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Showing 1–50 of 245 results

Advanced filters: Author: L Hartwell Clear advanced filters

RBM39 degrader invigorates innate immunity to eradicate neuroblastoma despite cancer cell plasticity

Cell state plasticity of neuroblastoma cells is linked to therapy resistance. Here, the authors develop a transcriptomic and epigenetic map of indisulam (RBM39 degrader) resistant neuroblastoma, demonstrating bidirectional cell state switching accompanied by increased NK cell activity, which they therapeutically enhance by the addition of an anti-GD2 antibody.

Shivendra Singh
Jie Fang
Jun Yang
ResearchOpen Access17 Sept 2025
Nature Communications

Volume: 16, P: 1-26
A bifunctional gene product involved in two phases of the yeast cell cycle

J. R. Piggott
R. Rai
B. L. A. Carter
Research22 Jul 1982
Nature

Volume: 298, P: 391-393
Genetic control of cell division in yeast cultured at different growth rates

M. N. JAGADISH
B. L. A. CARTER
Research01 Sept 1977
Nature

Volume: 269, P: 145-147
Recovery of Yeast from Transient Inhibition of DNA Synthesis

M. L. SLATER
Research01 Feb 1974
Nature

Volume: 247, P: 275-276
Replication of Yeast Chromosomal DNA

CAROL SHAW NEWLON
THOMAS D. PETES
WALTON L. FANGMAN
Research04 Jan 1974
Nature

Volume: 247, P: 32-35
Induction of yeast mating pheromone a-factor by α cells

Joan R. Strazdis
Vivian L. MacKay
Research06 Oct 1983
Nature

Volume: 305, P: 543-545
Genes which control cell proliferation in the yeast Saccharomyces cerevisiae

Peter E. Sudbery
Andrew R. Goodey
Bruce L. A. Carter
Research27 Nov 1980
Nature

Volume: 288, P: 401-404
Contribution of Deoxymethylpentoses to the Serological Specificity of Some Bacterial Polysaccharides, and the Recognition of a New Sugar, Paratose

D. A. L. DAVIES
A. M. STAUB
O. WESTPHAL
Research22 Mar 1958
Nature

Volume: 181, P: 822-823
Negative ions in the coma of comet Halley

P. Chaizy
H. Rème
D. A. Mendis
Research31 Jan 1991
Nature

Volume: 349, P: 393-396
A continuously oxygenated macroencapsulation system enables high-density packing and delivery of insulin-secreting cells

Insufficient oxygen limits the efficacy of cell encapsulation therapies for type 1 diabetes. Here, the authors develop an implantable system that continuously generates oxygen to support high-density islet cell survival and function, enabling diabetes reversal in rats without immunosuppression.

Tung T. Pham
Phuong L. Tran
Minglin Ma
ResearchOpen Access11 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Antineoplastic Components of Marine Animals

GEORGE R. PETTIT
JOHN F. DAY
HARRY B. WOOD
Research29 Aug 1970
Nature

Volume: 227, P: 962-963
Effect of chromosomal position on amplification of transfected genes in animal cells

Geoffrey M. Wahl
Bruno Robert de Saint Vincent
Margaret L. DeRose
Research09 Feb 1984
Nature

Volume: 307, P: 516-520
Structure–based rescue of common tumor–derived p53 mutants

Ania M. Wieczorek
Jennifer L.F. Waterman
Thanos D. Halazonetis
Research01 Oct 1996
Nature Medicine

Volume: 2, P: 1143-1146
Model calculations of the relative effects of CFCs and their replacements on stratospheric ozone

Donald A. Fisher
Charles H. Hales
Frode Stordal
Research05 Apr 1990
Nature

Volume: 344, P: 508-512
Lignans in man and in animal species

K. D. R. Setchell
A. M. Lawson
M. Axelson
Research23 Oct 1980
Nature

Volume: 287, P: 740-742
An unexpected protein interaction promotes drug resistance in leukemia

ABCC4 is a chemotherapeutic drug exporter highly expressed in acute myeloid leukemia. Here, the authors demonstrate that MPP1 anchors ABCC4 to the outer cell membrane mediating drug resistance in leukemic cells and identify antimycin A as a chemical probe that disrupts such interaction and restores sensitivity.

