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Pulmonary veno-occlusive disease (PVOD) is a fatal disease characterised by remodelling of pulmonary veins and haemosiderin accumulation in macrophages. Here the authors examine the lack of GCN2 in PVOD as this has been observed in human disease and deficiency of GCN2 in mouse and rat PVOD models alters transcriptome profiles and increases macrophage ferroptosis.

Lithium doping in spiro-OMeTAD negatively affects the long-term performance of perovskite solar cells. Qin and team map the degradation mechanism under repeated voltage cycling and how lithium-free dopants improve stability.

The Error-Catastrophe Theory posits that translation errors shorten lifespan, but direct evidence is limited. Here, the authors show that translational fidelity predicts longevity in yeast, with VPS70 as a shared genetic determinant of both traits.

This work proposes a wet-chemical etching assisted aberration-enhanced single-pulsed femtosecond laser nanolithography, named “WEALTH”, for manufacturing small-size, large-area, deep holey nanostructures, promising for emerging nanophotonic devices.

Electrochemical conversion of waste into valuable chemicals offers a sustainable alternative to traditional manufacturing routes. Here, the authors report a strategy for durable formamide synthesis from plastic-derived ethylene glycol and ammonia using commercial platinum foil catalysts.

Confining high-entropy nanoparticles in molecular sieves enhances catalytic performance but lacks scalable synthesis methods. This study presents a versatile quenching strategy, producing uniform HE-NPs@MSs with high propane dehydrogenation activity.

Inspired by the characteristics of textile-based flexible electronic sensors, the authors report a braided electronic cord with a low-cost, and automated fabrication to realize imperceptible, designable, and scalable user interfaces with the features of user-friendliness, excellent durability and rich interaction mode.

Palladium catalysed C-H functionalization ofsp³carbons typically requires the installation and subsequent removal of a temporary directing group. Here the authors report a method allowing C-H functionalization in carboxylic acids in which the carboxylate acts as a directing group.

Though realizing organic materials with deep blue emission is attractive for next-generation display technologies, achieving this emission in afterglow molecules remains a challenge. Here, the authors report blue organic afterglow via a strategy involving guest sensitization and matrix rigidification.

CYSLTR2 and P2RY6 are identified as endogenous ceramide receptors, and inhibition of these ameliorates atherosclerosis, particularly in chronic-kidney-disease-associated cardiovascular disease.

SeReNet is an accurate, generalizable, and efficient physics-driven self-supervised reconstruction network for light-field microscopy that enables day-long high-speed 3D intravital imaging of processes including immune responses and neural activity.

Saturated fatty acid (SFA) and unsaturated fatty acid (UFA) have distinct impacts on health. Here the authors demonstrate that the secretion of UFA esters from the liver requires PDI-MTP, while secretion of SFA esters could be PDI-MTP-independent.

Chen, et al identify peritendon CD26 expressing tendon stem/progenitor cells that contribute to tendon healing, as well as Tenascin-C/YAP dependent heterotopic ossification.

Lipid droplets (LDs) and endosomes play crucial roles in cellular processes, yet their interplay is poorly understood. Here, the authors develop an LD-specific probe, AP1-coumarin, and reveal dynamic interactions between LDs and endosomes, regulating lipid homeostasis.

The molecular mechanisms underlying the development of thrombocytopenia in multiple myeloma (MM) remain to be explored. Here, the authors show an association of thrombocytopenia with poor prognosis in MM and identify serine as a key metabolic regulator of thrombocytopenia.

Polyketide yields in Streptomyces are boosted by routing stored intracellular triacylglycerol into pathways that make industrially relevant products.

Covalent organic frameworks are typically synthesized using solvothermal conditions with high temperature and long reaction time. Here, the authors report a general and rapid microplasma electrochemistry strategy for the synthesis of covalent organic frameworks with high crystallinity under ambient conditions in minutes, avoiding high temperature and long reaction time.

Developed on cytology images of hydrothorax and ascites from 57,220 cases at four hospitals, a deep-learning model shows high accuracy in tumor origin prediction and presents prognostic value when patient treatment is consistent with the cancer origin predicted by the model.

