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Tamm states on subwavelength, reconfigurable plasmonic crystals are studied in the terahertz regime. By introducing an independently controlled plasmonic defect, an electromagnetically induced transparency phenomenon is revealed.

Light pulses with controllable parameters are desired for studying the fundamental properties of matter. Here the authors generate and use phase-manipulated and highly time-stable XUV pulse pairs to probe the coherent evolution and dephasing of XUV electronic coherences in helium and argon.

An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose current production involves a laborious extraction process from yew trees.

Embryonic development produces different cell types in response to a small number of inductive signals. Here, the authors characterise how maternal factors modify chromatin to specify initial competence in Xenopus tropicalis, finding that the pioneering activity of the pluripotency factors Pou5f3 and Sox3 establishes competence for germ layer formation by remodelling chromatin before the onset of signalling.

Bacterial large subunit assembly is rapid and intricate, involving complex RNA domain interactions. Here, authors use anti-sense oligonucleotide probing with cryo-EM to reveal early-stage domain consolidation and identify RNA foldons that guide late-stage assembly.

The combination of adaptive optics with an improved isoSTED nanoscope allows imaging of cells and tissues with sub-50-nm isotropic resolution.

Mucosal influenza vaccines promise enhanced protection but lack defined immune correlates of protection. Here, the authors conduct a phase I trial of an intranasal recombinant influenza A/H5 vaccine with a nanoemulsion adjuvant, demonstrating successful mucosal priming and broad cross-clade immune responses, advancing the development of intranasal influenza vaccines.

The folding of outer membrane proteins (OMPs) is catalyzed by the βbarrel assembly machinery (BAM). Here, structural and functional analyses of BAM stabilized in distinct conformations elucidate the roles of lateral gate opening and interactions of BAM with the lipid bilayer in OMP assembly.

Experimental observation of flux periodicity ϕ₀/2 for interference of the outermost edge mode of Fabry-Perot interferometers has been attributed to exotic electron pairing mechanisms. Here, the authors demonstrate that the interfering charges of a Fabry-Perot interferometer are single electrons

An analysis of fish and macroinvertebrate communities in European rivers over 32 years shows that inland ship traffic is associated with declining taxonomic richness, diversity and trait richness and with increased taxonomic evenness.

Patients with stage 4 or unresectable stage 3 melanoma refractory to first-line anti-programmed death protein 1 (PD-1) or anti-programmed cell death 1 ligand 1 have longer progression-free survival when treated with a combination of anti-cytotoxic T-lymphocyte protein 4 (CTLA-4) and anti-PD-1 versus anti-CTLA-4 alone.

Understanding the chemistry of perovskite precursor solutions enables improved film optoelectronic properties, allowing the fabrication of multijunction solar cells achieving power conversion efficiencies beyond the radiative limit of single-junction cells.

Cryo-electron microscopy was used to study human mechanistic target of rapamycin complex 1 (mTORC1) activation on lysosomal membranes, showing progressive recruitment by RAG–Ragulator, RHEB and RAPTOR, culminating in mTOR–membrane engagement and full enzyme activation.

Intraband electroluminescence (EL) from n-doped core–shell HgSe–CdSe colloidal quantum dots is observed around the wavelength of 5 µm. The measured EL quantum efficiency is 4.5% at the injection current of 2 A cm⁻², benefiting from the cascade effect. The power efficiency is 0.05%.

Coherent control of plasmon wavepackets is essential for quantum information processing using flying electron qubits. Here, the authors demonstrate a method to isolate and select electron channels contributing to a plasmon using a cavity formed by local constrictions, enabling precise control of plasmon eigenstates.

Focus-locking improves localization precision in single-molecule microscopy, but fiducials are often deposited at random and provide limited 3D compensation. Here, the authors fabricate 3D optical fiducials with nanometer accuracy by two-photon direct laser writing, and demonstrate isotropic 3D focus locking.

The authors report subnanosecond thermal transport on a gold–hexagonal boron nitrite interface governed by hyperbolic phonon–polariton coupling, demonstrating a cooling mechanism orders of magnitude faster than those relying on phonon-mediated processes.

La-substitution in BiFeO₃ enables an electric field-driven conversion of a multi-domain into a single ferroelectric domain accompanied by a single variant spin cycloid. A single domain multiferroic generates 400% larger non-local inverse spin Hall voltage at the output.

Nonlinear optical processes like higher-order harmonic generation in solids depend on several factors. Here the authors explore the optical nonlinearity of hexagonal boron nitride and find that enhanced nonlinearity is due to electron-phonon and phonon-polariton couplings.

Inspired by the rich ion dynamics and interplay in biological channels, the authors report cooperative and inhibitory ion transport in angstrom-scale acetate functionalized MoS₂ two-dimensional channels.

Kinetic energy put into a granular medium as a collective is typically dissipated as friction. The situation is different when forces are applied to the individual particles. An experiment now shows that when torques are applied to particles in a dense bed of microrollers, the grains roll uphill.

