Nature Search

Ixekizumab for the treatment of psoriatic arthritis: an Italian multicentric retrospective observational study

Stefano Gentileschi
Riccardo Terribili
Serena Guiducci
ResearchOpen Access19 Feb 2026
Scientific Reports

Volume: 16, P: 1-10
Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B

Type I interferons have been described to have protumor or antitumor functions depending on context. Here the authors show a protumor function for type I interferons in that they promote cancer stem cells by upregulating the chromatin remodeling factor KDM1B.

Martina Musella
Andrea Guarracino
Antonella Sistigu
ResearchOpen Access24 Aug 2022
Nature Immunology

Volume: 23, P: 1379-1392
A light-resuming strategy as a screening method for selecting Sec61 inhibitors down-modulating PD-L1 expression

Here the authors develop an assay capable of selecting Sec61 inhibitors by exploiting the inactivation of firefly luciferase, once translocated into the endoplasmic reticulum (ER), and the possibility of diverting and “re-lighting” luciferase into the cytosol by a Sec61 inhibitor.

Fulvia Vitale
Gianluca Scerra
Massimo D’Agostino
ResearchOpen Access06 Aug 2025
Nature Communications

Volume: 16, P: 1-14
MRP3 is a sex determining gene in the diatom Pseudo-nitzschia multistriata

Little is known about how sex is determined in diatoms. Here, Russo et al. show that in the diatom Pseudo-nitzschia multistriata, the gene MRP3 regulates mating type and the expression of four other mating-type biased genes.

Monia T. Russo
Laura Vitale
Maria I. Ferrante
ResearchOpen Access28 Nov 2018
Nature Communications

Volume: 9, P: 1-10
Author Correction: Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B

Martina Musella
Andrea Guarracino
Antonella Sistigu
Amendments and CorrectionsOpen Access17 Sept 2024
Nature Immunology

Volume: 25, P: 2166
Tissue Mineral Levels in Victims of Sudden Infant Death Syndrome II. Essential Minerals: Copper, Zinc, Calcium, and Magnesium

Marilyn M Erickson
Alphonse Poklis
Laura S Hillman
Research01 Oct 1983
Pediatric Research

Volume: 17, P: 784-787
Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease

Multi-ancestry genome-wide association analyses identify new risk loci for Parkinson’s disease, and fine-mapping and co-localization analyses implicate candidate genes whose expression is associated with disease susceptibility.

Jonggeol Jeffrey Kim
Dan Vitale
Ignacio Mata
ResearchOpen Access28 Dec 2023
Nature Genetics

Volume: 56, P: 27-36
Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing

Here the authors identify TNIP1 as a risk factor for a fatal neurodegenerative disorder and discover specific genetic loci associated with the three main subtypes of this disorder. The findings highlight distinct disease mechanisms, emphasizing the roles of immunity and the notch signaling pathway.

Cyril Pottier
Fahri Küçükali
Rosa Rademakers
ResearchOpen Access25 Apr 2025
Nature Communications

Volume: 16, P: 1-19
Quantitative X-ray phase-contrast digital histology of liver metastases in a mouse model

Lorenzo Massimi
Sara Vitale
Alessia Cedola
ResearchOpen Access26 May 2025
Scientific Reports

Volume: 15, P: 1-10
Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell subsets

Bhardwaj et al. report that adding Flt3 ligand to the treatment strategy effectively increased DC populations and increased T-cell responses in a randomized phase II trial of a DC-targeted vaccine for the melanoma antigen NY-ESO-1.

Nina Bhardwaj
Philip A. Friedlander
Steven P. Fling
Research16 Nov 2020
Nature Cancer

Volume: 1, P: 1204-1217
Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

Anthracyclines can induce a type 1 interferon response in tumor cells that may predict clinical response to these drugs.

Antonella Sistigu
Takahiro Yamazaki
Laurence Zitvogel
Research26 Oct 2014
Nature Medicine

Volume: 20, P: 1301-1309
Xanthohumol modulate autophagy and ER stress to counteract stemness and enhance cisplatin efficacy in head and neck squamous cell carcinoma

Vitale Del Vecchio
Ibone Rubio Sanchez-Pajares
Luigi Laino
ResearchOpen Access16 Apr 2025
Scientific Reports

Volume: 15, P: 1-13
Baseline T-lymphocyte subset absolute counts can predict both outcome and severity in SARS-CoV-2 infected patients: a single center study

Marco Iannetta
Francesco Buccisano
Loredana Sarmati
ResearchOpen Access17 Jun 2021
Scientific Reports

Volume: 11, P: 1-13
Phylogeography and genomic epidemiology of SARS-CoV-2 in Italy and Europe with newly characterized Italian genomes between February-June 2020

Alessia Lai
Annalisa Bergna
Dario Russignaga
ResearchOpen Access06 Apr 2022
Scientific Reports

Volume: 12, P: 1-12
β₂-AR inhibition enhances EGFR antibody efficacy hampering the oxidative stress response machinery

Vitale Del Vecchio
Luigi Mele
Vincenzo Desiderio
ResearchOpen Access19 Sept 2023
Cell Death & Disease

Volume: 14, P: 1-10
Vitreomacular interface abnormalities in the Ghanaian African

Winfried M. Amoaku
Laura Cushley
Christopher Ricks
ResearchOpen Access29 Sept 2023
Eye

Volume: 38, P: 578-584
The LRRK2 p.L1795F variant causes Parkinson’s disease in the European population

Lara M. Lange
Kristin Levine
Masharip Atadzhanov
ResearchOpen Access25 Mar 2025
npj Parkinson's Disease

Volume: 11, P: 1-10
Multiannual patterns of genetic structure and mating type ratios highlight the complex bloom dynamics of a marine planktonic diatom

