Nature Search

Electronic tuning of RuO₂ polarizes metal–oxygen redox for proton exchange membrane water electrolysis

Anode catalysts in proton-exchange-membrane water electrolyzers usually trade activity for stability. Here, the authors report an electronic-structure-tuning strategy that modulates the metal–oxygen redox behavior of RuO₂, yielding a catalyst that is both highly active and durable.

Xingen Lin
Peigen Liu
Yuen Wu
ResearchOpen Access30 Sept 2025
Nature Communications

Volume: 16, P: 1-12
Spotiphy enables single-cell spatial whole transcriptomics across an entire section

Spotiphy (spot imager with pseudo-single-cell-resolution histology) is a computational toolkit that transforms sequencing-based spatially resolved transcriptomics data into whole-transcriptome images with single-cell resolution.

Jiyuan Yang
Ziqian Zheng
Jiyang Yu
ResearchOpen Access12 Mar 2025
Nature Methods

Volume: 22, P: 724-736
Tetraspanin-enriched membrane domains regulate vascular leakage by altering membrane cholesterol accessibility to balance antagonistic GTPases

By regulating the level of accessible cholesterol on endothelial cells via OSBP/ORP-mediated transport, tetraspanin tunes the balance of Cdc42 and RhoA activities to affect vascular inflammation. Reducing accessible cholesterol by statin treatment or blocking its non-vesicular transport by OSBP/ORP inhibition can limit vascular inflammation.

Yingjun Ding
Junxiong Chen
Xin A. Zhang
Research29 Jul 2025
Nature Cardiovascular Research

Volume: 4, P: 1011-1033
scMINER: a mutual information-based framework for clustering and hidden driver inference from single-cell transcriptomics data

Single-cell data analysis is challenging due to inherent noise and sparsity. Here, authors introduce scMINER, a mutual information-based integrative tool to enhance clustering and reveal regulatory networks and hidden biological drivers by transforming scRNA-seq expression into activity profiles.

Qingfei Pan
Liang Ding
Jiyang Yu
ResearchOpen Access08 May 2025
Nature Communications

Volume: 16, P: 1-20
RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome homeostasis in astrocytes

LRRK2 variants are linked to Parkinson’s disease. Here, the authors solve the Cryo-EM structure of LRRK2 complexed to RAB12 and demonstrate that their interaction regulates cilia formation in astrocytes.

Xingjian Li
Hanwen Zhu
Zhenyu Yue
ResearchOpen Access29 Sept 2024
Nature Communications

Volume: 15, P: 1-16
Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation

Cyclic GMP-AMP synthase (cGAS) is critical in modulating cellular inflammation. Here, the authors report a class of cyclopeptide inhibitors of cGAS targeting protein DNA interaction and phase separation.

Xiaoquan Wang
Youqiao Wang
Junmin Quan
ResearchOpen Access02 Oct 2023
Nature Communications

Volume: 14, P: 1-14
Modular chimeric cytokine receptors with leucine zippers enhance the antitumour activity of CAR T cells via JAK/STAT signalling

Replacing the extracellular domains of heterodimeric cytokine receptors in chimeric antigen receptor T cells with two leucine zipper motifs leads to optimal JAK/STAT signalling and augments the effector function of the T cells.

Matthew Bell
Shannon Lange
Stephen Gottschalk
Research30 Nov 2023
Nature Biomedical Engineering

Volume: 8, P: 380-396
Research on high-precision localization method for transport robots in industrial environments based on Improved AMCL and QR code assistance

Siyu Chen
Tingping Feng
Simon X. Yang
ResearchOpen Access20 Feb 2025
Scientific Reports

Volume: 15, P: 1-20
Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function

Mouse models expressing liver apoE in the absence of brain apoE reveal detrimental effects of peripheral apoE4 associated with Alzheimer’s risk on cognition and amyloid pathology through compromising vascular integrity and function.

Chia-Chen Liu
Jing Zhao
Guojun Bu
Research01 Aug 2022
Nature Neuroscience

Volume: 25, P: 1020-1033
The Relationship between blood pressure parameters and left ventricular output in neonates

Ashraf Kharrat
Daniel Ibarra Rios
Amish Jain
Research15 Feb 2019
Journal of Perinatology

Volume: 39, P: 619-625
Ciliary transition zone proteins coordinate ciliary protein composition and ectosome shedding

Cilia project from cells to serve sensory functions, and ciliary disruption can result in multiple disorders known as ciliopathies. Here the authors show that the ciliopathy gene TCTN1 functions to regulate the ciliary transition zone and ectosome formation.

Liang Wang
Xin Wen
Muqing Cao
ResearchOpen Access09 Jul 2022
Nature Communications

Volume: 13, P: 1-14
Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia

Yang and colleagues perform a network system–pharmacology approach and clinical data integration, and identify LCK and BCL2 signaling as the molecular determinants of dasatinib response in pediatric and adult patients with T-ALL.

