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Showing 1–50 of 54 results

Advanced filters: Author: Jinke Wang Clear advanced filters

Author Correction: TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain

Yan Wang
Yingwei Gao
Yong Li
Amendments and CorrectionsOpen Access28 Jun 2018
Nature Communications

Volume: 9, P: 1
Targeting MondoA–TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment

Xu et al. identify the MondoA–TXNIP signalling axis as a regulator of antitumour immune surveillance in response to lactic acid in the tumour microenvironment.

Nannan Xu
Yemin Zhu
Xuemei Tong
Research22 Aug 2025
Nature Metabolism

Volume: 7, P: 1889-1904
Achieving flexible fairness metrics in federated medical imaging

Achieving fairness while preserving privacy in medical imaging tasks remains a significant challenge. Here, the authors present and comprehensively evaluate a federated learning framework to tackle both fairness and privacy issues, using a flexible regularization term to integrate multiple fairness criteria.

Huijun Xing
Rui Sun
Zhen Li
ResearchOpen Access08 Apr 2025
Nature Communications

Volume: 16, P: 1-12
Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation

Maintenance of proper membrane excitability is vital to neuronal function and in several neuronal types this relies on a balance between receptor-mediated excitation and inhibition. Here the authors report a crosstalk between excitatory kainate receptors and inhibitory glycine receptors that relies on the SUMOylation status of PKC.

Hao Sun
Li Lu
Yong Li
ResearchOpen Access19 Sept 2014
Nature Communications

Volume: 5, P: 1-17
Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3

Qiaojia Huang
Jianhua Yang
Bing Su
Research07 Dec 2003
Nature Immunology

Volume: 5, P: 98-103
A novel, covalent broad-spectrum inhibitor targeting human coronavirus M^pro

A novel covalent inhibitor, ISM3312, targets the main protease of multiple human coronaviruses, including drug-resistant strains, and shows broad antiviral activity. It offers a promising therapeutic strategy against current and future coronavirus threats.

Jing Sun
Deheng Sun
Jincun Zhao
ResearchOpen Access15 May 2025
Nature Communications

Volume: 16, P: 1-20
CAF-derived GLUT1 and its role in modulating ovarian cancer progression: a multi-dimensional analysis of the tumor microenvironment

Single-cell and multi-omics analysis reveals that CAF-derived GLUT1 promotes metabolic reprogramming and ovarian cancer progression through the TGF-β1/p38/MMP2/MMP9 signaling axis.

Dandan Zhang
Jinke Li
Kai Zhang
ResearchOpen Access08 Jul 2025
Communications Biology

Volume: 8, P: 1-18
Knowledge, attitudes, and willingness of patients with thyroid diseases toward thyroid thermal ablation techniques

Ying Liu
Lihong Liu
Shoujun Yu
ResearchOpen Access10 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain

SUMOylation is a post translational modification. Here the authors show that TRPV1, which conveys thermal nociception, is SUMOylated in DRGs in inflammatory conditions and contributes to pain behavior in mice.

Yan Wang
Yingwei Gao
Yong Li
ResearchOpen Access18 Apr 2018
Nature Communications

Volume: 9, P: 1-17
Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors

While the STING-type-I interferon pathway plays a key role in anti-tumour immunity, current direct STING agonists have limited therapeutic benefit. Here, the authors identify ENPP1 as a safer and more effective STING-modulating target than direct STING agonism, and use an AI-based drug design platform to design the ENPP1-selective inhibitor ISM5939.

Congying Pu
Hui Cui
Alex Zhavoronkov
ResearchOpen Access23 May 2025
Nature Communications

Volume: 16, P: 1-23
Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development

Memory T cells are particularly reliant on fatty acid oxidation as a source of energy. Here the authors show this reliance is controlled by AMPK sensing of glucose deprivation that triggers SENP1-Sirt3 signalling, driving fatty acid oxidation and memory differentiation in T cells via deacetylation of YME1L1 to induce mitochondrial fusion.

