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Whole-genome sequencing of 3,171 cultivated and 195 wild chickpea accessions is used to construct a chickpea pan-genome, providing insight into chickpea evolution and enabling breeding strategies that could improve crop productivity.

Breather solitons can be found in both physical and biological nonlinear systems. Here, Yuet al. demonstrate this type of soliton in silicon and silicon nitride microresonators, which advances the understanding of soliton-based comb-generation in microresonators.

Understanding the decay of persistent current in superconducting rings remains obscure. Here, the authors show detailed agreement between measurements of the persistent current in isolated flux-biased rings and Ginzburg-Landau theory over a wide range of parameters, providing a quantitative picture of the free energy landscape.

Multiplexed error-robust fluorescence in situ hybridization (MERFISH) together with deep-learning-based nucleus segmentation enabled the construction of a highly detailed and informative spatially resolved single-cell atlas of human fetal cortical development.

The most up-to-date combination of results on the properties of the Higgs boson is reported, which indicate that its properties are consistent with the standard model predictions, within the precision achieved to date.

The biosynthesis of the [FeFe] hydrogenase active site H-cluster requires several Fe–S proteins that perform poorly understood reactions. Now, a reaction intermediate trapped in the enzyme HydG is shown to contain a [(Cys)Fe(CO)(CN)] species identified as the first organometallic Fe moiety en route to the catalytic H-cluster.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Frequency comb synthesizers are important for metrology, but they have been difficult to use as frequency rulers in the terahertz region due to their low power. Consolinoet al. phase-lock a quantum cascade laser to a free-space-propagating terahertz comb, demonstrating that they can overcome this limitation.

In the electronic health record, using clinical notes to identify entities such as disorders and their temporality can inform many important analyses. Here, the authors present a framework for weakly supervised entity classification using medical ontologies and expert-generated rules.

A TLAF is an archetypal geometrically frustrated magnetic system, which serves as the foundation for many exotic states, including quantum spin-liquids. Here, Park et al perform INS measurements on BLCTO, which, combined with theoretical calculations, reveal distinctive fingerprints of spinon excitations, thereby suggesting proximity to a spin liquid even in the presence of strong XXZ anisotropy.

Hole-based spin qubits in planar Ge is a promising system for advancing scalable spin qubit processors. Here the authors demonstrate the strong hole charge-photon coupling and probe Wigner molecule states in a cavity-quantum dot hybrid architecture on planar Ge.

Chang, Cao et al. examine local trends associated with the diagnosis and treatment of de novo metastatic breast cancer. Findings show that black race, hypertension, diabetes, as well as the presence of visceral metastases are associated with a worse prognosis.

Neonatal antibiotic use is shown to reduce immune response to infant vaccines, accompanied by reduced abundance of Bifidobacteria in the gut microbiota, with experiments in mice indicating that probiotic therapy could be beneficial.

What can we learn from spatial patterns in the ocean? This study suggests planktonic patterns are uncorrelated from physical patchiness, poorly captured from satellite observations, and an underutilized window into ocean biogeochemistry.

This study reveals that in people with first episode of psychosis receiving oral antipsychotic medication, switching to long-acting injectable antipsychotic therapy may reduce psychotic relapses, especially in vulnerable subgroups, such as those with prior relapses or non-adherence to antipsychotic medication.

Ultrafast photoexcitation stabilizes new states of matter with rich out-of-equilibrium behaviours. Here, Lantzet al. report a transient non-thermal phase developing immediately after photoexcitation in V₂O₃, shedding a light on optical manipulation of strongly correlated systems.

Dual-comb spectroscopy is a powerful tool for realizing rapid spectroscopic measurements with high sensitivity and selectivity. Here, Yu et al. demonstrate silicon microresonator-based dual comb spectroscopy in the mid-infrared region, where strong vibrational resonances of many liquids exist.

The authors reveal that, in fruit fly ovaries, the protein Rhino is guided to specific regions of the genome by a combination of two histone modifications, enhancing understanding of how cells protect their DNA from harmful virus-like elements.

Carcinoma subtypes are normally linked to specific genetic alterations, but tissue mechanical changes also play a role. Now, aberrant morphologies resembling bladder carcinoma are shown to emerge from stiffness changes during epithelial overgrowth.

Chromosome-level genome assemblies of nine tetraploid and two diploid wild Oryza species provide insights into genome evolution within the genus Oryza and the potential for crop improvement and neodomestication.

The deformation mechanisms of twin boundaries in nanotwinned metallic materials are still unclear. Here the authors combine in situ transmission electron microscopy tensile tests and molecular dynamics simulations with a dislocation-based theoretical model to reveal the deformation mechanism of nanotwins.

When excitons in light-harvesting materials meet, they recombine and dissipate their energy. Here, the authors show that pairs of excitons can co-exist in aggregated materials and only annihilate when the aggregates are chemically connected.

The second Global Amphibian Assessment finds that the status of amphibians is continuing to deteriorate globally, driven predominantly by climate change, disease and habitat loss.

Two-dimensional materials are promising for electrochemical energy storage, conversion, catalysis, and sensing. Here the authors leverage strain engineering using a two-dimensional stacked carbon-MoS₂ material to control chemical storage pathways in MoS₂upon lithium metal insertion.

Active control of optical fields at the nanoscale is difficult to achieve. Here, the authors fabricate an on-chip graphene NEMS suspended a few tens of nanometres above nitrogen vacancy centres and demonstrate electromechanical control of the photons emitted by electrostatic tuning of the graphene NEMS position.

Interferometric detection schemes exploit phase-sensitive combination of spatially separated observation to increase sensitivity. Here, the authors combine data from two atomic comagnetometers separated by 860 km to improve limits on axion-like particles across nine orders of magnitude of mass range.

Material implementation of machine learning algorithms for advanced computing at cryogenic temperature remains rare. Here, the authors report a cryogenic in-memory computing platform using chiral edge states of magnetic topological insulators.

Correlating aromatic carbons attached to fluorine with meta-position hydrogens in fluorine-labelled phenylalanines can yield two-dimensional correlations with narrow linewidths in large proteins. Adapting phenylalanine-tRNA synthetase increases the incorporation rate, while expanding the genetic code enables site-specific incorporation of fluorinated phenylalanine. The resulting HC_F-transverse relaxation-optimized spectroscopy can illuminate protein dynamics and drive multiplexed drug discovery campaigns.

Great efforts are being made to develop advanced polygenic risk scores (PRS) to improve the prediction of complex traits and diseases. However most existing PRS are primarily trained on European ancestry populations, limiting their transferability to non-European populations. Here the authors propose a new multi-ancestry PRS method, PROSPER, to reduce disparity of PRS performance across ancestry groups.

The pseudo-gap phenomenon is central to the description of high-T_csuperconductivity in copper oxides. Here, the authors investigate nearly optimally doped YBCO using polarized neutron scattering to characterize intra-unit-cell magnetic correlations in relation with the pseudo-gap temperature.

Based on observations in crystalline MgF₂ and planar Si₃N₄ microresonators, scientists reveal that the existence of multiple and broad-beat notes in a Kerr-frequency comb is due to the formation dynamics of the comb itself. This work identifies the conditions requires for low-phase-noise performance and also helps to elucidate a number of yet-unexplained phenomena.

The phase transitions of rare earth nickelates have attracted intensive study as they arise from the complex interplay of charge, spin and lattice degrees of freedom. Here Guo et al. present evidence that LaNiO₃ has an unanticipated magnetically ordered metallic phase.