Yoshihiro Gocho
Jingjing Liu
Jun J. Yang
Research21 Jan 2021
Nature Cancer

Volume: 2, P: 284-299
A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation

Overexpression of human antigen R (HuR) correlates with high grade tumours and poor patient prognosis. Here, the authors engineer a TRIM21 biological PROTAC to demonstrate the benefit of a targeted protein degradation approach to deplete HuR, resulting in tumour growth inhibition in pre-clinical cancer models by altering the HuR-regulated proteome.

Alice Fletcher
Dean Clift
James Hunt
ResearchOpen Access04 Nov 2023
Nature Communications

Volume: 14, P: 1-14
CXCR6 orchestrates brain CD8⁺ T cell residency and limits mouse Alzheimer’s disease pathology

Chi and colleagues identify brain-resident CXCR6⁺PD-1⁺CD8⁺ T cells that interact with resident microglia to limit immune-mediated pathology in a mouse model of Alzheimer’s disease.

Wei Su
Jordy Saravia
Hongbo Chi
Research07 Sept 2023
Nature Immunology

Volume: 24, P: 1735-1747
Structural basis for the inhibition of Polo-like kinase 1

The activity of PLK1, a key mitotic regulator, is tightly regulated during the cell cycle through both phosphorylation and protein-protein interactions. The crystal structure of PLK1's kinase domain bound to the polo-box domain now provides a structural framework for the regulation of PLK1 through autoinhibition.

Jun Xu
Chen Shen
Junmin Quan
Research28 Jul 2013
Nature Structural & Molecular Biology

Volume: 20, P: 1047-1053
Surface-substituted Prussian blue analogue cathode for sustainable potassium-ion batteries

Aqueous potassium-ion batteries have emerged as a more sustainable technology to complement lithium-ion counterparts. Ge et al. engineer the surface of a potassium manganese hexacyanoferrate cathode material, achieving unprecedented electrochemical performance in full K-ion cells.

Junmin Ge
Ling Fan
Bingan Lu
Research13 Dec 2021
Nature Sustainability

Volume: 5, P: 225-234
Geometric regulation of histone state directs melanoma reprogramming

Junmin Lee et al. study the role of geometric features at the perimeter regions of melanoma aggregates in programming stem cell-like state through histone marks. They use a tumor microengineering approach in vitro and report a spatial enrichment of histone modifications with stemness markers. Their work uncovers a mechanotransduction signaling that regulates epigenetic modifiers to regulate tumorigenicity.

Junmin Lee
Thomas G. Molley
Kristopher A. Kilian
ResearchOpen Access03 Jul 2020
Communications Biology

Volume: 3, P: 1-9
Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging

Sarcopenia is the age-associated functional decline and atrophy of muscle fibers, and it has been proposed that it might be counteracted by inducing myofiber hypertrophy. Here, the authors show that expression levels of the ubiquitin ligase UBR4 are increased with ageing, and that whilst its genetic ablation rescues muscle atrophy, it is also associated with reduced protein quality and impaired force production in Drosophila and mouse models.

Liam C. Hunt
Bronwen Schadeberg
Fabio Demontis
ResearchOpen Access03 Mar 2021
Nature Communications

Volume: 12, P: 1-18
CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity

CRISPR screening and protein–protein interaction networks identify components and mechanisms of nutrient-dependent mTORC1 signalling in regulatory T cells and reveal how mTORC1 integrates immunological cues and nutrient signals for adaptive immunity.

Lingyun Long
Jun Wei
Hongbo Chi
Research18 Nov 2021
Nature

Volume: 600, P: 308-313
Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase

High-throughput screening and structure-guided design identified small-molecule inhibitors that prevent the interaction between N-terminally acetylated E2 conjugating enzyme UBE2M and DCN1, an E3 ligase for the ubiquitin-like protein Nedd8.

Daniel C Scott
Jared T Hammill
R Kip Guy
Research05 Jun 2017
Nature Chemical Biology

Volume: 13, P: 850-857
Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a

Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a.

Ying Cheng
Zhi-Meng Wang
Peng Jin
Research05 Nov 2018
Nature Neuroscience

Volume: 21, P: 1689-1703
CircTADA2A stabilizes p53 via interacting with TRIM28 and suppresses the maintenance of FLT3-ITD acute myeloid leukemia

Ran Li
Xiaolu Wu
Junmin Li
Research02 Apr 2025
Leukemia

Volume: 39, P: 1351-1361
Phase-pure two-dimensional layered perovskite thin films

Two-dimensional perovskites with phase-pure structures have considerable potential for optoelectronic applications because of their reduced defects, flattened energy landscape and enhanced lattice protection. This Perspective article investigates advancing progress on achieving phase-pure perovskite by tailoring the precursor interactions and preparation methods and discusses their prominent optoelectronic properties and applications.