Jianli He
Xun Shangguan
Jinke Cheng
ResearchOpen Access16 Jul 2021
Nature Communications

Volume: 12, P: 1-14
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells

Regulatory T (Treg) cells are important modulators of the tumor microenvironment. Here the authors perform transcriptome profiling of immune cells from patients with renal clear cell carcinoma to find a Treg signature that correlates with poorer prognosis, with CD177 being implicated as the main mediator for related alterations in Treg activity and tumor outcome.

Myung-Chul Kim
Nicholas Borcherding
Weizhou Zhang
ResearchOpen Access01 Oct 2021
Nature Communications

Volume: 12, P: 1-13
Mesaconic acid as a key metabolite with anti-inflammatory and anti-aging properties produced by Lactobacillus plantarum 124 from centenarian gut microbiota

Lei Wu
Hongxin He
Xingxiang He
ResearchOpen Access19 Aug 2025
npj Biofilms and Microbiomes

Volume: 11, P: 1-15
Tunneling current-controlled spin states in few-layer van der Waals magnets

Magnetic tunnel junctions consist of two magnetic layers, separated by a thin insulator. The simplicity belies the industrial importance: magnetic tunnel junctions have a very wide variety of applications in contemporary society. Here, Fu et al present a magnetic tunnel junction composed of single van der Waals magnetic insulator, CrI3, exhibiting remarkably low power consumption.

ZhuangEn Fu
Piumi I. Samarawickrama
Jifa Tian
ResearchOpen Access01 May 2024
Nature Communications

Volume: 15, P: 1-11
Correlation between superconductivity and bond angle of CrAs chain in non-centrosymmetric compounds A₂Cr₃As₃ (A = K, Rb)

Zhe Wang
Wei Yi
Zhongxian Zhao
ResearchOpen Access25 Nov 2016
Scientific Reports

Volume: 6, P: 1-8
Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis

TIP60-mediated crotonylation of the microtubule plus-end tracking protein EB1 at Lys66 regulates attachment of astral microtubules to the lateral cell cortex and spindle positioning.

Xiaoyu Song
Fengrui Yang
Xuebiao Yao
Research04 Oct 2021
Nature Chemical Biology

Volume: 17, P: 1314-1323
Hypoxia regulates overall mRNA homeostasis by inducing Met¹-linked linear ubiquitination of AGO2 in cancer cells

Met¹-linked linear ubiquitination (M¹-Ubi) is catalyzed by linear ubiquitin chain assembly complex (LUBAC). Here the authors show that Ago2 protein is M¹-Ubi modified by LUBAC complex under hypoxia condition leading to less association of miRNA target mRNAs to Ago2 protein and de-repression of miRNA targets.

Hailong Zhang
Xian Zhao
Jianxiu Yu
ResearchOpen Access13 Sept 2021
Nature Communications

Volume: 12, P: 1-20
SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis

The oncogenic activity of Hexokinase 2, the first rate-limiting enzyme of glycolysis, requires its mitochondrial localization. Here, the authors show that SUMOylation of hexokinase 2 disrupts its binding to mitochondria and protects cells from tumorigenesis in prostate cancer.

Xun Shangguan
Jianli He
Wei Xue
ResearchOpen Access22 Mar 2021
Nature Communications

Volume: 12, P: 1-14
P53 suppresses SENP3 phosphorylation to mediate G2 checkpoint

Yang Wang
Jing Tian
Jinke Cheng
ResearchOpen Access21 Apr 2020
Cell Discovery

Volume: 6, P: 1-9
MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche

A subset of intestinal stromal cells that is regulated by the kinase MAP3K2 protects intestinal stem cells against injury by producing the WNT agonist R-spondin 1.

Ningbo Wu
Hongxiang Sun
Bing Su
Research03 Mar 2021
Nature

Volume: 592, P: 606-610
Ultra-Broadband Acoustic Diode in Open Bend Tunnel by Negative Reflective Metasurface

Qingxuan Liang
Yong Cheng
Dichen Li
ResearchOpen Access31 Oct 2018
Scientific Reports

Volume: 8, P: 1-6
NR4A1 promotes LEF1 expression in the pathogenesis of papillary thyroid cancer

Cen Jiang
Jianli He
Jinke Cheng
ResearchOpen Access02 Feb 2022
Cell Death Discovery

Volume: 8, P: 1-8
The effect of anionic emulsifiers’ diversity and manufacturing processes on the stability and mechanical properties of the water-based epoxy-emulsified asphalt

Yi Peng
Jinke Miao
Tao Ao
ResearchOpen Access27 Sept 2024
Scientific Reports

Volume: 14, P: 1-22
Gene interfered-ferroptosis therapy for cancers

Improved therapeutic strategies are needed as drug resistance limits the therapeutic efficacy of several clinically approved cancer therapeutics. Here, the authors report a ferroptosis-based therapy using a combination of iron nanoparticles with gene interference to knockdown iron metabolic genes, FPN and LCN2.

