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The development of organic electronics calls for low-cost printing techniques that can prepare high quality, large-area organic single crystals. Here, Rigaset al. achieve this goal by combining spray printing and antisolvent crystallization and test the method on various materials and substrates.

Autonomous delivery of exogenous cargo into plant tissues is achieved by a nanocarrier system harnessing amino acid transporters, enabling force-free, species-independent uptake and ultra-low dose drought resistance in crops like soybean and maize.

Native top-down proteomics reveals epidermal growth factor receptor–estrogen receptor-alpha (EGFR–ER) signaling crosstalk in breast cancer cells and dissociation of nuclear transport factor 2 (NUTF2) dimers to modulate ER signaling and cell growth.

The interactions of CAR-T cells and solid tumors are modeled on a chip.

Aarrestad et al. show that, in contrast to psychedelics, the nonhallucinogenic psychoplastogen tabernanthalog promotes neuroplasticity through 5-HT_2AR activation without immediately increasing extracellular glutamate levels or immediate early gene expression.

Ricca et al discover a new family of tubular pili in Microcystis aeruginosa, a harmful algal bloom-forming cyanobacterium. These pili are crucial for buoyancy by forming cell micro-colonies, which increases drag and prevents sinking. The pili also enrich microcystin and co-localize with iron-enriched extracellular matrix components, suggesting a vital role in bloom proliferation.

Lee et al. use an aggregation-prone CLN4 mutant that causes lysosomal damage in neurons and show that in non-neurons, the ubiquitin ligase CHIP prevents CLN4-dependent lysotoxicity via microautophagy.

Airway mucus complicates treatment of respiratory disease by both defending the lungs and hindering inhaled drugs to cross the barriers. This Review explores translational advances in inhalable materials and biologics that enhance mucus protection or drug penetration.

There is considerable interest in transitioning industrial thermocatalytic reactions to renewable-driven processes, but the electrification of such reactions has been challenging. Now, it has been shown that bridging non-aqueous chemistry with aqueous electrochemistry through aqueous–non-aqueous interfacial proton-coupled electron transfer can enable electricity-driven hydrogen peroxide production.

John et al. show that upon classical activation, macrophages undergo nitric oxide-driven reprogramming of nucleotide metabolism, which affects immune functions and responses.

Dual cyclin A/B RxL inhibitors selectively kill small cell lung cancer cells and other cancer cells with high E2F activity.

Here, a combination of forward genetics and genome-wide association analyses has been used to show that variation at a single genetic locus in Arabidopsis thaliana underlies phenotypic variation in vegetative growth as well as resistance to infection. The strong enhancement of resistance mediated by one of the alleles at this locus explains the allele's persistence in natural populations throughout the world, even though it drastically reduces the production of new leaves.

Serino et al. show that seeing an infectious avatar approach the body in virtual reality triggers an immune response, indicating that the brain prepares the body to fight infections even for perceived, but not real, threats.

The authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55α hyperactivation. They identify B55α and Greatwall levels as biomarkers of responses to Greatwall-targeted therapy.

During evolution, how adaptive walks cross fitness valleys remains unclear. This integrative study on monkeyflowers reveals that convergence in large steps (floral color and gene expression) drives a shift in pollinator attraction despite non-optimal fit, paving paths to reproductive isolation.

Using a placebo-controlled, randomized crossover design, authors demonstrate that intranasal oxytocin modulated the processing of fearful facial expressions during an fMRI task in adults with antisocial personality disorder with psychopathy.

APC/C activity is transiently inhibited to generate a pulse of glycolysis that is required for mammalian cell cycle entry.

Bennu comprises components of intra- and extra-Solar System origins. The parent bodies of Bennu, Ryugu and CI chondrites likely formed from a shared but heterogeneous reservoir in the outer parts of the solar protoplanetary disk.

