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Showing 1–50 of 306 results

Advanced filters: Author: Hye In Yang Clear advanced filters

A spatially resolved human glioblastoma atlas reveals distinct cellular and molecular patterns of anatomical niches

Here, the authors map malignant and non-malignant cellular states in human glioma using integrated single-cell and spatial transcriptomics, revealing spatially organized tumor-microenvironment interactions and distinct oligodendrocyte-associated programs linked to disease progression.

Pranali Sonpatki
Hyun Jung Park
Nameeta Shah
ResearchOpen Access20 Feb 2026
Nature Communications

P: 1-22
Anti-TLR2 immunotherapy modulates neuron-to-oligodendrocyte propagation of α-synuclein in mouse and human models

The pathological mechanisms underlying multiple system atrophy (MSA) remain unclear. Here, the authors show in mouse and human MSA models that α-synuclein spreads from neurons to oligodendrocytes via TLR2 leading to myelination defects, and that blocking TLR2 prevents glial cytoplasmic inclusions and myelin damage.

Eun-Jin Bae
Sangwoo Ham
Seung-Jae Lee
ResearchOpen Access30 Jan 2026
Nature Communications

P: 1-18
A novel approach to preeclampsia early prediction addressing predictive uncertainty due to missing data in clinical dataset

Jin Woo Kim
Nari Kim
Hyun Mee Ryu
ResearchOpen Access12 Feb 2026
Scientific Reports

P: 1-14
Scalable in-situ fabrication of multimodal electronic skin for intelligent robotics and interactive systems

Hakhyun Lim
Jungrak Choi
Hye Jin Kim
ResearchOpen Access29 Jan 2026
npj Flexible Electronics

P: 1-11
Heterogeneous doping via nanoscale coating impacts the mechanics of Li intrusion in brittle solid electrolytes

Short-circuiting during fast charging through lithium dendrite intrusion into electrolytes is a major challenge in solid-state batteries. Here, using thermally annealed 3-nm-thick Ag coatings, lithium penetration into brittle electrolyte Li_6.6La₃Zr_1.6Ta_0.4O₁₂ is inhibited at local current densities of 250 mA cm⁻² due to an increase in surface fracture toughness.

Xin Xu
Teng Cui
William C. Chueh
Research16 Jan 2026
Nature Materials

P: 1-8
Differential expression of proteins related to START checkpoint of the cell cycle in human stomach, lung, cervix and liver cancers

Jae-Ryong Kim
Seong-Yong Kim
Jung-Hye Kim
ResearchOpen Access01 Jun 1997
Experimental & Molecular Medicine

Volume: 29, P: 123-128
Haplotype-level analysis of environmental DNA metabarcoding revealed the biogeography and phylogeography of freshwater fishes in Korean Peninsula

Muhammad Hilman Fu’adil Amin
Ah Ran Kim
Hyun-Woo Kim
ResearchOpen Access02 Feb 2026
Scientific Reports

Volume: 16, P: 1-17
Differential promoter methylation may be a key molecular mechanism in regulating BubR1 expression in cancer cells

Hye-Young Park
Yoon-Kyung Jeon
Chang-Woo Lee
ResearchOpen Access01 Apr 2007
Experimental & Molecular Medicine

Volume: 39, P: 195-204
Mutations of CDKN2 (MTS1/p16(INK4A)) and MTS2/p15(INK4B) genes in human stomach, hepatocellular, and cholangio-carcinomas

Jae-Ryong Kim
Seong-Yong Kim
Jung-Hye Kim
ResearchOpen Access01 Sept 1997
Experimental & Molecular Medicine

Volume: 29, P: 151-156
Alterations of CDKN2 (MTS1/p16INK4A) gene in paraffin-embedded tumor tissues of human stomach, lung, cervix and liver cancers

Jae-Ryong Kim
Seong-Yong Kim
Jung-Hye Kim
ResearchOpen Access01 Jun 1998
Experimental & Molecular Medicine

Volume: 30, P: 109-114
The power of genetic diversity in genome-wide association studies of lipids

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Research09 Dec 2021
Nature

Volume: 600, P: 675-679
A month–long effect from a single injection of microencapsulated human growth hormone

OluFunmi L. Johnson
Jeffrey L. Cleland
Scott D. Putney
Research01 Jul 1996
Nature Medicine

Volume: 2, P: 795-799
Retinoic acid inhibits inducible nitric oxide synthase expression in 3T3-L1 adipocytes

Jeong-Yeh Yang
Bon-Sun Koo
Jin-Woo Park
ResearchOpen Access01 Nov 2002
Experimental & Molecular Medicine

Volume: 34, P: 353-360
Engineered Sdd7 cytosine base editors with enhanced specificity

CRISPR base editors enable precise DNA changes but often cause off-target edits. Here, authors engineer two Sdd7 variants that minimize bystander and off-target mutations and show enhanced precision when delivered as ribonucleoproteins via engineered virus-like particles.