Maria Valeria Ruggiero
Marina Buffoli
Marina Montresor
ResearchOpen Access12 Mar 2024
Scientific Reports

Volume: 14, P: 1-11
β₂-AR blockade potentiates MEK1/2 inhibitor effect on HNSCC by regulating the Nrf2-mediated defense mechanism

Luigi Mele
Vitale Del Vecchio
Antonio Barbieri
ResearchOpen Access13 Oct 2020
Cell Death & Disease

Volume: 11, P: 1-14
Hydrogen sulfide prevents apoptosis of human PMN via inhibition of p38 and caspase 3

Laura Rinaldi
Giuliana Gobbi
Marco Vitale
Research30 Jan 2006
Laboratory Investigation

Volume: 86, P: 391-397
Objective quantification of homophily in children with and without disabilities in naturalistic contexts

Chitra Banarjee
Yudong Tao
Daniel S. Messinger
ResearchOpen Access17 Jan 2023
Scientific Reports

Volume: 13, P: 1-11
Biomolecular analysis of the Epigravettian human remains from Riparo Tagliente in northern Italy

Biomolecular investigation of Epigravettian human remains from Riparo Tagliente in northern Italy using paleogenetics, stable isotopes and radiocarbon dating.

Orhan Efe Yavuz
Gregorio Oxilia
Cosimo Posth
ResearchOpen Access30 Oct 2024
Communications Biology

Volume: 7, P: 1-8
Diagnostic accuracy of liver stiffness measurement for the diagnosis of veno-occlusive disease/sinusoidal obstruction syndrome after hematopoietic stem cell transplantation (HSCT), the ELASTOVOD STUDY: an investigator-initiated, prospective, multicentre diagnostic clinical trial

Federico Ravaioli
Antonio Colecchia
Francesca Bonifazi
Research19 Apr 2025
Bone Marrow Transplantation

Volume: 60, P: 978-993
Microfabricated intracortical extracellular matrix-microelectrodes for improving neural interfaces

Wen Shen
Suradip Das
Mark G. Allen
ResearchOpen Access24 Sept 2018
Microsystems & Nanoengineering

Volume: 4, P: 1-15
Brivanib in combination with Notch3 silencing shows potent activity in tumour models

Catia Giovannini
Anna Maria Salzano
Laura Gramantieri
ResearchOpen Access15 Feb 2019
British Journal of Cancer

Volume: 120, P: 601-611
Analysis of the ATR-Chk1 and ATM-Chk2 pathways in male breast cancer revealed the prognostic significance of ATR expression

Anna Di Benedetto
Cristiana Ercolani
Marcello Maugeri-Saccà
ResearchOpen Access14 Aug 2017
Scientific Reports

Volume: 7, P: 1-9
Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

Clodagh Towns
Madeleine Richer
Masharip Atadzhanov
ResearchOpen Access12 Sept 2023
npj Parkinson's Disease

Volume: 9, P: 1-6
Clonal expansion behind a marine diatom bloom

Maria Valeria Ruggiero
Domenico D'Alelio
Marina Montresor
Research21 Nov 2017
The ISME Journal

Volume: 12, P: 463-472
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi
Ilio Vitale
Guido Kroemer
ReviewsOpen Access23 Jan 2018
Cell Death & Differentiation

Volume: 25, P: 486-541

Search

Ixekizumab for the treatment of psoriatic arthritis: an Italian multicentric retrospective observational study

Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B

A light-resuming strategy as a screening method for selecting Sec61 inhibitors down-modulating PD-L1 expression

MRP3 is a sex determining gene in the diatom Pseudo-nitzschia multistriata

Author Correction: Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B

Tissue Mineral Levels in Victims of Sudden Infant Death Syndrome II. Essential Minerals: Copper, Zinc, Calcium, and Magnesium

Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease

Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing

Quantitative X-ray phase-contrast digital histology of liver metastases in a mouse model

Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell subsets

Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

Xanthohumol modulate autophagy and ER stress to counteract stemness and enhance cisplatin efficacy in head and neck squamous cell carcinoma

Baseline T-lymphocyte subset absolute counts can predict both outcome and severity in SARS-CoV-2 infected patients: a single center study

Phylogeography and genomic epidemiology of SARS-CoV-2 in Italy and Europe with newly characterized Italian genomes between February-June 2020

β₂-AR inhibition enhances EGFR antibody efficacy hampering the oxidative stress response machinery

Vitreomacular interface abnormalities in the Ghanaian African

The LRRK2 p.L1795F variant causes Parkinson’s disease in the European population

Multiannual patterns of genetic structure and mating type ratios highlight the complex bloom dynamics of a marine planktonic diatom

β₂-AR blockade potentiates MEK1/2 inhibitor effect on HNSCC by regulating the Nrf2-mediated defense mechanism

Hydrogen sulfide prevents apoptosis of human PMN via inhibition of p38 and caspase 3

Objective quantification of homophily in children with and without disabilities in naturalistic contexts

Biomolecular analysis of the Epigravettian human remains from Riparo Tagliente in northern Italy

Diagnostic accuracy of liver stiffness measurement for the diagnosis of veno-occlusive disease/sinusoidal obstruction syndrome after hematopoietic stem cell transplantation (HSCT), the ELASTOVOD STUDY: an investigator-initiated, prospective, multicentre diagnostic clinical trial

Microfabricated intracortical extracellular matrix-microelectrodes for improving neural interfaces

Brivanib in combination with Notch3 silencing shows potent activity in tumour models

Analysis of the ATR-Chk1 and ATM-Chk2 pathways in male breast cancer revealed the prognostic significance of ATR expression

Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

Clonal expansion behind a marine diatom bloom

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

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