Nature Search

Gene-modified pig-to-human liver xenotransplantation

A gene-edited pig liver transplanted into a human recipient remains functional after 10 days and indicates that porcine organs could help meet the growing demand for liver transplants.

Kai-Shan Tao
Zhao-Xu Yang
Ke-Feng Dou
ResearchOpen Access26 Mar 2025
Nature

Volume: 641, P: 1029-1036
NLSTseg: A Pixel-level Lung Cancer Dataset Based on NLST LDCT Images

Kun-Hui Chen
Yi-Hui Lin
Jing-Wen Huang
ResearchOpen Access23 Aug 2025
Scientific Data

Volume: 12, P: 1-12
Investigating the role of undercoordinated Pt sites at the surface of layered PtTe₂ for methanol decomposition

Methanol on under-coordinated Pt sites at surface Te vacancies on layered PtTe2 decomposes at a probability >90 % which ultimately produces gaseous molecular hydrogen, methane, water and formaldehyde.

Jing-Wen Hsueh
Lai-Hsiang Kuo
Meng-Fan Luo
ResearchOpen Access22 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Integration of a (–Cu–S–)_n plane in a metal–organic framework affords high electrical conductivity

Metal–organic frameworks that contain metal–sulfur chains have been demonstrated to exhibit good electrical conductivity. Here, the authors integrate a 2D metal–sulfur plane into a metal–organic framework, reporting a single crystal with a high conductivity of 10.96 S/cm.

Abhishek Pathak
Jing-Wen Shen
Kuang-Lieh Lu
ResearchOpen Access12 Apr 2019
Nature Communications

Volume: 10, P: 1-7
Safflor yellow A protects neonatal rat cardiomyocytes against anoxia/reoxygenation injury in vitro

Jia-lin Duan
Jing-wen Wang
Ai-dong Wen
Research11 Feb 2013
Acta Pharmacologica Sinica

Volume: 34, P: 487-495
Antibody-independent mechanisms regulate the establishment of chronic Plasmodium infection

In rodent models, only a minority of infecting Plasmodium parasites, expressing one of several clusters of virulence-associated pir genes, establishes a chronic infection in a manner that is independent of adaptive immunity.

Thibaut Brugat
Adam James Reid
Jean Langhorne
Research06 Feb 2017
Nature Microbiology

Volume: 2, P: 1-9
The Role of Catalase C262T Gene Polymorphism in the Susceptibility and Survival of Cancers

Cheng-Di Wang
Yan Sun
Yu-Lin Ji
ResearchOpen Access26 May 2016
Scientific Reports

Volume: 6, P: 1-8
Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases

The authors present an extensive profile of host transcriptional respones to a diverse group of pathogens and allergens. In doing so, they identify TH1, type I IFN, TH17, and TH2 responses, that underlie each immune response in both the blood and lung, which represents a global profile of host-pathogen immune responses.

Akul Singhania
Christine M. Graham
Anne O’Garra
ResearchOpen Access28 Jun 2019
Nature Communications

Volume: 10, P: 1-21
MiR-221/222 promote epithelial-mesenchymal transition by targeting Notch3 in breast cancer cell lines

Yuan-Ke Liang
Hao-Yu Lin
Guo-Jun Zhang
ResearchOpen Access06 Aug 2018
npj Breast Cancer

Volume: 4, P: 1-9
Reciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs

Jing-Wen Lyu
Bo Yuan
Wen-Hao Zhou
ResearchOpen Access04 Feb 2016
Scientific Reports

Volume: 6, P: 1-6
Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression

Cancer cells adapt to the changing microenvironment by activating different pathways through multiple mechanisms. Here the authors identify long noncoding RNAMIR31HGas a HIF-1α co-activator required for the induction of the hypoxic response and show its oncogenic role in oral carcinogenesis.

Jing-Wen Shih
Wei-Fan Chiang
Hsing-Jien Kung
ResearchOpen Access22 Jun 2017
Nature Communications

Volume: 8, P: 1-16
Meplazumab, a CD147 antibody, for severe COVID-19: a double-blind, randomized, placebo-controlled, phase 3 clinical trial

Huijie Bian
Liang Chen
Ping Zhu
ResearchOpen Access14 Apr 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-8
Comprehensive RNA-seq analysis of benign prostatic hyperplasia (BPH) in rats exposed to testosterone and estradiol

Xiao-Hu Tang
Zhi-Yan Liu
Guang-Heng Luo
ResearchOpen Access22 Jan 2025
Scientific Reports

Volume: 15, P: 1-14
Comparison of whole blood and spleen transcriptional signatures over the course of an experimental malaria infection

Carlos Talavera-López
Yaw Bediako
Jean Langhorne
ResearchOpen Access01 Nov 2019
Scientific Reports

Volume: 9, P: 1-12
Identification of chikusetsusaponin IVa as a novel lysine-specific demethylase 1 inhibitor that ameliorates high fat diet-induced MASLD in mice

Yu-wen Liu
Ru-yue Luo
Jia-lin Duan
Research20 Nov 2024
Acta Pharmacologica Sinica

Volume: 46, P: 632-652
Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria

Jing-wen Lin
Jan Sodenkamp
Jean Langhorne
ResearchOpen Access03 Feb 2017
Scientific Reports

Volume: 7, P: 1-13
Paired rRNA-depleted and polyA-selected RNA sequencing data and supporting multi-omics data from human T cells