Hye-Yeon Hwang
Minyoung Lee
Daesik Kim
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-13
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
Structural insights into the human niacin receptor HCA2-G_i signalling complex

Hydroxyl-carboxylic acid receptor 2 (HCA2) functions as a high-affinity receptor for nicotinic acid (vitamin B3). Here, authors report the cryo-EM structure of the HCA2-G_i complex with the agonist MK-6892 and inactive state crystal structures of mutation stabilized HCA2, to describe the mechanism of HCA2 signaling.

Yang Yang
Hye Jin Kang
Zhi-Jie Liu
ResearchOpen Access27 Mar 2023
Nature Communications

Volume: 14, P: 1-11
YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells

Fibroblastic reticular cells (FRC) are important for lymph node (LN) structure and function. Here the authors show that the YAP/TAZ complex downstream of Hippo signalling regulates FRC commitment and maturation, with YAP/TAZ deficiency impairing FRC differentiation, while hyperactivation of YAZ/TAZ inducing myofibroblastic FRCs and LN fibrosis.

Sung Yong Choi
Hosung Bae
Gou Young Koh
ResearchOpen Access24 Jan 2020
Nature Communications

Volume: 11, P: 1-15
Prevalence of sarcopenia and sarcopenic obesity in Korean adults: The Korean Sarcopenic Obesity Study (KSOS)

Tae Nyun Kim
Sae Jeong Yang
Kyung Mook Choi
ResearchOpen Access04 Mar 2009
Nature Precedings

P: 1
Bioelectrical impedance analysis to assess body water status during fluid infusion in a rat model of extracorporeal membrane oxygenation

Soojin Lee
Seunghwan Song
Yang Hyun Cho
ResearchOpen Access25 Sept 2025
Scientific Reports

Volume: 15, P: 1-10
Regulation of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MEK/ERK activation in human stomach cancer cell lines

Kyung Hee Lee
Eun Young Choi
Jae-Ryong Kim
ResearchOpen Access01 Feb 2006
Experimental & Molecular Medicine

Volume: 38, P: 27-35
Colorectal microenvironment determines the prognosis of colorectal cancer

Yeong Hak Bang
Ji Hye Choi
Woong-Yang Park
ResearchOpen Access07 Jan 2026
Experimental & Molecular Medicine

Volume: 58, P: 110-125
Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy

IgE is a critical component of the allergic response and therapeutic targeting can alleviate symptomology. Here the authors propose the combined use of Bifidobacterium longum and a FcεRIα extracellular domain linked to a IgD/IgG4 hybrid Fc domain fusion protein called IgE_TRAP and show reduction of mast cell and IgE levels in models of food allergy.

Seong Beom An
Bo-Gie Yang
Myoung Ho Jang
ResearchOpen Access27 Sept 2022
Nature Communications

Volume: 13, P: 1-16
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

Ken Suzuki
Konstantinos Hatzikotoulas
Eleftheria Zeggini
ResearchOpen Access19 Feb 2024
Nature

Volume: 627, P: 347-357
Oral reovirus reshapes the gut microbiome and enhances antitumor immunity in colon cancer

Here, the authors show that oral administration of an oncolytic reovirus (RC402) elicits robust suppression of multifocal tumor lesions and antitumor immunity through extensive rewiring of the host immunity and the gut microbiome.

Won Suk Lee
Seung Joon Lee
Chan Kim
ResearchOpen Access22 Oct 2024
Nature Communications

Volume: 15, P: 1-15
Immune cells in experimental acute kidney injury

The immune system has a vital role in the renal response to acute kidney injury (AKI). In this Review, Hye Ryoun Jang and Hamid Rabb describe current understanding of the function of the innate and adaptive immune systems in the early and late injury phases of ischaemic and nephrotoxic AKI, and describe the influence of immune cells on recovery and long-term outcome following AKI.

