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Long-read genome assemblies for seven Japanese, three North American and one primitive Glycine max cultivars highlight gene-level structural variation underlying distinct seed morphology phenotypes.

During plant cultivation, denitrification process can release greenhouse gas nitrous oxide (N₂O) to atmosphere. Here, the authors develop a soybean–bradyrhizobial symbiosis system with enhanced capacity to reduce N₂O emissions using the incompatibility between two soybean R genes and their effector present in bradyrhizobia.

The XRISM Resolve spectrum of the galactic neutron star X-ray binary, GX 13+1, reveals one of the densest winds ever seen in absorption lines.

Fujioka et al. show that, under starvation, yeast Atg1 forms droplets that concentrate autophagy factors, boosting Atg8 lipidation and clustering vesicles. These droplets likely serve as hubs that generate membrane seeds for autophagosome formation.

Soybean mosaic virus (SMV) is a potyvirus that reduces soybean yield and seed quality worldwide. Here, the authors reveal that the resistance gene Rsv4 encodes an RNase H family protein with dsRNA-degrading activity, and it can enter the viral replication compartment and degrade viral dsRNA.

Beta-relaxation in glasses is commonly attributed to the confined motions of constituent atoms in nanosized domains, but there is no direct evidence so far. Here, Zhu et al. show the correlation between the evolution of spatial heterogeneity at nanoscale and beta-relaxation below glass transition point.

Even mild drought impacts crop production significantly. Here, the authors develop an experimental mild drought system induced by ridges in the field and find that phosphate starvation response occurs before ABA response in early mild drought.

Mitochondrial uncoupling is a treatment strategy for metabolic diseases that reduces the efficiency of mitochondrial oxidative phosphorylation and ATP generation. Here the authors characterize the pharmacokinetic and therapeutic properties of the liver-localized mitochondrial uncoupler OPC-163493, which leads to amelioration of diabetes and hypertension in several rodent disease models.

The calving of the Mertz Glacier occurred in 2010 in East Antarctica, brought on by the re-positioning of a large iceberg. Using satellite data, this study shows a reduction in sea ice production following the calving, interpreted as a potential regime shift towards reduced sea ice production for the coming decades.

Liquid-liquid phase separation of p62/SQSTM1 has been previously described, although the significance in vivo remains unclear. Here the authors show p62 droplets contain ubiquitin, autophagy-related proteins and Keap1 to serve as platform of not only autophagosome formation but also Nrf2 activation.

Antarctic Bottom Water fills much of the global abyssal ocean, and is known to form in three main sites in the Southern Ocean. Data from instrumented elephant seals and moorings suggest an additional source of bottom-water formation in the Cape Darnley polynya that is driven by sea-ice production.

Genetically grafting macrocyclic peptides into the structural loops of fragment crystallizable regions can make them surrogate receptor agonists with longer half-lives in circulation and enhanced penetration of the blood–brain barrier.

Prediction for resetting of circadian rhythms is sometimes complicated by dose and drug combinations. Here, authors found that dose-dependent resetting follows a simple law by parameterizing the response characteristics.

The authors show that the appearance of anomalously low oxygen and acidified water on the Chukchi Plateau, a high-seas fishable area of the western Arctic Ocean, is associated with a change in basin-scale ocean circulation related to the recent sea ice loss.

Antarctic bottom water is important for the global climate system, but its main source in East Antarctica was altered recently because of calving of the Mertz Glacier Tongue. The authors model this event and find large changes in dense water exports from the region.

Observations of a luminous quasar from the high-resolution spectrometer Resolve aboard XRISM revealed highly inhomogeneous wind structure outflowing from a supermassive black hole, which probably consists of up to a million clumps.

The central dogma of molecular biology requires many proteins, but how these proteins arose during evolution remains unclear. Here, authors reveal that a subset of RNA polymerases and ribosomal proteins featuring four distinct β-barrel folds diversified from a common ancestor.

Robbins and colleagues show that cigarette smoke-induced endothelial dysfunction enables atherosclerotic plaque macrophages to drive abdominal aortic aneurysm formation in a mouse model of atherosclerosis.

Cooled liquids that fail to reach their thermodynamic ground state either form gels or glasses. Their formation is thought to be promoted by stable local atomic structures. The role of these local structures has now been verified in experiments that also show that their structural variety is much larger than expected.

Fast bond exchange reactions is critical for the design of vitrimer and vitrimer-like materials but are not sufficiently explored. Here, the authors use fast bond exchange between α-(acyloxymethyl)acrylate and carboxylic acid resulting in rapid stress relaxation and excellent processability owing to the highly efficient network rearrangement.

This study describes RK-701, an inhibitor of histone methyltransferases G9a/GLP, as a promising therapeutic candidate for sickle cell disease and a universal role of BGLT3 lncRNA in fetal hemoglobin reactivation by chemical inducers including RK-701.

While the hippocampus is well-known to store specific memories, it can also learn common features that are shared across individual memories. Here, the authors show how this ability arises from dual input pathways and how it can inspire better machine learning methods.

Switchable polymerization holds considerable potential for the synthesis of highly sequence-controlled multiblock. Here the authors show a self-switchable polymerization enabled by simple alkali metal carboxylate catalysts that directly polymerize six component mixtures into polymers consisting of up to 11 blocks.

Current methods to assess circadian biological parameters can be labor intensive. Here, the authors establish a method for estimating circadian entrainment characteristics using simple experiments and mathematical modeling, revealing the responsiveness of circadian rhythms to diverse stimuli in the mammalian circadian clock.

Using a computational model to quantify difficulty in reconstructing images from compressed codes, Lin et al. show that reconstruction errors interface perception and memory by modulating how well images are encoded.

In this Perspective, de Magalhães explores the evolutionary relationship between cancer and ageing, proposing that the need to minimize cancer risk early in life may contribute to tissue degeneration later on, representing a trade-off that constrains the evolution of longer lifespans.

Glutathione is a key antioxidant that plays an important neuroprotective role in the brain. Here, Kinoshita et al.show that levels of glutathione exhibit diurnal fluctuations that are indirectly regulated by the microRNA miR-96-5p, and that this microRNA plays a neuroprotective role against oxidative stress.

X-ray spectroscopic observations of the Centaurus galaxy cluster with the X-Ray Imaging and Spectroscopy Mission satellite show that the hot gas flows along the line of sight relative to the central galaxy.

Researchers cancel out the Dick effect through a synchronous frequency comparison between two optical lattice clocks based on ⁸⁷Sr and ⁸⁸Sr atoms. This scheme achieves an Allan standard deviation of around 10⁻¹⁷, which represents a significant advantage when using a large number (2,000) of atoms in an optical clock.

Normal epithelial intestine organisation requires Wnt and Hedgehog signalling activity. Here, the authors show that parafibromin can activate both pathways in a mutually exclusive manner and is important for intestinal homeostasis.

Hypoparathyroidism and osteoporosis can be treated with parathyroid hormone, but frequent injections are required. Here the authors develop a small-molecule agonist for the parathyroid hormone type I receptor that can be administered orally, and demonstrate its efficacy in rats.