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Showing 201–250 of 312 results

Advanced filters: Author: James. D Griffin Clear advanced filters

Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity

McMillin et al. describe a drug screening platform that takes into account the tumor microenvironment, in particular tumor-stromal interactions, enabling the screening of the antitumor activity of candidate anticancer agents in the context of such interactions. The in vitro tumor cell–specific bioluminescence imaging assay is both high throughput and scalable.

Douglas W McMillin
Jake Delmore
Constantine S Mitsiades
Research14 Mar 2010
Nature Medicine

Volume: 16, P: 483-489
Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution

The genome sequences of the neglected human-infective malaria species Plasmodium malariae and P. ovale provide new insights into their biology that are pertinent to understanding their epidemiology and to the broader agenda of malaria elimination.

Gavin G. Rutledge
Ulrike Böhme
Thomas D. Otto
ResearchOpen Access25 Jan 2017
Nature

Volume: 542, P: 101-104
Synthesis of procaspases-3 and -7 during apoptosis in prostate cancer cells

Cai Bowen
H James Voeller
Edward P Gelmann
Research17 May 1999
Cell Death & Differentiation

Volume: 6, P: 394-401
Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

The Human BioMolecular Atlas Program (HuBMAP) presents its production phase: the generation of spatial maps of functional tissue units across organs from diverse populations and the creation of tools and infrastructure to advance biomedical research.

Sanjay Jain
Liming Pei
Michael P. Snyder
Reviews19 Jul 2023
Nature Cell Biology

Volume: 25, P: 1089-1100
Utility and precision evidence of technology in the treatment of type 1 diabetes: a systematic review

Jacobsen, Sherr et al. evaluate the utility of novel technologies in the treatment of type 1 diabetes. Their systematic review finds technologies such as continuous glucose monitoring, insulin pumps, and decision support tools improve important measures (e.g., HbA1c, time in range, quality of life) allowing precision-directed uptake of technology.

Laura M. Jacobsen
Jennifer L. Sherr
Paul W. Franks
ResearchOpen Access05 Oct 2023
Communications Medicine

Volume: 3, P: 1-24
Inhibition of the deubiquitinating enzyme USP47 as a novel targeted therapy for hematologic malignancies expressing mutant EZH2

Jing Yang
Ellen L. Weisberg
James D. Griffin
Research17 Jan 2022
Leukemia

Volume: 36, P: 1048-1057
Understanding COVID-19-associated coagulopathy

Here, the authors consider our emerging understanding of COVID-19-associated coagulopathy. They focus on the complex interactions between innate immune, coagulation and fibrinolytic pathways that can lead to potentially life-threatening thrombosis following SARS-CoV-2 infection.

Edward M. Conway
Nigel Mackman
James H. Morrissey
Reviews05 Aug 2022
Nature Reviews Immunology

Volume: 22, P: 639-649
BRD9 degraders as chemosensitizers in acute leukemia and multiple myeloma

Ellen Weisberg
Basudev Chowdhury
James D. Griffin
ResearchOpen Access19 Jul 2022
Blood Cancer Journal

Volume: 12, P: 1-10
Mitochondrial transplantation normalizes transcriptomic and proteomic shift associated with ischemia reperfusion injury in neonatal hearts donated after circulatory death

Ilias P. Doulamis
Aspasia Tzani
James D. McCully
ResearchOpen Access28 Dec 2024
Scientific Reports

Volume: 14, P: 1-13
The phosphatidylinositol polyphosphate 5-phosphatase SHIP and the protein tyrosine phosphatase SHP-2 form a complex in hematopoietic cells which can be regulated by BCR/ABL and growth factors

Martin Sattler
Ravi Salgia
James D Griffin
Research06 Nov 1997
Oncogene

Volume: 15, P: 2379-2384
Production of cattle lacking prion protein

Jürgen A Richt
Poothappillai Kasinathan
Yoshimi Kuroiwa
Research31 Dec 2006
Nature Biotechnology

Volume: 25, P: 132-138
The human body at cellular resolution: the NIH Human Biomolecular Atlas Program

HuBMAP supports technology development, data acquisition, and spatial analyses to generate comprehensive molecular and cellular three-dimensional tissue maps.