Hye Ryoun Jang
Hamid Rabb
Reviews21 Oct 2014
Nature Reviews Nephrology

Volume: 11, P: 88-101
Enhancement of radiosensitivity by combined ceramide and dimethylsphingosine treatment in lung cancer cells

Hye-Won Park
Jie-Young Song
Yeon-Sook Yun
ResearchOpen Access01 Oct 2004
Experimental & Molecular Medicine

Volume: 36, P: 411-419
Adaptation of the quality of oncology nursing care scale for patients undergoing cancer treatment in South Korea

Hae Jeong An
Hye Young Min
Jungmin Lee
ResearchOpen Access21 Apr 2025
Scientific Reports

Volume: 15, P: 1-11
Protein kinase A mediates microglial activation induced by plasminogen and gangliosides

Kyoung-Jin Min
Myung-Soon Yang
Eun-hye Joe
ResearchOpen Access01 Oct 2004
Experimental & Molecular Medicine

Volume: 36, P: 461-467
Does Erector Spinae Plane Block Have a Visceral Analgesic Effect?: A Randomized Controlled Trial

Hye-Mee Kwon
Doo-Hwan Kim
Jong-Hyuk Lee
ResearchOpen Access21 May 2020
Scientific Reports

Volume: 10, P: 1-8
Impact of IgG monitoring and machine learning based prediction on outcomes of ABO incompatible kidney transplantation in blood type O recipients

Youngmin Ko
Jin-Myung Kim
Hyunwook Kwon
ResearchOpen Access25 Nov 2025
Scientific Reports

Volume: 15, P: 1-10
SLC6A14-mediated glutamine promotes SYTL4–CXCL8 axis activation to drive gemcitabine resistance and immune evasion in pancreatic cancer

Hyeon Woong Kang
Ju Hyun Kim
Joon Seong Park
ResearchOpen Access25 Dec 2025
Experimental & Molecular Medicine

Volume: 57, P: 2943-2956
Adenoviral mediated hepatocyte growth factor gene attenuates hyperglycemia and β cell destruction in overt diabetic mice

Mi-Kyoung Park
Duk-Kyu Kim
Hye-Jeong Lee
ResearchOpen Access01 Dec 2003
Experimental & Molecular Medicine

Volume: 35, P: 494-500
Maintenance of CD8+T-cell anergy by CD4+CD25+ regulatory T cells in chronic graft-versus-host disease

Juyang Kim
Hye J Kim
Byungsuk Kwon
ResearchOpen Access01 Oct 2006
Experimental & Molecular Medicine

Volume: 38, P: 494-501
Transcriptional targeting of gene expression in breast cancer by the promoters of protein regulator of cytokinesis 1 and ribonuclease reductase 2

Hye Jin Yun
Young-Hwa Cho
Wongi Seol
ResearchOpen Access20 Jun 2008
Experimental & Molecular Medicine

Volume: 40, P: 345-353
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.

Anubha Mahajan
Cassandra N. Spracklen
Andrew P. Morris
Research12 May 2022
Nature Genetics

Volume: 54, P: 560-572
Intraoperative hypotension after remimazolam or propofol induction with sevoflurane maintenance in angiotensin II receptor blockers-treated patients: a randomized controlled trial

Hye Jin Kim
Namo Kim
So Yeon Kim
ResearchOpen Access13 Nov 2025
Scientific Reports

Volume: 15, P: 1-8
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Factors associated with shock-refractory prehospital cardiac arrest

Kyung Hun Yoo
Byuk Sung Ko
Hye Jee Joo
ResearchOpen Access18 Aug 2025
Scientific Reports

Volume: 15, P: 1-9
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

Heterozygous mutateons in the caspase-8 cleavage site of RIPK1 cause a range of autoinflammatory symptoms in humans, and caspase-8 cleavage of RIPK1 in a mouse model limits TNF-induced cell death and inflammation.

