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By resonant excitation of an InAs quantum dot embedded in a microcavity, a deterministic single-photon source is demonstrated. Single-photon purity of 0.9795(6), photon indistinguishability of 0.9856(13), and an overall end-to-end efficiency of 0.712(18) are simultaneously obtained.

Quantum information cannot be copied, posing challenges for long-distance communication due to signal losses. Here the quantum relay architecture using a single-photon source enhances the signal-to-noise ratio of quantum information transmission.

Decoy-state quantum key distribution from a satellite to a ground station is achieved with much greater efficiency than is possible over the same distance using optical fibres.

A quantum two-level system can be coherently excited by a phase-locked dichromatic electromagnetic field. This technique can make single-photon generation more efficient as the pump light does not overlap in frequency with the emitted single photons.

Single-photon sources with a single-photon efficiency of 0.60, a single-photon purity of 0.975 and an indistinguishability of 0.975 are demonstrated. This is achieved by fabricating elliptical resonators around site-registered quantum dots.

Fault-tolerant manipulation of quantum bits is demonstrated experimentally on an eight-photon cluster state using topological error correction.

Pulse-excited resonance-fluorescence single-photons are generated on demand from a single quantum dot embedded in a microcavity under s-shell excitation with an ultrafast laser source.

Boson sampling with three, four and five photons with high efficiency, purity and indistinguishability is realized using a quantum dot–micropillar as the single-photon source. A record-breaking sampling rate of 4.96 kHz is achieved.

The antiangiogenic agent apatinib has been shown to clinically improve responses to immune checkpoint inhibitors in several cancer types. Here the authors report the results of a phase II clinical trial of camrelizumab (anti-PD1) and apatinib plus induction chemotherapy and concurrent chemoradiotherapy in stage N3 nasopharyngeal carcinoma.

Robotic surgery has been demonstrated to improve short-term outcomes for patients with gastric cancer who received a gastrectomy, but the long-term effects are less clear. Here, the authors report the survival outcomes of their phase 2 randomized controlled trial comparing robotic to laparoscopic distal gastrectomy in patients with resectable gastric cancer.

The current throughput of conventional organic chemical synthesis is usually a few experiments for each operator per day. Here the authors develop a robotic system for ultra-high-throughput chemical synthesis, online characterization and large-scale condition screening of photocatalytic reactions.

Photonic platforms are a prominent host on which practical quantum information technology applications can be leveraged and scaled. The authors discuss the state-of-the-art capabilities and give an outlook on optical technologies towards the realization of quantum computation, communications and metrology.

Separation of multi-component mixtures is an extremely difficult task. Pore integration strategy offers an approach for assembling ordered pores with specific functions on demand to achieve the one-step separation of multi-component complex mixtures.

The formation mechanisms for periodic heterostructures are still poorly understood. Here, the authors propose a versatile approach to synthesize one-dimensional segmented heterostructures and reveal a stress-induced ordering mechanism through phase-field simulations.

Quantum teleportation of single-photon qubits from a ground observatory to a satellite in low-Earth orbit via an uplink channel is achieved with a fidelity that is well above the classical limit.

Dual-comb spectroscopy with time–frequency dissemination and high-power frequency combs enables sensing CO₂ and H₂O over a 113 km turbulent open-air path, with a sensing precision as high as 2 parts per million of CO₂.

Neoadjuvant treatment represents a therapeutic option for locally advanced gastric cancer (LAGC). Here the authors report the results of a randomized phase 2 trial of camrelizumab (anti-PD1) and apatinib (anti-VEGFR2) combined with nab-paclitaxel plus S-1 versus chemotherapy alone as neoadjuvant treatment for LAGC.

Researchers demonstrate the creation of an eight-photon Schrödinger-cat state with genuine multipartite entanglement by developing noise-reduction multiphoton interferometer and post-selection detection. The ability to control eight individual photons will enable new multiphoton entanglement experiments in previously inaccessible parameter regimes.

With the help of two photonic controlled-NOT gates, a three-logical-qubit concatenated Greenberger–Horne–Zeilinger (C-GHZ) state encoded by a six-photon graph state is experimentally created. Observation of the dynamics of distillability evolving under a collective noisy environment revealed that the C-GHZ state is more robust than the conventional GHZ state.