Michael P. Snyder
Shin Lin
James Anderson
ReviewsOpen Access09 Oct 2019
Nature

Volume: 574, P: 187-192
A comparison of machine learning methods to classify radioactive elements using prompt-gamma-ray neutron activation data

Jino Mathew
Rohit Kshirsagar
Michael E. Fitzpatrick
ResearchOpen Access19 Jun 2023
Scientific Reports

Volume: 13, P: 1-15
Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness

Marte S. Dragset
Thomas R. Ioerger
Magnus Steigedal
ResearchOpen Access06 Aug 2019
Scientific Reports

Volume: 9, P: 1-11
Ex vivo purging by adenoviral p53 gene therapy does not affect NOD-SCID repopulating activity of human CD34⁺ cells

Manabu Hirai
Drake LaFace
James Talmadge
Research21 Dec 2001
Cancer Gene Therapy

Volume: 8, P: 936-947
Small molecule inhibition of deubiquitinating enzyme JOSD1 as a novel targeted therapy for leukemias with mutant JAK2

Jing Yang
Ellen L. Weisberg
Sara J. Buhrlage
Research29 Jul 2021
Leukemia

Volume: 36, P: 210-220
Evaluation of ERK as a therapeutic target in acute myelogenous leukemia

Ellen Weisberg
Chengcheng Meng
James D. Griffin
Research27 Aug 2019
Leukemia

Volume: 34, P: 625-629
Peat-based gnotobiotic plant growth systems for Arabidopsis microbiome research

This protocol describes two peat-based plant growth systems for microbiome research in Arabidopsis. While both systems support microbe-free plants and input microbiota control, GnotoPots have advantages for throughput and FlowPots for versatility.

James M. Kremer
Reza Sohrabi
Sheng Yang He
Protocols28 Apr 2021
Nature Protocols

Volume: 16, P: 2450-2470
Variation in the fitted filtration efficiency of disposable face masks by sex

Edward R. Pennington
Jacob S. Griffin
Steven E. Prince
ResearchOpen Access02 Jul 2024
Journal of Exposure Science & Environmental Epidemiology

Volume: 35, P: 683-690
Apoptosis in hematopoietic cells (FL5.12) caused by interleukin-3 withdrawal: relationship to caspase activity and the loss of glutathione

Heidi K Bojes
Xiang Feng
Gerald M Cohen
Research11 Jan 1999
Cell Death & Differentiation

Volume: 6, P: 61-70
Disease-modifying therapies and features linked to treatment response in type 1 diabetes prevention: a systematic review

Felton et al. conducted a systematic review to evaluate studies testing disease-modifying therapies and features linked to treatment response for type 1 diabetes prevention. While the quality of prevention and intervention trials is found to be high, precision analyses on factors associated with treatment response are of poorer quality.

Jamie L. Felton
Kurt J. Griffin
Paul W. Franks
ResearchOpen Access05 Oct 2023
Communications Medicine

Volume: 3, P: 1-16
Beta-adrenergic agonism protects mitochondrial metabolism in the pancreatectomised rat heart

Ross T. Lindsay
Louise Thisted
Andrew J. Murray
ResearchOpen Access21 Aug 2024
Scientific Reports

Volume: 14, P: 1-14
Inhibition of the deubiquitinase USP10 induces degradation of SYK

Jing Yang
Chengcheng Meng
James D. Griffin
ResearchOpen Access04 Feb 2020
British Journal of Cancer

Volume: 122, P: 1175-1184
Author Correction: A genomic catalog of Earth’s microbiomes

Stephen Nayfach
Simon Roux
Emiley A. Eloe-Fadrosh
Amendments and CorrectionsOpen Access01 Apr 2021
Nature Biotechnology

