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Showing 1–50 of 112 results

Advanced filters: Author: Hiroyuki Fujiwara Clear advanced filters

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
ADAR1 as a prognostic marker for patients with colorectal cancer and synchronous liver metastasis and a predictor of chemotherapy efficacy

Kaori Nitta
Kunitoshi Shigeyasu
Toshiyoshi Fujiwara
ResearchOpen Access23 Jul 2025
Scientific Reports

Volume: 15, P: 1-9
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Production of human α-interferon in silkworm using a baculovirus vector

Susumu Maeda
Takashi Kawai
Mitsuru Furusawa
Research13 Jun 1985
Nature

Volume: 315, P: 592-594
Cilnidipine, an N+L-Type Dihydropyridine Ca Channel Blocker, Suppresses the Occurrence of Ischemia/Reperfusion Arrhythmia in a Rabbit Model of Myocardial Infarction

Hiroshi Nagai
Shinya Minatoguchi
Hisayoshi Fujiwara
Research01 Apr 2005
Hypertension Research

Volume: 28, P: 361-368
Carbon-13 Nuclear Magnetic Resonance Spectroscopy of Poly(vinyl acetate) and Poly(vinyl alcohol)

Yoshio Inoue
Riichirô Chûjô
Hiroyuki Iimuro
Research01 Apr 1973
Polymer Journal

Volume: 4, P: 244-252
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Complete sequencing and characterization of 21,243 full-length human cDNAs

Toshio Ota
Yutaka Suzuki
Sumio Sugano
Research21 Dec 2003
Nature Genetics

Volume: 36, P: 40-45
descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques

Poor access to suitable light-sheet microscopes remains a big obstacle for many end-users in biomedical research. Here, the authors present descSPIM, a low-cost, low-expertise light-sheet microscope for routine 3D imaging of cleared samples.

Kohei Otomo
Takaki Omura
Etsuo A. Susaki
ResearchOpen Access12 Jun 2024
Nature Communications

Volume: 15, P: 1-19
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Longitudinal MRI study over 20 years of cervical posterior extensor muscle area in asymptomatic subjects

Hiroyuki Izumida
Kenshi Daimon
Kota Watanabe
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial

In view of previous work suggesting that low-voltage areas may promote atrial fibrillation, a multicenter, randomized controlled trial tested the hypothesis that ablation of low-voltage areas in addition to pulmonary vein isolation might reduce the recurrence of atrial arrhythmic events, but found no significant benefit to the combined procedure.

Masaharu Masuda
Akihiro Sunaga
Takuya Ohashi
ResearchOpen Access30 Apr 2025
Nature Medicine

Volume: 31, P: 1661-1667
Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer

A small inversion of chromosome 2p has been found in a significant proportion of non-small-cell lung cancer patients. This inversion gives rise to a fusion protein comprising portions of EML4 and the anaplastic lymphoma kinase, ALK, which functions as a transforming oncogenes. Oncogenic translocations are frequent in haematopoietic tumours, but have only rarely been found in solid tumours.

Manabu Soda
Young Lim Choi
Hiroyuki Mano
Research11 Jul 2007
Nature

Volume: 448, P: 561-566
Carrier cell-mediated cell lysis of squamous cell carcinoma by squamous cell carcinoma antigen 1 promoter-driven oncolytic adenovirus

Katsuyuki Hamada
Ting Zhang
Hiroyuki Hamakawa
ResearchOpen Access08 May 2009
Nature Precedings

P: 1
Immune evasion from macrophages by NEAT1-induced CD24 in liver cancer

Hiroyuki Tsuchiya
Takehiko Hanaki
Daisuke Nanba
Research12 Aug 2025
Oncogene

Volume: 44, P: 3652-3664
Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection

The synthesis of NPY and its receptor Y1R increases in lung phagocytes during severe influenza virus infection, leading to the induction of SOCS3 and impaired antiviral response and increased pro-inflammatory cytokine production.

Seiki Fujiwara
Midori Hoshizaki
Yumiko Imai
Research19 Nov 2018
Nature Microbiology

Volume: 4, P: 258-268
In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus

Hiroyuki Kishimoto
Toru Kojima
Toshiyoshi Fujiwara
Research01 Oct 2006
Nature Medicine

Volume: 12, P: 1213-1219
ADAR1 is a promising risk stratification biomarker of remnant liver recurrence after hepatic metastasectomy for colorectal cancer

Nanako Hata
Kunitoshi Shigeyasu
Toshiyoshi Fujiwara
ResearchOpen Access06 Feb 2023
Scientific Reports

Volume: 13, P: 1-10
Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch

JMJD1A is essential for thermogenic gene induction in brown adipose tissue. Here the authors show that white adipose tissue beige-ing requires both β-adrenergic-dependent phosphorylation of S265 and demethylation activity of JMJD1A while brown adipose tissue-driven thermogenesis requires β-adrenergic dependent phosphorylation of S265 but is independent of H3K9me2 demethylation.