Due to high rate of metastasis, lymphadenectomy is a cornerstone of the surgical treatment of gastric cancer however the accurate dissection of lymph nodes (LN) can be challenging. Here, the authors present the long-term outcomes of a randomised control trial investigating indocyanine green fluorescence image-guided LN retrieval in gastric cancer patients undergoing laparoscopic gastrectomy.

The application of quantum computing to computational chemistry faces various experimental and theoretical challenges. Now, a quantum simulation on a noisy quantum device has achieved chemical accuracy for small H₂ and LiH molecules.

A source of entangled photons that emits one — and only one — pair of photons on demand has now been realized in a semiconductor chip. The solid-state source will be a useful resource for experiments in optical quantum information.

Quantum teleportation of independent qubits and entanglement distribution have been demonstrated over free-space channels of about 100 kilometres, representing an important step towards a global quantum network.

Creating entangled photon states becomes technologically ever more difficult as the number of particles increases, and the current record stands at six entangled photons. However, using both their polarization and momentum degrees of freedom, up to ten-qubit states can be encoded in ‘only’ five photons, as has now been demonstrated.

A nested purification protocol is developed by combining entanglement purification and swapping. It works for the spontaneous parametric downconversion sources as well as other physical systems that suffer from double-pair emission noise.

Emission of single photons can be achieved by using defects in two-dimensional crystals as a source of luminescence.

Researchers propose a new type of multiphoton entangled state and demonstrate its working principles of measurement-based quantum computation in correlation space. With four- and six-qubit states, they realize a universal set of single-qubit rotations, two-qubit entangling gates and further Deutsch's algorithm.

Expression patterns of immune checkpoints in patients with gastric cancer remain poorly characterized. Here the authors propose an immune scoring system based on the expression of six immunosuppressive ligands to improve the prognostic accuracy in gastric cancer patients and drive the selection of candidates for adjuvant chemotherapy.

A scalable approach is provided for preparing and verifying intermediate-scale genuine entanglement on a 66-qubit superconducting quantum processor.

A quantum key distribution with a key rate of 115.8 Mb s^–1 is demonstrated over 10 km standard optical fibre. To this end, a high-speed and stable system, an integrated transmitter for low error modulation and multipixel superconducting nanowire single-photon detectors are developed.

By using 1 W optical frequency combs and nanowatt-level linear optical sampling modules, a time–frequency dissemination over a free-space link of 113 km is achieved with a stability of less than 4 × 10⁻¹⁹ at 10,000 s.

A quantum network that combines 700 fibre and two ground-to-satellite links achieves quantum key distribution between more than 150 users over a combined distance of 4,600 kilometres.

The first field test of quantum teleportation is implemented over a 30 km optical fibre network with independent quantum light sources. To establish a robust quantum teleportation system in the real world, several feedback mechanisms are developed.

An efficient entanglement-based quantum key distribution is sent from the Micius satellite to two ground observatories 1,120 kilometres apart to establish secure quantum cryptography for the exchange of quantum keys.

Li Dong Wang and colleagues report a genome wide association study for esophageal squamous cell carcinoma in the Chinese population. They identify two risk loci at PLCE1 and C20orf54.

Dongxin Lin, Philip Taylor, Li-Dong Wang and colleagues have now pooled three genome-wide association analyses of esophageal squamous cell carcinoma, finding two new risk loci at genome-wide significance and an HLA class II locus of significance in high-risk populations. They reanalyze the strength of evidence for previously published risk loci.

High-performance quantum light sources based on semiconductor quantum dots coupled to microcavities are showing their promise in long-distance solid-state quantum networks.

The quantum teleportation of composite quantum states of a single photon encoded in both spin and orbital angular momentum is achieved, with a teleportation fidelity above the classical limit, by quantum non-demolition measurement assisted discrimination of the Bell states describing the entanglement of the two degrees of freedom.

Photonics is one of the key platforms for emerging quantum technologies, but its full potential can only be harnessed by exploiting miniaturization via on-chip integration. This Roadmap charts new directions and discusses the challenges associated with the hybrid integration of a variety of materials, devices and components.