Hao Gu
Junmin Xia
Guichuan Xing
Reviews10 May 2023
Nature Reviews Materials

Volume: 8, P: 533-551
Multimodal joint deconvolution and integrative signature selection in proteomics

Presenting a deconvolution algorithm to dissect the bulk proteome by leveraging the information shared between the transcriptome and proteome, the output can be used for further downstream analyses, such as cs-protein Quantitative Trait Loci (cspQTL) mapping and cell type-specific pathology.

Yue Pan
Xusheng Wang
Qian Li
ResearchOpen Access24 Apr 2024
Communications Biology

Volume: 7, P: 1-9
Histone deacetylase inhibition enhances extracellular vesicles from muscle to promote osteogenesis via miR-873-3p

Ming Chen
Yi Li
Peifu Tang
ResearchOpen Access30 Sept 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-19
Superficial vimentin mediates DENV-2 infection of vascular endothelial cells

Jie Yang
Lingyun Zou
Xiancai Rao
ResearchOpen Access02 Dec 2016
Scientific Reports

Volume: 6, P: 1-12
Ca²⁺-mediated mitochondrial inner membrane permeabilization induces cell death independently of Bax and Bak

Giovanni Quarato
Fabien Llambi
Douglas R. Green
Research20 Jun 2022
Cell Death & Differentiation

Volume: 29, P: 1318-1334
Ceramides and sphingosine-1-phosphate mediate the distinct effects of M1/M2-macrophage infusion on liver recovery after hepatectomy

Hang Sun
Shibo Sun
Kai Wang
ResearchOpen Access26 Mar 2021
Cell Death & Disease

Volume: 12, P: 1-16
Structural basis for dimerization of the death effector domain of the F122A mutant of Caspase-8

Chen Shen
Jianwen Pei
Junmin Quan
ResearchOpen Access13 Nov 2018
Scientific Reports

Volume: 8, P: 1-10
Indoor wet cells as a habitat for melanized fungi, opportunistic pathogens on humans and other vertebrates

Xiaofang Wang
Wenying Cai
Sybren de Hoog
ResearchOpen Access16 May 2018
Scientific Reports

Volume: 8, P: 1-10
The first Conus genome assembly reveals a primary genetic central dogma of conopeptides in C. betulinus

Chao Peng
Yu Huang
Qiong Shi
ResearchOpen Access23 Feb 2021
Cell Discovery

Volume: 7, P: 1-14

Search

Electronic tuning of RuO₂ polarizes metal–oxygen redox for proton exchange membrane water electrolysis

Spotiphy enables single-cell spatial whole transcriptomics across an entire section

Tetraspanin-enriched membrane domains regulate vascular leakage by altering membrane cholesterol accessibility to balance antagonistic GTPases

scMINER: a mutual information-based framework for clustering and hidden driver inference from single-cell transcriptomics data

RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome homeostasis in astrocytes

Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation

Modular chimeric cytokine receptors with leucine zippers enhance the antitumour activity of CAR T cells via JAK/STAT signalling

Research on high-precision localization method for transport robots in industrial environments based on Improved AMCL and QR code assistance

Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function

The Relationship between blood pressure parameters and left ventricular output in neonates

Ciliary transition zone proteins coordinate ciliary protein composition and ectosome shedding

Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia

A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation

CXCR6 orchestrates brain CD8⁺ T cell residency and limits mouse Alzheimer’s disease pathology

Structural basis for the inhibition of Polo-like kinase 1

Surface-substituted Prussian blue analogue cathode for sustainable potassium-ion batteries

Geometric regulation of histone state directs melanoma reprogramming

Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging

CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity

Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase

Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a

CircTADA2A stabilizes p53 via interacting with TRIM28 and suppresses the maintenance of FLT3-ITD acute myeloid leukemia

Phase-pure two-dimensional layered perovskite thin films

Multimodal joint deconvolution and integrative signature selection in proteomics

Histone deacetylase inhibition enhances extracellular vesicles from muscle to promote osteogenesis via miR-873-3p

Superficial vimentin mediates DENV-2 infection of vascular endothelial cells

Ca²⁺-mediated mitochondrial inner membrane permeabilization induces cell death independently of Bax and Bak

Ceramides and sphingosine-1-phosphate mediate the distinct effects of M1/M2-macrophage infusion on liver recovery after hepatectomy

Structural basis for dimerization of the death effector domain of the F122A mutant of Caspase-8

Indoor wet cells as a habitat for melanized fungi, opportunistic pathogens on humans and other vertebrates

The first Conus genome assembly reveals a primary genetic central dogma of conopeptides in C. betulinus

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