 348-357
Identification and bioinformatics analysis of genes associated with pyroptosis in spinal cord injury of rat and mouse

Fu-Sheng Liu
Hai-Long Huang
Fu-Bing Liu
ResearchOpen Access18 Jun 2024
Scientific Reports

Volume: 14, P: 1-14
Ovary and uterus related adverse events associated with statin use: an analysis of the FDA Adverse Event Reporting System

Xue-feng Jiao
Hai-long Li
Ling-li Zhang
ResearchOpen Access20 Jul 2020
Scientific Reports

Volume: 10, P: 1-10
FN1 shapes the behavior of papillary thyroid carcinoma through alternative splicing of EDB region

Mian Liu
Pei Chen
Shi Chang
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-16
A multifactorial risk scoring system for the prediction of early relapse in CMML patients with allo-HSCT: a nationwide representative multicenter study

Jian-Ying Zhou
Yu-Xiu Chen
Xiao-Hui Zhang
Research25 Nov 2024
Bone Marrow Transplantation

Volume: 60, P: 310-318
KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC

Jinghan Li
Daiwang Shi
Hong-Xu Liu
ResearchOpen Access27 Feb 2024
Cell Death & Disease

Volume: 15, P: 1-14
Development of a base editor for convenient and multiplex genome editing in cyanobacteria

An efficient cytosine base editor was developed in cyanobacteria, which allows rapid and precise C → T point mutation and gene inactivation. This genome editing tool will accelerate the metabolic engineering and fundamental researches in cyanobacteria.

Xing-Da Li
Ling-Mei Liu
Weizhong Chen
ResearchOpen Access14 Aug 2024
Communications Biology

Volume: 7, P: 1-11
An integrative pan-cancer analysis of biological and clinical impacts underlying ubiquitin-specific-processing proteases

Di Chen
Zhen Ning
Hai-long Piao
Research11 Sept 2019
Oncogene

Volume: 39, P: 587-602
Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryl oleate as potential biomarker of prostate cancer

Jia Li
Shancheng Ren
Guowang Xu
ResearchOpen Access11 Feb 2016
Scientific Reports

Volume: 6, P: 1-11
Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate

Yu-Qing Wu
Chen-Song Zhang
Sheng-Cai Lin
ResearchOpen Access19 Sept 2023
Cell Research

Volume: 33, P: 835-850
Multidirectional characterization of cellular composition and spatial architecture in human multiple primary lung cancers

Yawei Wang
Di Chen
Hong-Xu Liu
ResearchOpen Access25 Jul 2023
Cell Death & Disease

Volume: 14, P: 1-16
Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress

Yue Zong
Chen-Song Zhang
Sheng-Cai Lin
Research04 Apr 2019
Cell Research

Volume: 29, P: 460-473
AMPK-PDZD8-GLS1 axis mediates calorie restriction-induced lifespan extension

Mengqi Li
Yu Wang
Chen-Song Zhang
CorrespondenceOpen Access19 Sept 2024
Cell Research

Volume: 34, P: 806-809
Chemokine receptor CXCR4 regulates CaMKII/CREB pathway in spinal neurons that underlies cancer-induced bone pain

Xue-Ming Hu
Hui Zhang
Wen Shen
ResearchOpen Access21 Jun 2017
Scientific Reports

Volume: 7, P: 1-12
Genomic Characterization of Diverse Gyroviruses Identified in the Feces of Domestic Cats

Jiang-Ting Niu
Shu-Shuai Yi
Hao Dong
ResearchOpen Access16 Sept 2019
Scientific Reports

Volume: 9, P: 1-10
KIF2A regulates the spindle assembly and the metaphase I-anaphase I transition in mouse oocyte

Ming-Huang Chen
Yu Liu
Hai-Long Wang
ResearchOpen Access19 Dec 2016
Scientific Reports

Volume: 6, P: 1-12
Coherence transformations in single qubit systems

Hai-Long Shi
Xiao-Hui Wang
Heng Fan
ResearchOpen Access01 Nov 2017
Scientific Reports

Volume: 7, P: 1-12
Orbital angular momentum complex spectrum analyzer for vortex light based on the rotational Doppler effect

Hai-Long Zhou
Dong-Zhi Fu
Xin-Liang Zhang
ResearchOpen Access11 Nov 2016
Light: Science & Applications

Volume: 6, P: e16251
Mifepristone Repairs Region-Dependent Alteration of Synapsin I in Hippocampus in Rat Model of Depression

Li-Min Wu
Hui Han
Jiang-Ning Zhou
Research28 Mar 2007
Neuropsychopharmacology

Volume: 32, P: 2500-2510
Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1

Mengqi Li
Chen-Song Zhang
Sheng-Cai Lin
CorrespondenceOpen Access21 Dec 2020
Cell Research

Volume: 31, P: 478-481
Advances of surface-enhanced Raman and IR spectroscopies: from nano/microstructures to macro-optical design

This review focuses on the advance of optical design from nano/micro to macro in SERS and SEIRA, especially on the optical coupling between nano/micro and macro scales.

Hai-Long Wang
En-Ming You
Zhong-Qun Tian
ReviewsOpen Access04 Aug 2021
Light: Science & Applications

Volume: 10, P: 1-19

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