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Parity-time symmetry breaking and related non-Hermitian phenomena, such as high-order exceptional points, have attracted significant interest across various experimental platforms. Here the authors demonstrate a third-order exceptional point induced by parity-time symmetry breaking in a dissipative trapped ion.

Aqueous two-phase systems have potential as biomimetic materials, but often lack stability and are prone to collapse. Here, the authors use interfacial assembly of chitin nanofibres and cellulose nanocrystals to prepare a biobased system with permeability and switchable motility.

There are many quantum systems that act as high-quality quantum harmonic oscillators, and they can be used to store quantum information using the Gottesman–Kitaev–Preskill code. Entangling gates have now been demonstrated between two of these qubits.

Patients with myelodysplastic syndromes (MDS) have limited therapeutic options. Here the authors show that functionally impaired NK cells contribute to immune escape of pre-malignant clones in early stage MDS and that NK adoptive cell therapy can be considered to prevent or delay the development of MDS.

The detection of the auroral footprint of Jupiter’s moon Callisto is challenging, but a shift in Jupiter’s bright main auroral oval could provide an opportunity for potential detections. Here, the authors show observation of the ultraviolet footprint of Callisto using Juno spacecraft data, benefiting from such opportunity.

Psychometric network models have become increasingly popular in psychology and the social sciences. Huth et al. show that a large proportion of reported network findings are based on weak or inconclusive evidence inviting caution when interpreting results.

Continuous time crystals are phases of matter that spontaneously break continuous time-translation symmetry and have been realised in non-equilibrium systems. Here the authors couple a continuous time crystal formed by magnon Bose-Einstein condensate in superfluid 3He to an oscillator and show that the coupled system obeys the optomechanical Hamiltonian.

Here, the authors present efficient local ancestry inference algorithms to analyse the population of origin for each individual and variant in the UK Biobank, improving controls for population structure and revealing immune-related genetic patterns.

How the brain supports speaking and listening during conversation of its natural form remains poorly understood. Here, by combining intracranial EEG recordings with Natural Language Processing, the authors show broadly distributed frontotemporal neural signals that encode context-dependent linguistic information during both speaking and listening..

Interactions between qubits and defect-related two-level systems in superconducting qubit devices are a major source of noise fluctuations that hinder error-mitigation performance. Here, the authors experimentally show that modulating this interaction can reduce noise fluctuation and improve error mitigation performance.

How age affect the immune response to malaria is not fully understood. Here, the authors characterise the transcriptome and serum inflammatory cytokines in children and adults in response to malaria, showing that there is an increase of inflammatory chemokine and cellular responses in adults compared to children.

The temporal characterization of few-femtosecond vacuum ultraviolet pulses bring new opportunities for investigating ultrafast light-matter interactions.

A new analysis of Dawn’s observations reveals Vesta’s moment of inertia, indicating limited central density variation. This finding suggests that Vesta did not undergo full differentiation, challenging conventional models of Vesta’s formation and evolution.

Yap and colleagues identify an extramitotic role for the centralspindlin complex, a Rho signalling regulator during cytokinesis. They show that centralspindlin interacts with α-catenin, and promotes epithelial junctional integrity by recruiting the ECT2 RhoGEF to the zonula adherens, as well as by inhibiting the junctional localization of the p190 B RhoGAP.

Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.

Altered pre-mRNA splicing frequently causes disease, yet how sequence variants alter splicing remains enigmatic. Here the authors use deep indel mutagenesis and deep learning tools to reveal the regulatory architecture of human exons and identify splicing-modulating antisense oligonucleotides.

Nguyen, Collier et al. find a mitochondria–lysosome inflammatory pathway regulated by the SUMO E3 ligase MAPL, which promotes vesicular mtDNA transport to lysosomes and subsequent gasdermin-dependent lysosomal permeabilization to activate pyroptosis.

Chronic Kidney Disease affects 1 in 10 people worldwide with prevalence continuing to rise, thus there is a need to identify novel biomarkers that can add value to existing clinical and biochemical risk predictors. Here the authors identify miR190a-5p as potential indicator of kidney health and disease progression in patients with chronic kidney disease.