Volume: 39, P: 521
Publisher Correction: A genomic catalog of Earth’s microbiomes

Stephen Nayfach
Simon Roux
Emiley A. Eloe-Fadrosh
Amendments and CorrectionsOpen Access18 Nov 2020
Nature Biotechnology

Volume: 39, P: 520
Double Replacement Gene Targeting for the Production of a Series of Mouse Strains with Different Prion Protein Gene Alterations

Richard C. Moore
Nicola J. Redhead
David W. Melton
Research01 Sept 1995
Bio/Technology

Volume: 13, P: 999-1004
Author Correction: Global diversity and biogeography of bacterial communities in wastewater treatment plants

Linwei Wu
Daliang Ning
Jizhong Zhou
Amendments and Corrections14 Nov 2019
Nature Microbiology

Volume: 4, P: 2579
Conjugating uncoupler compounds with hydrophobic hydrocarbon chains to achieve adipose tissue selective drug accumulation

Mei Ying Ng
Zhi Jian Song
Thilo Hagen
ResearchOpen Access28 Feb 2024
Scientific Reports

Volume: 14, P: 1-17
Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review

Bodhini et al. systematically review the evidence on sociodemographic, clinical, behavioral, and molecular factors that modify the effect of interventions for type 2 diabetes prevention. The certainty of evidence that such factors modify the effectiveness of lifestyle and behavioral interventions is low to very low.

Dhanasekaran Bodhini
Robert W. Morton
Ruth J. F. Loos
ResearchOpen Access05 Oct 2023
Communications Medicine

Volume: 3, P: 1-17
STEROIDS IMPROVE SURVIVAL IN EXPERIMENTAL NEONATAL SEPTIC SHOCK

Thom E Lobe
Dennis Gore
David N Herndon
Research01 Apr 1987
Pediatric Research

Volume: 21, P: 202
Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease

Blanca Scheijen
James D Griffin
Reviews21 May 2002
Oncogene

Volume: 21, P: 3314-3333
Precision gestational diabetes treatment: a systematic review and meta-analyses

Benham, Gingras, McLennan, Most, Yamamoto, Aiken et al. conduct two systematic reviews and meta-analyses to evaluate whether a precision-based medicine approach can be adopted to improve the clinical management of gestational diabetes (GDM). They find some precision markers that may improve the treatment course of GDM but further research is needed.

Jamie L. Benham
Véronique Gingras
Paul W. Franks
ResearchOpen Access05 Oct 2023
Communications Medicine

Volume: 3, P: 1-13
Precision subclassification of type 2 diabetes: a systematic review

Misra, Wagner et al. systematically review if strategies to subclassify type 2 diabetes (T2D) are associated with high quality evidence and patient outcomes. Cluster-based stratification yields T2D subtypes that associate with outcomes, suggesting subclassification could have future clinical use.

Shivani Misra
Robert Wagner
Miriam S. Udler
ResearchOpen Access05 Oct 2023
Communications Medicine

Volume: 3, P: 1-19
A Phase II study of neoadjuvant axitinib for reducing the extent of venous tumour thrombus in clear cell renal cell cancer with venous invasion (NAXIVA)

Grant D. Stewart
Sarah J. Welsh
Robert J. Jones
ResearchOpen Access23 Jun 2022
British Journal of Cancer

Volume: 127, P: 1051-1060
International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium

Gabriel A. Brat
Griffin M. Weber
Isaac S. Kohane
ResearchOpen Access19 Aug 2020
npj Digital Medicine

Volume: 3, P: 1-9
Function-related replacement of bacterial siderophore pathways

Hilke Bruns
Max Crüsemann
Nadine Ziemert
ResearchOpen Access15 Aug 2017
The ISME Journal

Volume: 12, P: 320-329
Association of early dysnatremia with mortality in the neonatal intensive care unit: results from the AWAKEN study

Abby M. Basalely
Russell Griffin
Sandra Juul
Research13 Nov 2021
Journal of Perinatology

Volume: 42, P: 1353-1360
Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C

Charlotte Sumner and colleagues report that mutations in the ankyrin repeat region of TRPV4 cause Charcot-Marie-Tooth disease type 2C. Their functional studies indicate that the mutations result in increased channel activity.

