Nature Search

The X-Age Project to construct a Chinese aging clock

In this Perspective, members of the Aging Biomarker Consortium outline the X-Age Project, an Aging Biomarker Consortium plan for building standardized aging clocks in China. The authors discuss the project roadmap and its aims of decoding aging heterogeneity, detecting accelerated aging early and evaluating geroprotective interventions.

Jiaming Li
Mengmeng Jiang
Guang-Hui Liu
Reviews09 Sept 2025
Nature Aging

Volume: 5, P: 1669-1685
CLDN18.2–targeting antibody–drug conjugate IBI343 in advanced gastric or gastroesophageal junction adenocarcinoma: a phase 1 trial

In this multicenter phase 1 trial, treatment with IBI343, a CLDN18.2-targeting antibody–drug conjugate, was safe and showed encouraging clinical responses in patients with advanced gastric or gastroesophageal junction adenocarcinoma.

Jia Liu
Jianwei Yang
Lin Shen
ResearchOpen Access16 Jul 2025
Nature Medicine

Volume: 31, P: 3028-3036
Synergistic effects of SAE/CaCO₃ on enhancing sulfate resistance in High-Strength cementitious composites

Lei Ren
Puyan Wang
Mingfang Ba
ResearchOpen Access02 Oct 2025
Scientific Reports

Volume: 15, P: 1-15
Mitigating ion flux vortex enables reversible zinc electrodeposition

Uneven zinc growth limits the reversibility of zinc metal batteries. Here, authors use in situ X-ray computed tomography and fluid dynamics simulations to reveal how synthetic clay coating suppresses chaotic ion flow, enabling uniform zinc growth and stable cycling in a large-scale pouch cell.

Yuhang Dai
Wenjia Du
Guanjie He
ResearchOpen Access08 Aug 2025
Nature Communications

Volume: 16, P: 1-10
Design of tomato picking robot detection and localization system based on deep learning neural networks algorithm of Yolov5

Jianwei Zhao
Wei Bao
Jiaqing Du
ResearchOpen Access20 Feb 2025
Scientific Reports

Volume: 15, P: 1-16
Three-dimensional structure determination from a single view

Most schemes for three-dimensional (3D) structure determination of an object require multiple measurements over various orientations, or a means of scanning it section by section. A 3D imaging modality, termed ankylography, is now presented that under certain circumstances enables complete 3D structure determination from a single diffraction measurement. This approach could find broad applications in the physical and life sciences.

Kevin S. Raines
Sara Salha
Jianwei Miao
Research16 Dec 2009
Nature

Volume: 463, P: 214-217
Biomarkers of ageing of humans and non-human primates

The use of biomarkers of ageing is crucial for investigating age-related processes. This Review discusses biomarkers of ageing and of ageing-associated physiological changes, at the cellular, tissue and organism levels in humans and non-human primates.

Zeming Wu
Jing Qu
Guang-Hui Liu
Reviews11 Sept 2025
Nature Reviews Molecular Cell Biology

Volume: 26, P: 826-847
ROS-induced cytosolic release of mitochondrial PGAM5 promotes colorectal cancer progression by interacting with MST3

Dysregulation of mitochondrial reactive oxygen species (mtROS) contributes to intestinal tumorigenesis. Here the authors report that excessive mtROS induces the release of mitochondrial PGAM5 into cytoplasm and subsequent dephosphorylation of MST3 kinase, promoting colorectal cancer progression.

Shiyang Wang
Xi Wu
Zhengquan Yu
ResearchOpen Access06 Feb 2025
Nature Communications

Volume: 16, P: 1-19
Consistent patterns of common species across tropical tree communities

Inventory data from more than 1 million trees across African, Amazonian and Southeast Asian tropical forests suggests that, despite their high diversity, just 1,053 species, representing a consistent ~2.2% of tropical tree species in each region, constitute half of Earth’s 800 billion tropical trees.

Declan L. M. Cooper
Simon L. Lewis
Stanford Zent
ResearchOpen Access10 Jan 2024
Nature

Volume: 625, P: 728-734
TMCO1-mediated Ca²⁺ leak underlies osteoblast functions via CaMKII signaling

TMCO1 is a recently described endoplasmic reticular Ca²⁺ channel. Here, the authors show it is important for osteoblast function and bone formation in mice, and identify a novel pathway linking local increases in Ca²⁺ at the ER surface with the posttranslational modification of RUNX2.

Jianwei Li
Caizhi Liu
Yingxian Li
ResearchOpen Access08 Apr 2019
Nature Communications

Volume: 10, P: 1-14
Selective electrosynthesis of hydroxylamine from aqueous nitrate/nitrite by suppressing further reduction

Electroreduction of nitrate or nitrite offers an appealing route for hydroxylamine synthesis but remains challenging due to its intermediate nature. Here, authors present a selective and fast electrosynthesis of hydroxylamine by tuning metal phthalocyanine activity and removing side reaction sites.

