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Showing 1–50 of 750 results
Advanced filters: Author: Joshua Martin Clear advanced filters
  • Here the authors perform a trans expression quantitative trait locus meta-analysis study of over 3,700 people and link a USP18 variant to expression of 50 inflammation genes and lupus risk, highlighting how genetic regulation of immune responses drives autoimmune disease and informs new therapies.

    • Krista Freimann
    • Anneke Brümmer
    • Kaur Alasoo
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Available wheat genomes are annotated by projecting Chinese Spring gene models across the new assemblies. Here, the authors generate de novo gene annotations for the 9 wheat genomes, identify core and dispensable transcriptome, and reveal conservation and divergence of gene expression balance across homoeologous subgenomes.

    • Benjamen White
    • Thomas Lux
    • Anthony Hall
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Giardini et al. present an imaging method that combines quantitative measurements of cardiac electrophysiology with high-resolution three-dimensional structural reconstructions, enabling the detection of arrhythmogenic electrical coupling between cardiomyocytes and non-myocytes in murine hearts.

    • Francesco Giardini
    • Camilla Olianti
    • Leonardo Sacconi
    ResearchOpen Access
    Nature Cardiovascular Research
    P: 1-21
  • Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

    • Matthew A. Reyna
    • David Haan
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17
  • Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

    • Maximilian Zenk
    • Ujjwal Baid
    • Spyridon Bakas
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20
  • The authors demonstrate deeply subwavelength light confinement in the terahertz spectral range by exploiting the strong light–matter coupling and hyperbolicity of phonon polaritons in hafnium-based dichalcogenides.

    • Ryan A. Kowalski
    • Niclas S. Mueller
    • Joshua D. Caldwell
    ResearchOpen Access
    Nature Materials
    P: 1-7
  • Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

    • Céline Bellenguez
    • Fahri Küçükali
    • Jean-Charles Lambert
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 412-436
  • The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

    • Lauri A. Aaltonen
    • Federico Abascal
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 82-93
  • EchoNext, a deep learning model for electrocardiograms trained and validated in diverse health systems, successfully detects many forms of structural heart disease, supporting the potential of artificial intelligence to expand access to heart disease screening at scale.

    • Timothy J. Poterucha
    • Linyuan Jing
    • Pierre Elias
    ResearchOpen Access
    Nature
    Volume: 644, P: 221-230
  • The authors present a multicenter database to investigate the neural correlates of dreaming, including physiological, behavioral and experiential data. This database could boost the research on the mechanisms of dreaming in humans and the signatures of consciousness.

    • William Wong
    • Rubén Herzog
    • Naotsugu Tsuchiya
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • A high-resolution, global atlas of mortality of children under five years of age between 2000 and 2017 highlights subnational geographical inequalities in the distribution, rates and absolute counts of child deaths by age.

    • Roy Burstein
    • Nathaniel J. Henry
    • Simon I. Hay
    ResearchOpen Access
    Nature
    Volume: 574, P: 353-358
  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768
  • Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

    • Esther Rheinbay
    • Morten Muhlig Nielsen
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 102-111
  • Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

    • Shimin Shuai
    • Federico Abascal
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

    • Marta Paczkowska
    • Jonathan Barenboim
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16
  • Superior mechanical properties in natural composites are frequently achieved by the inclusion of locally orientated reinforcing particles. Here, the authors implement this design strategy synthetically by employing a 3D magnetic printing protocol to create programmable composite architectures.

    • Joshua J. Martin
    • Brad E. Fiore
    • Randall M. Erb
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-7
  • The authors show human embryo lineage specification in the blastocyst is driven by differential FGF/ERK signaling, which segregates yolk sac-fated hypoblast and embryonic epiblast. They establish naïve embryonic stem cells based on these insights.

    • Claire S. Simon
    • Afshan McCarthy
    • Kathy K. Niakan
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • Automated iterative small-molecule synthesis has generally been limited to around one carbon–carbon bond-forming step per day. Now, a next-generation automated synthesizer enables rapid, automated, iterative synthesis of a variety of small molecules. Improvements to chemistry and automation leads to a tenfold decrease in reaction time over previous automated platforms.

    • Wesley Wang
    • Nicholas H. Angello
    • Martin D. Burke
    Research
    Nature Synthesis
    Volume: 3, P: 1031-1038
  • This study explores how climate change and population growth shape flood exposure. By 2100, exposure could rise from 1.6 to 1.9 billion people, driven 21% by climate change and 77% by population growth, with low-income and urban regions most affected.

    • Justin S. Rogers
    • Marco P. Maneta
    • Joshua P. Hacker
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • The cause of abnormal alveolar regeneration in idiopathic pulmonary fibrosis is unknown. Here, the authors generated a temporo-spatial cellular map of the regenerating niche and, using unbiased mathematical methods, identified a spatial interaction between a subset of macrophages and aberrant alveolar epithelial cells across all stages of the disease.