Aaron Pitre
Yubin Ge
John D. Schuetz
ResearchOpen Access16 Nov 2017
Nature Communications

Volume: 8, P: 1-14
Cell checkpoint and radiosensitivity

John P. Murnane
Jeffrey L. Schwartz
Research02 Sept 1993
Nature

Volume: 365, P: 22
Global climate change and US agriculture

Richard M. Adams
Cynthia Rosenzweig
L. Hartwell Allen Jr
Research17 May 1990
Nature

Volume: 345, P: 219-224
House dust and inorganic urinary arsenic in two Arizona mining towns

Tracy A Hysong
Jefferey L Burgess
Mary Kay O'Rourke
Research13 May 2003
Journal of Exposure Science & Environmental Epidemiology

Volume: 13, P: 211-218
Phagocytosis in Mammalian Hair

L. P. S. PIPER
Research01 Feb 1967
Nature

Volume: 213, P: 596
Use of Modified ‘Bentone-34’ for the Gas Chromatographic Separation of Aromatic Hydrocarbons

J. V. MORTIMER
P. L. GENT
Research23 Feb 1963
Nature

Volume: 197, P: 789-790
CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cells

There is an unmet need to discover suitable targets for CAR-T therapy in patients with acute myeloid leukemia (AML). Here the authors show that GRP78, a key regulator of the unfolded protein response, is highly expressed on the surface of primary AML blasts, but not on normal lymphocytes and hematopoietic progenitor cells, and that GRP78-CAR T have anti-AML activity in preclinical models.

Nikhil Hebbar
Rebecca Epperly
M. Paulina Velasquez
ResearchOpen Access31 Jan 2022
Nature Communications

Volume: 13, P: 1-14
Respiratory Distress in a Newborn Foal with Failure to form Lung Lining Film

P. D. ROSSDALE
R. E. PATTLE
L. W. MAHAFFEY
Research30 Sept 1967
Nature

Volume: 215, P: 1498-1499
The effects of iron-dextran on squirrel monkeys (Saimiri sciurea)

R L Carter
W H Percival
F J Roe
Research01 Mar 1968
British Journal of Cancer

Volume: 22, P: 116-121
Sun–climate links

T. M. L. Wigley
News & Views27 Nov 1980
Nature

Volume: 288, P: 317-318
Modular chimeric cytokine receptors with leucine zippers enhance the antitumour activity of CAR T cells via JAK/STAT signalling

Replacing the extracellular domains of heterodimeric cytokine receptors in chimeric antigen receptor T cells with two leucine zipper motifs leads to optimal JAK/STAT signalling and augments the effector function of the T cells.

Matthew Bell
Shannon Lange
Stephen Gottschalk
Research30 Nov 2023
Nature Biomedical Engineering

Volume: 8, P: 380-396
Carcinogenesis in rabbits injected at birth with 7,12-dimethylbenz(a)anthracene.

F J Roe
R L Carter
W H Percival
Research01 Dec 1967
British Journal of Cancer

Volume: 21, P: 815-820
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines

Here, the authors describe a potent and selective CK1a molecular glue degrader with a broad antiproliferative potency. Crystallographic data provide rationale for the high degradation efficacy displayed by this compound.

Gisele Nishiguchi
Lauren G. Mascibroda
Zoran Rankovic
ResearchOpen Access16 Jan 2024
Nature Communications

Volume: 15, P: 1-17
Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2

Lars J. Cisek
Jeffry L. Corden
Research29 Jun 1989
Nature

Volume: 339, P: 679-684
Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse transcriptase (TERT) expression via ZNF148.

Jun Fang
Jinping Jia
Laufey T. Amundadottir
ResearchOpen Access27 Apr 2017
Nature Communications

Volume: 8, P: 1-17
Chromosomal instability is correlated with telomere erosion and inactivation of G2 checkpoint function in human fibroblasts expressing human papillomavirus type 16 E6 oncoprotein

Leonid Filatov
Vita Golubovskaya
William K Kaufmann
Research23 Apr 1998
Oncogene

Volume: 16, P: 1825-1838
Oncogene ect2 is related to regulators of small GTP-binding proteins

Toru Miki
Cheryl L. Smith
Timothy P. Fleming
Research01 Apr 1993
Nature

Volume: 362, P: 462-465
A protein linkage map of Escherichia coli bacteriophage T7

Paul L. Bartel
Jennifer A. Roecklein
Stanley Fields
Research01 Jan 1996
Nature Genetics

Volume: 12, P: 72-77
A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1

Triazole antifungals are widely used and exert their action by inhibiting ergosterol biosynthesis. Here, Rybak et al show that these drugs both inhibit ergosterol biosynthesis and induce accumulation of pathway intermediates that directly induce inhibition of sterol synthesis.

Jeffrey M. Rybak
Jinhong Xie
Jarrod R. Fortwendel
ResearchOpen Access29 Apr 2024
Nature Communications

Volume: 15, P: 1-16
Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection

Two distinct pathways control inflammasome activation during Aspergillus fumigatus infection. The C-type lectin receptor (CLR) pathway activates MAPK and NF-κB signalling, whereas Toll-like receptor (TLR) signalling is activated through MyD88 and TRIF. Both pathways activate transcription factor IRF1, which induces antifungal effector IRGB10.