Yirong Tang
Zhan Jiang
Yongye Liang
ResearchOpen Access12 Nov 2024
Nature Communications

Volume: 15, P: 1-10
Association of the triglyceride glucose index with myocardial ischemia in patients with minimal to moderate coronary artery disease

Zengfa Huang
Ruiyao Tang
Xiang Wang
ResearchOpen Access30 Oct 2024
Scientific Reports

Volume: 14, P: 1-9
Lack of incremental prognostic value of triglyceride glucose index beyond coronary computed tomography angiography features for major events

Zengfa Huang
Ruiyao Tang
Xiang Wang
ResearchOpen Access27 Oct 2024
Scientific Reports

Volume: 14, P: 1-9
Anoctamin 1 controls bone resorption by coupling Cl⁻ channel activation with RANKL-RANK signaling transduction

Osteoclast over-activation leads to bone loss and chloride homeostasis is important for osteoclast function. Here, the authors show that Anoctamin 1 controls bone resorption by coupling Cl⁻ channel activation with RANKL-RANK signaling transduction.

Weijia Sun
Shuai Guo
Yingxian Li
ResearchOpen Access24 May 2022
Nature Communications

Volume: 13, P: 1-15
Prognostic value of coronary CTA-based classifications for predicting major events without obstructive coronary artery disease

Zengfa Huang
Beibei Cao
Xiang Wang
ResearchOpen Access30 Jun 2023
Scientific Reports

Volume: 13, P: 1-8
Evaluation of a novel elbow joint torque measurement device in healthy subjects and stroke patients: a randomized trial

Qingqin Xu
Mengxuan Hu
Hemu Chen
ResearchOpen Access13 Apr 2025
Scientific Reports

Volume: 15, P: 1-12
An injury-induced serotonergic neuron subpopulation contributes to axon regrowth and function restoration after spinal cord injury in zebrafish

The mechanisms involved in regeneration of the spinal cord after injury are unclear. Here, the authors show that a subpopulation of intraspinal serotonergic neurons localized at the injury site stimulates axonal regrowth of interneurons via 5-HT1B receptor, resulting in recovery of function following SCI in zebrafish.

Chun-Xiao Huang
Yacong Zhao
Jianren Song
ResearchOpen Access07 Dec 2021
Nature Communications

Volume: 12, P: 1-13
Assessment and validation of spot urine in estimating the 24-h urinary sodium, potassium, and sodium/potassium ratio in Chinese adults

Jianwei Xu
Xiaofu Du
Jing Wu
ResearchOpen Access28 Oct 2019
Journal of Human Hypertension

Volume: 34, P: 184-192
Hexagonal 2H-MoSe₂ broad spectrum active photocatalyst for Cr(VI) reduction

Haipeng Chu
Xinjuan Liu
Changqing Sun
ResearchOpen Access13 Oct 2016
Scientific Reports

Volume: 6, P: 1-10
An easy gene assembling strategy for light-promoted transfection by combining host-guest interaction of cucurbit[7]uril and gold nanoparticles

Jianwei Du
Peng Zhang
Youxiang Wang
ResearchOpen Access20 Jul 2017
Scientific Reports

Volume: 7, P: 1-10
Glaucocalyxin A exerts anticancer effect on osteosarcoma by inhibiting GLI1 nuclear translocation via regulating PI3K/Akt pathway

Jianwei Zhu
Yang Sun
Qi Zhang
ResearchOpen Access13 Jun 2018
Cell Death & Disease

Volume: 9, P: 1-16
The tomato genome sequence provides insights into fleshy fruit evolution

This paper reports the genome sequence of domesticated tomato, a major crop plant, and a draft sequence for its closest wild relative; comparative genomics reveal very little divergence between the two genomes but some important differences with the potato genome, another important food crop in the genus Solanum.

Shusei Sato
Satoshi Tabata
René M. Klein Lankhorst
ResearchOpen Access30 May 2012
Nature

Volume: 485, P: 635-641
Publisher Correction: Association of the triglyceride glucose index with myocardial ischemia in patients with minimal to moderate coronary artery disease

Zengfa Huang
Ruiyao Tang
Xiang Wang
Amendments and CorrectionsOpen Access19 Nov 2024
Scientific Reports

Volume: 14, P: 1
Three-dimensional coordinates of individual atoms in materials revealed by electron tomography

Electron tomography is used to create a 3D reconstruction of a tungsten needle that allows the positions of individual atoms to be localized with a precision of 19 picometres, without using averaging or assuming the sample crystallinity.

