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Showing 1–50 of 193 results

Advanced filters: Author: Kenji Hashimoto Clear advanced filters

Correction: Central-peripheral neuroimmune dynamics in psychological stress and depression: insights from current research

Xiao Feng
Min Jia
Jian-Jun Yang
Amendments and CorrectionsOpen Access15 Sept 2025
Molecular Psychiatry

P: 1
Correction: Cardiovascular diseases and depression: A meta-analysis and Mendelian randomization analysis

Jun Zeng
Yuting Qiu
Yan Wei
Amendments and CorrectionsOpen Access14 May 2025
Molecular Psychiatry

Volume: 30, P: 4444
An Apparatus for High Speed Measurements of Small-Angle X-Ray Scattering Profiles with a Linear Position Sensitive Detector

Takeji Hashimoto
Shoji Suehiro
Hiromichi Kawai
Research01 May 1981
Polymer Journal

Volume: 13, P: 501-516
Erratum: Parthenogenetic activation of oocytes in c-mos-deficient mice

Naohiro Hashimoto
Nobumoto Watanabe
Shinichi Aizawa
Amendments and Corrections04 Aug 1994
Nature

Volume: 370, P: 391
Parthenogenetic activation of oocytes in c-mos-deficient mice

Naohiro Hashimoto
Nobumoto Watanabe
Shinichi Aizawai
Research07 Jul 1994
Nature

Volume: 370, P: 68-71
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Cardiovascular diseases and depression: A meta-analysis and Mendelian randomization analysis

Jun Zeng
Yuting Qiu
Yan Wei
ResearchOpen Access17 Apr 2025
Molecular Psychiatry

Volume: 30, P: 4234-4246
Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice

Sepsis-associated encephalopathy (SAE) is a severe and often fatal consequence of sepsis. Here authors show in a mouse model of sepsis that γδ T17 cells, migrating from the small intestine to the meninges, play a pathological role via activation of STING in microglia, leading to an increase in C1q-tagged synapses, which are subsequently pruned.

Yuming Wu
Yujing Zhang
Jiancheng Zhang
ResearchOpen Access23 Jul 2025
Nature Communications

Volume: 16, P: 1-18
Topology meets time-reversal symmetry breaking in FeSe_1−xTe_x superconductors

The authors employ zero-field muon spin relaxation to study time-reversal symmetry breaking (TRSB) in FeSe_1−xTe_x. For x = 0.64 with the highest superconducting transition temperature T_c = 14.5 K, which is known to host a topological surface state and Majorana zero modes within vortices, they find a TRSB superconducting state in the bulk.

Masaki Roppongi
Yipeng Cai
Takasada Shibauchi
ResearchOpen Access23 Jul 2025
Nature Communications

Volume: 16, P: 1-8
Author Correction: Topology meets time-reversal symmetry breaking in FeSe_1−xTe_x superconductors

Masaki Roppongi
Yipeng Cai
Takasada Shibauchi
Amendments and CorrectionsOpen Access05 Aug 2025
Nature Communications

Volume: 16, P: 1
Phencyclidine-Induced Cognitive Deficits in Mice are Improved by Subsequent Subchronic Administration of Fluvoxamine: Role of Sigma-1 Receptors

Kenji Hashimoto
Yuko Fujita
Masaomi Iyo
Research22 Feb 2006
Neuropsychopharmacology

Volume: 32, P: 514-521
Rac1 is required for the formation of three germ layers during gastrulation

Kazuhiro Sugihara
Norio Nakatsuji
Motoya Katsuki
Research13 Jan 1999
Oncogene

Volume: 17, P: 3427-3433
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

Duško llić
Yasuhide Furuta
Shinichi Aizawa
Research12 Oct 1995
Nature

Volume: 377, P: 539-544
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Central-peripheral neuroimmune dynamics in psychological stress and depression: insights from current research

Xiao Feng
Min Jia
Jian-Jun Yang
ReviewsOpen Access03 Jul 2025
Molecular Psychiatry

Volume: 30, P: 4881-4898
A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance

Glutamate transporters mediate neurotransmitter reuptake at glutamatergic synapses. Here the authors show that CDC42 effector protein CDC42EP4 supports efficient glutamate clearance by promoting the tethering of a glutamate transporter GLAST to perisynaptic clusters of septins in Bergmann glia.