Guida Landouré
Anselm A Zdebik
Charlotte J Sumner
Research27 Dec 2009
Nature Genetics

Volume: 42, P: 170-174
Receptor tyrosine kinase Axl is required for resistance of leukemic cells to FLT3-targeted therapy in acute myeloid leukemia

I-K Park
B Mundy-Bosse
M A Caligiuri
Research19 Jun 2015
Leukemia

Volume: 29, P: 2382-2389
VarLOCK: sequencing-independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance

Xinsheng Nan
Patrick Hardinge
Tomasz P. Jurkowski
ResearchOpen Access27 Nov 2023
Scientific Reports

Volume: 13, P: 1-17
Relationship among three common hematological premalignant conditions

Nicholas J. Boddicker
Sameer A. Parikh
Susan L. Slager
ResearchOpen Access05 May 2023
Leukemia

Volume: 37, P: 1719-1722
De novo tissue formation using custom microporous annealed particle hydrogel provides long-term vocal fold augmentation

Lauren J. Pruett
Hannah L. Kenny
James J. Daniero
ResearchOpen Access23 Feb 2023
npj Regenerative Medicine

Volume: 8, P: 1-10
Correction: Evaluation of ERK as a therapeutic target in acute myelogenous leukemia

Ellen Weisberg
Chengcheng Meng
James D. Griffin
Amendments and Corrections06 Mar 2020
Leukemia

Volume: 34, P: 2543
Differential expression and signaling of CBL and CBL-B in BCR/ABL transformed cells

Martin Sattler
Yuri B Pride
James D Griffin
Research21 Feb 2002
Oncogene

Volume: 21, P: 1423-1433
Precision treatment of beta-cell monogenic diabetes: a systematic review

Naylor et al. systematically review the efficacy of treatments for beta-cell monogenic diabetes. Limited evidence from the mostly non-randomized, small studies supports no treatment in glucokinase-related hyperglycemia and sulfonylureas for HNF1A-diabetes; further evidence is needed on the optimum treatments in these and other monogenic subtypes.

Rochelle N. Naylor
Kashyap A. Patel
Tiinamaija Tuomi
ResearchOpen Access18 Jul 2024
Communications Medicine

Volume: 4, P: 1-17
The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis

Katherine A. Davies
Maria C. Tanzer
James M. Murphy
Research14 Feb 2018
Cell Death & Differentiation

Volume: 25, P: 1567-1580
Enforced CDK4 expression in a hematopoietic cell line confers resistance to the G1 arrest induced by ionizing radiation

Michael F Reed
Vivian F Liu
Mark E Ewen
Research09 Dec 1998
Oncogene

Volume: 17, P: 2961-2971
Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571

Wen-Lan Wang
Mary Ellen Healy
Ravi Salgia
Research21 Jul 2000
Oncogene

Volume: 19, P: 3521-3528
Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73

Jarvis et al demonstrate that expanded human Tregs switch their metabolism to aerobic glycolysis and show enhanced suppressive function through hypoxia-inducible factor 1-alpha (HIF1A)-driven acquisition of CD73 expression, which along with CD39, enables expanded Tregs to convert ATP to immunosuppressive adenosine. Given this, the data suggests that Treg expansion protocols should be optimised for CD39/CD73 co-expression to enhance therapeutic potential.

Lorna B. Jarvis
Daniel B. Rainbow
Joanne L. Jones
ResearchOpen Access14 Oct 2021
Communications Biology

Volume: 4, P: 1-14
FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignancies

Jing Chen
Benjamin H Lee
Dwight Gary Gilliland
Research08 Aug 2005
Oncogene

Volume: 24, P: 8259-8267

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