Jinliang Gao
Tao Luo
Jinke Wang
ResearchOpen Access07 Sept 2021
Nature Communications

Volume: 12, P: 1-16
Spin–orbit torque-assisted switching in magnetic insulator thin films with perpendicular magnetic anisotropy

By virtue of strong spin-orbit coupling, a current-carrying heavy metal may generate a torque on the magnetization of an interfaced ferromagnetic metal. Here, the authors demonstrate how this effect assists the magnetic reversal of ferromagnetic insulators with perpendicular magnetic anisotropy.

Peng Li
Tao Liu
Mingzhong Wu
ResearchOpen Access01 Sept 2016
Nature Communications

Volume: 7, P: 1-8
Underground well water level observation grid dataset from 2005 to 2022

Mengran Wang
Jiaqi Yao
Hui Lu
ResearchOpen Access02 May 2025
Scientific Data

Volume: 12, P: 1-9
SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation

Regulatory T cells are crucial for the establishment and maintenance of peripheral immune tolerance, yet the mechanisms regulating their stability and function remain to be fully elucidated. Here the authors show SENP3 maintains Treg cell stability and function via BACH2 deSUMOylation.

Xiaoyan Yu
Yimin Lao
Qiang Zou
ResearchOpen Access08 Aug 2018
Nature Communications

Volume: 9, P: 1-11
SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane

PTEN is a tumour suppressor that inhibits activation of the phosphatidylinositol 3-kinase pathway. These authors show that PTEN is SUMOylated on two lysine residues and that this modification is required for binding to acidic phospholipids and blocking tumour formation in mice.

Jian Huang
Jie Yan
Jianxiu Yu
Research19 Jun 2012
Nature Communications

Volume: 3, P: 1-12
Origin of colossal dielectric permittivity of rutile Ti_0.9In_0.05Nb_0.05O₂: single crystal and polycrystalline

Yongli Song
Xianjie Wang
Jinke Tang
ResearchOpen Access12 Feb 2016
Scientific Reports

Volume: 6, P: 1-8
Invariant NK T cells counteract HCC metastasis by mediating the migration of splenic CD4⁺ T cells into the white pulp and infiltration of B cells

Splenic iNKT promotes the entry of CD4⁺ T cells into the white pulp through secretion of IFN-γ. CD4⁺ T cells regulate splenic B cells migrate to the liver and inhibit HCC metastasis.

Jinke Geng
Mengxiao Xie
Mutian Han
ResearchOpen Access03 Mar 2025
Communications Biology

Volume: 8, P: 1-15
Prediction of coating degradation based on “Environmental Factors–Physical Property–Corrosion Failure” two-stage machine learning

Weiting Chen
Lingwei Ma
Dawei Zhang
ResearchOpen Access10 Jun 2025
npj Materials Degradation

Volume: 9, P: 1-13
Magnetic hard gap due to bound magnetic polarons in the localized regime

Gaurab Rimal
Jinke Tang
ResearchOpen Access08 Feb 2017
Scientific Reports

Volume: 7, P: 1-7
GILT stabilizes cofilin to promote the metastasis of prostate cancer

Dunsheng Han
Zhiming Wu
Gang Chen
ResearchOpen Access16 Jan 2025
Cell Death Discovery

Volume: 11, P: 1-14
Loss of Fbxo45 in AT2 cells leads to insufficient histone supply and initiates lung adenocarcinoma

Lian Li
Junya Li
Jianxiu Yu
Research13 Dec 2024
Cell Death & Differentiation

Volume: 32, P: 1273-1293
Targeting SIRT3 sensitizes glioblastoma to ferroptosis by promoting mitophagy and inhibiting SLC7A11