The use of TCR engineered T cells holds promise for treatment of tumours, but is limited by awareness of clinically effective TCR molecules. Here the authors identify an MHC II restricted TCR that targets viral E7 of human papillomavirus type 18 and show effectivity in a murine model of solid tumour.

Porphyrins are produced at scale through metabolic engineering and optimization of CPIII purification.

Understanding genetic regulation and the underlying mechanism for genetic associations with human phenotypes is complicated by cellular heterogeneity and linkage disequilibrium. Here, the authors propose an analytical framework to decode genetic variation of gene regulation at both cell-type and single-nucleotide levels.

Intensity adaptive optics employs a dual-feedback loop to recover non-uniform intensity distribution and energy loss at the pupil plane, validated in both sensor-based and sensorless formats.

Researchers have achieved the elusive monopole topological defect modes in 3D Dirac crystals with hedgehog mass configurations, completing the bulk topological-defect correspondence in full three dimensions and providing an optimal single mode resonance for future exploration.

Microwell-seq is used to generate single-cell, whole-body expression landscapes of zebrafish, Drosophila and earthworm. A deep-learning model, Nvwa, predicts gene expression from DNA sequence and identifies regulatory programs shared across eight species.

The bone tumour microenvironment plays an essential role in multiple myeloma (MM) development. Here, the authors show that bone collagen degradation provides glycine to support MM progression through glutathione and purine synthesis.

Schizophrenia is a severe psychiatric disorder and the pathogenesis remains unclear. Here, the authors show a potential role for synaptotagmin-11 in schizophrenia-related behavior through dopamine over-transmission.

Group 3 innate lymphoid cells (ILC3s) have important functions in inflammatory bowel disease. Here, the authors show that TL1A/DR3 signalling stimulates ILC3s to produce GM-CSF, thereby recruiting inflammatory cells, which results in subsequent IL-23-dependent loss of ILC3s and further intestinal inflammation.

This study identifies a positive-feedback loop between the ACC and the VTA that mediates the mutual exacerbation between hyperalgesia and comorbid anxiodepressive-like behaviors and, thereby, the chronicity of neuropathic pain.

Traditional metallaphotocatalysis often requires two or more separate catalysts and is considered to be costly and not tolerant towards a wide substrate scope. Here the authors realize metallaphotocatalysis with a bifunctional dirhodium tetracarboxylate as single catalyst component to merge carbenoid chemistry and ¹O₂ chemistry.

Singh and colleagues show Tigit controls the generation of germinal center-derived plasma cell precursors that give rise to long-lived differentiated progeny in the bone marrow.

Zhang, Liu and colleagues identify and characterize cell death in rapidly proliferating CD8⁺ T cells resulting from excessive ammonia accumulation and subsequent lysosomal dysfunction and mitochondrial damage.

StrucGP offers a de novo glycan mapping method to determine detailed N-glycan structures at the site-specific level.

North Pacific dust flux and modelling results provide new evidence for long-term land-atmosphere-ocean interactions associated with the onset and intensification of the Northern Hemisphere Glaciation.

Using rat and mouse models of pulmonary hypertension and patients’ data, Shu, Liu, Zhou et al. show that the concomitant increase in immunoglobulin E (IgE) and mast cells expressing the effector receptor FcεRIα has an important role in pulmonary vascular remodeling, and genetic and pharmacological inhibition of the IgE–FcεRIα signaling alleviated the progression of pulmonary hypertension in animal models.

3D-printed glass holds great potential. However, it is challenging to control both the dimension and the resolution of the printed material. Here, authors present a one-photon 3D printing approach to produce high-performance fused silica glass with sub-micron resolution and millimetric dimensions.

Activation of white adipose tissue (WAT) thermogenesis alleviates obesity-associated metabolic disorders in rodents. Here the authors report that the m6 A RNA modification reader YTHDF1 promotes WAT thermogenesis in a study with male mice, and may be a potential target for the treatment of obesity.

Most piezoelectric coefficients in piezoelectric ceramics are zero, resulting in many piezoelectric vibration modes cannot be excited. Here, the authors propose an orderly stacked structure to achieve all nonzero piezoelectric coefficients.