Yohei Abe
Yosuke Fujiwara
Juro Sakai
ResearchOpen Access19 Apr 2018
Nature Communications

Volume: 9, P: 1-16
Molecular cloning, mapping, and characterization of a novel human gene, MTA1-L1, showing homology to a metastasis-associated gene, MTA1

Manabu Futamura
Hiroyuki Nishimori
T. Tokino
Research01 Jan 1999
Journal of Human Genetics

Volume: 44, P: 52-56
TP0586532, a non-hydroxamate LpxC inhibitor, reduces LPS release and IL-6 production both in vitro and in vivo

Kiyoko Fujita
Iichiro Takata
Hiroyuki Sugiyama
Research05 Jan 2022
The Journal of Antibiotics

Volume: 75, P: 136-145
Reference values for bone metabolism in a Japanese cohort survey randomly sampled from a basic elderly resident registry

Ryosuke Tokida
Masashi Uehara
Hiroyuki Kato
ResearchOpen Access09 Apr 2021
Scientific Reports

Volume: 11, P: 1-7
A phase 2 study of intraperitoneal carboplatin plus intravenous dose-dense paclitaxel in front-line treatment of suboptimal residual ovarian cancer

Kosei Hasegawa
Muneaki Shimada
Keiichi Fujiwara
ResearchOpen Access31 Jan 2020
British Journal of Cancer

Volume: 122, P: 766-770
Photoactivatable oncolytic adenovirus for optogenetic cancer therapy

Yasuko Hagihara
Ayaka Sakamoto
Hiroyuki Mizuguchi
ResearchOpen Access23 Jul 2020
Cell Death & Disease

Volume: 11, P: 1-9
Oncolytic virus-mediated p53 activation boosts the antitumor immunity of a p53-transduced dendritic cell vaccine

Motohiko Yamada
Hiroshi Tazawa
Toshiyoshi Fujiwara
ResearchOpen Access19 Jul 2025
npj Vaccines

Volume: 10, P: 1-12
Regulatory T cells induce a suppressive immune milieu and promote lymph node metastasis in intrahepatic cholangiocarcinoma

Daisuke Konishi
Yuzo Umeda
Toshiyoshi Fujiwara
ResearchOpen Access21 May 2022
British Journal of Cancer

Volume: 127, P: 757-765
DNA methylation is reconfigured at the onset of reproduction in rice shoot apical meristem

The shoot apical meristem of flowering plants transitions from forming leaves to floral organs. Here Higo et al. show that DNA methylation of many transposons that are hypermethylated in gametes is established in the SAM before flowering, suggesting it protects against harmful transposition long before germ cell differentiation.

Asuka Higo
Noriko Saihara
Hiroyuki Tsuji
ResearchOpen Access14 Aug 2020
Nature Communications

Volume: 11, P: 1-12
Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole–imidazole polyamide conjugate

RAS, identified over 30 years ago as a potent oncogene, is one of the most commonly mutated genes in cancer. Here the authors show that KR12, an alkylating reagent that specifically cleaves the DNA coding for the G12D and G12V activated variants of KRAS, limits the growth of KRAS mutant cells in vitro and in vivo.

Kiriko Hiraoka
Takahiro Inoue
Hiroki Nagase
Research27 Apr 2015
Nature Communications

Volume: 6, P: 1-8
Kinetic Studies on the Radical Polymerization of Butadiene Derivatives

Mikiharu Kamachi
Hiroyuki Umetani
Shun-ichi Nozakura
Research01 Mar 1986
Polymer Journal

Volume: 18, P: 211-217
Changes in cross-sectional areas of posterior extensor muscles in thoracic spine: a 10-year longitudinal MRI study

Hitoshi Umezawa
Kenshi Daimon
Kota Watanabe
ResearchOpen Access30 Aug 2022
Scientific Reports

Volume: 12, P: 1-8
Reevaluating the therapeutic role of extended lymph node dissection in the era of robot-assisted radical prostatectomy

Atsuro Sawada
Koshiro Nishimoto
Takahiro Inoue
ResearchOpen Access21 May 2025
Scientific Reports

Volume: 15, P: 1-13
Pruritus is common in patients with chronic liver disease and is improved by nalfurafine hydrochloride

Shuhei Yoshikawa
Takeharu Asano
Hirosato Mashima
ResearchOpen Access04 Feb 2021
Scientific Reports

Volume: 11, P: 1-8
Tumor-specific delivery of biologics by a novel T-cell line HOZOT