Natsumi Ageta-Ishihara
Maya Yamazaki
Makoto Kinoshita
ResearchOpen Access10 Dec 2015
Nature Communications

Volume: 6, P: 1-16
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
A protein language model for exploring viral fitness landscapes

Ito et al. present CoVFit, an AI model that predicts variant fitness (transmissibility) from spike protein sequences alone. They further demonstrate its utility in forecasting viral evolution via single amino acid mutations.

Jumpei Ito
Adam Strange
Kei Sato
ResearchOpen Access13 May 2025
Nature Communications

Volume: 16, P: 1-16
Differential brain volume between obese and underweight cognitively normal older adults with frailty in the JPSC-AD

Naoki Ishizuka
Hiroshi Akasaka
Yutaka Kiyohara
ResearchOpen Access04 Jun 2025
Scientific Reports

Volume: 15, P: 1-12
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Scalable preparation of furanosteroidal viridin, β-viridin and viridiol from Trichoderma virens

Wen Zhang
Kazu Sunami
Yuta Murai
ResearchOpen Access24 Jan 2025
Scientific Reports

Volume: 15, P: 1-8
Association between diaphragm excursion and whole-body muscle mass in older adults: an observational study

Shuji Ouchi
Toru Yamada
Masayoshi Hashimoto
ResearchOpen Access03 Jul 2025
Scientific Reports

Volume: 15, P: 1-8
Relevance of pepsinogen, gastrin, and endoscopic atrophy in the diagnosis of autoimmune gastritis

Hiroshi Kishikawa
Kenji Nakamura
Jiro Nishida
ResearchOpen Access10 Mar 2022
Scientific Reports

Volume: 12, P: 1-12
Author Correction: High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade

Kobe C. Yuen
Li-Fen Liu
Sanjeev Mariathasan
Amendments and Corrections05 Feb 2021
Nature Medicine

Volume: 27, P: 560
Unveiling unique expression patterns of D20S16 satellite DNA in human embryonic development

Yajie Hu
Kenji Mizuguchi
Kosuke Hashimoto
ResearchOpen Access23 Jul 2025
Scientific Reports

Volume: 15, P: 1-14
Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant

XBB.1.5 of SARS-CoV-2 is a descendant of XBB.1 and has mutations in spike and ORF8, making it more infectious to humans. Here, the authors examined in detail the differences in virological properties of the two variants.

Tomokazu Tamura
Takashi Irie
Takasuke Fukuhara
ResearchOpen Access08 Feb 2024
Nature Communications

Volume: 15, P: 1-17
Mathematical mechanistic model representing the cancer immunity cycle under radiation effects

Taisuke Takayanagi
Koichi Miyazaki
Kenji Chamoto
ResearchOpen Access06 Jun 2025
Scientific Reports

Volume: 15, P: 1-14
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Minocycline Attenuates Hyperlocomotion and Prepulse Inhibition Deficits in Mice after Administration of the NMDA Receptor Antagonist Dizocilpine

Lin Zhang
Yukihiko Shirayama
Kenji Hashimoto
Research17 Jan 2007
Neuropsychopharmacology

Volume: 32, P: 2004-2010
Adenosine A₁ Receptor Agonists Block the Neuropathological Changes in Rat Retrosplenial Cortex after Administration of the NMDA Receptor Antagonist Dizocilpine

Naoe Okamura
Kenji Hashimoto
Masaomi Iyo
Research05 Nov 2003
Neuropsychopharmacology

Volume: 29, P: 544-550
Effects of Age and Gender on the Expression of Brain-Derived Neurotrophic Factor mRNA in Rat Retrosplenial Cortex Following Administration of Dizocilpine

Hideyuki Matsuki
Yukihiko Shirayama
Yoshio Minabe
Research01 Aug 2001
Neuropsychopharmacology

Volume: 25, P: 258-266
Enzymologic Studies and Therapy of Leigh's Disease Associated with Pyruvate Decarboxylase Deficiency

Kenji Toshima
Yasuhiro Kuroda
Kunio Ii
Research01 Jun 1982
Pediatric Research

Volume: 16, P: 430-435
Possible role of the gut microbiota–brain axis in the antidepressant effects of (R)-ketamine in a social defeat stress model

Chun Yang
Youge Qu
Kenji Hashimoto
ResearchOpen Access18 Dec 2017
Translational Psychiatry

Volume: 7, P: 1-11
Structural basis for receptor-binding domain mobility of the spike in SARS-CoV-2 BA.2.86 and JN.1

JN.1 lineage is a globally dominant variant of SARS-CoV-2. Here, the authors examine structural insights into the BA.2.86 and JN.1 spike dynamics to help understand the mechanisms underlying SARS-CoV-2 infection and its neutralizing-antibody evasion.

