Nature Search

Research on intelligent regulation of layered water injection based on reinforcement learning SAC algorithm

Jinzhao Hu
Deli Jia
Fushen Ren
ResearchOpen Access26 Sept 2025
Scientific Reports

Volume: 15, P: 1-17
CRISPRi screen identifies FprB as a synergistic target for gallium therapy in Pseudomonas aeruginosa

In this work, authors show that deletion of FprB enhances the antibacterial activity of gallium against Pseudomonas aeruginosa, revealing a combination strategy and demonstrating the utility of CRISPRi-seq for therapeutic target discovery.

Yu Zhang
Tingting Zhang
Xue Liu
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-19
Structure of the complex of C1q-like 3 protein with adhesion-GPCR BAI3

This study reports the structural characterization of C1q-like protein 3 (C1ql3) with adhesion-GPCR brain-specific angiogenesis inhibitor-3 (BAI3).

Yi Miao
Haoqing Wang
Thomas C. Südhof
ResearchOpen Access03 May 2025
Communications Biology

Volume: 8, P: 1-6
Probing spectral features of quantum many-body systems with quantum simulators

Probing spectral properties of complex quantum many-body systems is challenging with existing theoretical and experimental techniques. Here, the authors introduce quantum simulations as a potential alternative to scattering spectroscopy for estimating the spectral features of many-body systems.

Jinzhao Sun
Lucia Vilchez-Estevez
M. S. Kim
ResearchOpen Access06 Feb 2025
Nature Communications

Volume: 16, P: 1-13
Experimental quantum computational chemistry with optimized unitary coupled cluster ansatz

The application of quantum computing to computational chemistry faces various experimental and theoretical challenges. Now, a quantum simulation on a noisy quantum device has achieved chemical accuracy for small H₂ and LiH molecules.

Shaojun Guo
Jinzhao Sun
Jian-Wei Pan
Research11 Jun 2024
Nature Physics

Volume: 20, P: 1240-1246
LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development

How epigenetic regulation affects pancreatic development is unclear. Here, the authors show that the histone demethylase LSD1 regulates the epigenetic state of developmental enhancers during pancreatic specification and controls how these enhancers respond to extracellular signals, namely retinoic acid.

Nicholas K. Vinckier
Nisha A. Patel
Maike Sander
ResearchOpen Access29 Apr 2020
Nature Communications

Volume: 11, P: 1-15
A functional variant of SUMO4, a new IκBα modifier, is associated with type 1 diabetes

Dehuang Guo
Manyu Li
Cong-Yi Wang
Research11 Jul 2004
Nature Genetics

Volume: 36, P: 837-841
The beneficial role of Asian-based RecurIndex test in the prognostic prediction in Chinese male breast cancer patients

Shuo Zhang
Beichen Liu
Yunjiang Liu
ResearchOpen Access07 Apr 2021
Scientific Reports

Volume: 11, P: 1-8
Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors

Enhancers for endodermal organs are primed at the chromatin level prior to lineage induction by FOXA pioneer transcription factors; how pervasive this is, is not well known. Here the authors show that only a small subset of organ-specific enhancers are bound and primed by FOXA prior to lineage induction, whereas the majority do not undergo chromatin priming and engage FOXA upon lineage induction.

Ryan J. Geusz
Allen Wang
Maike Sander
ResearchOpen Access17 Nov 2021
Nature Communications

Volume: 12, P: 1-19
Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk

Single-cell ATAC-seq analysis of human pancreatic islet cells identifies different cell clusters and transcription factors that underlie lineage- and state-specific regulation and helps prioritize type 2 diabetes risk variants.

Joshua Chiou
Chun Zeng
Kyle J. Gaulton
Research01 Apr 2021
Nature Genetics

Volume: 53, P: 455-466
Migration and plugging laws of plugging-selection balls in fine profile control process of layered waterflooding wells

Yan An
Fushen Ren
Min Luo
ResearchOpen Access13 Jan 2025
Scientific Reports

Volume: 15, P: 1-16
The intelligent selenium-enriched tea withering control system

Shuang Ren
Sanjun Liu
Didi Lu
ResearchOpen Access15 Jan 2025
Scientific Reports

Volume: 15, P: 1-12
Comprehensive large-scale nucleic acid–testing strategies support China’s sustained containment of COVID-19