Rui Xu
Chien-Chun Chen
Jianwei Miao
Research21 Sept 2015
Nature Materials

Volume: 14, P: 1099-1103
Joint analysis of the metabolomics and transcriptomics uncovers the dysregulated network and develops the diagnostic model of high-risk neuroblastoma

Bang Du
Fei Zhang
Wancun Zhang
ResearchOpen Access09 Oct 2023
Scientific Reports

Volume: 13, P: 1-16
HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation

Yuheng Li
Weijia Sun
Yingxian Li
ResearchOpen Access23 Oct 2023
Bone Research

Volume: 11, P: 1-16
Mechanical stimulation controls osteoclast function through the regulation of Ca²⁺-activated Cl⁻ channel Anoctamin 1

An essential role of the Ca2+-activated Cl⁻ channel, Anoctamin 1, is identified in mediating the response of osteoclasts to mechanical stimulation. Ano1 knockout in osteoclasts inhibits unloading- induced osteoclast activation and unloading-induced bone loss.

Weijia Sun
Yuheng Li
Yingxian Li
ResearchOpen Access13 Apr 2023
Communications Biology

Volume: 6, P: 1-13
The mechanosensitive lncRNA Neat1 promotes osteoblast function through paraspeckle-dependent Smurf1 mRNA retention

Caizhi Liu
Xingcheng Gao
Yingxian Li
ResearchOpen Access24 Feb 2022
Bone Research

Volume: 10, P: 1-16
Process knowledge graph modeling techniques and application methods for ship heterogeneous models

Jianwei Dong
Xuwen Jing
Lei Li
ResearchOpen Access21 Feb 2022
Scientific Reports

Volume: 12, P: 1-14
The association of knowledge, attitudes and behaviors related to salt with 24-h urinary sodium, potassium excretion and hypertensive status

Xiaofu Du
Le Fang
Jieming Zhong
ResearchOpen Access16 Aug 2022
Scientific Reports

Volume: 12, P: 1-12
Kinetics of plasma cfDNA predicts clinical response in non-small cell lung cancer patients

Xiaorong Zhou
Chenchen Li
Michael Y. Sha
ResearchOpen Access07 Apr 2021
Scientific Reports

Volume: 11, P: 1-12
Association between 24-h urinary sodium and potassium excretion and blood pressure among Chinese adults aged 18–69 years

Xiaofu Du
Le Fang
Jieming Zhong
ResearchOpen Access10 Feb 2021
Scientific Reports

Volume: 11, P: 1-11
The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease

Yongli Song
Christian F. Guerrero-Juarez
Zhengquan Yu
Research26 May 2020
Cell Research

Volume: 30, P: 854-872
Knockdown of MSI2 inhibits metastasis by interacting with caveolin-1 and inhibiting its ubiquitylation in human NF1-MPNST cells

Kang Yang
Jianwei Du
Jie Zhang
ResearchOpen Access30 Jun 2020
Cell Death & Disease

Volume: 11, P: 1-13
Correction: Knockdown of MSI2 inhibits metastasis by interacting with caveolin-1 and inhibiting its ubiquitylation in human NF1-MPNST cells

Kang Yang
Jianwei Du
Jie Zhang
Amendments and CorrectionsOpen Access31 Jul 2020
Cell Death & Disease

Volume: 11, P: 1
Karrikins delay soybean seed germination by mediating abscisic acid and gibberellin biogenesis under shaded conditions

Yongjie Meng
Feng Chen
Wenyu Yang
ResearchOpen Access23 Feb 2016
Scientific Reports

Volume: 6, P: 1-12
GENFIRE: A generalized Fourier iterative reconstruction algorithm for high-resolution 3D imaging

Alan Pryor Jr.
Yongsoo Yang
Jianwei Miao
ResearchOpen Access05 Sept 2017
Scientific Reports

Volume: 7, P: 1-12
Targeting ferroptosis opens new avenues for the development of novel therapeutics

Shumin Sun
Jie Shen
Junxia Min
ReviewsOpen Access21 Sept 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-30
Building two indica rice reference genomes with PacBio long-read and Illumina paired-end sequencing data

Jianwei Zhang
Ling-Ling Chen
Qifa Zhang
ResearchOpen Access13 Sept 2016
Scientific Data

Volume: 3, P: 1-8
Hypothalamus-pituitary-gonad axis transcriptome profiling for sex differentiation in Acipenser sinensis

Hejun Du
Jianbo Jian
Lei Chen
ResearchOpen Access13 Jun 2019
Scientific Data

Volume: 6, P: 1-8
A comparative review of the aqueous corrosion of glasses, crystalline ceramics, and metals

Gerald S. Frankel
John D. Vienna
Jincheng Du
ReviewsOpen Access03 May 2018
npj Materials Degradation

Volume: 2, P: 1-17

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