Search

The authors report a catalyst featuring Rh-Zn dual sites in a MoS₂ lattice integrated with TiO₂ for the photocatalytic carbonylation of CH₄ with CO and O₂ to CH₃COOH with a high productivity of 152.0 μmol g_cat.⁻¹ h⁻¹ and selectivity of 96.5%.

Rechargeable Na/Cl₂ and Li/Cl₂ batteries are produced with a microporous carbon positive electrode, aluminium chloride in thionyl chloride as the electrolyte, and either sodium or lithium as the negative electrode.

The microglia–neuron interactions contributing to neuronal hyperexcitability are unclear. Here, the authors show how GABA and C3 signaling coordinate microglial engulfment of inhibitory synapses, driving excitatory–inhibitory imbalance and neuronal hyperexcitability in epilepsy.

Follicle-stimulating hormone (FSH) is involved in mammalian reproduction, but several studies have suggested a role of FSH and its receptor in extragonadal tissue. Here, the authors show that FSH orchestrates glucose-stimulated insulin secretion (GSIS) via its receptor on pancreatic β-cells, with pre-menopausal FSH levels dose-dependently promoting GSIS and postmenopausal FSH levels inhibiting this effect.

Mycobacterium tuberculosis suppresses the production of inflammatory cytokines by host cells through the host-mediated ubiquitination of a mycobacterial protein, enhancing the interaction of a host signalling inhibitor with another signalling molecule.

The primary entry route of vanilloid ligands to the vanilloid-binding site in transient receptor potential vanilloid 1 (TRPV1) is found to be a distinct and targetable hydrophobic pathway at the TRPV1–cell membrane interface rather than through direct membrane penetration.

The formation of tertiary lymphoid structures (TLS) is promising for boosting cancer immunotherapy, but it is challenging to develop potential inducers for TLS formation. Here, the authors report a covalent organic framework (COF) that is able to trigger TLS formation.

SARS-CoV-2 variants with immune escape capability highlight the need for the development of cross-neutralising vaccines and regimens. Here, the authors assess the immunogenicity and safety of NVSI-06-08, that integrates antigens from multiple SARS-CoV-2 strains into a single immunogen, as a heterologous booster in adults previously vaccinated with the inactivated vaccine.

Autonomous delivery of exogenous cargo into plant tissues is achieved by a nanocarrier system harnessing amino acid transporters, enabling force-free, species-independent uptake and ultra-low dose drought resistance in crops like soybean and maize.

Measuring the impact of energy policies towards emissions reduction and other sustainability goals is critical for designing effective future policy. Meng et al. assess the impact of energy policies in 42 Asia–Pacific countries and find that strategies are more effective than laws or regulations.

Catalytic syngas conversion is an essential part of sustainable chemical production but is hindered by the trade-off between conversion activity and product selectivity. Here the authors address this challenge by developing a catalytic shunt strategy.

A high-resolution microscopy screen of candidate nucleolar proteins identifies URB1 as a protein that is confined to the periphery of the dense fibrillar component, with key roles in pre-ribosomal RNA folding and processing.

Cheng et al. developed an autophagy-based targeted protein degradation platform by conjugating polyethylenimine to antibodies, designated as autophagy-inducing antibodies, which can degrade proteins in vivo and enable the degradation of multiple proteins at the same time.

In a prospective observational study, symptoms of anxiety and/or depression were associated with worse response to first-line treatment with immunotherapy in patients with advanced non-small-cell lung cancer.

Despite the importance of chiral macrocycles, their synthesis has lagged behind those of normal and medium-sized rings. Now a bio-inspired catalytic metallic dipole relay strategy enables access to the synthesis of axially chiral 14-, 15- and 20-membered macrocyclic products.

Pollen tubes constantly search for and respond to female cues for guided growth and efficient sperm delivery. In this study, the researchers characterized three MLO genes in Arabidopsis whose mutants showed twisting pollen tubes and deficiency in ovule targeting. As an ancient and vital gene family in plants, MLOs are also involved in pathogen resistance and plant–environment interactions.

The researchers demonstrate direct measurement and complete characterization of structured electronic wave packets created within a prototypical Fano resonance. The method may be broadly applicable to the study of ultrafast processes, especially electronic ones, in complex systems, as well as coherent control of such systems on their fundamental timescales.

Significant progress has been made in the field of CRISPR diagnostics, but it is still challenging to achieve multiplexed detection. Here authors exploit CRISPR-Cas12a cis-cleavage to develop a multiplexed assay which includes a portable device incorporating multiplexed PCR, Cas12a cis-cleavage, and lateral flow detection.

Investigating the inner structure of baryons is important to further our understanding of the strong interaction. Here, the BESIII Collaboration extracts the absolute value of the ratio of the electric to magnetic form factors and its relative phase for e + e − → J/ψ → ΛΣ decays, enhancing the signal thanks to the vacuum polarisation effect at the J/ψ peak.

An endohedral metallofullerene–polymer layer, which features ultrafast electron extraction and in situ encapsulation, improves the efficiency and stability of perovskite solar cells.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

m6A modification has been reported to play roles in many developmental and pathological processes, but its role in AKI remains poorly understood. Here, the authors show the role and the mechanism of the m6A demethylase, ALKBH5 on IRI induced AKI.

Thermoelectric materials could reduce energy losses by converting waste heat from various processes into electricity. To cater to the needs of wearable devices, the authors design Bi₂Te₃-based thin films that show both excellent thermoelectric performance and long-sought flexibility.

A quantum microsatellite, with a payload weighing only 23 kilograms, in combination with portable ground stations that weigh merely 100 kilograms, is capable of performing space-to-ground real-time quantum key distribution.

The genomic epidemiology of Acinetobacter baumannii, which is rising in virulence and multidrug resistance, was explored. This study examined bloodstream infection isolates from Chinese patients in 2011–2021, revealing increased genetic diversity and dominance of highly virulent ST208.

Local shear stress from an atomic force microscope tip can control the crystal directions in thin oxide films. This approach enables the manipulation of local magnetic anisotropy in ferromagnetic metals.

Cryo-electron microscopy structures of the human mitochondrial pyruvate carrier provide insights into its architecture, substrate transport mechanism and inhibition by the drug UK5099, with implications for the development of treatments for various metabolic diseases.

LMNA-related dilated cardiomyopathy (DCM) is an inherited cardiomyopathy featured by early-onset lethal arrhythmias, but the underlying mechanisms remain unclear. Here, the authors show that manipulation of impaired SIRT1 activity and excessive oxidative stress may offer new therapeutic strategies for LMNA-related DCM.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

The thymocyte development protein Tespa1 is known to translate T cell receptor signals by affecting the calcium signalling cascade, but it is not clear how. Here the authors show that Tespa1 recruits IP3R1 to the TCR signalling complex.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.