Hisano Yajima
Yuki Anraku
Takao Hashiguchi
ResearchOpen Access07 Oct 2024
Nature Communications

Volume: 15, P: 1-14
Correction: Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine

Wei Yao
Qianqian Cao
Ji-chun Zhang
Amendments and CorrectionsOpen Access08 Dec 2021
Molecular Psychiatry

Volume: 27, P: 1630
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Relationship between Augmentation Index and Flow-Mediated Vasodilation in the Brachial Artery

Junko Soga
Shuji Nakamura
Yukihito Higashi
Research01 Jul 2008
Hypertension Research

Volume: 31, P: 1293-1298
Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas

The EWS-ATF1 fusion gene causes clear cell sarcoma (CCS). Here, the authors show that the downstream effects of EWS-ATF1 expression are strictly context dependent, and reveal the cell of origin for CCS to be Tppp3-expressing cells in peripheral nerves.

Shingo Komura
Kenji Ito
Yasuhiro Yamada
ResearchOpen Access05 Sept 2019
Nature Communications

Volume: 10, P: 1-19
Antihypertensive Efficacy and Safety of Fixed-Dose Combination Therapy with Losartan plus Hydrochlorothiazide in Japanese Patients with Essential Hypertension

Takao Saruta
Toshio Ogihara
Kihito Takahashi
Research01 Aug 2007
Hypertension Research

Volume: 30, P: 729-739
The complement C3-complement factor D-C3a receptor signalling axis regulates cardiac remodelling in right ventricular failure

Right ventricular (RV) failure is clinically crucial, but there is no specific therapy. Here, the authors show that the complement alternative pathway is activated in RV failure and that blockade of the pathway ameliorates RV failure in mice.

Shogo Ito
Hisayuki Hashimoto
Shinsuke Yuasa
ResearchOpen Access15 Sept 2022
Nature Communications

Volume: 13, P: 1-12
Killer immunoglobulin-like receptor genotype did not correlate with response to anti-PD-1 antibody treatment in a Japanese cohort

Yoshihiro Ishida
Chisa Nakashima
Kenji Kabashima
ResearchOpen Access29 Oct 2018
Scientific Reports

Volume: 8, P: 1-6
Lack of metabolism in (R)-ketamine’s antidepressant actions in a chronic social defeat stress model

Kai Zhang
Yuko Fujita
Kenji Hashimoto
ResearchOpen Access05 Mar 2018
Scientific Reports

Volume: 8, P: 1-8
Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

XBB is the first recombinant, globally dominant variant of SARS-CoV-2. Here, the authors examine the variant’s origins and virological properties, showing it is the first example of SARS-CoV-2 improving its fitness through recombination.

Tomokazu Tamura
Jumpei Ito
Kei Sato
ResearchOpen Access16 May 2023
Nature Communications

Volume: 14, P: 1-20
Catalytic mechanism and endo-to-exo selectivity reversion of an octalin-forming natural Diels–Alderase

Enzymatic Diels–Alder reactions are of high synthetic interest, but mechanistic insights remain scarce. Now, a structure of the Diels–Alderase CghA in complex with its product is reported, a catalytic mechanism proposed and the enzyme is engineered to form the energetically disfavoured exo adduct.

Michio Sato
Shinji Kishimoto
Kenji Watanabe
Research01 Mar 2021
Nature Catalysis

Volume: 4, P: 223-232
B cell-derived GABA elicits IL-10⁺ macrophages to limit anti-tumour immunity

A paper in Nature demonstrates that B cell-derived GABA promotes monocyte differentiation into anti-inflammatory macrophages able to limit anti-tumour T cell cytotoxicity.

Baihao Zhang
Alexis Vogelzang
Sidonia Fagarasan
ResearchOpen Access03 Nov 2021
Nature

Volume: 599, P: 471-476
Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin

How APCs encounter T cells in the periphery remains unclear. Kabashima and colleagues show that dendritic cells form macrophage-dependent clusters in dermal perivascular areas for efficient in situ proliferation and activation of T cells.

Yohei Natsuaki
Gyohei Egawa
Kenji Kabashima
Research21 Sept 2014
Nature Immunology

Volume: 15, P: 1064-1069
Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study

Norio Okada
Shintaro Iwama
Hiroshi Arima
ResearchOpen Access03 Feb 2020
British Journal of Cancer

Volume: 122, P: 771-777

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