Highly performing fuel cell catalysts tested at the fundamental level rarely translate well to full devices, in part due complicated ionomer-catalyst interfaces at the heart of devices, where the electrochemical reactions occur. Here the authors demonstrate ionomerless-thin-film-deposited cathodes that have comparable activity trends across fundamental tests and fuel cells.

Cell-type-resolved spatial proteomics of the skin from patients with toxic epidermal necrolysis reveals that it is driven by JAK/STAT signaling, leading to successful treatment of this potentially fatal condition in patients using JAK inhibitors.

In this study, the authors describe SANA, a nitroalkene derivative of salicylate, as a potential activator of creatine-dependent energy expenditure and thermogenesis in adipose tissue. Preclinical and clinical data from this paper also suggest that SANA improves glucose homeostasis and promotes weight loss in mice and humans.

The electrical properties of nanostructured networks are often dominated by junctions between the particles. Here, Gabett et al. develop transport models and utilise impedance spectroscopy to quantify the factors limiting conduction in these systems.

It can be challenging for conventional electrochemical measurements to distinguish different types of charge storage mechanisms in electrochemical systems. Here the authors develop an in situ ultraviolet–visible spectroscopy approach as a powerful and affordable tool for this purpose.

Bird wings use microscopic hooks to maintain connection between feathers during flight. Kevin PT Haughn and colleagues report an electro-adhesive alternative for engineered morphing wings, thus fastening feathers to improve manoeuvrability in flight.

Caloric restriction improves Alzheimer’s Disease outcomes in mice, but this diet not only reduces calories, but imposes a prolonged fast between meals. Here, the authors show this fast is essential to improve Alzheimer’s pathology and cognition.

Dietary n-6 PUFAs enhance adipose tissue expandability through the PPARγ–LPCAT3 membrane remodelling axis.

The development of modern flexible electronics calls for new materials with extreme stretchability and high conductivity. Here, Mates et al. show a printable material made of commercially-available elastomers and carbon nanofibres, which exhibits low resistance and water-repellency at strain up to 500%.

XopC2 effectors are present in many plant bacterial pathogens. Here the authors show that XopC2 has kinase activity and enhances disease susceptibility by phosphorylating the OSK1 protein, which increases its interaction with the jasmonate receptor COI1b to promote JA signaling and stomatal opening.

Some animals and insects can change the colour of their skin, but mimicking such function in man-made materials is complex. Here, the authors demonstrate an all-solution processed chameleon-inspired stretchable e-skin capable of interactive colour changes and tactile sensing.

The taurine–taurine transporter axis is a critical dependency of aggressive myeloid leukaemias.

Here the authors show that human pancreatic islets adapt during pregnancy with increased α-cell area and GLP-1 abundance, while key differences from islet adaptations in mouse pregnancy include unchanged β-cell PRLR abundance and absent β-cell 5-HT_2B receptor expression.

Using a germ-free BTBR mouse model of ASD-like behaviors, here the researchers demonstrated that the absence of gut microbiota significantly reduced social deficits, repetitive behaviors, and neuroinflammation.

Nuclear calcium oscillations initiate plant–arbuscular mycorrhiza and nitrogen-fixing bacteria symbioses for nutrient acquisition, with a newly discovered autoactive CNGC15 mutant enhancing these partnerships, potentially improving crop nutrition and reducing inorganic fertilizer dependence.

RNA translation is a core cell process that is deregulated in cancer. Here, the authors show that a machine learning approach, RiboTIE, can reconstruct RNA translation in cancer and non-cancer cells. In medulloblastoma, a brain cancer, RiboTIE enables discovery of subtype-specific microproteins.

The whitefly Bemisia tabaci defends against plant glucosinolate toxins by serial addition of glucose moieties catalyzed by a pair of glycoside hydrolases, preventing toxin activation during feeding on the plant tissue.

With increasing river flow, sand dunes on the riverbed initially grow and eventually flatten out. However, flume experiments show that dune height distributions under high flow are bimodal, suggesting flickering between high and low dune heights.