Benoit Briard
Rajendra Karki
Thirumala-Devi Kanneganti
Research03 Dec 2018
Nature Microbiology

Volume: 4, P: 316-327
Cell cycle control by timer and sizer in Chlamydomonas

Lorraine Donnan
Peter C. L. John
Research18 Aug 1983
Nature

Volume: 304, P: 630-633
Rb regulates proliferation and rod photoreceptor development in the mouse retina

Jiakun Zhang
Jonathan Gray
Michael A Dyer
Research29 Feb 2004
Nature Genetics

Volume: 36, P: 351-360
p53 missense but not truncation mutations are associated with low levels of p21^CIP1/WAF1mRNA expression in primary human sarcomas

S Mousses
N Gokgoz
I L Andrulis
ResearchOpen Access12 Jun 2001
British Journal of Cancer

Volume: 84, P: 1635-1639
The Xenopus localized messenger RNA An3 may encode an ATP-dependent RNA helicase

R. Gururajan
H. Perry-O'Keefet
D. L. Weeks
Research21 Feb 1991
Nature

Volume: 349, P: 717-719
Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer

A multi-modal analysis of pre-metastatic liver biopsies from patients with localized pancreatic cancer with a minimum of 3 years of follow-up shows that immunological, proliferative and metabolomic features distinguish patients who develop metastases from disease-free survivors and can be used to predict outcomes.

Linda Bojmar
Constantinos P. Zambirinis
David Lyden
Research28 Jun 2024
Nature Medicine

Volume: 30, P: 2170-2180
Spontaneous X chromosome MI and MII nondisjunction events in Drosophila melanogaster oocytes have different recombinational histories

Kara E. Koehler
Christina L. Boulton
R. Scott Hawley
Research01 Dec 1996
Nature Genetics

Volume: 14, P: 406-414
Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

Alan F. Wahl
Karen L. Donaldson
Denise A. Galloway
Research01 Jan 1996
Nature Medicine

Volume: 2, P: 72-79
Control of de nova Isocitrate Lyase Synthesis in Chlorella

W. McCULLOUGH
P. C. L. JOHN
Research13 Oct 1972
Nature

Volume: 239, P: 402-405
Identification of a Gl-type cyclin puc1⁺ in the fission yeast Schizosaccharomyces pombe

Susan L. Forsburg
Paul Nurse
Research16 May 1991
Nature

Volume: 351, P: 245-248
TCP1 complex is a molecular chaperone in tubulin biogenesis

Michael B. Yaffe
George W. Farr
Himan Sternlicht
Research16 Jul 1992
Nature

Volume: 358, P: 245-248
The whole-genome landscape of medulloblastoma subtypes

Genomic analysis of 491 medulloblastoma samples, including methylation profiling of 1,256 cases, effectively assigns candidate drivers to most tumours across all molecular subgroups.

Paul A. Northcott
Ivo Buchhalter
Peter Lichter
ResearchOpen Access20 Jul 2017
Nature

Volume: 547, P: 311-317
Observations on the RNA Metabolism of Leukaemic Cell Cultures

R. L. TYNDALL
E. TEETER
Research01 Jul 1967
Nature

Volume: 215, P: 79-80
Clustering of missense mutations in the ataxia-telanglectasia gene in a sporadic T-cell leukaemia

Igor Vořechovský
Liping Luo
Martin A.R. Yuille
Research01 Sept 1997
Nature Genetics

Volume: 17, P: 96-99
NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells

William Evans and colleagues find that the proinflammatory genes CASP1 and NLRP3 are expressed at higher levels in primary acute lymphoblastic leukemia cells that are resistant than in those that are sensitive to glucocorticoid treatment. They find that CASP1 mediates glucocorticoid resistance through cleavage of the glucocorticoid receptor.

Steven W Paugh
Erik J Bonten
William E Evans
Research04 May 2015
Nature Genetics

Volume: 47, P: 607-614
The preference for sugar over sweetener depends on a gut sensor cell

Buchanan, Rupprecht, Kaelberer and colleagues show that the preference for sugar over sweetener in mice depends on gut neuropod cells. Akin to other sensor cells, neuropod cells swiftly communicate the precise identity of stimuli to drive food choices.

Kelly L. Buchanan
Laura E. Rupprecht
Diego V. Bohórquez
ResearchOpen Access13 Jan 2022
Nature Neuroscience

Volume: 25, P: 191-200

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