GTPase-activating proteins (GAPs) often contain regulatory PH domains. In this work, Soubias et al, using an integrated structure-function approach, discovered a mechanism where a GAP PH domain binds directly to a GTPase to induce allosteric changes facilitating GTP hydrolysis.

Rho kinases regulate the actin cytoskeleton by controlling stress fibre formation. Truebestein et al.show that the length of its coiled-coil determines ROCK2 function, and propose that the coiled coil acts as a spacer, targeting kinase activity to a discrete distance from the membrane.

The Southern Ocean seasonal ice zone can be divided into 3 dynamical regimes based on the magnitude and sign of the mean submesoscale vertical heat flux using instrumented seal data.

Multimode ultrastrong coupling between 3D photonic-crystal cavity modes and the cyclotron resonance of a 2D electron gas reveals distinct coupling scenarios governed by the cavity’s spatial profile and potential intermode ground-state correlations.

Cerebral cavernous malformation (CCM) is a life-threatening disorder in which blood vessels in the brain are prone to hemorrhage. Kevin Whitehead et al. now show that CCM2, mutations in which are associated with CCM, is needed for specific aspects of endothelial cell function involving RhoA GTPase. These defects can be partially restored by statin treatment, suggesting a potential therapeutic intervention for individuals with CCM. The role of CCM2 in the endothelium is also explored in another paper published in this issue of Nature Medicine, by Benjamin Kleaveland et al

Despite TRPV4’s medical importance, the mechanisms of ligand-mediated channel gating and its regulation by Rho GTPase are unclear. Here, the authors report the structures of TRPV4 in complex with RhoA and ligands, offering atomic-level insights into their functions.

The lack of reliable coating methods for amorphous zeolitic imidazolate framework (aZIF) materials hinders their development for applications such as photolithography and separation membranes. Supported by computational fluid dynamics modeling, the authors develop a spin-coating technique to deposit aZIF films from dilute precursors and demonstrate their wafer-scale use in advanced lithographic processes.

The composition of Earth’s inner core can be constrained by the supercooling required for its formation. Based on molecular dynamic simulations this work shows that inner core nucleation from an iron-carbon composition fits geophysical constraints.

PIX proteins activate the small GTPases Rac and Cdc42, and are known to have numerous functions in a variety of cell types. Using a genetic screen in C. elegans, the authors find that PIX-1 is required for the assembly or stability of integrin adhesion complexes between muscle cells.

Here the authors employ quantum electrodynamics to formulate thermal emission effects in time-modulated media, resulting in innovative thermal emitters. They show that time modulation induces strong field fluctuations in epsilon-near-zero bodies, enabling narrowband emission across the entire range of wavevectors, from near to far-field regimes.

Despite improving therapeutic options, the prognosis for patients with metastatic castration-resistance prostate cancer (mCRPC) remains poor. Here, the authors identify MCL1 copy number alterations as a prognostic and predictive biomarker, demonstrating its therapeutic potential as a drug target, either alone or in combination, in patients with mCRPC.

Understanding charge storage in supercapacitors remains a challenge. Here, authors use operando X-ray scattering to show that selective anion immobilization in MOF-based electrodes leads to a cation-driven charge storage mechanism.

The authors develop a computational tool to design NMR pulses, based on the GRadient Assisted Pulse Engineering approach, that can calculate optimal pulse shapes on the fly during the measurements, to match specific samples and hardware, overcoming the limitations of pre-designed pulses.

The maximum precision achievable in quantum metrology is in general tractable only in few-body scenarios or in case of uncorrelated local noise. Here, the authors show a tensor networks method to compute such bounds in cases with large number of probes and short-range spatial and temporal noise correlations.

2D superlattices of colloidal quantum dots are challenging to fabricate over large areas without cracks. Here, Pinna et al. demonstrate how applying lateral pressure during self-assembly of PbS quantum dots improves order and coverage, enabling large-area, crack-free films with high electron mobility.

Analysis of samples from the asteroid Ryugu provide evidence of late fluid flow in a carbonaceous asteroid, indicating that such bodies may have retained two to three times more water than previously thought.

α-Synuclein accumulation in putaminal synapses is hypothesised to drive Parkinson’s disease progression. This study demonstrates synaptic pSer129 α-synuclein enrichment in early-stage Parkinson’s disease, and its link with dopaminergic denervation and cortical Lewy body pathology.