Bottom-up fabrication of GNR heterojunctions exhibiting atomically perfect heterojunction interfaces can be obtained from a single molecular precursor via post-growth modification

A model of compositional state spaces in the hippocampus shows latent learning and rapid generalization. Bakermans et al. show that this model predicts the emergence of place responses in replay.

Infection by Plasmodium falciparum can manifest as diverse symptoms and outcomes with different treatment requirements. Here the authors use metabolomics, proteomics and transcriptomics data from 79 children to identify potential omics signatures that correlate with different extent and nature of inflammation to provide insights into the development of future treatments.

Multidrug efflux pumps actively expel a wide range of toxic substrates from bacteria and play a major role in drug resistance. Here authors show the in situ structure of the efflux pump AcrAB-TolC obtained by electron cryo-tomography and subtomogram averaging.

Recent experiments have shown the formation of ferroelectric domains in twisted van der Waals bilayers. Here, the authors report near-field infrared nano-imaging and nano-photocurrent measurements to investigate ferroelectricity in minimally twisted WSe₂ by visualizing the plasmonic and photo-thermoelectric response of an adjacent graphene monolayer.

While fluid restriction is typically recommended for patients with chronic heart failure, this randomized clinical trial showed no difference in health status, as assessed by patient-reported outcomes, between patients recommended to a liberal versus a restrictive fluid regimen over the course of 3 months in an outpatient setting.

Unidirectional spin Hall magnetoresistance enables the new spintronic devices but is limited by the low amplitude or working temperature. Here, the authors report the large unidirectional spin Hall magnetoresistance in a topological insulator and ferromagnetic metal bilayer system at relatively higher temperature.

Spin-based electronics offers significantly improved efficiency, but a major challenge is the electric manipulation of spin. Here, Powalla et al find a large gate induced spinpolarization in graphene/WTe2 heterostructures, illustrating the potential of such heterostructures for spintronics.

Turajlic and colleagues assess longitudinal antibody and cellular immune responses against SARS-CoV-2 variants of concern in patients with cancer, following either recovery from SARS-CoV-2 infection or vaccination, in two back-to-back reports from the CAPTURE study.

Several recent works have demonstrated current based control of antiferromagnetic order, with the potential that such switching could be used for information processing and storage. Here, Haley et al demonstrate that in Fe_xNbS₂, this switching is non-local, with magnetic order changing due to an applied current at distances much larger than the spin diffusion length in the material.

The sub-terahertz rotational transitions of polar molecules can be used as frequency bases to create low-cost, low-power miniaturized clocks.

Antibodies that lock KRAS mutants in inactive conformations facilitate drug discovery.

Atoms can be used as highly sensitive magnetic-field sensors. By exploiting the effects of electric fields on the optical transitions of excited Rydberg states, it is now demonstrated that it is also possible to probe very weak microwave electric fields with atoms.

Electrolyte gating enables the accumulation of large carrier densities in two-dimensional electron systems. Here, the authors demonstrate that a few-atom thick layer of hexagonal boron nitride can dramatically improve carrier mobility in an electrolyte-gated system by limiting chemical reactions and disorder.

Energy consumption and compute density are challenges for computing systems. Here researchers show an optical computing architecture using micrometre-scale VCSEL transmitter arrays enabling 7 fJ energy per operation and a potential compute density of 6 tera-operations mm⁻² s⁻¹.

In this study, authors introduce small molecular taxon-specific markers for bacterial detection directly in complex matrices using MS-based (spatial) metabolomics. This method has the potential to advance microbiological diagnostics and host-microbe research.

High-spectral-purity frequency-agile room-temperature THz sources are foundational elements for imaging, sensing, metrology, and communications. Here a parametric oscillator-photomixer chip with coherent 2.8-octave tunable THz radiation is achieved.

An X-ray structure is presented for metabotropic glutamate receptor 5, a class C G-protein-coupled glutamate receptor linked to fragile X syndrome and neurological disorders; this study provides insights into the protein’s mechanism of action.

We report superconductivity, in a limited region of displacement field and density, in 5.0° twisted bilayer WSe₂ with a maximum critical temperature of 426 mK, establishing that moiré flat-band superconductivity extends beyond graphene structures.

In cohort B of the phase 2 SWOG S1512 trial, pembrolizumab monotherapy in patients with unresectable desmoplastic melanoma elicited a complete response rate of 37% and an objective response rate of 89%, supporting a new treatment option for this tumor type.

Hunter et al. use RNA labelling to investigate RNA transfer between organs in mice. They show that RNA potentially moves en masse from liver to kidney and that this movement is augmented in acute liver injury, although the physiological relevance of the phenomenon is not yet known.

The RXFP1 relaxin receptor is a critical mediator of physiological adaptation to pregnancy and an emerging drug target. RXFP1 activation was found to entail an unexpected mechanism of ectodomain disinhibition resulting in downstream signaling.

A twin-field quantum key distribution protocol based on optical coherence is deployed over a 254-kilometre commercial telecom network, demonstrating that coherence-based quantum communication can be aligned with existing telecommunication infrastructure.

Mid-infrared 2 μm InAs/InP quantum-dot lasers is first demonstrated, with a low threshold current density of 118 A cm⁻² per layer and a maximum operating temperature of 50 °C.