Najoua Lalaoui
Steven E. Boyden
John Silke
Research11 Dec 2019
Nature

Volume: 577, P: 103-108
Precision nutrition for hypertension: tea, coffee, antioxidant vitamins interactions with polygenic risk in multi-ethnic populations

Haeng Jeon Hur
Hye Jeong Yang
Sunmin Park
Research08 Jan 2026
European Journal of Clinical Nutrition

P: 1-15
Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis

Intestinal TM6SF2 is found to interact with fatty acid-binding protein 5 to modulate the secretion of fatty acids and the composition of the gut microbiota, thereby protecting against metabolic dysfunction-associated steatohepatitis.

Xiang Zhang
Harry Cheuk-Hay Lau
Jun Yu
ResearchOpen Access08 Jan 2025
Nature Metabolism

Volume: 7, P: 102-119
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency

Here, the authors describe biallelic loss-of-function variants in human SHARPIN in individuals with autoinflammation and immunodeficiency, termed sharpenia. They also successfully treat one of these individuals with TNF inhibitors.

Hirotsugu Oda
Kalpana Manthiram
Daniel L. Kastner
Research12 Apr 2024
Nature Immunology

Volume: 25, P: 764-777
Population-level amplification of gene regulation by programmable gene transfer

Gene regulation in engineered microbial populations is often tuned at individual cell levels. Now, a population-wide amplification system has been devised that expands the dynamic range of plasmid transfer and gene regulation in bacteria.

Hye-In Son
Grayson S. Hamrick
Lingchong You
Research08 Jan 2025
Nature Chemical Biology

Volume: 21, P: 939-948
Methyl-β-cyclodextrin inhibits cell growth and cell cycle arrest via a prostaglandin E(2) independent pathway

Young-Ae Choi
Byung Rho Chin
Suk-Hwan Baek
ResearchOpen Access01 Feb 2004
Experimental & Molecular Medicine

Volume: 36, P: 78-84
Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome

Excessive NLRP3 inflammasome activation underlies inflammatory diseases such as gout. Here the authors show that orphan nuclear receptor small heterodimer partner protein (SHP) negatively regulates NLRP3, and its loss leads to accumulation of damaged mitochondria and gout-like immunopathology.

Chul-Su Yang
Jwa-Jin Kim
Eun-Kyeong Jo
ResearchOpen Access06 Feb 2015
Nature Communications

Volume: 6, P: 1-11
Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-α mRNA

Min-Ju Chae
Hye Youn Sung
Woong-Yang Park
ResearchOpen Access30 Nov 2009
Experimental & Molecular Medicine

Volume: 41, P: 824-831
Matrin3 mediates differentiation through stabilizing chromatin loop-domain interactions and YY1 mediated enhancer-promoter interactions

Alterations in proteins within nuclear compartments often lead to changes in chromosomal architecture. Here, using acute targeted protein degradation, the authors reveal that the nuclear complex protein Matrin3 directly mediates differentiation through stabilizing chromatin loop domain interactions.

Tianxin Liu
Qian Zhu
Stuart H. Orkin
ResearchOpen Access10 Feb 2024
Nature Communications

Volume: 15, P: 1-18
CRISPR/Cas9 targeting events cause complex deletions and insertions at 17 sites in the mouse genome

CRISPR/Cas9 gene editing has been used to generate mutations in several mouse genes. Here, the authors show that targeting events using single guide RNAs cause large deletions at 17 sites in the mouse genome, suggesting that careful genotyping is needed and sequential targeting may avoid such deletions.

Ha Youn Shin
Chaochen Wang
Lothar Hennighausen
ResearchOpen Access31 May 2017
Nature Communications

Volume: 8, P: 1-10
CFP1 governs uterine epigenetic landscapes to intervene in progesterone responses for uterine physiology and suppression of endometriosis

Progesterone (P₄) signalling is involved in physiological control of the endometrium and contributes to the pathogenesis of endometrial diseases such as endometriosis. Here the authors report that CFP1, a regulator of histone methylation, controls endometrial responses to P₄ and lack of endometrial CFP1 leads to failure of embryo implantation and exacerbated experimental endometriosis in mice.

Seung Chel Yang
Mira Park
Haengseok Song
ResearchOpen Access03 Jun 2023
Nature Communications

Volume: 14, P: 1-15
α_1B-Adrenoceptors mediate adrenergically-induced renal vasoconstrictions in rats with renal impairment

Md Abdul Hye Khan
Munavvar Abdul Sattar
Edward James Johns
Research01 Feb 2008
Acta Pharmacologica Sinica

Volume: 29, P: 193-203

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