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In vitro transcribed circular RNAs (ivcRNAs) offer a stable and efficient platform for protein replacement therapy. Here, the authors show that localized ivcRNA delivery restores MSI2 and SOX5 expression in chondrocytes, mitigating osteoarthritis progression in mice.

Charge transport and extraction in polycrystalline perovskite films are often hindered by inefficient carrier transfer across grain domain boundaries (GDBs). Here, authors employ supramolecular assisted Rb+ delivery for in-situ GDB bridging, achieving efficiency of 26.02% for perovskite solar cells.

The contribution of the extracellular matrix and its degradation to the aging process is not well understood. Here, the authors show that degraded elastin fragments, which increase in the circulation with age, promote aging, while counteracting elastin fragment signals alleviates inflammation, promotes healthy aging and extends lifespan.

An integrate-and-fire artificial neuron combining a dynamic random-access memory and an inverter based on wafer-scale monolayer molybdenum disulfide films can emulate intrinsic plasticity, the photopic and scotopic adaptation of the human visual system, and achieve temporal information encoding.

Preparing room temperature phosphorescent materials from biomass is important but challenging. Here, the authors report the use of liquid monomer 2-hydroxyethyl acrylate for dissolution of lignin and subsequent solvent-free preparation of lignin-based RTP materials.

The diagnosis and prognosis of chronic kidney disease (CKD) relies on invasive renal biopsies, which can be clinically constrained. Here, the authors develop a non-invasive model using retinal images that can be used to screen for CKD and identify five common pathological types of CKD.

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

Ultrasound particle image velocimetry (uPIV) is widely used for blood flow measurement but is limited by the diffraction limit. Jingyi Yin, Jiabin Zhang, Jue Zhang and colleagues propose enhanced ultrasound particle image velocimetry (EuPIV), which enables dynamic microflow imaging with higher spatial resolution.

Authors present a bispecific antiviral design targeting the virus and the host that simultaneously offers broad-spectrum protection against multiple existing transmissible human-pathogenic coronaviruses, including the Paxlovid-resistant SARS-CoV-2 mutants.

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

Thin films of a single-crystal dielectric—antimony oxide—can be epitaxially grown at wafer scales on graphene-covered copper surfaces and then used to transfer dielectric/graphene stacks, or be integrated as a two-dimensional dielectric onto other materials.

Spatial molecular imaging analysis of human pancreatic adenocarcinomas describes multicellular neighborhoods in the tumor microenvironment. Ligand–receptor analysis using optimal transport-based SCOTIA identifies interleukin-6 as a mediator of chemoresistance.

The role of m⁶A in plants’ response to nutrient-deficiency stress remains unclear. Here, the authors report that Pi starvation-induced m⁶A modifications stabilize Pi starvation response (PSR)-related mRNAs, such as PHR1, to facilitate PSR signaling.

A novel covalent inhibitor, ISM3312, targets the main protease of multiple human coronaviruses, including drug-resistant strains, and shows broad antiviral activity. It offers a promising therapeutic strategy against current and future coronavirus threats.

Mass cytometry with signal amplification enables measurement of low-abundance proteins.

Adipocytes store lipid in spherical droplets whose size is determined by lipid exchange and transfer proteins. Sun et al.show that Perilipin1 promotes the growth of lipid droplets by activating the lipid transfer protein Fsp27.

The authors report a wet-chemistry-based method to fabricate amorphous, transferable high-k copper calcium titanate thin films as dielectrics for two-dimensional electronic devices.

The dissemination of plasmid-encoded tigecycline resistance gene tet(X) poses a global threat to public health, necessitating the development of innovative strategies. Here, the authors reveal that the supplementation of L-methionine not only facilitates intracellular accumulation of tigecycline but also reduces tet(X) expression by augmenting the 5mC methylation modification in its promoter region, thereby overcoming plasmid-mediated high-level tigecycline resistance.

Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.

A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

Genome-wide association analyses of two oral glucose tolerance test-derived measures of postprandial insulin resistance discover ten new loci. Functional characterization identifies nine candidate genes implicated in the regulation of GLUT4.

A new ultra-specific enhancement strategy for Cas12a via iterative crRNA design. A PAM-free one-pot detection platform for SARS-CoV-2 variants demonstrates significant potential for in vitro diagnostics.

The global pattern of the mammalian methylome is formed by changes in methylation and demethylation. Here the authors describe a metric methylation concurrence that measures the ratio of unmethylated CpGs inside the partially methylated reads and show that methylation concurrence is associated with epigenetically regulated tumour suppressor genes.

An improved ATAC-seq approach is used to describe a genome-wide view of accessible chromatin and cis-regulatory elements in mouse preimplantation embryos, allowing construction of a regulatory network of early development that helps to identify key modulators of lineage specification.

Lattice shrinkage is a dominating factor for the strain-induced change of the electronic properties in vdW layered materials. Here, the authors discover a piezoresistivity in pressurized β′-In2Se3, which originates from the intralayer atomic motions.

A high-quality draft genome assembly of Musa balbisiana (the banana B-genome) is reported. Comparative genomic and gene functional analyses provide insights into the subgenome evolution and functional divergence between the A- and B-subgenomes.

By combining p-type transistors made with silicon-on-insulator technology and n-type transistors made with two-dimensional molybdenum disulfide, heterogeneous complementary field-effect transistors can be fabricated on the wafer scale.

Reliable transfer techniques are critical for the integration of 2D materials with arbitrary substrates. Here, the authors describe a method to transfer 4-inch and A4-sized defect-free graphene films onto rigid and flexible substrates with controllable conformal contact, leading to improved electrical properties and uniformity.

Here, the authors demonstrate the application of machine learning to optimize the device fabrication process for wafer-scale 2D semiconductors, and eventually fabricate digital, analog, and optoelectrical circuits.

One of the cellular functions of the tumour suppressor PTEN is to maintain genome stability. Here, the authors show that PTEN depletion leads to mitotic spindle shortening and chromosome misalignment due to aberrant EG5 activation.

OTUD6A, a deubiquitinase, is amplified in prostate cancer and correlates with poor survivability, increasing the growth of prostate cancer cell lines and PDX models. OTUD6A stabilizes the expression of Brg1 and AR through the removal of K27- and K11-linked polyubiquination.