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Here the authors reveal via whole genome sequencing of an East Asian AD cohort a common variant locus (APCDD1), rare noncoding variants in excitatory neurons, and short tandem repeat expansions, suggesting a cumulative effects model for Alzheimer’s risk.

A cross-ancestry GWAS meta-analysis of β-amyloid deposition in East Asian and European populations identifies a novel SORL1 locus and highlights its differential expression in microglia associated with β-amyloid positivity.

A gold-embedded oxide interlayer can be used to create metal–interlayer–semiconductor contacts for two-dimensional materials that exhibit low series resistance and Fermi level depinning.

The characterization of protein–protein interactions by combined single-molecule pull-down and single-molecule co-immunoprecipitation assays uncovers, for specific cancers, their dependence on signalling complexes of the human epidermal growth-factor receptor.

Carbon monoxide dehydrogenases (CODH) employ artificial electron mediators like viologens for biocatalysis, but little is known about the interaction between the mediators and the enzyme. Here, the authors discover the critical site for viologen interactions at the D-cluster of Carboxydothermus hydrogenoformans CODH2 via alanine mutations and crystallography, and report variants with increased ethyl viologen affinity.

Here the authors present the cryo-EM structures of heteromeric TRPC1/TRPC4 channel and provide structure–function insights into its heteromer-specific properties.

While light-driven water splitting offers a means to produce renewable H₂ fuel, water oxidation limits performances and yields low-value products. Here, authors demonstrate a photoelectrochemical cell that converts lignocellulosic biomass into valuable products alongside H₂.

The efficacy of a B-cell-lymphoma-2-homology-3 mimetic can be predicted by profiling the rewired status of the network of interactions among proteins of the B-cell-lymphoma-2 family via single-molecule pull-down and co-immunoprecipitation.

Carbon dioxide and helium data support lateral advection of carbon-rich cratonic mantle below the East African Rift System, which concentrates deep carbon and causes active carbonatite magmatism near the craton edge.

The ER-mitochondria contact sites are crucial for exchanging phospholipids. Here, Kim et al. present crystal structures of mitoguardin-2 (MIGA2) which reveal that MIGA2 directly binds phospholipids and transfers them between the ER and mitochondria.

Atomic level engineering of graphene-based materials is highly demanded for the customized structures and properties. Here, the authors show heteroatom dopant-specific unzipping of carbon nanotubes as a reliable and controllable route to customized 'intact crystalline' graphene-based nanostructures.

Transfer of CO₂ from Earth’s interior to the atmosphere happens largely by volcanic degassing. Measurements of CO₂ emissions from faults in the East African Rift system imply that tectonic degassing is also important for deep carbon release.

The vascular cambium is a lateral meristem that is particularly active during secondary growth. Here, several signalling pathways (peptide, receptor, auxin and cytokinin) are linked together to explain how vascular development is regulated.

RNA G-quadruplex is a secondary RNA structure formed by G-rich sequences. Now a zinc-finger protein has been identified to target the G-quadruplex motifs of two key factors in phloem differentiation, leading to a new translational regulatory pathway.

Tip-enhanced vibrational spectroscopy at room temperature is complicated by molecular conformational dynamics, photobleaching, contaminations, and chemical reactions in air. This study demonstrates that a sub-nm protective layer of Al₂O₃ provides robust conditions for probing single-molecule conformations.

The poor catalyst stability for oxygen evolution in acidic media has been a long-time issue. Here, authors demonstrate iridium on MoO₃ exhibits a low overpotential for oxygen evolution and excellent durability in acidic media due to the high oxidation state of iridium metal on MoO₃.

A learning-in-simulation framework for wearable robots uses dynamics-aware musculoskeletal and exoskeleton models and data-driven reinforcement learning to bridge the gap between simulation and reality without human experiments to assist versatile activities.

The impact of metal nanoparticles on the reactivity of mixed-conducting oxide fuel cell electrodes is identified and quantified.

Identification of neurotransmitters remains challenging for surface enhanced Raman spectroscopy (SERS) due to presence of noise. Here, the authors present spread spectrum SERS, which by encoding excited light and decoding SERS signals enables detection of unlabelled neurotransmitters at attomolar concentrations.

Tough and healable elastomers are promising materials to realize resilient soft robots but mechanical enhancements often lead to higher stiffness that deteriorates actuation strains. Here, the authors introduce liquid metal nanoparticles into carboxyl polyurethane elastomer to sensitize a dielectric elastomer actuator with responsiveness to electric fields and NIR light.

A dual-ligand passivation system comprising photocrosslinkable ligands and dispersing ligands enables quantum dots to be universally compatible with solution-based patterning techniques.

PPARg is differentially expressed in bladder cancer subtypes. Here, the authors show in mice that when an activated form of PPARg is expressed in basal bladder cells tumours do not form, however in the presence of injury the basal cells differentiate into luminal cells.

The nuclear receptor Pparg regulates urothelial differentiation in vitro but its role in healthy urothelium is unclear. Here, the authors show that PPAR gamma mediates urothelial development during both homeostasis (via mitochondrial function) and following infection, via an inflammatory response.

In plants, brassinosteroids (BR) counter the suppressive effect of abscisic acid (ABA) on early seedling development. Ryu et al.show that ABA regulator genes are suppressed by a complex containing the BR-activated protein BES1, a histone deacetylase, and the transcriptional corepressor TOPLESS.

Many experiments have been performed that study rectification by exciting electrons to tunnel across a single quantum barrier. Here, the authors take a 2-dimensional approach by combining 2D closed-loop tunneling barriers with broken symmetry to enable geometrically controllable rectification of THz fields.

The geochemical signature of mantle upwelling-induced magmatism is observable in groundwater on the Korean Peninsula, according to geochemical data of volatiles from fault-related fluids combined with three-dimensional seismic tomography.