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Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology.

This paper determines the oxygen fugacity of the Chang’e-6 basalts from the South Pole–Aitken (SPA) basin on the farside of the Moon. The results show that the mantle beneath the farside SPA basin is more reduced than that beneath the nearside, as determined by the Apollo and Chang’e-5 basalts.

Treating myocardial reperfusion injury via nanotherapy is challenging due to clearance by the mononuclear phagocyte system. Here, the authors target the spleen to reduce acute heart injury and improve long-term cardiac function via transient IRF7 inhibition.

Wild relatives of wheat provide a valuable source of genes and allelic variants for wheat improvement. Here, the authors identify a type-B response regulator (RR) AcRR1 from Agropyron cristatum and show its potential of boosting wheat yield by increasing the grain number per spike and promoting early heading.

Currently, a serious public health crisis caused by PFAS is of great concern worldwide. Here, the authors propose a treatment-train strategy that combines Zn-based EC with the existing AC/AER devices to enable the broad-spectrum removal of hundreds of PFAS from fluorochemical production effluents.

Here, the authors use cryo electron tomography to investigate the in-situ assembly mechanisms of clustered protocadherin γB4, uncovering the functional contributions of full-length γB4 and role played by specific domains.

Oxidative stress is closely linked with nonalcoholic steatohepatitis (NASH). Here, the authors show that palmitic acid stimulates NASH by inhibiting PRDX1 to increase oxidative stress, while rosmarinic acid improves NASH by activating PRDX1 to reduce oxidative stress.

Cell fate decisions remain poorly understood at the molecular level. Here Ming et al. show that BMP4 as the signal diverting cell fate away from epiblast/pluripotency to hypoblast/primitive endoderm fate during JGES reprogramming by promoting the dissociation of SALL4 from NuRD.

Sakuranetin is an important phytoalexin. The authors find that sakuranetin in rice attenuates endocytosis of effectors from the fungus Magnaporthe oryzae and enhances resistance against rice blast.

The authors induce a phase boundary similar to Pb(Zr, Ti)O₃’s morphotropic phase boundary structure in (K, Na)NbO₃-based ceramics, which exhibit high residual polarization as well as a significantly improved piezoelectric constant d₃₃.

Resistance to ferroptosis in hepatocellular carcinoma remains to be understood. Here, the authors identify S100 calcium binding protein P (S100P) as a ferroptosis suppressor in HCC cells, which promotes lysosomal degradation of acetyl-CoA carboxylase alpha (ACC1) to downregulate lipid biosynthesis.

Long noncoding RNAs (lncRNAs) may contribute to cancer progression. Here the authors show that LncRNA INHEG modulates rRNA 2’-O-methylation and facilitates mRNA translation to promote glioma stem cell renewal and growth.

The lunar mantle may have remained reduced, according to the oxygen fugacity of 2.0 Ga Chang’e-5 basalt that is similar to 3.6 − 3.0 Ga Apollo basalts and pyroclastic glasses.

In situ reduction deposition is a scalable method for fabricating metal/MXene composites, but rational control remains difficult. Now an in situ reduction strategy for synthesizing metal/MXene composites with precise control over metal size, deposition site and nanostructure has been demonstrated.

This work reports a heterogeneous two transistor capacitorless eDRAM combining Si and MoS2 to solve the short data retention problem while preserving a high sense margin. The retention and sense margin show improvements of 1000 and 100 times respectively compared to full Si and MoS2 counterparts.

Mazdutide is a once-weekly glucagon-like peptide-1 (GLP-1) and glucagon receptor dual agonist. Here, the authors show mazdutide was well tolerated over 24 weeks and demonstrated significant and clinically meaningful body weight loss, compared with placebo, in Chinese overweight adults or adults with obesity.

Controllable synthesis of higher alcohols from CO hydrogenation remains a great challenge. Here the authors show that potassium-decorated edge-rich MoS₂ enables selective CO hydrogenation to higher alcohols by regulating the reaction kinetics of C-O cleavage, C-C coupling and desorption of alcohols.