Xiaohe Li
Wenlong Zhang
Rong Cai
ResearchOpen Access23 Feb 2024
Cell Death & Disease

Volume: 15, P: 1-14
NF-κB-activated oncogene inhibition strategy for cancer gene therapy

Wei Dai
Jian Wu
Xinyi Xia
ResearchOpen Access03 Sept 2024
Cancer Gene Therapy

Volume: 31, P: 1632-1645
Network models of prostate cancer immune microenvironments identify ROMO1 as heterogeneity and prognostic marker

Lei Wang
Xudong Liu
Xinqiang Song
ResearchOpen Access07 Jan 2022
Scientific Reports

Volume: 12, P: 1-19
Deep supervision and atrous inception-based U-Net combining CRF for automatic liver segmentation from CT

Peiqing Lv
Jinke Wang
Changfa Shi
ResearchOpen Access10 Oct 2022
Scientific Reports

Volume: 12, P: 1-14
SUMO suppresses and MYC amplifies transcription globally by regulating CDK9 sumoylation

Fang Yu
Guang Shi
Jiemin Wong
Research27 Mar 2018
Cell Research

Volume: 28, P: 670-685
Mitotic SENP3 activation couples with cGAS signaling in tumor cells to stimulate anti-tumor immunity

Gaolei Hu
Yalan Chen
Jinke Cheng
ResearchOpen Access22 Jul 2022
Cell Death & Disease

Volume: 13, P: 1-11
Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

A potent and selective catalytic inhibitor of p300/CBP histone acetyltransferases suppresses tumour proliferation across multiple cell lineages, illustrating the therapeutic potential of drug-like small molecules that target histone acetyltransferases.

Loren M. Lasko
Clarissa G. Jakob
Kenneth D. Bromberg
Research27 Sept 2017
Nature

Volume: 550, P: 128-132
Genetic mutations in NF-κB pathway genes were associated with the protection from hepatitis C virus infection among Chinese Han population

Ming Yue
Ting Tian
Peng Huang
ResearchOpen Access25 Jul 2019
Scientific Reports

Volume: 9, P: 1-11
Targeting Src family kinase member Fyn by Saracatinib attenuated liver fibrosis in vitro and in vivo

Guifang Du
Jing Wang
Yinying Lu
ResearchOpen Access12 Feb 2020
Cell Death & Disease

Volume: 11, P: 1-12
Cancer therapy with a CRISPR-assisted telomerase-activating gene expression system

Wei Dai
Xinhui Xu
Jinke Wang
Research29 Jan 2019
Oncogene

Volume: 38, P: 4110-4124
CRISPR-typing PCR (ctPCR), a new Cas9-based DNA detection method

Qiao Wang
Beibei Zhang
Jinke Wang
ResearchOpen Access20 Sept 2018
Scientific Reports

Volume: 8, P: 1-13
Cancer gene therapy by NF-κB-activated cancer cell-specific expression of CRISPR/Cas9 targeting telomeres

Wei Dai
Jian Wu
Jinke Wang
Research07 Feb 2020
Gene Therapy

Volume: 27, P: 266-280
Towards weathering and corrosion resistant, self-warning and self-healing epoxy coatings with tannic acid loaded nanocontainers

Jinke Wang
Weimin Tan
Dawei Zhang
ResearchOpen Access20 May 2023
npj Materials Degradation

Volume: 7, P: 1-12
Atomic structure of human TOM core complex

Wenhe Wang
Xudong Chen
Maojun Yang
ResearchOpen Access29 Sept 2020
Cell Discovery

Volume: 6, P: 1-10
MUC1 triggers lineage plasticity of Her2 positive mammary tumors

Zhi Pang
Xinran Dong
Lei Huang
Research23 Apr 2022
Oncogene

Volume: 41, P: 3064-3078
SENP1 Is a Crucial Regulator for Cell Senescence through DeSUMOylation of Bmi1

Nansong Xia
Juan Cai
Yong Zuo
ResearchOpen Access23 Sept 2016
Scientific Reports

Volume: 6, P: 1-11

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