Zhongjie Li
Fengfeng Liu
Zijian Feng
Correspondence15 Apr 2021
Nature Medicine

Volume: 27, P: 740-742
Comparing watershed black locust afforestation and natural revegetation impacts on soil nitrogen on the Loess Plateau of China

Zhao Jin
Xiangru Li
Buli Cui
ResearchOpen Access26 Apr 2016
Scientific Reports

Volume: 6, P: 1-8
An open-access database and analysis tool for perovskite solar cells based on the FAIR data principles

Making large datasets findable, accessible, interoperable and reusable could accelerate technology development. Now, Jacobsson et al. present an approach to build an open-access database and analysis tool for perovskite solar cells.

T. Jesper Jacobsson
Adam Hultqvist
Eva Unger
ResearchOpen Access13 Dec 2021
Nature Energy

Volume: 7, P: 107-115
PRKAR2A deficiency protects mice from experimental colitis by increasing IFN-stimulated gene expression and modulating the intestinal microbiota

Lumin Wei
Rongjing Zhang
Lifu Wang
ResearchOpen Access04 Aug 2021
Mucosal Immunology

Volume: 14, P: 1282-1294
Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway

Wei Jiang
Jinzhao Wang
Yi Zhang
Research21 Aug 2012
Cell Research

Volume: 23, P: 122-130
Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells

Jun Jing
Ning Ding
Bing Yao
ResearchOpen Access14 Aug 2020
Cell Death & Disease

Volume: 11, P: 1-15
Efficient generation of functional neurons from mouse embryonic stem cells via neurogenin-2 expression

We present a protocol for generating mouse ESC-derived induced neuronal cells via lentiviral Tet-On inducible expression of NGN2 for the direct comparison of human and mouse neuronal populations.

Yingfei Liu
Jinzhao Wang
Marius Wernig
Protocols18 Aug 2023
Nature Protocols

Volume: 18, P: 2954-2974
One-pot hydrothermal synthesis of CdS decorated CuS microflower-like structures for enhanced photocatalytic properties

Xiaolong Deng
Chenggang Wang
Xijin Xu
ResearchOpen Access20 Jun 2017
Scientific Reports

Volume: 7, P: 1-12
Different hydrogen isotope fractionations during lipid formation in higher plants: Implications for paleohydrology reconstruction at a global scale

Jinzhao Liu
Weiguo Liu
Hong Yang
ResearchOpen Access25 Jan 2016
Scientific Reports

Volume: 6, P: 1-10
CO₂-breathing and piercing polymersomes as tunable and reversible nanocarriers

Anchao Feng
Jiamei Liang
Jinying Yuan
ResearchOpen Access29 Mar 2016
Scientific Reports

Volume: 6, P: 1-10

Search

Research on intelligent regulation of layered water injection based on reinforcement learning SAC algorithm

CRISPRi screen identifies FprB as a synergistic target for gallium therapy in Pseudomonas aeruginosa

Structure of the complex of C1q-like 3 protein with adhesion-GPCR BAI3

Probing spectral features of quantum many-body systems with quantum simulators

Experimental quantum computational chemistry with optimized unitary coupled cluster ansatz

LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development

A functional variant of SUMO4, a new IκBα modifier, is associated with type 1 diabetes

The beneficial role of Asian-based RecurIndex test in the prognostic prediction in Chinese male breast cancer patients

Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors

Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk

Migration and plugging laws of plugging-selection balls in fine profile control process of layered waterflooding wells

The intelligent selenium-enriched tea withering control system

Comprehensive large-scale nucleic acid–testing strategies support China’s sustained containment of COVID-19

Comparing watershed black locust afforestation and natural revegetation impacts on soil nitrogen on the Loess Plateau of China

An open-access database and analysis tool for perovskite solar cells based on the FAIR data principles

PRKAR2A deficiency protects mice from experimental colitis by increasing IFN-stimulated gene expression and modulating the intestinal microbiota

Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway

Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells

Efficient generation of functional neurons from mouse embryonic stem cells via neurogenin-2 expression

One-pot hydrothermal synthesis of CdS decorated CuS microflower-like structures for enhanced photocatalytic properties

Different hydrogen isotope fractionations during lipid formation in higher plants: Implications for paleohydrology reconstruction at a global scale

CO₂-breathing and piercing polymersomes as tunable and reversible nanocarriers

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