Teppei Onishi
Hiroshi Tazawa
Toshiyoshi Fujiwara
ResearchOpen Access30 Nov 2016
Scientific Reports

Volume: 6, P: 1-10
Randomised phase II trial of mFOLFOX6 plus bevacizumab versus mFOLFOX6 plus cetuximab as first-line treatment for colorectal liver metastasis (ATOM trial)

Eiji Oki
Yasunori Emi
Yoshihiko Maehara
ResearchOpen Access09 Jul 2019
British Journal of Cancer

Volume: 121, P: 222-229
Distinct variants affecting differential splicing of TGFBR1 exon 5 cause either Loeys–Dietz syndrome or multiple self-healing squamous epithelioma

Takayuki Fujiwara
Norifumi Takeda
Issei Komuro
Research30 Apr 2018
European Journal of Human Genetics

Volume: 26, P: 1151-1158
Disaster-related trauma and blood pressure among young children: a follow-up study after Great East Japan earthquake

Masahiro Watanabe
Hiroyuki Hikichi
Ichiro Kawachi
Research22 Mar 2019
Hypertension Research

Volume: 42, P: 1215-1222
Highly Isotactic Poly(vinyl alcohol) Derived from tert-Butyl Vinyl Ether V. Viscoelastic Behavior of Highly Isotactic Poly(vinyl alcohol) Films

Hiroyuki Ohgi
Toshiaki Sato
Fumitaka Horii
Reviews07 Sept 2006
Polymer Journal

Volume: 38, P: 1055-1060
Isolation and characterization of a novel actin filament-binding protein from Saccharomyces cerevisiae

Takeshi Asakura
Takuya Sasaki
Yoshimi Takai
Research21 Jan 1998
Oncogene

Volume: 16, P: 121-130
The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models

The treatment of ROS1-rearranged non-small cell lung cancer with the TKI crizotinib is limited due to the emergence of resistance. Here, the authors develop a new ROS1/NTRK inhibitor, DS-6051b, which overcomes crizotinib resistance in preclinical models.

Ryohei Katayama
Bo Gong
Takeshi Isoyama
ResearchOpen Access09 Aug 2019
Nature Communications

Volume: 10, P: 1-12
Impact of aspirin on biochemical recurrence of prostate cancer after robot assisted radical prostatectomy in a multicenter retrospective cohort study

Shuhei Suzuki
Hiromitsu Negoro
Takashi Kobayashi
ResearchOpen Access15 Jan 2025
Scientific Reports

Volume: 15, P: 1-10
PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation

Processing the value of reward is thought to involve the rostromedial caudate (rmCD), but a causal demonstration is lacking in primates. Here the authors use chemogenetics and PET imaging to show that inactivation of rmCD leads to impairments in reward value judgments.

Yuji Nagai
Erika Kikuchi
Takafumi Minamimoto
ResearchOpen Access06 Dec 2016
Nature Communications

Volume: 7, P: 1-8
Does B-Type Natriuretic Peptide Predict the New Onset of Hypertension?

Hiroyuki Takase
Yasuaki Dohi
Genjiro Kimura
Research01 Sept 2008
Hypertension Research

Volume: 31, P: 1737-1744
Concept, study design, and baseline nighttime blood pressure control status of the WISDOM–Night Study using a wrist-type oscillometric home blood pressure monitoring device

Kazuomi Kario
Naoko Tomitani
Satoshi Hoshide
Research12 Oct 2024
Hypertension Research

Volume: 48, P: 592-603
Reproducible on–off switching of solid-state luminescence by controlling molecular packing through heat-mode interconversion

Toshiki Mutai
Hiroyuki Satou
Koji Araki
Research21 Aug 2005
Nature Materials

Volume: 4, P: 685-687
Cultivation of previously uncultured microorganisms with a continuous-flow down-flow hanging sponge (DHS) bioreactor, using a syntrophic archaeon culture obtained from deep marine sediment as a case study

This two-stage bioreactor-mediated approach for culturing previously uncultured microorganisms involves enrichment of indigenous organisms by using a continuous-flow down-flow hanging sponge bioreactor and subsequent selective batch cultivation.

Hiroyuki Imachi
Masaru K. Nobu
Ken Takai
Protocols14 Sept 2022
Nature Protocols

Volume: 17, P: 2784-2814
Therapeutic effect of curcumin derivative GT863 on prion-infected mice

Kenta Teruya
Ayumi Oguma
Katsumi Doh-ura
ResearchOpen Access14 Feb 2025
Scientific Reports

Volume: 15, P: 1-10
Thromboxane A₂ modulates interaction of dendritic cells and T cells and regulates acquired immunity

Kenji Kabashima
Takahiko Murata
Shuh Narumiya
Research01 Jun 2003
Nature Immunology

Volume: 4, P: 694-701

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