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Here, the authors map malignant and non-malignant cellular states in human glioma using integrated single-cell and spatial transcriptomics, revealing spatially organized tumor-microenvironment interactions and distinct oligodendrocyte-associated programs linked to disease progression.

High-frequency exchange resonance in antiferromagnetically coupled ferrimagnets lasts longer than ferromagnetic resonance near the compensation point due to unequal damping in the two sublattices, promising sub-THz coherent spintronic applications.

Osteoarthritis is a marked by cartilage loss and limited by the absence of effective disease modifying treatments. Here, the authors show that orphan nuclear receptor small heterodimer partner (SHP) protects cartilage by suppressing IKKβ dependent NF κB signaling, highlighting it as a potential therapeutic target.

Intestinal glucose excretion is a gut-based mechanism contributing to improved glycemic control after weight-loss surgery. Here, the authors describe a signaling pathway that drives intestinal glucose uptake and luminal excretion, identifying a potential therapeutic target for diabetes and weight loss.

Breeding crops with delayed senescence could plausibly increase grain yield. Here the authors show that variation at the rice SGR locus contributes to differences in senescence between indica and japonica subspecies and show that introgression can increase yield in an elite indica rice variety.

Here, the authors show that transient, mosaic induction of Yamanaka factors in the epidermis can promote skin repair beyond reprogramming cells. They also influence neighboring epithelial cells and immune–mesenchymal niches by reshaping injury response programs.

Anion-exchange-membrane electrolysis needs durable carbon supports, yet native defects corrode under harsh operating conditions. Here, the authors report that oxide-hybridized carbon serves as a durable catalyst support while facilitating the supply of reactant hydroxide ions.

Fabrication of fully stretchable organic light-emitting diodes incorporating an intrinsically stretchable exciplex-assisted phosphorescent layer along with MXene-contact stretchable electrodes is described, demonstrating high efficiency and mechanical compliance for applications in next-generation wearable and deformable displays.

Whole-genome and transcriptome analysis of 1,364 cases of breast cancer from South Korea broadens our understanding of breast cancer biology and reveals genomic features that connect tumour biology with treatment responses and clinical outcomes.

The pursuit of high-energy-density batteries is often limited by slurry-based processing, because thicker electrodes suffer from reaction heterogeneity. Now, by molecularly engineering the carbon–binder network, a dry electrode architecture is introduced that enables stable high-voltage operation without the need to redesign active materials or the electrolyte.

Accurate assessment of endometrial receptivity remains a challenge in infertility care. Here, authors present a patient-derived vascularised endometrium-on-a-chip and a scoring system for receptivity evaluation.

Vassy, Dornisch and colleagues developed a genomics-based prostate cancer risk model to support a randomized clinical trial of precision screening in a national healthcare system.

Tau protein has been observed to form condensates in various contexts. Here, the authors show that tau can form DNA-anchored droplets that organize nearby microtubules, pointing to a role in mitosis.

Cell death induced by metal ions is promising for cancer immunotherapy but sometimes limited by effective loading/release into tumor sites. Here this group reports a binary mineral nanoparticles incorporating both Ca2+ and Na+ ions to enhance the cytotoxic effects of ion interference in cancer immunotherapy.

By controlling the coalescence of multiple unidirectional grains on vicinal sapphire substrates, wafer-scale channels of single-crystalline molybdenum disulfide can be grown, which exhibit coherent quantum transport across large length scales.

Determining graphene domain size and distribution is important for realizing functional electronic devices. Here, the authors use liquid crystals to study graphene surfaces, via the liquid crystal molecules aligning with the domains, and use nematic to smectic transitions to study defects.

RNA modifications are crucial regulators of gene expression but have been hard to detect accurately. Here, the authors introduce DeepRM, which uses a massive high-quality training dataset to detect and quantify m6A with near-perfect accuracy, producing a comprehensive human m6A atlas.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

The authors develop a handheld photoacoustic probe integrating a fiber scanner and transparent ultrasound transducer. They demonstrate rapid, high-resolution 3D imaging of vessels and lymphatics in living animals, confirming translational potential.

Researchers identified three distinct white matter hyperintensity progression patterns, validated in both patients and healthy individuals. Each pattern links to different vascular risks and outcomes, improving stroke prediction.

Determinants of WEE1 inhibitor sensitivity in cancer cells are largely undefined. Here, the authors show that WEE1 inhibitors beyond their cell cycle perturbing effects also lead to paradoxical activation of the integrated stress response kinase GCN2.

Accurate identification of cell types in vast single-cell datasets is a major challenge. Here, authors deliver scICE, a computational tool that ensures clustering consistency with up to 30-fold speed improvement, empowering more robust and rapid insights.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

An intestinal organoid model recapitulates human microfold (M) cell function and transcriptomic profiling and biochemical assays demonstrate that M cells uptake and present antigens to the immune system via the class II major histocompatibility complex.

Semiconductors are promising for high performance spintronics but the low functioning temperature hampers their applications. Here the authors achieve a strong room temperature modulation of spin-dependent resistance in GaN nanowires, which marks an important step towards practical spintronic devices.

A major challenge for spin based electronics is the electrical control of magnetization. Here, Kang et al demonstrate how electric field control of the Rashba effect in a Pt/Co/AlOx can enable control of the spin-orbit torque and allow for field free switching of the magnetization.

Adipose CoA handling is critical for lipid metabolism and homeostasis. Here, the authors identify TMEM120A as an ER-resident CoA binding protein enriched in adipocytes that promotes fatty acid recycling to support energy metabolism and limit lipotoxic stress, while its loss leads to adipose inflammation and metabolic dysfunction under high-fat diet conditions.

Two-dimensional molybdenum disulfide (MoS₂)-based active arrays made by growing wafer-scale trilayer MoS₂ directly on a polyimidine substrate achieve high-fidelity spatiotemporal neuronal monitoring in vitro and in living mice.

All-solid-state batteries face major hurdles from electrode volume changes that generate stress and compromise long-term stability. Here, authors demonstrate cobalt-based metal-organic frameworks that buffer strain, enabling low-strain, durable operation with notably improved cycling performance.

Nanobubbles in liquid phase are puzzling, because their internal pressure is estimated to be unphysically large. Here, Shin et al. visualize the dynamics of nanobubbles in water encapsulated by graphene membrane and show fast gas diffusion through ultrathin water layer between two coalescing bubbles.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.