Li Chen
Ruirui Yang
Lu Chen
ResearchOpen Access09 Nov 2020
Scientific Data

Volume: 7, P: 1-7
Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models

Gan Wang
Meng-Li Yang
Ren Lai
ResearchOpen Access01 Dec 2020
Cell Research

Volume: 31, P: 17-24
Short-read and long-read RNA sequencing of mouse hematopoietic stem cells at bulk and single-cell levels

Xiuran Zheng
Dan Zhang
Jing-wen Lin
ResearchOpen Access29 Nov 2021
Scientific Data

Volume: 8, P: 1-10
Contribution and underlying mechanisms of CXCR4 overexpression in patients with systemic lupus erythematosus

Li-dan Zhao
Di Liang
Xuan Zhang
Research26 Sept 2016
Cellular & Molecular Immunology

Volume: 14, P: 842-849
Notch3 inhibits epithelial–mesenchymal transition in breast cancer via a novel mechanism, upregulation of GATA-3 expression

Hao-Yu Lin
Yuan-Ke Liang
Guo-Jun Zhang
ResearchOpen Access13 Aug 2018
Oncogenesis

Volume: 7, P: 1-15
Differential immune responses in pregnant patients recovered from COVID-19

Ge Chen
Yiming Zhang
Kezhen Li
ResearchOpen Access29 Jul 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-15
Integrated single-cell RNA sequencing analysis reveals distinct cellular and transcriptional modules associated with survival in lung cancer

Li Zhang
Yiming Zhang
Weimin Li
ResearchOpen Access14 Jan 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-13
Notch3 inhibits cell proliferation and tumorigenesis and predicts better prognosis in breast cancer through transactivating PTEN

Yong-Qu Zhang
Yuan-Ke Liang
Guo-Jun Zhang
ResearchOpen Access18 May 2021
Cell Death & Disease

Volume: 12, P: 1-16
Combination of Electroacupuncture and Grafted Mesenchymal Stem Cells Overexpressing TrkC Improves Remyelination and Function in Demyelinated Spinal Cord of Rats

Ying Ding
Rong-Yi Zhang
Yuan-Shan Zeng
ResearchOpen Access16 Mar 2015
Scientific Reports

Volume: 5, P: 1-14
Therapeutic potential and pharmacological mechanisms of Traditional Chinese Medicine in gout treatment

Jing-wen Guo
Guo-qiang Lin
Shi-jun He
Reviews17 Jan 2025
Acta Pharmacologica Sinica

Volume: 46, P: 1156-1176
Transcriptome analysis of blood and spleen in virulent and avirulent mouse malaria infection

Yuancun Zhao
Caroline Hosking
Jing-wen Lin
ResearchOpen Access04 Aug 2020
Scientific Data

Volume: 7, P: 1-10
Nucleic acid drug vectors for diagnosis and treatment of brain diseases

Zhi-Guo Lu
Jie Shen
Xin Zhang
ReviewsOpen Access17 Jan 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-53

Search

Gene-modified pig-to-human liver xenotransplantation

NLSTseg: A Pixel-level Lung Cancer Dataset Based on NLST LDCT Images

Investigating the role of undercoordinated Pt sites at the surface of layered PtTe₂ for methanol decomposition

Integration of a (–Cu–S–)_n plane in a metal–organic framework affords high electrical conductivity

Safflor yellow A protects neonatal rat cardiomyocytes against anoxia/reoxygenation injury in vitro

Antibody-independent mechanisms regulate the establishment of chronic Plasmodium infection

The Role of Catalase C262T Gene Polymorphism in the Susceptibility and Survival of Cancers

Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases

MiR-221/222 promote epithelial-mesenchymal transition by targeting Notch3 in breast cancer cell lines

Reciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs

Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression

Meplazumab, a CD147 antibody, for severe COVID-19: a double-blind, randomized, placebo-controlled, phase 3 clinical trial

Comprehensive RNA-seq analysis of benign prostatic hyperplasia (BPH) in rats exposed to testosterone and estradiol

Comparison of whole blood and spleen transcriptional signatures over the course of an experimental malaria infection

Identification of chikusetsusaponin IVa as a novel lysine-specific demethylase 1 inhibitor that ameliorates high fat diet-induced MASLD in mice

Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria

Paired rRNA-depleted and polyA-selected RNA sequencing data and supporting multi-omics data from human T cells

Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models

Short-read and long-read RNA sequencing of mouse hematopoietic stem cells at bulk and single-cell levels

Contribution and underlying mechanisms of CXCR4 overexpression in patients with systemic lupus erythematosus

Notch3 inhibits epithelial–mesenchymal transition in breast cancer via a novel mechanism, upregulation of GATA-3 expression

Differential immune responses in pregnant patients recovered from COVID-19

Integrated single-cell RNA sequencing analysis reveals distinct cellular and transcriptional modules associated with survival in lung cancer

Notch3 inhibits cell proliferation and tumorigenesis and predicts better prognosis in breast cancer through transactivating PTEN

Combination of Electroacupuncture and Grafted Mesenchymal Stem Cells Overexpressing TrkC Improves Remyelination and Function in Demyelinated Spinal Cord of Rats

Therapeutic potential and pharmacological mechanisms of Traditional Chinese Medicine in gout treatment

Transcriptome analysis of blood and spleen in virulent and avirulent mouse malaria infection

Nucleic acid drug vectors for diagnosis and treatment of brain diseases

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