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In this work, the authors report that citronellal stimulates skin renewal by promoting keratinocyte proliferation through the activation of TRPV3. Structural and functional analysis elucidate that essential oil ligands activate TRPV3 channels by competitively displacing endogenous lipids from the vanilloid site. These findings can help move skin healthcare forward.

Huber and colleagues utilize a multi-omic analytical pipeline to define an axis of proliferative drive involving mTOR, MYC and OXPHOS metabolic activity that is associated with disease heterogeneity and outcome in clinical cohorts of CLL.

An annually resolved 3476-year tree-ring record from the Tibetan Plateau reveals severe 20^th century droughts and highlights the interplay between the Asian Monsoon and Westerlies. Droughts are often linked to the collapse of dynasties.

The sterile insect technique involves the introduction of sterile males to induce sterility in females and reduce population size. Here, the authors show that sterile males may also reduce female density and inhibit female blood feeding through mating harassment.

NOTCH mutations are frequent in B cell malignancies. Here the authors use retroviral transduction of primary malignant B cells from Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL) patients to show that NOTCH1/2-mutations facilitate mechanism of immune escape.

Brassica oleracea is plant species comprising economically important vegetable crops. Here, the authors report the draft genome sequence of B. oleracea and, through a comparative analysis with the closely related B. rapa, reveal insights into Brassicaevolution and divergence of interspecific genomes and intraspecific subgenomes.

Ni-based catalysts are highly reactive for DRM, but they tend to deactivate quickly due to sintering and/or coking. Here a simple method for anchoring dispersed Ni sites in dealuminated Beta zeolite, enhancing metal-support interactions, results in a catalyst with superior stability and performance for DRM.

X-ray crystallographic analysis of thymine DNA glycosylase (TDG) in complex with DNA containing 5-carboxylcytosine (5caC) analogs reveals that 5caC is a preferred substrate of TDG, providing support for a 5-methylcytosine demethylation pathway involving 5-methylcytosine oxidation and removal by base-excision repair glycosylases.

Liebers and colleagues present a prospective non-interventional trial in 80 individuals with hematologic cancer investigating the potential of ex vivo drug response profiling and show it to be clinically feasible.

Proteomics can be used to refine cancer classification. Here, the authors characterise chronic lymphocytic leukaemia patients by proteogenomics, and identified a subtype of patients with poor prognosis associated with aberrant B cell receptor signalling.

De novo genome assemblies of 12 species from Aurantioideae and pangenome analyses provide insights into the origin and evolution of the orange subfamily and the genetic basis of flavor in citrus fruits.

G protein-coupled receptors (GPCRs) are a critical target in modern drug development across a wide range of indications. Here the authors provide a comprehensive characterization of a typical GPCR, the angiotensin II (AngII) type 1 receptor (AT1R), and provide insight into its activation mechanism that suggest avenues for the design of allosteric GPCR modulators.

Immunoglobulin (Ig) rearrangement and translocation information are usually obtained by targeted sequencing of the respective loci. Here, the authors present the IgCaller algorithm, which extracts Ig heavy and light chain genetic properties from short-read whole-genome sequencing results to provide a feasible alternative to direct sequencing.

The study reconstructed Holocene seasonal temperatures using 1,310 pollen records covering the Northern Hemisphere landmass, and show that both summer and winter temperatures peaked at ~7 ka BP, but with significant spatial variability.

S-nitrosylation can influence many pathophysiological processes. Here the authors show that the coupling efficiency of GNAI2 with CXCR5 is enhanced by S-nitrosylation of GNAI2, leading to Hippo-YAP dysfunction in endothelium, and plays a role in diabetes-accelerated atherosclerosis.

Martin-Subero and colleagues analyze DNA methylation patterns in B-cell tumors and their normal cells of origin, and develop epiCMIT, a methylation-based mitotic clock with prognostic relevance.

In DNA demethylation, human TET proteins are evolutionarily tuned to be less reactive towards 5hmC and facilitate its generation as a potentially stable mark for regulatory functions.

Copper is a transition metal ion essential for the regulation of cellular oxidative stress and ATP production. Now, the inhibition of copper-trafficking proteins by a small molecule has been shown to significantly reduce proliferation of cancer cells. The results indicate that copper-trafficking proteins could represent new anti-tumour therapeutic targets.

Fingolimod is a sphingosine-1 phosphate (S1P) receptor modulator and an immune modulator in use as a treatment for the remitting-relapsing form of multiple sclerosis. Hait et al. show that the active form of fingolimod can inhibit neuronal class I histone deacetylases (HDACs), modulate gene expression in the brain and facilitate memory extinction. The authors also show spatial and associative memory deficits in mutant mice lacking the enzyme necessary for formation of the active form of fingolimod.

Haematopoiesis and the generation of lymphoid cell subsets are controlled by delicate genetic programs enforced via epigenetic regulation. Here the authors show that Pcid2 interacts with ZNHIT1, a component of the SRCAP chromatin remodelling complex, to critically modulate the differentiation of multipotent progenitors.

Colella, Wongnak et al. test pet dogs and cats from metropolitan areas of eight countries in East and Southeast Asia for zoonotic parasites. The authors identify factors associated with potential exposure to zoonotic parasites, including animal characteristics and human living conditions.