Acinetobacter baumannii is a major cause of hospital-acquired infections, yet its virulence factors, particularly lipooligosaccharides, are not well understood. Here, the authors synthesize A. baumannii lipid A(s) and their corresponding monophosphate derivatives, revealing that specific acylation patterns enhance immunological activity, as well as an inverted binding mode in the TLR4/MD-2 receptor complex.
- Xin-Ru Li
- Janet Jia-Yin Tan
- Kwok-Kong Tony Mong