The regulation of oncogenic protein sulfiredoxin-1 (SRX) remains to be understood. Here the authors show that SRX is targeted for ubiquitination and degradation by Keap1, the substrate-specific adaptor of the Cullin3 RING E3 ubiquitin ligase complex. Inactivation of Keap1 leads to accumulation of SRX and progression of colorectal cancer.

Any TFs other than OCT4 that can individually induce the formation of mouse iPSCs are currently lacking. Here, Xiao et.al. report a single-SALL4-mediated somatic reprogramming method and reveal the underlying mechanism of this process.

Analysis of lunar soils sampled by the Chang’e-5 mission suggests that impact glass beads may host a substantial inventory of solar wind-derived water on the Moon’s surface.

In peripheral artery disease (PAD), this randomized trial assessed whether nicotinamide riboside (NR), with and without resveratrol, improved walking, compared to placebo. Here, the authors show that NR meaningfully improves 6-min walk, and resveratrol did not add benefit to NR alone.

The use of synthetic chromosomes and the recombinase-based SCRaMbLE system could enable rapid strain evolution through massive chromosome rearrangements. Here the authors present ReSCuES, which uses auxotrophic markers to rapidly identify yeast with rearrangements for strain engineering.

Aryl hydrocarbon receptor is best known as an inducer of detoxification enzymes in response to xenobiotics, but is also increasingly recognized as a negative regulator of immune responses. Here the authors show that it inhibits transcription of a key component of the inflammasome, a sensor of cellular infection-associated stress.

Laboratory analysis of returned Chang’E-5 samples from the lunar surface show their hydroxyl contents to be on the weak end of lunar hydration features.

A reusable camellia meal-based adhesive with reliability and responsiveness is designed by leveraging the cooperation of dynamic covalent bonds (DCBs) and dynamic noncovalent bonds (DNBs). These dual dynamic bonds synergy strategy allows the resulting adhesive with a much-improved and multi-purposed adhesion properties (2.1/1.06 MPa to wood in dry/wet condition) and remarkable adhesion maintenance against harsh environmental factors (organic solvents, salt, acid, alkali, temperature, soaking time). With the assistance of synergistic dynamic network, our adhesive also possesses enhanced mildew resistance and reusable adhesion, contributing to break the inherent limitation in biomaterials.

Somatic reprogramming involves both transcriptional and epigenetic resetting, but we don’t yet fully understand this process. Here they show that Jdp2, Glis1, Esrrb, and Sall4 can mediate reprogramming by recruiting the NuRD complex to close chromatin, highlighting a potential role in cell fate control.

The NLRP3 inflammasome controls the response of the host to pathogens; precise regulation is required to limit autoimmune diseases. Here, the authors identify the E3 ligase TRIM31 that aids the ubiquitin-mediated proteasomal degradation of NLRP3, which may be a therapeutic target for alleviating disease.

Abdominal fat deposition is an important trait in chickens farmed for food. Here, the authors study this trait by integrating -omics data from several sources to construct a 3D chromatin map and validate key variants.

The lack of efficient, inexpensive catalysts hinders large-scale application of hydrogen evolution reaction (HER). Here, the authors report a MoS₂ nanofoam catalyst with co-confined Se in the surface and Co in the inner layer, exhibiting high large-current-density HER activity and durability.

RIPK1 is a critical kinase which mediates necroptosis, apoptosis and inflammation. Regulation of RIPK1 by ubiquitination is being intensively investigated. Here, the authors made knock-in RIPK1-K612R mice and demonstrate that this mutation alters the RIPK1 ubiquitinylation pattern and inhibits its prodeath kinase activity in response to TNFα but sensitizes cell death to TLRs signals.

The molecular mechanisms that regulate T_H17 cell diversity are poorly understood. Ouyang et al. show that the transcription factor interferon regulatory factor-8 is required for T_H17-cell differentiation and that its absence increases the severity of an experimental model of colitis.