    • Praveen Weeratunga
    • Bethany Hunter
    • Ling-Pei Ho
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17
  • A cross-ancestry meta-analysis of genome-wide association studies identifies association signals for stroke and its subtypes at 89 (61 new) independent loci, reveals putative causal genes, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as potential drug targets, and provides cross-ancestry integrative risk prediction.

    • Aniket Mishra
    • Rainer Malik
    • Stephanie Debette
    ResearchOpen Access
    Nature
    Volume: 611, P: 115-123
  • An analysis of the impact of logging intensity on biodiversity in tropical forests in Sabah, Malaysia, identifies a threshold of tree biomass removal below which logged forests still have conservation value.

    • Robert M. Ewers
    • C. David L. Orme
    • Cristina Banks-Leite
    ResearchOpen Access
    Nature
    Volume: 631, P: 808-813
  • The relationship between single-neuron activity and theta oscillations in the human brain remains unclear. Here, the authors demonstrate that human theta-phase locking is influenced by various properties of the local field potential and characterize its dynamics during spatial memory encoding and retrieval.

    • Tim A. Guth
    • Armin Brandt
    • Lukas Kunz
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20
  • Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

    • Joshua S. Weinstock
    • Jayakrishnan Gopakumar
    • Siddhartha Jaiswal
    Research
    Nature
    Volume: 616, P: 755-763
  • With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

    • Matthew H. Bailey
    • William U. Meyerson
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-27
  • In a post-hoc analysis of circulating tumor DNA (ctDNA) features from patients with metastatic prostate cancer treated with [177Lu]Lu–PSMA-617 or cabazitaxel in the randomized phase 2 TheraP trial, low ctDNA levels at baseline were predictive of clinical benefit from [177Lu]Lu–PSMA-617, and PTEN or ATM alterations were identified as potential biomarkers of response.

    • Edmond M. Kwan
    • Sarah W. S. Ng
    • Alison Y. Zhang
    Research
    Nature Medicine
    Volume: 31, P: 2722-2736
  • Bleaching threatens corals worldwide as the oceans warm from climate change. Here the authors provide insight into intergenerational acclimatization potential by identifying metabolomic signatures of coral resistance to bleaching at all stages of development, including in the new generation.

    • Ty N. F. Roach
    • Crawford Drury
    • Robert A. Quinn
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

    • Constance H. Li
    • Stephenie D. Prokopec
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-24
  • Despite exporting nutrient-rich seafood, developing countries import seafood with higher nutrient density per dollar than developed nations. These nutritional bargains are linked to differences in processing and product forms of traded seafood.

    • Yaqin Liu
    • Martin D. Smith
    • Tsugumi Yamashita
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • Scintillators are used for converting X-ray energy into visible light in imaging technologies. Here, the authors present a scalable fabrication approach for large-area nanostructured scintillators, and achieve six-fold enhancement in light yield compared to unpatterned scintillators.

    • Louis Martin-Monier
    • Simo Pajovic
    • Charles Roques-Carmes
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-8
  • Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

    • Cristian Pattaro
    • Alexander Teumer
    • Caroline S. Fox
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-19
  • A pulse of ocean acidification is reconstructed from the boron isotope composition of fossilized oysters at the Triassic-Jurassic boundary, implicating ocean acidification from volcanic outgassing as a kill mechanism during the extinction event.

    • Molly Trudgill
    • James W. B. Rae
    • Sarah E. Greene
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • A remora-inspired mechanical underwater adhesive device adheres securely to a range of soft substrates and maintains performance under extreme pH and moisture conditions, with potential applications in biosensing and drug delivery.

    • Ziliang Kang
    • Johanna A. Gomez
    • Giovanni Traverso
    ResearchOpen Access
    Nature
    Volume: 643, P: 1271-1280
  • A study demonstrates a public generator of random numbers based on device-independent techniques, with the randomness being fully auditable and traceable.

    • Gautam A. Kavuri
    • Jasper Palfree
    • Lynden K. Shalm
    Research
    Nature
    Volume: 642, P: 916-921
  • Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

    • Moritz Gerstung
    • Clemency Jolly
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 122-128
  • Alatrakchi and colleagues profile immune cells from liver and blood obtained from patients with MASLD/MASH using single-cell sequencing. They note increased immunoregulatory programs that correlated with increased fibrogenesis and disease progression.

    • Owen P. Martin
    • Michael S. Wallace
    • Nadia Alatrakchi
    Research
    Nature Immunology
    Volume: 26, P: 1596-1611
  • Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.

    • Itziar de Rojas
    • Sonia Moreno-Grau
    • Agustín Ruiz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16