Search

Kang et al. uncover an anterograde signalling pathway that coordinates the transition of chloroplast function from biogenesis to degeneration, ensuring the timely onset of leaf senescence.

Microporous polymer membranes are promising for gas separation but are prone to aging, reducing performance. Here the authors use a defluorination-induced crosslinking method on aryl-ether-free aromatic polymers, forming a membrane for CO₂ separation.

GI forms an inactive nuclear condensate that is dispersed at high temperatures by FKF1 binding to GI’s intrinsically disordered region. The resulting FKF1–GI complex promotes SVP degradation, accelerating flowering at high ambient temperatures.

Using evoked and resting-state fMRI, the effects of isolation and enrichment housing on sensory development in male mice were tested. Enrichment improved sensorimotor responses, while isolation impaired network segregation and olfactory function.

Chimeric antigen receptor (CAR)-T cell is a promising therapy for hematological malignancy, but further optimization is still desirable. Here the authors show that incorporating CD99, a membrane protein expressed on activated T cells, transmembrane and juxtamembrane domains into CAR design helps improve CAR-T efficacy in vitro and in vivo in mice.

Microbiome-secreted proteins act as key modulators of host-microbiome crosstalk. Here, the authors show that Amuc_1409 protein, secreted from Akkermansia muciniphila, plays a key role in intestinal homeostasis by regulating intestinal stem cells through interaction with E-cadherin, indicating its potential as a biomolecule for improving gut health.

Arabidopsis repairs leaf wounds by reprogramming mesophyll cells into epidermal-like cells that build a ligno-suberized barrier topped with cuticle. ATML1 directs this process via ethylene–RbohE and jasmonic acid–RbohD signalling across cell layers in space and time.

The Purcell effect predicts a spontaneous emission rate enhancement of several orders of magnitude, but experimental demonstrations have been much lower. Here, Song et al. show emission enhancement of Er³⁺ions in a metallic nanocavity with a 170 Purcell factor at room temperature and 55% extraction efficiency.

Eukaryotic algae and cyanobacteria can produce hydrogen in the presence of little or no oxygen. Here, the authors show that two microalgal strains are capable of producing hydrogen under aerobic conditions, and provide new insights into the natural evolution of oxygen-tolerant hydrogenase.

High-concentration lithium polysulfides in lean electrolyte lithium–sulfur batteries hinder stable cycling. Here, authors introduce a reversible calcium additive that regulates polysulfides chemistry and catalyzes sulfur redox reactions, improving energy density with stable cycling.

Although quantum fluctuations of the spins occur on a local scale, they can have a macroscopic impact on the properties of magnets. Here, the authors observe the macroscopic influence of magnetic quantum fluctuations on the dielectric properties of a multiferroic oxide.

Light trapped in the active polymeric layer limits the total efficiency of polymer light-emitting diodes. Here, Lee et al.get round this bottleneck by enhancing light extraction in waveguide optical modes via ripple-shaped nanostructures that spontaneously form on ZnO electrode surfaces.

Cryptococcus neoformans is a fungal pathogen that causes meningoencephalitis. Here the authors describe the production of a gene-deletion mutant collection representing most C. neoformansnon-essential transcription factors, providing insight into the signalling networks that govern the biology and pathogenicity of this fungus.

Hereditary deafness lacks effective biological treatments. Here, the authors develop a base editing therapy that corrects a common MPZL2 deafness gene mutation in a humanized mouse model and restores hearing, highlighting base editing as a potential treatment for hereditary deafness.

Lee et al. analyse clinical, behavioural, and MRI features in patients with temporomandibular disorders to identify predictors of chronic pain. Using machine learning and deep neural networks, authors develop models that accurately predict chronicity based on jaw joint damage, bruxism, sleep disturbance, and symptom duration.

Achieving uniform Li plating in solid-state batteries is key for their practical application. Here, the authors integrate a silver-doped lithium argyrodite layer in initially anode-free all-solid-state batteries, promoting uniform lithium plating and cell operation under a low stack pressure of 2 MPa through silver exsolution.

The genetic link between placenta function and congenital heart defects has been established, though the cellular mechanisms underlying this connection is less clear. Here they show that PIBF1 regulates syncytiotrophoblast fusion and that loss of PIBF1 also negatively impacts heart development, providing a potential link between the development of these two organs.

There is still need for representative models of intrahepatic cholangiocarcinoma (ICC) subtypes. Here, the authors develop organoids for two recently suggested ICC subtypes and identify distinct transcriptional profiles and potential therapeutic targets.

Design of electrocatalyst in lithium sulfur batteries is important to improve electrochemical performance. Here, authors use protective carbon layer to modulate the metal p-band center and prevent undesirable phase change of electrocatalyst for realizing 1 A h level lithium sulfur pouch cell.

Increasing the activity of the proteasome can prevent the accumulation of protein aggregates within the cell. Han et al.show that nanoparticle-mediated delivery of purified proteasomes to cells reduces proteotoxic stress resulting from tau overexpression, and prevents to accumulation of tau aggregates.

Aging impairs muscle and bone health, and exercise is known to mitigate this decline, partly through secreted factors. Here, the authors show that the muscle-derived factor CLCF1, which declines with age but is restored by exercise, mediates musculoskeletal benefits in aged mice.

Low threshold power is required for the application of lasers in photonic integrated circuits in order to reduce power consumption. Here Janget al. propose and demonstrate a nanoisland quantum well laser operating at room temperature with an ultralow threshold of 210 nW absorbed at 980 nm.

Although artificial skins can facilitate the healing of damaged skin, the restoration of tactile functions remain a challenge. Here, Kang et al. report an artificial skin with an implantable tactile sensor that can simultaneously replace the tactile function by nerve stimulation and promote skin regeneration.

To better understand the etiology of frailty, the authors perform a large genetic study. They identified 45 additional variants and implicated MET, CHST9, ILRUN, APOE, CGREF1 and PPP6C as potential causal genes, linking frailty to immune regulation, metabolism and cellular signaling.

Mechanochemistry offers a paradigm shift by enabling ammonia synthesis under near-ambient conditions. Here, the authors present an innovative mechanochemical approach that employs silicon nitride as a defect-inducing physical promoter to facilitate ammonia production.

Laser-matter interaction has been intensively studied in equilibrium states, but irreversible processes in a highly nonequilibrium state at nanoscales remains elusive due to experimental challenges. Here, Ihm et al. image heterogeneous melting of gold nanoparticles with nanometer and picosecond resolution.

Recent work proposed to search for quantum spin liquid in honeycomb cobaltates. Here the authors identify Cu₃Co₂SbO₆ as a promising candidate for quantum spin liquid research, revealing bond-dependent frustrated magnetism and robust spin fluctuations in the unconventional paramagnetic region via optical spectroscopy.

The coupling of surface plasmons and excitons in organic materials can improve the performance of organic optoelectronic devices. Carbon-dot-supported silver nanoparticles have now been used to improve the efficiency of polymer light-emitting diodes and polymer solar cells.

Characterization of plasma membrane proteins is important in understanding fundamental biological processes and developing new drugs, but their separation remains a challenge. Now, a synthetic receptor–ligand pair based on ferrocene derivatives and cucurbit[7]uril is shown to have exceptionally high binding affinity, and enables membrane proteins to be isolated efficiently without any contamination from naturally biotinylated molecules.